PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus T05A10.1m C44B9.4 23791784 intact exp G C44B9.4 zyg-8 14704431 biogrid,i2d,mint,intact,dip exp C44B9.4 mdt-11 23791784 intact exp G F53F8.1 C44B9.4 23791784 intact exp C44B9.4 rbr-2 23791784 intact exp G EOR-1, R11E3.6a C44B9.4 23791784 intact exp G C44B9.4 F49H12.1a 23791784 intact exp G C44B9.4 R06C7.9a 23791784 intact exp C44B9.4 Y54F10AM.1 23791784 intact exp C44B9.4 Y106G6H.14 23549480 intact exp G C44B9.4 T18H9.6 23791784 intact exp G C44B9.4 Y111B2A.10a 23791784 intact exp G hmp-1 C44B9.4 unassigned1274 intact exp G T04D1.3d C44B9.4 23549480 intact exp G Y51A2D.17 C44B9.4 23791784 intact exp C44B9.4 T20H4.2 23791784 intact exp nhr-111 C44B9.4 23791784 intact exp C44B9.4 prx-13 23549480 intact exp C44B9.4 egl-13 23791784 intact exp G Nuclear receptor protein, Y45G5AM.1a C44B9.4 23791784 intact exp G C44B9.4 T12E12.2 23791784 intact exp Y45F10D.13a C44B9.4 23549480,19447967 biogrid,intact exp G C44B9.4 T27A8.2 23791784 intact exp C44B9.4 Inhibitor of growth protein 23791784 intact exp G C44B9.4 F23D12.5 23791784 intact exp C44B9.4 mys-1 23791784 intact exp G Non-specific protein-tyrosine kinase C44B9.4 23549480 intact exp G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q95QC4 Q18605 - 14704431 - X 2 Q95QC4 Q18605 two hybrid 14704431 direct interaction X 2 Q18605 G5EC32 two hybrid 19447967 direct interaction X 2 Q95QC4 Q18605 two hybrid 14704431 physical association X 2 Q9BI74 Q18605 two hybrid 23791784 physical association X 2 G5EDU4 Q18605 two hybrid 23791784 physical association X 2 Q18605 G5EE56 two hybrid 23549480 physical association X 2 Q18605 Q19951 two hybrid 23549480 physical association X 2 Q18605 A5A8Q9 two hybrid 23549480 physical association X 2 Q18605 O45521 two hybrid 23791784 physical association X 2 Q18605 Q21777 two hybrid 23791784 physical association X 2 Q18605 Q22550 two hybrid 23791784 physical association X 2 Q18605 Q22621 two hybrid 23791784 physical association X 2 Q18605 Q22826 two hybrid 23791784 physical association X 2 Q18605 Q23541 two hybrid 23791784 physical association X 2 Q18605 B5U8M3 two hybrid 23791784 physical association X 2 Q18605 Q9BKZ8 two hybrid 23791784 physical association X 2 Q22430 Q18605 two hybrid 23791784 physical association X 2 Q9BHL4 Q18605 two hybrid 23791784 physical association X 2 Q9TYU5 Q18605 two hybrid 23791784 physical association X 2 Q95QC4 Q18605 two hybrid pooling approach 14704431 physical association X 2 Q18605 O62482 two hybrid pooling approach 19447967 physical association X 2 Q18605 O62482 two hybrid pooling approach 19447967 physical association X 2 Q18605 O62482 two hybrid pooling approach 19447967 physical association X 2 Q18605 G5EC32 two hybrid 23549480 physical association X 2 Q18605 Q9U2Z5 two hybrid 23549480 physical association X 2 Q18605 O62259 two hybrid 23791784 physical association X 2 Q18605 Q19760 two hybrid 23791784 physical association X 2 Q18605 G5EEL3 two hybrid 23791784 physical association X 2 Q18605 G5EEM0 two hybrid 23791784 physical association X 2 Q23045 Q18605 two hybrid 23791784 physical association X 2 Q9N5S3 Q18605 two hybrid 23791784 physical association X 2 Q9XWJ8 Q18605 two hybrid 23791784 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B athp-1 cec-6 MI:0018(two hybrid) 23791784 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_33109 prey bait athp-1 prx-13 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23595 prey bait athp-1 egl-13 MI:0018(two hybrid) 23791784 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_33259 prey bait athp-1 mdt-27 MI:0018(two hybrid) 23791784 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_33124 prey bait nhr-111 athp-1 MI:0018(two hybrid) 23791784 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_32160 bait prey sorb-1 athp-1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 19447967 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact) UniProt_22836|UniProt_23009|UniProt_22910 bait|bait|bait prey|prey|prey athp-1 ztf-15 MI:0018(two hybrid) 23791784 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_33064 prey bait athp-1 Y106G6H.14 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23791 prey bait athp-1 T27A8.2 MI:0018(two hybrid) 23791784 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_33188 prey bait athp-1 sma-9 MI:0018(two hybrid) 23791784 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_31415 prey bait athp-1 CELE_T20H4.2 MI:0018(two hybrid) 23791784 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_33131 prey bait athp-1 zyg-8 MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0007(anti tag coimmunoprecipitation) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0465(dip)|MI:0471(mint)|(intact) DIP_4764|MINT_3321|UniProt_29155 -|prey|prey -|bait|bait athp-1 CELE_Y111B2A.10 MI:0018(two hybrid) 23791784 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_33488 prey bait athp-1 mdt-11 MI:0018(two hybrid) 23791784 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_33499 prey bait athp-1 nhr-239 MI:0018(two hybrid) 23791784 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_33524 prey bait athp-1 lsy-2 MI:0018(two hybrid) 23791784 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_33654 prey bait athp-1 mys-1 MI:0018(two hybrid) 23791784 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_33739 prey bait klf-2 athp-1 MI:0018(two hybrid) 23791784 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_32277 bait prey athp-1 jmjd-3.2 MI:0018(two hybrid) 23791784 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_32929 prey bait athp-1 unc-57 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23760 prey bait athp-1 ing-3 MI:0018(two hybrid) 23791784 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_34013 prey bait athp-1 rbr-2 MI:0018(two hybrid) 23791784 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_33314 prey bait athp-1 sorb-1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23869 prey bait athp-1 nhr-114 MI:0018(two hybrid) 23791784 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_31734 prey bait athp-1 nhr-70 MI:0018(two hybrid) 23791784 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_31707 prey bait athp-1 src-1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23900 prey bait athp-1 eor-1 MI:0018(two hybrid) 23791784 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_31658 prey bait

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q22826 Q18605 Q22826 ATHP-1 0.183 23791784 Q18605 G5EEL3 ATHP-1 NHR-70 0.183 23791784 Q18605 B5U8M3 ATHP-1 SMA-9 0.183 23791784 Q18605 G5EEM0 ATHP-1 NHR-114 0.183 23791784 Q19760 Q18605 JMJD-3.2 ATHP-1 0.183 23791784 Q9BI74 Q18605 MDT-11 ATHP-1 0.183 23791784 Q18605 O62259 ATHP-1 KLF-2 0.183 23791784 Q22430 Q18605 CEC-6 ATHP-1 0.183 23791784 Q23045 Q18605 EGL-13 ATHP-1 0.183 23791784 Q22550 Q18605 MDT-27 ATHP-1 0.183 23791784 Q22621 Q18605 Q22621 ATHP-1 0.183 23791784 Q9U2Z5 Q18605 Q9U2Z5 ATHP-1 0.183 23549480 Q9N5S3 Q18605 LSY-2 ATHP-1 0.183 23791784 Q23541 Q18605 RBR-2 ATHP-1 0.183 23791784 Q19951 Q18605 PRX-13 ATHP-1 0.183 23549480 Q21777 Q18605 ZTF-15 ATHP-1 0.183 23791784 Q18605 O45521 ATHP-1 NHR-111 0.183 23791784 Q18605 O62482 ATHP-1 SORB-1 0.126 19447967 Q9XWJ8 Q18605 ING-3 ATHP-1 0.183 23791784 Q95QC4 Q18605 ZYG-8 ATHP-1 0.155 14704431 Q9BHL4 Q18605 Q9BHL4 ATHP-1 0.183 23791784 Q9BKZ8 Q18605 NHR-239 ATHP-1 0.183 23791784 Q9TYU5 Q18605 MYS-1 ATHP-1 0.183 23791784 Q18605 G5EC32 ATHP-1 SORB-1 0.183 23549480 Q18605 G5EDU4 ATHP-1 EOR-1 0.183 23791784 Q18605 G5EE56 ATHP-1 SRC-1 0.183 23549480 Q18605 A5JYX3 ATHP-1 A5JYX3 0.332 26780296 Q18605 B1V8A0 ATHP-1 UNC-57 {ECO:0000312|WORMBASE:T04D1.3D} 0.183 23549480