PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Ceprp21 Uncharacterized protein T18D3.7 14704431 biogrid,intact exp G Ceprp21 fem-2 19123269 intact exp Ceprp21 F54D1.1 18692475,unassigned701 biogrid,intact exp Ceprp21 ZK930.3a 14704431 biogrid,intact exp G Ceprp21 Y113G7B.23c 14704431 biogrid,intact exp G Ceprp21 tir-1 14704431 biogrid,intact exp G Ceprp21 T08E11.4 14704431 intact exp Ceprp21 ima-2 14704431 biogrid,intact exp G Ceprp21 M110.4a 18692475,unassigned701 biogrid,intact exp G T24E12.6b Ceprp21 14704431 biogrid,intact exp Ceprp21 W04D2.1a 14704431 biogrid,intact exp G Ceprp21 Y48E1B.7 18692475,unassigned701 biogrid,intact exp Ceprp21 Y39B6A.12b 14704431 biogrid,intact exp Ceprp21 vav-1 23549480 intact exp G Ceprp21 R12B2.2 18692475,unassigned701 biogrid,intact exp G Ceprp21 T08E11.2 14704431 biogrid exp Ceprp21 F11A10.2 18692475,unassigned701,14704431 biogrid,intact exp, ortho G Ceprp21 T13H5.4 18692475,unassigned701,14704431 biogrid,intact exp, ortho G Ceprp21 pbs-3 18692475,unassigned701 biogrid,intact exp, ortho G Ceprp21 mtr-4 ortho G Ceprp21 Ceprp21 ortho G Histone deacetylase Ceprp21 ortho G Ceprp21 mog-2 ortho G Ceprp21 F53H1.1a ortho G Ceprp21 Uncharacterized protein T27F2.1 ortho G Ceprp21 H27M09.1 ortho G Ceprp21 enol-1 ortho Ceprp21 Putative pre-mRNA-splicing factor ATP-dependent RNA helicase F56D2.6 ortho G Ceprp21 rpt-2 ortho G Ceprp21 Y116A8C.12 ortho G Ceprp21 DNA helicase ortho G Ceprp21 C07H6.4 ortho G Ceprp21 Y39G10AR.14a ortho Ceprp21 Ubiquitin carboxyl-terminal hydrolase ortho G Ceprp21 Y57G7A.10 ortho G Ceprp21 M03C11.7 ortho G Ceprp21 C29F9.7 ortho G Ceprp21 hda-6 ortho G Ceprp21 snr-3 ortho G Ceprp21 pas-1 ortho G Ceprp21 R12E2.3 ortho G Ceprp21 pbs-6 ortho G Ceprp21 Putative U5 small nuclear ribonucleoprotein 200 kDa helicase ortho G Ceprp21 Y39E4B.1 ortho G Ceprp21 ZK616.4 ortho G Ceprp21 Y53F4B.22a ortho G Ceprp21 C46F11.4 ortho G Ceprp21 dhc-1 ortho G Ceprp21 pas-5 ortho G Ceprp21 C35A5.9 ortho Ceprp21 lgg-2 ortho G Ceprp21 kin-3 ortho G Ceprp21 D1081.8 ortho G Ceprp21 WW domain-containing protein ZK1098.1 ortho G Ceprp21 K08D10.3a ortho G Ceprp21 snr-1 ortho G Ceprp21 snr-4 ortho G Ceprp21 F09D1.1 ortho G Ceprp21 prp-8 ortho G Ceprp21 cul-3 ortho G Ceprp21 F58E10.3a ortho G Ceprp21 F53B7.3 ortho G Ceprp21 K08D10.4 ortho G Ceprp21 cand-1 ortho G Ceprp21 Y110A7A.8 ortho G Ceprp21 F21D5.7 ortho G Ceprp21 F27C1.6 ortho G Ceprp21 D1054.15a ortho G Ceprp21 spt-16 ortho G Ceprp21 C36B1.5 ortho G Ceprp21 F41E6.4a ortho G Ceprp21 npp-17 ortho G Ceprp21 K02F2.3 ortho G Ceprp21 lgg-1 ortho G Ceprp21 T08A11.2 ortho G Ceprp21 Putative transcription elongation factor S-II ortho Ceprp21 C50F2.3 ortho G Ceprp21 rsp-3 ortho G Ceprp21 mcm-5 ortho Ceprp21 Y59A8B.6 ortho G Ceprp21 gsk-3 ortho G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q86DA5-2 G5ECL3 - 14704431 - X 2 G5EF87 G5ECL3 - 14704431 - X 2 G5ECL3 - 14704431 - X 2 G5ECL3 - 14704431 - X 2 Q23158 G5ECL3 - 14704431 - X 2 O76640 G5ECL3 - 14704431 - X 2 Q22469 G5ECL3 - 14704431 - X 2 G5ECL3 - 14704431 - X 2 G5ECL3 P91276 - 14704431 - X 2 G5ECL3 Q8MYP3 - 14704431 - X 2 G5ECL3 Q19335 - 14704431 - X 2 G5EF87 G5ECL3 two hybrid 14704431 direct interaction X 2 G5ECL3 Q21954 two hybrid 18692475 direct interaction X 2 G5ECL3 Q86DA5-5 two hybrid 14704431 direct interaction X 2 G5ECL3 two hybrid 14704431 direct interaction X 2 O45950 G5ECL3 two hybrid 18692475 direct interaction X 2 A9D7R4 G5ECL3 two hybrid 14704431 direct interaction X 2 Q22469 G5ECL3 two hybrid 18692475 direct interaction X 2 Q22469 G5ECL3 two hybrid 18692475 direct interaction X 2 Q22469 G5ECL3 two hybrid 14704431 direct interaction X 2 Q20763 G5ECL3 two hybrid 18692475 direct interaction X 2 G5ECL3 Q19335 two hybrid 18692475 direct interaction X 2 G5ECL3 B5BM24 two hybrid 18692475 direct interaction X 2 G5ECL3 Q23237 two hybrid 18692475 direct interaction X 2 G5ECL3 Q19335 two hybrid 18692475 direct interaction X 2 G5ECL3 Q19335 two hybrid 14704431 direct interaction X 2 G5ECL3 P91276 two hybrid 14704431 direct interaction X 2 G5ECL3 Q9XVU8 two hybrid 14704431 direct interaction X 2 G5ECL3 Q8MYP3 two hybrid 14704431 direct interaction X 2 G5ECL3 Q23664 two hybrid 14704431 direct interaction X 2 G5ECL3 two hybrid 14704431 direct interaction X 2 G5EF87 G5ECL3 two hybrid 14704431 physical association X 2 O44878 G5ECL3 two hybrid 14704431 physical association X 2 G5ECL3 two hybrid 14704431 physical association X 2 Q23158 G5ECL3 two hybrid 14704431 physical association X 2 O76640 G5ECL3 two hybrid 14704431 physical association X 2 Q22469 G5ECL3 two hybrid 14704431 physical association X 2 G5ECL3 Q19335 two hybrid 14704431 physical association X 2 G5ECL3 Q86DA5 two hybrid 14704431 physical association X 2 G5ECL3 P91276 two hybrid 14704431 physical association X 2 G5ECL3 Q8MYP3 two hybrid 14704431 physical association X 2 G5ECL3 Q23664 two hybrid 14704431 physical association X 2 G5EF87 G5ECL3 two hybrid pooling approach 14704431 physical association X 2 Q21531 G5ECL3 two hybrid - physical association X 2 Q21531 G5ECL3 two hybrid - physical association X 2 O44878 G5ECL3 two hybrid pooling approach 14704431 physical association X 2 Q45FX5 G5ECL3 two hybrid 23549480 physical association X 2 G5ECL3 Q21954 two hybrid - physical association X 2 Q23158 G5ECL3 two hybrid pooling approach 14704431 physical association X 2 O76640 G5ECL3 two hybrid pooling approach 14704431 physical association X 2 Q22544 G5ECL3 two hybrid pooling approach 14704431 physical association X 2 O45950 G5ECL3 two hybrid - physical association X 2 Q22469 G5ECL3 two hybrid pooling approach 14704431 physical association X 2 Q22469 G5ECL3 two hybrid - physical association X 2 Q22469 G5ECL3 two hybrid - physical association X 2 Q20763 G5ECL3 two hybrid - physical association X 2 G5ECL3 Q19335 two hybrid pooling approach 14704431 physical association X 2 G5ECL3 Q86DA5 two hybrid pooling approach 14704431 physical association X 2 G5ECL3 P91276 two hybrid pooling approach 14704431 physical association X 2 G5ECL3 Q8MYP3 two hybrid pooling approach 14704431 physical association X 2 G5ECL3 Q23664 two hybrid pooling approach 14704431 physical association X 2 G5ECL3 P49594 two hybrid pooling approach 19123269 physical association X 2 G5ECL3 P49594 two hybrid array 19123269 physical association X 2 G5ECL3 Q19335 two hybrid - physical association X 2 G5ECL3 Q19335 two hybrid - physical association X 2 G5ECL3 Q23237 two hybrid - physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Pqbp1 prp-21 MI:0018(two hybrid) 18692475 taxid:10090(Mus musculus) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction) (biogrid) BIOGRID_28684 prey bait ima-2 prp-21 MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_24717|UniProt_28602 prey|prey bait|bait lin-38 prp-21 MI:0018(two hybrid) pubmed:unassigned701 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_24769 prey bait F54D1.1 prp-21 MI:0018(two hybrid)|MI:0018(two hybrid) 18692475 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_25317|BIOGRID_28680 prey|prey bait|bait fem-2 prp-21 MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach) 19123269 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_19528|UniProt_21440 prey|prey bait|bait vab-23 prp-21 MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_28609|BIOGRID_24725 prey|prey bait|bait vav-1 prp-21 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_24116 bait prey pbs-3 prp-21 MI:0018(two hybrid)|MI:0018(two hybrid) 18692475 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_24989|BIOGRID_28711 bait|bait prey|prey tir-1 prp-21 MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_24716|UniProt_28598 prey|prey bait|bait math-41 prp-21 MI:0007(anti tag coimmunoprecipitation) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_28601 prey bait ifg-1 prp-21 MI:0018(two hybrid)|MI:0018(two hybrid) taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_25147|UniProt_25146 prey|prey bait|bait bed-1 prp-21 MI:0007(anti tag coimmunoprecipitation) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_28607 prey bait math-39 prp-21 MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction) (biogrid) BIOGRID_24718 prey bait T18D3.7 prp-21 MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_28603|BIOGRID_24720 prey|prey bait|bait T24E12.6 prp-21 MI:0007(anti tag coimmunoprecipitation) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_28606 prey bait T13H5.4 prp-21 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid) 14704431,18692475 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact)|(biogrid)|(biogrid)|(intact)|(intact) BIOGRID_28683|UniProt_24543|BIOGRID_24719|BIOGRID_28617|UniProt_28600|UniProt_25163 prey|prey|prey|bait|prey|bait bait|bait|bait|prey|bait|prey repo-1 prp-21 MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 14704431,18692475 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact)|(biogrid)|(biogrid)|(intact)|(intact) BIOGRID_24715|UniProt_28599|BIOGRID_28679|BIOGRID_29066|UniProt_25172|UniProt_24956 prey|prey|prey|bait|prey|bait bait|bait|bait|prey|bait|prey R12B2.2 prp-21 MI:0018(two hybrid)|MI:0018(two hybrid) 18692475 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_28682|UniProt_25149 prey|prey bait|bait atn-1 prp-21 MI:0007(anti tag coimmunoprecipitation) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_28605 prey bait prp-21 swsn-1 MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_28604|BIOGRID_24723 bait|bait prey|prey bed-1 prp-21 MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction) (biogrid) BIOGRID_24724 prey bait