PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus nhr-5 mdt-8 23791784 intact exp unc-98 mdt-8 23791784 intact exp T22H9.4 mdt-8 23791784 intact exp K01A2.10 mdt-8 19123269 intact exp G nhr-62 mdt-8 23791784 intact exp mec-3 mdt-8 23791784 intact exp G F16H11.5 mdt-8 23791784 intact exp G MAD-like-1 homolog, R03E9.1 mdt-8 23791784 intact exp G F46G10.6 mdt-8 23791784 intact exp G unc-62 mdt-8 23791784 intact exp G ZK1290.4c mdt-8 23791784 intact exp G T27B1.2 mdt-8 23791784 intact exp Y52E8A.2 mdt-8 23791784 intact exp F45E1.7b mdt-8 23549480 intact exp G F08G12.3 mdt-8 23791784 intact exp G Y62E10A.17b mdt-8 23791784 intact exp G nhr-23 mdt-8 23791784 intact exp hmp-1 mdt-8 unassigned1274 intact exp G C46H3.2a mdt-8 23791784 intact exp G Eyes absent homolog mdt-8 23791784 intact exp G F26A10.2 mdt-8 23791784 intact exp G mdt-8 Y38H6C.14 14704431 biogrid,i2d,mint,intact,dip exp Hypoxia-inducible factor 1 mdt-8 23791784 intact exp Y75B8A.35a mdt-8 23791784 intact exp G K08A2.5a mdt-8 23791784 intact exp G mdt-8 F32A11.6 23791784 intact exp C26E6.2 mdt-8 23791784 intact exp ceh-43 mdt-8 23791784 intact exp G nhr-47 mdt-8 23791784 intact exp G F13G3.1 mdt-8 23791784 intact exp Y51H4A.4a mdt-8 23791784 intact exp G C34C6.6a mdt-8 23791784 intact exp mdt-8 Y11D7A.12a 23791784 intact exp W04G5.9 mdt-8 19123269 intact exp F18A1.3b, LIR-1A protein mdt-8 23791784 intact exp G daf-16 mdt-8 23791784 intact exp G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9XX47 Q9U1W2 - 14704431 - X 2 Q9XX47 Q9U1W2 two hybrid 14704431 direct interaction X 2 Q9XX47 Q9U1W2 two hybrid 14704431 physical association X 2 G2HK15 Q9U1W2 two hybrid 23791784 physical association X 2 Q17370 Q9U1W2 two hybrid 23791784 physical association X 2 Q18273 Q9U1W2 two hybrid 23791784 physical association X 2 Q18225 Q9U1W2 two hybrid 23791784 physical association X 2 Q18662 Q9U1W2 two hybrid 23791784 physical association X 2 Q19496 Q9U1W2 two hybrid 23791784 physical association X 2 Q9U1W2 G5EBR0 two hybrid 23791784 physical association X 2 Q9U1W2 G5EGD2 two hybrid 23791784 physical association X 2 Q9U1W2 Q19212 two hybrid 23791784 physical association X 2 Q9U1W2 Q5H9N3 two hybrid 23791784 physical association X 2 Q9U1W2 Q9N3H6 two hybrid 23791784 physical association X 2 Q9U1W2 Q9TXN8 two hybrid 23791784 physical association X 2 Q9U1W2 Q9U1S5 two hybrid 23791784 physical association X 2 Q09989 Q9U1W2 two hybrid 23549480 physical association X 2 P09088 Q9U1W2 two hybrid 23791784 physical association X 2 O17670 Q9U1W2 two hybrid 23791784 physical association X 2 H2KZA1 Q9U1W2 two hybrid 23791784 physical association X 2 Q19807 Q9U1W2 two hybrid 23791784 physical association X 2 O02279 Q9U1W2 two hybrid 23791784 physical association X 2 Q19418 Q9U1W2 two hybrid 23791784 physical association X 2 Q9TZ50 Q9U1W2 two hybrid pooling approach 19123269 physical association X 2 Q9TZ50 Q9U1W2 two hybrid array 19123269 physical association X 2 Q18711 Q9U1W2 two hybrid 23791784 physical association X 2 Q9U1W2 P41828 two hybrid 23791784 physical association X 2 Q9U1W2 Q19203 two hybrid 23791784 physical association X 2 Q9U1W2 Q22829 two hybrid 23791784 physical association X 2 Q9U1W2 Q9N5D6 two hybrid 23791784 physical association X 2 Q9U1W2 Q9NA51 two hybrid 23791784 physical association X 2 Q9U1W2 Q9NAE4 two hybrid 23791784 physical association X 2 Q9U1W2 Q9XV46 two hybrid 23791784 physical association X 2 O16850 Q9U1W2 two hybrid 23791784 physical association X 2 Q9XWR1 Q9U1W2 two hybrid 23791784 physical association X 2 O18173 Q9U1W2 two hybrid pooling approach 19123269 physical association X 2 O18173 Q9U1W2 two hybrid array 19123269 physical association X 2 G5EG44 Q9U1W2 two hybrid 23791784 physical association X 2 Q9XX47 Q9U1W2 two hybrid pooling approach 14704431 physical association X 2 Q18426 Q9U1W2 two hybrid 23791784 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B eya-1 mdt-8 MI:0018(two hybrid) 23791784 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_33795 prey bait nhr-5 mdt-8 MI:0018(two hybrid) 23791784 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_33813 prey bait mdt-8 dmd-8 MI:0018(two hybrid) 23791784 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_33815 bait prey nhr-23 mdt-8 MI:0018(two hybrid) 23791784 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_33797 prey bait mdt-8 K01A2.10 MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach) 19123269 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_21104|UniProt_19195 bait|bait prey|prey zip-7 mdt-8 MI:0018(two hybrid) 23791784 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_33814 prey bait unc-98 mdt-8 MI:0018(two hybrid) 23791784 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_33804 prey bait sdpn-1 mdt-8 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_24176 bait prey nhr-45 mdt-8 MI:0018(two hybrid) 23791784 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_33807 prey bait nhr-47 mdt-8 MI:0018(two hybrid) 23791784 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_33798 prey bait mxl-3 mdt-8 MI:0018(two hybrid) 23791784 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_33803 prey bait mdt-8 nhr-88 MI:0018(two hybrid) 23791784 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_33792 bait prey pat-9 mdt-8 MI:0018(two hybrid) 23791784 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_33809 prey bait C46H3.2 mdt-8 MI:0018(two hybrid) 23791784 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_33802 prey bait zip-1 mdt-8 MI:0018(two hybrid) 23791784 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_33816 prey bait nhr-62 mdt-8 MI:0018(two hybrid) 23791784 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_33793 prey bait Y52E8A.2 mdt-8 MI:0018(two hybrid) 23791784 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_33811 prey bait mec-3 mdt-8 MI:0018(two hybrid) 23791784 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_33796 prey bait ztf-2 mdt-8 MI:0018(two hybrid) 23791784 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_33806 prey bait CELE_F08G12.3 mdt-8 MI:0018(two hybrid) 23791784 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_33805 prey bait daf-16 mdt-8 MI:0018(two hybrid) 23791784 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_33794 prey bait mdt-8 lir-1 MI:0018(two hybrid) 23791784 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_33789 bait prey ceh-43 mdt-8 MI:0018(two hybrid) 23791784 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_33800 prey bait mdt-8 moe-3 MI:0018(two hybrid) 23791784 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_33817 bait prey nfi-1 mdt-8 MI:0018(two hybrid) 23791784 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_33810 prey bait unc-62 mdt-8 MI:0018(two hybrid) 23791784 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_33812 prey bait mdt-8 flh-1 MI:0018(two hybrid) 23791784 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_33818 bait prey mdt-8 CELE_Y38H6C.14 MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) MI:0471(mint)|MI:0465(dip)|(intact)|(biogrid) MINT_2907|DIP_4389|UniProt_28779|BIOGRID_24909 prey|-|prey|prey bait|-|bait|bait mdt-8 aptf-2 MI:0018(two hybrid) 23791784 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_33788 bait prey W04G5.9 mdt-8 MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach) 19123269 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_19578|UniProt_21490 bait|bait prey|prey prx-5 mdt-8 MI:0018(two hybrid) 23791784 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_33801 prey bait mdt-8 mdl-1 MI:0018(two hybrid) 23791784 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_33790 bait prey flh-2 mdt-8 MI:0018(two hybrid) 23791784 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_33799 prey bait mdt-8 hif-1 MI:0018(two hybrid) 23791784 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_33791 bait prey CELE_F26A10.2 mdt-8 MI:0018(two hybrid) 23791784 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_33808 prey bait

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9U1W2 Q09989 MDT-8 SDPN-1 0.183 23549480 Q9U1W2 Q22829 MDT-8 PAT-9 0.183 23791784 Q9U1W2 Q18273 MDT-8 CEH-43 0.183 23791784 Q9U1W2 Q18426 MDT-8 PRX-5 0.183 23791784 Q9U1W2 Q18711 MDT-8 MXL-3 0.183 23791784 Q9U1W2 Q5H9N3 MDT-8 NFI-1 0.183 23791784 Q9U1W2 Q19203 MDT-8 UNC-98 0.183 23791784 Q9U1W2 Q19212 MDT-8 Q19212 0.183 23791784 Q9U1W2 Q19496 MDT-8 NHR-45 0.183 23791784 Q9U1W2 Q9N3H6 MDT-8 Q9N3H6 0.183 23791784 Q9U1W2 P09088 MDT-8 MEC-3 0.183 23791784 Q9U1W2 Q9TZ50 MDT-8 Q9TZ50 0.236 19123269 Q9U1W2 O18173 MDT-8 O18173 0.236 19123269 Q9U1W2 Q9TXN8 MDT-8 DMD-8 0.183 23791784 Q9U1W2 Q9U1S5 MDT-8 ZIP-1 0.183 23791784 Q9U1W2 A5JYX3 MDT-8 A5JYX3 0.183 26780296 Q9U1W2 G5EBR0 MDT-8 LIR-1 0.183 23791784 Q9U1W2 H2KZA1 MDT-8 NHR-88 0.183 23791784 Q9U1W2 O02279 MDT-8 NHR-62 0.183 23791784 Q9U1W2 O16850 MDT-8 DAF-16 0.183 23791784 Q9U1W2 O17670 MDT-8 EYA-1 0.183 23791784 Q9U1W2 Q17370 MDT-8 NHR-47 0.183 23791784 Q9U1W2 Q18225 MDT-8 FLH-2 0.183 23791784 Q9U1W2 Q18662 MDT-8 Q18662 0.183 23791784 Q9U1W2 Q19418 MDT-8 ZTF-2 0.183 23791784 Q9U1W2 Q19807 MDT-8 Q19807 0.183 23791784 Q9U1W2 Q9N5D6 MDT-8 UNC-62 0.183 23791784 Q9U1W2 Q9NA51 MDT-8 NHR-5 0.183 23791784 Q9U1W2 Q9NAE4 MDT-8 ZIP-7 0.183 23791784 Q9XV46 Q9U1W2 MOE-3 MDT-8 0.183 23791784 Q9XWR1 Q9U1W2 FLH-1 MDT-8 0.183 23791784 Q9XX47 Q9U1W2 Q9XX47 MDT-8 0.126 14704431 Q9U1W2 P41828 MDT-8 NHR-23 0.183 23791784 Q9U1W2 G2HK15 MDT-8 APTF-2 0.183 23791784 Q9U1W2 G5EG44 MDT-8 MDL-1 0.183 23791784 Q9U1W2 G5EGD2 MDT-8 HIF-1 0.183 23791784