PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus cul-2 F08G12.4 17609115 intact exp Y77E11A.7a F08G12.4 19123269 intact exp Hypoxia-inducible factor 1 F08G12.4 11595184 biogrid exp F08G12.4 Y82E9BR.15 17304241 biogrid,intact exp secs-1 F08G12.4 19123269 intact exp

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9BKS1 Q19213 two hybrid 17304241 direct interaction X 2 Q19213 G5EGD2-5 affinity chromatography technology 11595184 physical association X 2 Q19213 anti tag coimmunoprecipitation 17609115 physical association C 9 H2L0E0 Q19213 two hybrid array 19123269 physical association X 2 Q9BKS1 Q19213 two hybrid 17304241 physical association X 2 Q18953 Q19213 two hybrid pooling approach 19123269 physical association X 2 Q18953 Q19213 two hybrid array 19123269 physical association X 2 Q19213 H2L0E1 two hybrid pooling approach 19123269 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B secs-1 vhl-1 MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach) 19123269 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_18529|UniProt_20445 prey|prey bait|bait vhl-1 Y77E11A.7 MI:0398(two hybrid pooling approach) 19123269 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_18631 bait prey vhl-1 Y77E11A.7 MI:0398(two hybrid pooling approach) 19123269 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_20547 bait prey vhl-1 hif-1 MI:0004(affinity chromatography technology) 11595184 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (biogrid) BIOGRID_28356 bait prey vhl-1 elc-1 MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology) 17304241 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|(intact)|(intact)|(biogrid) UniProt_90095|UniProt_1490|651648|BIOGRID_28518 bait|bait|bait|bait prey|prey|prey|prey

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q19213 H2L0E0 VHL-1 H2L0E0 0.126 19123269 Q19213 G5EGD2 VHL-1 HIF-1 0.21 11595184 Q19213 H2L0E1 VHL-1 H2L0E1 0.126 19123269 Q9BKS1 Q19213 ELC-1 VHL-1 0.309 17304241 Q19213 Q18953 VHL-1 SECS-1 0.236 19123269