PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus rbx-1 csn-1 12781129 intact exp G rbx-1 mel-26 17403899 biogrid exp G TPR repeat-containing protein ZK370.8 rbx-1 18692475,unassigned701 biogrid,mint,intact exp G rbx-1 csn-6 12781129 intact exp, ortho G cul-2 rbx-1 17609115 biogrid,intact exp, ortho G rbx-1 cul-5 17184777 mint,intact exp, ortho C47D12.7a, Kel-1 protein rbx-1 ortho G lin-23 rbx-1 ortho G rskn-1 rbx-1 ortho G SerRS rbx-1 ortho G let-70 rbx-1 ortho G T19E7.3a rbx-1 ortho G mfb-1 rbx-1 ortho G hmp-2 rbx-1 ortho G F40F4.5 rbx-1 ortho G cul-1 rbx-1 ortho G hsp-1 rbx-1 ortho G rbx-1 R166.5b ortho G rbx-1 Y87G2A.9 ortho G rbx-1 F30A10.3 ortho G rbx-1 Y82E9BR.15 ortho rbx-1 ned-8 ortho G grk-1 rbx-1 ortho G pas-1 rbx-1 ortho G hint-1 rbx-1 ortho G rbx-1 dre-1 ortho G Zinc finger protein ZPR1 homolog rbx-1 ortho G cand-1 rbx-1 ortho G cul-3 rbx-1 ortho G rbx-1 rbx-1 ortho G apl-1 rbx-1 ortho G dcaf-1 rbx-1 ortho G F48E8.7a rbx-1 ortho rbx-1 Y71G12B.15a ortho G pgam-5 rbx-1 ortho G csn-5 rbx-1 ortho G rbx-1 pas-2 ortho G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q23457 Q94420 enzymatic study 17403899 direct interaction X 2 Q23457 Q17390-2 affinity chromatography technology 17609115 physical association X 2 Q23457 Q02335 two hybrid 18692475 direct interaction X 2 Q23457 anti tag coimmunoprecipitation 17609115 physical association C 9 Q23457 Q95PZ0 two hybrid 12781129 physical association X 2 Q23457 Q9GS00 two hybrid 12781129 physical association X 2 Q23457 Q23639 two hybrid 17184777 physical association X 2 Q23457 Q23639 two hybrid 17184777 physical association X 2 Q23457 Q02335 two hybrid - physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B ZK370.8 rbx-1 MI:0018(two hybrid)|MI:0018(two hybrid) 18692475 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(intact) MINT_6332|UniProt_24810 prey|prey bait|bait rbx-1 csn-1 MI:0018(two hybrid) 12781129 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_196 prey bait rbx-1 cul-5 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0397(two hybrid array)|MI:0018(two hybrid)|MI:0397(two hybrid array) 17184777 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact)|MI:0471(mint)|(intact)|MI:0471(mint) UniProt_1252|UniProt_1253|603533|MINT_3829|603536|MINT_3828 prey|bait|prey|bait|bait|prey bait|prey|bait|prey|prey|bait rbx-1 csn-6 MI:0018(two hybrid) 12781129 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_195 prey bait

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q23457 Q02335 RBX-1 Q02335 0.454 unassigned701,18692475 Q23639 Q23457 CUL-5 RBX-1 0.309 17184777 Q9GS00 Q23457 CSN-1 RBX-1 0.309 12781129 Q95PZ0 Q23457 CSN-6 RBX-1 0.309 12781129 Q94420 Q23457 MEL-26 RBX-1 0.183 17403899 Q23457 Q17390 RBX-1 CUL-2 0.21 17609115