PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Y40C5A.1 Y106G6H.14 23549480 intact exp G T17H7.4d Y106G6H.14 23549480 intact exp G Y40B1A.3b Y106G6H.14 23549480 intact exp JC8.10b, Synaptojanin UNC-26A Y106G6H.14 23549480 intact exp R02F2.5 Y106G6H.14 23549480 intact exp Adenylyl cyclase-associated protein Y106G6H.14 23549480 intact exp G C07G1.4b Y106G6H.14 23549480 intact exp G W02G9.3 Y106G6H.14 14704431 biogrid,i2d exp Y106G6H.14 Y4C6B.1 23549480 intact exp Y106G6H.14 R06C1.3a 23549480 intact exp F58B6.2 Y106G6H.14 23549480 intact exp Y48E1B.1 Y106G6H.14 23549480 intact exp C44B9.4 Y106G6H.14 23549480 intact exp G C07D10.2b Y106G6H.14 23549480 intact exp G Epidermal growth factor receptor pathway substrate 8 splice variant A, Y57G11C.24g Y106G6H.14 23549480 intact exp G sap-49 Y106G6H.14 23549480 intact exp F46H5.6 Y106G6H.14 23549480 intact exp C49H3.6a Y106G6H.14 23549480 intact exp G UNC-34, Y50D4C.1a Y106G6H.14 23549480 intact exp G C25A11.4a Y106G6H.14 23549480 intact exp G F59E12.9 Y106G6H.14 23549480,14704431 biogrid,i2d,mint,intact,dip exp C47D12.2 Y106G6H.14 14704431 biogrid,i2d,mint,intact,dip exp G EHS-1, ZK1248.3a Y106G6H.14 23549480 intact exp G rpl-3 Y106G6H.14 14704431 biogrid,i2d,mint,intact,dip exp G cyk-1 Y106G6H.14 23549480 intact exp F15B9.4 Y106G6H.14 23549480 intact exp F43B10.2a Y106G6H.14 23549480 intact exp C33B4.3c Y106G6H.14 23549480 intact exp kel-8 Y106G6H.14 14704431 intact exp G apl-1 Y106G6H.14 ortho G Y106G6H.14 Y106G6H.14 ortho G ZC404.9 Y106G6H.14 ortho rib-1 Y106G6H.14 ortho G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q18668 Q9U2Z5 - 14704431 - X 2 Q9U2Z5 - 14704431 - X 2 Q9U2Z5 O01900 - 14704431 - X 2 Q9U2Z5 P50880 - 14704431 - X 2 Q18668 Q9U2Z5 two hybrid 14704431 direct interaction X 2 Q9U2Z5 P50880 two hybrid 14704431 direct interaction X 2 Q9U2Z5 O01900 two hybrid 14704431 direct interaction X 2 Q9U2Z5 two hybrid 14704431 direct interaction X 2 Q9U2Z5 G5ED84 two hybrid 14704431 physical association X 2 Q18668 Q9U2Z5 two hybrid 14704431 physical association X 2 Q9U2Z5 P50880 two hybrid 14704431 physical association X 2 Q9U2Z5 O01900 two hybrid 14704431 physical association X 2 F5GUF0 Q9U2Z5 two hybrid 23549480 physical association X 2 G5ED33 Q9U2Z5 two hybrid 23549480 physical association X 2 G5ED33 Q9U2Z5 two hybrid 23549480 physical association X 2 Q95YA9 Q9U2Z5 two hybrid 23549480 physical association X 2 Q95YA9 Q9U2Z5 two hybrid 23549480 physical association X 2 Q3Y407 Q9U2Z5 two hybrid 23549480 physical association X 2 Q3Y407 Q9U2Z5 two hybrid 23549480 physical association X 2 Q9U2Z5 G5ED84 two hybrid pooling approach 14704431 physical association X 2 Q9U2Z5 Q9TYU9 two hybrid 23549480 physical association X 2 Q9U2Z5 O18195 two hybrid 23549480 physical association X 2 Q9U2Z5 D9N122 two hybrid 23549480 physical association X 2 Q9U2Z5 Q19479 two hybrid 23549480 physical association X 2 Q9U2Z5 Q9UB01 two hybrid 23549480 physical association X 2 Q18668 Q9U2Z5 two hybrid pooling approach 14704431 physical association X 2 Q9N3Z0 Q9U2Z5 two hybrid 23549480 physical association X 2 Q8MPW4 Q9U2Z5 two hybrid 23549480 physical association X 2 Q8MPW4 Q9U2Z5 two hybrid 23549480 physical association X 2 O61701 Q9U2Z5 two hybrid 23549480 physical association X 2 O61701 Q9U2Z5 two hybrid 23549480 physical association X 2 Q21648 Q9U2Z5 two hybrid 23549480 physical association X 2 B3CJ53 Q9U2Z5 two hybrid 23549480 physical association X 2 Q18605 Q9U2Z5 two hybrid 23549480 physical association X 2 Q9U2Z5 P50880 two hybrid pooling approach 14704431 physical association X 2 Q9U2Z5 O01900 two hybrid pooling approach 14704431 physical association X 2 Q9U2Z5 Q17782 two hybrid 23549480 physical association X 2 Q9U2Z5 Q17795 two hybrid 23549480 physical association X 2 Q9U2Z5 Q09442 two hybrid 23549480 physical association X 2 Q9U2Z5 Q95QQ9 two hybrid 23549480 physical association X 2 Q9U2Z5 Q09442 two hybrid 23549480 physical association X 2 Q9U2Z5 G4RTG4 two hybrid 23549480 physical association X 2 Q9U2Z5 B7WN72 two hybrid 23549480 physical association X 2 Q9U2Z5 O01900 two hybrid 23549480 physical association X 2 Q9U2Z5 G5EG53 two hybrid 23549480 physical association X 2 B5WWM0 Q9U2Z5 two hybrid 23549480 physical association X 2 Q1XFY2 Q9U2Z5 two hybrid 23549480 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B R02F2.5 Y106G6H.14 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_24315 prey bait C47D12.2 Y106G6H.14 MI:0398(two hybrid pooling approach)|MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid)|MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) MI:0471(mint)|(intact)|MI:0465(dip)|(biogrid) MINT_7221|UniProt_30002|DIP_1618|BIOGRID_21907 bait|bait|-|bait prey|prey|-|prey Y106G6H.14 kel-8 MI:0007(anti tag coimmunoprecipitation) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_28675 bait prey Y106G6H.14 eps-8 MI:0018(two hybrid)|MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_23803|UniProt_24320 bait|bait prey|prey bath-44 Y106G6H.14 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_24306 prey bait inft-2 Y106G6H.14 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23793 prey bait Y106G6H.14 unc-34 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23801 bait prey cas-1 Y106G6H.14 MI:0018(two hybrid)|MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_24311|UniProt_23794 prey|prey bait|bait sap-49 Y106G6H.14 MI:0018(two hybrid)|MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_23788|UniProt_24308 prey|prey bait|bait athp-1 Y106G6H.14 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23791 prey bait pat-12 Y106G6H.14 MI:0018(two hybrid)|MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_24317|UniProt_23798 prey|prey bait|bait F59E12.9 Y106G6H.14 MI:0398(two hybrid pooling approach)|MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 14704431,23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(intact)|(biogrid)|(intact)|MI:0465(dip) MINT_2798|UniProt_28676|BIOGRID_24792|UniProt_23796|DIP_4285 prey|prey|prey|prey|- bait|bait|bait|bait|- Y106G6H.14 ajm-1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23789 bait prey Y106G6H.14 unc-26 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23797 bait prey O61899 Y106G6H.14 MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14704431 taxid:0() taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|MI:0465(dip) MINT_2799|DIP_4286 prey|- bait|- wsp-1 Y106G6H.14 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_24307 prey bait Y106G6H.14 ehs-1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_24321 bait prey grd-7 Y106G6H.14 MI:0018(two hybrid)|MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_24313|UniProt_23795 prey|prey bait|bait cyk-1 Y106G6H.14 MI:0018(two hybrid)|MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_24310|UniProt_23792 prey|prey bait|bait Y106G6H.14 wve-1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_24316 bait prey ddl-2 Y106G6H.14 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_24319 prey bait rpl-3 Y106G6H.14 MI:0398(two hybrid pooling approach)|MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid)|MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) MI:0471(mint)|(intact)|(biogrid)|MI:0465(dip) MINT_2797|UniProt_28674|BIOGRID_24791|DIP_4284 prey|prey|prey|- bait|bait|bait|- Y106G6H.14 inft-1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_24314 bait prey C49H3.6 Y106G6H.14 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_24309 prey bait Y106G6H.14 CELE_Y40B1A.3 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23799 bait prey tag-343 Y106G6H.14 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_24312 prey bait Y106G6H.14 CELE_Y4C6B.1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23800 bait prey Y106G6H.14 shn-1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23790 bait prey Y40C5A.1 Y106G6H.14 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_24318 prey bait

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9U2Z5 Q21648 Q9U2Z5 Q21648 0.183 23549480 Q9U2Z5 Q18605 Q9U2Z5 ATHP-1 0.183 23549480 Q9U2Z5 Q19479 Q9U2Z5 INFT-2 0.183 23549480 Q9U2Z5 Q1XFY2 Q9U2Z5 TAG-343 0.183 23549480 Q9U2Z5 O61899 Q9U2Z5 O61899 0.033 14704431 Q9U2Z5 Q95QA6 Q9U2Z5 PAT-12 0.183 23549480 Q9U2Z5 Q95QQ9 Q9U2Z5 Q95QQ9 0.183 23549480 Q9U2Z5 Q95YA9 Q9U2Z5 CAS-1 0.332 23549480 Q9U2Z5 Q9TYU9 Q9U2Z5 EXC-6 0.183 23549480 Q9U2Z5 B5WWM0 Q9U2Z5 B5WWM0 0.183 23549480 Q9U2Z5 D9N122 Q9U2Z5 EHS-1 0.183 23549480 Q9U2Z5 F5GUF0 Q9U2Z5 WVE-1 0.183 23549480 Q9U2Z5 G5ECL2 Q9U2Z5 UNC-26 {ECO:0000312|WORMBASE:JC8.10B} 0.183 23549480 Q9U2Z5 O18195 Q9U2Z5 DDL-2 0.183 23549480 Q9U2Z5 O61701 Q9U2Z5 CYK-1 0.332 23549480 Q9U2Z5 P50880 Q9U2Z5 RPL-3 0.155 14704431 Q9U2Z5 Q09442 Q9U2Z5 SAP-49 0.183 23549480 Q9U2Z5 Q17782 Q9U2Z5 BATH-44 0.183 23549480 Q9U2Z5 Q17795 Q9U2Z5 WSP-1 0.183 23549480 Q9U2Z5 Q18668 Q9U2Z5 Q18668 0.155 14704431 Q9U2Z5 Q3Y407 Q9U2Z5 GRD-7 0.332 23549480 Q9U2Z5 Q9N3Z0 Q9U2Z5 SQST-2 0.183 23549480 Q9UB01 Q9U2Z5 Q9UB01 Q9U2Z5 0.183 23549480 Q9U2Z5 B7WN72 Q9U2Z5 SHN-1 0.183 23549480 Q9U2Z5 G4RTG4 Q9U2Z5 AJM-1 0.183 23549480 Q9U2Z5 G5ED33 Q9U2Z5 EPS-8 0.183 23549480 Q9U2Z5 G5ED84 Q9U2Z5 KEL-8 0.126 14704431 Q9U2Z5 G5EG53 Q9U2Z5 UNC-34 0.183 23549480 Q9U2Z5 O01900 Q9U2Z5 O01900 0.309 23549480,14704431