PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus ubl-1 H04J21.3b 14704431 biogrid,i2d,mint,intact,dip exp ubl-1 Y105E8A.11 14704431 biogrid,i2d,mint,intact,dip exp G ubl-1 Guanine nucleotide exchange factor subunit R06F6.8 14704431 biogrid,mint,intact,dip exp G ubl-1 Uncharacterized protein R06F6.12 18692475,unassigned701 biogrid,mint,intact exp G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P37165 Q9NEY7 - 14704431 - X 2 P37165 O61208 - 14704431 - X 2 P37165 - 14704431 - X 2 P37165 O61208 two hybrid 14704431 physical association X 2 P37165 Q9NEY7 two hybrid 14704431 physical association X 2 Q09417 P37165 two hybrid 14704431 physical association X 2 P37165 Q8ITY3 two hybrid pooling approach 14704431 physical association X 2 P37165 Q9NEY7 two hybrid pooling approach 14704431 physical association X 2 Q09417 P37165 two hybrid pooling approach 14704431 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B gip-1 ubl-1 MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) MI:0465(dip) DIP_2658 - - ubl-1 R06F6.8 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) MI:0465(dip)|(biogrid)|(intact) DIP_2669|BIOGRID_23118|UniProt_31055 -|bait|bait -|prey|prey ubl-1 R06F6.12 MI:0018(two hybrid)|MI:0018(two hybrid) 18692475 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_25153|BIOGRID_29226 null|bait prey|prey ubl-1 Y105E8A.11 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) MI:0465(dip)|(biogrid)|(intact) DIP_4279|BIOGRID_24786|UniProt_28668 -|prey|prey -|bait|bait ubl-1 gip-1 MI:0007(anti tag coimmunoprecipitation) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_31044 prey bait