PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus ubq-1 C16A3.8 14704431 biogrid,i2d exp G klp-6 ubq-1 14704431 biogrid exp G ubq-1 bar-1 15820693 biogrid exp G ubq-1 dkf-1 16613842 biogrid exp ubq-1 C07G1.5 21193406 biogrid exp G F38B7.2b ubq-1 i2d exp G ubq-1 ahcy-1 i2d exp G W02G9.3 ubq-1 i2d exp C04F12.3, IKB-1 ubq-1 14704431 biogrid exp ubq-1 R07H5.1 i2d exp C24G6.7 ubq-1 15820693 biogrid exp ubq-1 rrc-1 23549480 intact exp G ubq-1 brd-1 16628214 intact exp ubq-1 cav-1 24595290 biogrid exp G stam-1 ubq-1 21193406 biogrid exp G ubq-1 C34C6.6a i2d exp ubq-1 T22D1.9 14704431 biogrid,i2d exp, ortho G ubq-1 dcn-1 15988528 biogrid,i2d exp, ortho W02D3.1 ubq-1 ortho G ubq-1 rpt-1 ortho G ubq-1 aak-2 ortho G ubq-1 brap-2 ortho G ubq-1 Ribosome production factor 2 homolog ortho ubq-1 ZK742.1a ortho G ubq-1 vha-9 ortho G ubq-1 C47E12.5a ortho G ubq-1 T24B8.1a ortho G ubq-1 sec-15 ortho G Cell division protein kinase 5, T27E9.3 ubq-1 ortho G ubq-1 C53D5.6 ortho G Y92H12A.2a ubq-1 ortho G ZC518.3d ubq-1 ortho G ubq-1 rps-5 ortho G DNA polymerase ubq-1 ortho G ubq-1 mpk-1 ortho G ubq-1 cts-1 ortho G ubq-1 cgh-1 ortho G ubq-1 rpl-3 ortho G ubq-1 F17C11.8 ortho G ubq-1 rack-1 ortho G Stress-induced-phosphoprotein 1, CeSTI1, STI1 ubq-1 ortho C06G3.5a ubq-1 ortho G ubq-1 D2085.1 ortho G B0205.3 ubq-1 ortho G ubq-1 cct-6 ortho G ubq-1 pgk-1 ortho G Probable trans-2-enoyl-CoA reductase 1, mitochondrial ubq-1 ortho G ubq-1 cor-1 ortho ubq-1 Zinc finger CCCH domain-containing protein 15 homolog ortho G ubq-1 rpb-2 ortho G ubq-1 rps-7 ortho G ubq-1 Y105E8A.16 ortho G ubq-1 ZK20.3 ortho G ubq-1 Y37E3.8a ortho G ubq-1 kin-1 ortho G ubq-1 rpn-3 ortho G ubq-1 rps-12 ortho G ubq-1 F28B3.8 ortho G ubq-1 rps-3 ortho G ubq-1 C45B2.5 ortho G ubq-1 Uncharacterized F-box/LRR-repeat protein C02F5.7 ortho G ubq-1 Y110A2AM.3 ortho ubq-1 let-70 ortho G ubq-1 Glucose-6-phosphate isomerase ortho G F41E6.13a ubq-1 ortho G F56H1.4 ubq-1 ortho G ubq-1 usp-7 ortho G ubq-1 Uncharacterized NOP5 family protein K07C5.4 ortho G ubq-1 ufd-2 ortho ubq-1 Coatomer subunit alpha ortho G Putative H/ACA ribonucleoprotein complex subunit 4 ubq-1 ortho G ubq-1 prp-8 ortho G DNA-directed RNA polymerase ubq-1 ortho G ubq-1 Y79H2A.6 ortho G ubq-1 gop-2 ortho G ubq-1 W09B6.2 ortho ubq-1 png-1 ortho G ubq-1 ama-1 ortho rpt-2 ubq-1 ortho G F30F8.8 ubq-1 ortho G ubq-1 usp-14 ortho G ubq-1 Y87G2A.9 ortho G ubq-1 C01G10.8 ortho G rpn-11 ubq-1 ortho G ubq-1 rbbp-5 ortho ubq-1 T07D4.4a ortho ubq-1 Y71G12B.15a ortho G ubq-1 dph-1 ortho G ubq-1 mel-32 ortho G ubq-1 pbs-4 ortho G ubq-1 Y47G6A.6 ortho G ubq-1 C39F7.4 ortho G pcn-1 ubq-1 ortho ubq-1 alx-1 ortho G T05C3.5 ubq-1 ortho G ubq-1 pas-3 ortho G ubq-1 rps-13 ortho G ubq-1 copb-2 ortho G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P0CG71 G5EC43 - 14704431 - X 2 P0CG71 - 14704431 - X 2 P0CG71 Q9U3C8 - 15988528 - X 2 P0CG71 - 15294159 - X 2 P0CG71 Q9GZH5 - 11559592 - X 2 P0CG71 G5EFS1 - 14704431 - X 2 P0CG71 Q94051 affinity chromatography technology 24595290 physical association X 2 P0CG71 Q9U3C8-2 pull down 15988528 direct interaction X 2 P0CG71 Q18033 two hybrid 14704431 direct interaction X 2 P0CG71 Q8MQ04 two hybrid 14704431 direct interaction X 2 P0CG71 O01498 pull down 21193406 direct interaction X 2 P0CG71 Q9XUJ7 affinity chromatography technology 16613842 physical association X 2 Q18825 P0CG71 affinity chromatography technology 15820693 physical association X 2 P0CG71 G5EFS1 two hybrid 14704431 direct interaction X 2 P0CG71 Q9GZH5 two hybrid 14704431 direct interaction X 2 P0CG71 Q17796 pull down 21193406 direct interaction X 2 P0CG71 affinity chromatography technology 15820693 physical association X 2 P27604 P0CG71 two hybrid 14704431 physical association X 2 P0CG71 Q21633 comigration in sds page 19553937 covalent binding X 2 P0CG71 Q18033 two hybrid 14704431 physical association X 2 P0CG71 G5EG83 two hybrid 14704431 physical association X 2 P0CG71 G5EFF7 two hybrid 14704431 physical association X 2 P0CG71 G5ED84 two hybrid 14704431 physical association X 2 P0CG71 two hybrid 14704431 physical association X 2 P0CG71 G5EFS1 two hybrid 14704431 physical association X 2 P0CG71 Q18426 two hybrid 14704431 physical association X 2 P0CG71 two hybrid 14704431 physical association X 2 P0CG71 Q20149 two hybrid 14704431 physical association X 2 Q93930 P0CG71 two hybrid 14704431 physical association X 2 P27604 P0CG71 two hybrid pooling approach 14704431 physical association X 2 Q20498 P0CG71 two hybrid 23549480 physical association X 2 P0CG71 Q8MQ04 two hybrid pooling approach 14704431 physical association X 2 P0CG71 Q18033 two hybrid pooling approach 14704431 physical association X 2 P0CG71 G5ED84 two hybrid pooling approach 14704431 physical association X 2 P0CG71 Q9GZH5 two hybrid pooling approach 11559592 physical association X 2 P0CG71 G5EFS1 two hybrid pooling approach 14704431 physical association X 2 P0CG71 Q18426 two hybrid pooling approach 14704431 physical association X 2 P0CG71 O18672 two hybrid pooling approach 14704431 physical association X 2 P0CG71 Q20149 two hybrid pooling approach 14704431 physical association X 2 Q93930 P0CG71 two hybrid pooling approach 14704431 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B ubq-1 bar-1 MI:0004(affinity chromatography technology) 15820693 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (biogrid) BIOGRID_26372 prey bait ubq-1 Q9U3S0 MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:0() MI:0915(physical association) MI:0465(dip) DIP_1199 - - stam-1 ubq-1 MI:0004(affinity chromatography technology) 21193406 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction) (biogrid) BIOGRID_28370 bait prey ubq-1 rrc-1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23982 prey bait ubq-1 rpn-1 MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction) (biogrid) BIOGRID_24256 prey bait ubq-1 thoc-2 MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) MI:0465(dip) DIP_1358 - - ubq-1 hgrs-1 MI:0004(affinity chromatography technology) 21193406 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction) (biogrid) BIOGRID_28369 prey bait ubq-1 Q21493 MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:0() MI:0915(physical association) MI:0465(dip) DIP_2967 - - grl-1 ubq-1 MI:0004(affinity chromatography technology) 15820693 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (biogrid) BIOGRID_26369 bait prey ubq-1 cav-1 MI:0004(affinity chromatography technology) 24595290 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (biogrid) BIOGRID_29643 prey bait ubq-1 zen-4 MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction) (biogrid) BIOGRID_23442 prey bait ubq-1 ikb-1 MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction) (biogrid) BIOGRID_21419 prey bait ubq-1 dkf-1 MI:0004(affinity chromatography technology) 16613842 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (biogrid) BIOGRID_28389 prey bait

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q18825 P0CG71 BAR-1 UBQ-1 0.21 15820693 Q9XUJ7 P0CG71 DKF-1 UBQ-1 0.21 16613842 Q18033 P0CG71 THOC-2 UBQ-1 0.033 14704431 Q20498 P0CG71 RRC-1 UBQ-1 0.183 23549480 Q94051 P0CG71 CAV-1 UBQ-1 0.21 24595290 Q9U3S0 P0CG71 Q9U3S0 UBQ-1 0.033 14704431 P0CG71 O01498 UBQ-1 STAM-1 0.309 21193406 Q21493 P0CG71 Q21493 UBQ-1 0.033 14704431