PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus C04F12.3, IKB-1 ubq-2 14704431 intact exp F38B7.2b ubq-2 14704431 biogrid,i2d,mint,intact,dip exp G ubq-2 C16A3.8 14704431 i2d,mint,intact exp G F15C11.2 ubq-2 14704431 mint,intact,dip exp ahcy-1 ubq-2 14704431 biogrid,i2d,mint,intact,dip exp G ubq-2 R01H2.6 19553937 dip exp G ubq-2 T22D1.9 11559592 i2d,mint,intact exp G ubq-2 R07H5.1 14704431 biogrid,i2d,mint,intact,dip exp kel-8 ubq-2 14704431 intact exp G W02G9.3 ubq-2 14704431 biogrid,i2d exp ubq-2 C34C6.6a 14704431 biogrid,i2d,mint,intact,dip exp W05B5.1g ubq-2 14704431 biogrid exp G klp-6 ubq-2 14704431 mint,intact exp G ubq-2 dcn-1 i2d exp F15C11.2a ubq-2 14704431 biogrid exp, ortho G ubq-2 ubq-2 14704431 intact exp, ortho G ubq-2 C17H12.14 ortho G 1G758 ubq-2 ortho G ubq-2 pbs-4 ortho G ubq-2 K07G5.2 ortho G ubq-2 lin-45 ortho G ubq-2 cdc-42 ortho G ubq-2 rps-2 ortho G ubq-2 tpi-1 ortho G hmp-2 ubq-2 ortho G ubq-2 Y105E8A.16 ortho G ubq-2 C01G6.4 ortho G ubq-2 gsk-3 ortho G ubq-2 Density-regulated protein homolog ortho C09G12.9 ubq-2 ortho F53F10.4 ubq-2 ortho G ubq-2 sma-6 ortho G ubq-2 lpd-7 ortho G ubq-2 F17C11.8 ortho G ubq-2 K08E3.7a ortho G ubq-2 vdac-1 ortho G ubq-2 par-1 ortho G rps-3 ubq-2 ortho G ubq-2 hda-6 ortho G rpl-4 ubq-2 ortho G ubq-2 rpl-13 ortho G hsp-1 ubq-2 ortho G ubq-2 rpt-1 ortho G Stress-induced-phosphoprotein 1, CeSTI1, STI1 ubq-2 ortho ubq-2 usp-14 ortho G Y37D8A.9b ubq-2 ortho G ubq-2 vps-28 ortho G ubq-2 daf-21 ortho G rps-21 ubq-2 ortho G dpy-23 ubq-2 ortho G rps-5 ubq-2 ortho G pas-1 ubq-2 ortho G sem-5 ubq-2 ortho G ubq-2 R106.2 ortho ubq-2 ZC404.9 ortho ubq-2 Probable ATP-dependent RNA helicase DHX35 homolog ortho G ubq-2 Ubiquitin carboxyl-terminal hydrolase ortho G ubq-2 C07G1.5 ortho G ubq-2 Mitochondrial Rho GTPase, Miro ortho C01G8.5b, ERM-1B ubq-2 ortho G ubq-2 fzo-1 ortho G H14N18.1a ubq-2 ortho G ubq-2 rps-4 ortho G Dicer-related helicase, F15B10.2a ubq-2 ortho ubq-2 C55A6.10a ortho G ubq-2 daf-2 ortho G ubq-2 Y71G12B.15a ortho G ubq-2 ubc-1 ortho G E01B7.1 ubq-2 ortho G ubq-2 usp-7 ortho G ubq-2 rps-25 ortho G rpl-35 ubq-2 ortho G rpl-33 ubq-2 ortho G ubq-2 Y48G8AL.1a ortho ubq-2 C44B7.2a ortho ubq-2 pink-1 ortho F22D3.6, Paracaspase ubq-2 ortho G usp-46 ubq-2 ortho G ubq-2 F38A5.13 ortho G ubq-2 C47E12.5a ortho G rps-14 ubq-2 ortho G ubq-2 D2013.5 ortho G rps-8 ubq-2 ortho G tag-277 ubq-2 ortho G Proline dehydrogenase 1, mitochondrial ubq-2 ortho G ubq-2 hrdl-1 ortho G F53A3.3a ubq-2 ortho G ubq-2 Ubiquitin-fold modifier-conjugating enzyme 1, Ufm1-conjugating enzyme 1 ortho G ubq-2 rps-7 ortho G ubq-2 sptl-2 ortho G pcn-1 ubq-2 ortho ubq-2 F13B9.8b ortho G let-70 ubq-2 ortho G B0205.3 ubq-2 ortho G ubq-2 sel-10 ortho G ubq-2 pas-3 ortho G rpl-24.1 ubq-2 ortho G ubq-2 Probable DNA topoisomerase 2 ortho G ubq-2 arr-1 ortho G ubq-2 Y37E3.8a ortho G ubq-2 T24B8.1a ortho G ubq-2 cul-1 ortho G ubq-2 tomm-20 ortho G ubq-2 T07F12.1 ortho

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P49632 - 14704431 - X 2 P49632 - 14704431 - X 2 P49632 - 14704431 - X 2 P27604 P49632 - 14704431 - X 2 P49632 Q93930 - 14704431 - X 2 P49632 Q20149 - 14704431 - X 2 P49632 Q18426 - 14704431 - X 2 P49632 G5EFF7 - 14704431 - X 2 P49632 Q7JM90 two hybrid 14704431 direct interaction X 2 P49632 two hybrid 14704431 direct interaction X 2 P49632 two hybrid 14704431 direct interaction X 2 P49632 two hybrid 14704431 direct interaction X 2 P27604 P49632 two hybrid 14704431 direct interaction X 2 P49632 G5EFF7 two hybrid 14704431 direct interaction X 2 P49632 Q20149 two hybrid 14704431 direct interaction X 2 P49632 Q93930 two hybrid 14704431 direct interaction X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B O61899 ubq-2 MI:0018(two hybrid) 14704431 taxid:0() taxid:6239(Caenorhabditis elegans) MI:0915(physical association) MI:0465(dip) DIP_4848 - - ubq-2 prx-5 MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) MI:0465(dip) DIP_4842 - - ubq-2 CELE_W05B5.1 MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction) (biogrid) BIOGRID_25378 bait prey ubq-2 ubql-1 MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction) (biogrid) BIOGRID_25373 bait prey ahcy-1 ubq-2 MI:0018(two hybrid)|MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|MI:0465(dip) BIOGRID_25375|DIP_4846 prey|- bait|- ubq-2 F38B7.2 MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) MI:0465(dip) DIP_4845 - - ubq-2 cytb MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:185456() MI:0407(direct interaction) (biogrid) BIOGRID_25374 bait prey ubq-2 CC8.1 MI:0018(two hybrid)|MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|MI:0465(dip) BIOGRID_25372|DIP_4843 bait|- prey|- ubq-2 prx-14 MI:0018(two hybrid)|MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|MI:0465(dip) BIOGRID_25376|DIP_4847 bait|- prey|- uniprotkb:(gene name) ubq-2 MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) MI:0465(dip) DIP_4844 - - ubq-2 Q9XUK9 MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:0() MI:0915(physical association) MI:0465(dip) DIP_4849 - -

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P49632 P27604 UBQ-2 AHCY-1 0.183 14704431