PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus ufd-1 F59E12.5b 18692475,11731503,unassigned701,14704431 biogrid,i2d,mint,intact,dip exp G cdc-48.1 ufd-1 20977550 biogrid exp G F59E12.4b ufd-1 14704431 intact,dip exp G cdc-48.2 ufd-1 20977550 biogrid exp G M05D6.2 ufd-1 19123269 intact exp G ufd-1 T22D1.9 ortho G ufd-1 Y54G2A.31 ortho G ufd-1 T22C1.6 ortho G K07A12.4a ufd-1 ortho G ufd-1 Y46G5A.12 ortho G ufd-1 F23C8.4 ortho G F25G6.6 ufd-1 ortho G ufd-1 npp-17 ortho G tRNA-splicing ligase RtcB homolog ufd-1 ortho G ufd-1 Inositol 1,4,5-trisphosphate receptor itr-1 ortho G ufd-1 age-1 ortho G ufd-2 ufd-1 ortho ufd-1 ldh-1 ortho G ufd-1 H06H21.6 ortho G ufd-1 ZK20.3 ortho G C56C10.1 ufd-1 ortho G ufd-1 MDF-2, Y69A2AR.30a ortho Stress-induced-phosphoprotein 1, CeSTI1, STI1 ufd-1 ortho hrdl-1 ufd-1 ortho G C42C1.15 ufd-1 ortho grs-1 ufd-1 ortho G F48E8.7a ufd-1 ortho B0491.7 ufd-1 ortho G TPR repeat-containing protein T20B12.1 ufd-1 ortho G ufd-1 ufd-1 ortho G ufd-1 Putative pre-mRNA-splicing factor ATP-dependent RNA helicase F56D2.6 ortho G R12E2.3 ufd-1 ortho G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q95QZ9 Q19584 - 14704431 - X 2 Q95QZ9 Q19584 - 14704431 - X 2 O01894 Q19584 two hybrid 14704431 physical association X 2 Q19584 Q95QZ7 two hybrid 14704431 physical association X 2 H2KYU6 Q19584 two hybrid pooling approach 14704431 physical association X 2 G5ECL1 Q19584 two hybrid pooling approach 19123269 physical association X 2 G5ECL1 Q19584 two hybrid array 19123269 physical association X 2 O01894 Q19584 two hybrid 11731503 physical association X 2 Q95QZ9 Q19584 two hybrid pooling approach 14704431 physical association X 2 Q95QZ9 Q19584 two hybrid - physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B cdc-48.2 ufd-1 MI:0004(affinity chromatography technology) 20977550 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction) (biogrid) BIOGRID_28471 prey bait cdc-48.1 ufd-1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 20977550 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_28458|BIOGRID_28465 bait|prey prey|bait ufd-1 M05D6.2 MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach) 19123269 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_18731|UniProt_20643 prey|prey bait|bait ufd-1 npl-4.1 MI:0007(anti tag coimmunoprecipitation) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_30407 bait prey ufd-1 npl-4.2 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0007(anti tag coimmunoprecipitation) 14704431,18692475 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(intact)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|(intact) MINT_4553|UniProt_25108|MINT_4550|MINT_4552|MINT_4551|MINT_310|UniProt_30408 bait|bait|bait|bait|bait|bait|bait prey|prey|prey|prey|prey|prey|prey ufd-1 Q95QZ8 MI:0398(two hybrid pooling approach) 14704431 taxid:6239(Caenorhabditis elegans) taxid:0() MI:0915(physical association) MI:0471(mint) MINT_309 bait prey ufd-1 npl-4.1 MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) MI:0465(dip) DIP_2023 - - npl-4.2 ufd-1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 11731503,14704431,18692475 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (intact)|(biogrid)|MI:0465(dip) UniProt_845|BIOGRID_29074|DIP_2024 bait|prey|- prey|bait|-

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q19584 P54812 UFD-1 CDC-48.2 0.309 20977550 Q19584 G5ECL1 UFD-1 G5ECL1 0.236 19123269 Q19584 O01894 UFD-1 NPL-4.2 0.332 14704431,11731503 Q95QZ7 Q19584 NPL-4.1 UFD-1 0.033 14704431 Q95QZ9 Q19584 NPL-4.2 UFD-1 0.416 unassigned701,18692475,14704431 Q19584 H2KYU6 UFD-1 NPL-4.1 0.126 14704431 Q19584 P54811 UFD-1 CDC-48.1 0.454 20977550