PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus F46A9.5 F54D5.9 19123269 intact exp F46A9.5 cyp-31a2 18692475,unassigned701 biogrid,intact exp G F46A9.5 C27D9.1 18692475,unassigned701 biogrid,intact exp F46A9.5 dre-1 23431138,19123269 biogrid,intact exp G F46A9.5 B0391.11a 19123269 intact exp F46A9.5 F08A8.7 19123269 intact exp F46A9.5 C14B1.3 18692475,unassigned701,19123269 biogrid,intact exp G F46A9.5 T05H4.2 18692475,unassigned701,19123269 biogrid,intact exp F46A9.5 fsn-1 18692475,unassigned701,19123269 biogrid,intact exp G xbp-1 F46A9.5 18692475,unassigned701 biogrid,intact exp G F46A9.5 C08E3.7 19123269 intact exp F46A9.5 sel-10 11731503,18718460,10615043,19123269,14704431 biogrid,intact exp G F46A9.5 Y113G7B.5b 19123269 intact exp F46A9.5 F46F11.6 18692475,unassigned701,19123269 biogrid,intact exp G F46A9.5 F46A9.5 19123269 intact exp G F46A9.5 cul-1 18718460 biogrid exp G F46A9.5 Uncharacterized F-box protein C27F2.7 18692475,unassigned701 biogrid,intact exp F46A9.5 Y37H2C.3 19123269 intact exp F46A9.5 Y113G7B.1b 19123269 intact exp F46A9.5 C31C9.3 19123269 intact exp G F46A9.5 T10E9.1 19123269 intact exp

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants G5ECU1 Q93794 - 10615043 - X 2 G5ECU1 Q93794 - 14704431 - X 2 G5ECU1 Q93794 - 12679813 - X 2 G5ECU1 Q93794 - 11731503 - X 2 G5ECU1 - 11731503 - X 2 G5ECU1 Q93725 - 11731503 - X 2 G5ECU1 - 15208641 - C 4 G5ECU1 - 11731503 - X 2 G5ECU1 Q17962 two hybrid 18692475 direct interaction X 2 G5ECU1 Q18223 two hybrid 18692475 direct interaction X 2 G5ECU1 G5EGT6 two hybrid 18692475 direct interaction X 2 O16525 G5ECU1 two hybrid 18692475 direct interaction X 2 Q18262 G5ECU1 two hybrid 18692475 direct interaction X 2 G5ECU1 Q93794-2 two hybrid 18718460 direct interaction X 2 G5ECU1 Q17389 two hybrid 18718460 direct interaction X 2 G5ECU1 two hybrid 18692475 direct interaction X 2 G5ECU1 two hybrid 18692475 direct interaction X 2 G5ECU1 P91305 two hybrid 18692475 direct interaction X 2 G5ECU1 A0FLQ8 two hybrid 18692475 direct interaction X 2 G5ECU1 Q94251 affinity chromatography technology 23431138 physical association X 2 G5ECU1 Q93794-2 two hybrid 14704431 direct interaction X 2 G5ECU1 Q93794 two hybrid 14704431 physical association X 2 G5ECU1 Q93794 two hybrid pooling approach 10615043 physical association X 2 G5ECU1 Q93794 two hybrid 11731503 physical association X 2 G5ECU1 Q93794 two hybrid pooling approach 14704431 physical association X 2 G5ECU1 Q93794 two hybrid pooling approach 19123269 physical association X 2 G5ECU1 Q2YS44 two hybrid pooling approach 19123269 physical association X 2 G5ECU1 O17198 two hybrid pooling approach 19123269 physical association X 2 G5ECU1 O17198 two hybrid pooling approach 19123269 physical association X 2 G5ECU1 Q17962 two hybrid pooling approach 19123269 physical association X 2 G5ECU1 Q18223 two hybrid pooling approach 19123269 physical association X 2 G5ECU1 Q93794 two hybrid array 19123269 physical association X 2 G5ECU1 Q2YS44 two hybrid array 19123269 physical association X 2 G5ECU1 O17198 two hybrid array 19123269 physical association X 2 G5ECU1 O17198 two hybrid array 19123269 physical association X 2 G5ECU1 Q17962 two hybrid array 19123269 physical association X 2 G5ECU1 Q18223 two hybrid array 19123269 physical association X 2 G5ECU1 Q17962 two hybrid - physical association X 2 G5ECU1 G5EGT6 two hybrid - physical association X 2 G5ECU1 Q18223 two hybrid - physical association X 2 G5ECU1 G5EE07 two hybrid - physical association X 2 O16525 G5ECU1 two hybrid pooling approach 19123269 physical association X 2 O16525 G5ECU1 two hybrid pooling approach 19123269 physical association X 2 O16525 G5ECU1 two hybrid array 19123269 physical association X 2 O16525 G5ECU1 two hybrid array 19123269 physical association X 2 O16525 G5ECU1 two hybrid - physical association X 2 G5EDX9 G5ECU1 two hybrid pooling approach 19123269 physical association X 2 G5EDX9 G5ECU1 two hybrid pooling approach 19123269 physical association X 2 G5EDX9 G5ECU1 two hybrid array 19123269 physical association X 2 G5EDX9 G5ECU1 two hybrid array 19123269 physical association X 2 Q18262 G5ECU1 two hybrid - physical association X 2 G5ECU1 P91305 two hybrid pooling approach 19123269 physical association X 2 G5ECU1 Q20775 two hybrid pooling approach 19123269 physical association X 2 G5ECU1 G5ECU1 two hybrid pooling approach 19123269 physical association X 2 G5ECU1 Q94251 two hybrid pooling approach 19123269 physical association X 2 G5ECU1 Q2YS43 two hybrid pooling approach 19123269 physical association X 2 G5ECU1 Q2YS43 two hybrid pooling approach 19123269 physical association X 2 G5ECU1 G5EGS1 two hybrid pooling approach 19123269 physical association X 2 G5ECU1 O45285 two hybrid pooling approach 19123269 physical association X 2 G5ECU1 P91305 two hybrid array 19123269 physical association X 2 G5ECU1 Q20775 two hybrid array 19123269 physical association X 2 G5ECU1 Q94251 two hybrid array 19123269 physical association X 2 G5ECU1 Q94251 two hybrid array 19123269 physical association X 2 G5ECU1 Q2YS43 two hybrid array 19123269 physical association X 2 G5ECU1 Q2YS43 two hybrid array 19123269 physical association X 2 G5ECU1 G5EGS1 two hybrid array 19123269 physical association X 2 G5ECU1 O45285 two hybrid array 19123269 physical association X 2 G5ECU1 P91305 two hybrid - physical association X 2 Q18255 G5ECU1 two hybrid - physical association X 2 Q18255 G5ECU1 two hybrid - physical association X 2 Q9NDU9 G5ECU1 two hybrid pooling approach 19123269 physical association X 2 Q9NDU9 G5ECU1 two hybrid array 19123269 physical association X 2 O01606 G5ECU1 two hybrid pooling approach 19123269 physical association X 2 O01606 G5ECU1 two hybrid array 19123269 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B fbxa-116 skr-1 MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach) 19123269 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_20912|UniProt_18998 bait|bait prey|prey C27F2.7 skr-1 MI:0018(two hybrid)|MI:0018(two hybrid) 18692475 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_24539|BIOGRID_29180 prey|prey bait|bait fbxa-167 skr-1 MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach) 19123269 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_20234|UniProt_18320 prey|prey bait|bait C27D9.1 skr-1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 18692475 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction) (intact)|(intact)|(biogrid)|(biogrid) UniProt_24719|UniProt_24704|BIOGRID_29179|BIOGRID_28977 prey|bait|prey|bait bait|prey|bait|prey fog-2 skr-1 MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach) 19123269 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact)|(intact) UniProt_19000|UniProt_18999|UniProt_20910|UniProt_20911 prey|bait|prey|bait bait|prey|bait|prey F54D5.9 skr-1 MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach) 19123269 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_18994|UniProt_20905 prey|prey bait|bait CELE_T10E9.1 skr-1 MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach) 19123269 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_18997|UniProt_20909 prey|prey bait|bait C14B1.3 skr-1 MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach) 19123269 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact) UniProt_25271|UniProt_18164|UniProt_20079 prey|bait|bait bait|prey|prey dre-1 skr-1 MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach) 19123269 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact) UniProt_20903|UniProt_18991|UniProt_20906 bait|prey|prey prey|bait|bait fbxa-164 skr-1 MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach) 19123269 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact)|(intact) UniProt_20026|UniProt_18112|UniProt_18111|UniProt_20027 bait|prey|bait|prey prey|bait|prey|bait skr-1 cyp-31a2 MI:0018(two hybrid) pubmed:unassigned701 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_24706 prey bait skr-1 fbxa-213 MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach) 19123269 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_19003|UniProt_20916 prey|prey bait|bait F46F11.6 skr-1 MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 18692475,19123269 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|(intact)|(intact)|(biogrid) UniProt_20902|UniProt_25272|UniProt_18990|BIOGRID_29181 bait|prey|bait|prey prey|bait|prey|bait skr-1 xbp-1 MI:0018(two hybrid)|MI:0018(two hybrid) 18692475 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_24541|BIOGRID_29182 bait|bait prey|prey skr-1 fbxa-101 MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach) 19123269 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact)|(intact) UniProt_18617|UniProt_18618|UniProt_20531|UniProt_20532 prey|bait|prey|bait bait|prey|bait|prey fbxa-196 skr-1 MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach) 18692475,19123269 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact)|(biogrid)|(intact)|(intact) UniProt_25273|UniProt_20907|UniProt_20908|BIOGRID_29183|UniProt_18996|UniProt_18995 prey|prey|bait|prey|prey|bait bait|bait|prey|bait|bait|prey cul-1 skr-1 MI:0018(two hybrid) 18718460 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction) (biogrid) BIOGRID_28477 bait prey fbxa-152 skr-1 MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach) 19123269 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_19823|UniProt_17909 bait|bait prey|prey sel-10 skr-1 MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0007(anti tag coimmunoprecipitation)|MI:0397(two hybrid array)|MI:0018(two hybrid) 10615043,11731503,14704431,18718460,19123269 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid)|(intact)|(biogrid)|(intact)|(intact)|(intact)|(intact) UniProt_20904|BIOGRID_23009|3300|BIOGRID_28476|UniProt_18992|UniProt_30952|UniProt_1140|UniProt_851 prey|bait|bait|bait|prey|bait|bait|prey bait|prey|prey|prey|bait|prey|prey|bait fsn-1 skr-1 MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 18692475,19123269 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact)|(intact)|(intact) BIOGRID_29178|UniProt_20203|UniProt_18288|UniProt_24811 prey|bait|bait|prey bait|prey|prey|bait

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9NDU9 G5ECU1 FBXA-152 SKR-1 0.236 19123269 Q18223 G5ECU1 FSN-1 SKR-1 0.49 19123269,unassigned701,18692475 Q2YS44 G5ECU1 FBXA-116 SKR-1 0.236 19123269 Q2YS43 G5ECU1 FOG-2 SKR-1 0.416 19123269 G5EDX9 G5ECU1 FBXA-101 SKR-1 0.416 19123269 G5EGS1 G5ECU1 FBXA-213 SKR-1 0.236 19123269 O45285 G5ECU1 FBXA-167 SKR-1 0.236 19123269 O17198 G5ECU1 FBXA-164 SKR-1 0.416 19123269 Q20775 G5ECU1 Q20775 SKR-1 0.236 19123269 Q18262 G5ECU1 Q18262 SKR-1 0.332 unassigned701,18692475 Q93794 G5ECU1 SEL-10 SKR-1 0.772 10615043,14704431,18718460,11731503,19123269 O01606 G5ECU1 O01606 SKR-1 0.236 19123269 Q17962 G5ECU1 Q17962 SKR-1 0.376 19123269,unassigned701 O16525 G5ECU1 FBXA-196 SKR-1 0.376 19123269,unassigned701 P91305 G5ECU1 P91305 SKR-1 0.376 19123269,unassigned701 Q94251 G5ECU1 DRE-1 SKR-1 0.396 19123269,23431138 G5ECU1 G5ECU1 SKR-1 SKR-1 0.155 19123269 G5EE07 G5ECU1 XBP-1 SKR-1 0.183 unassigned701 G5EGT6 G5ECU1 CYP-31A2 SKR-1 0.183 unassigned701 Q18255 G5ECU1 Q18255 SKR-1 0.332 unassigned701 Q17389 G5ECU1 CUL-1 SKR-1 0.309 18718460