PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus B0336.6 Adenomatous polyposis coli protein-related protein 1, APC-related protein 1 unassigned1274 intact exp G B0336.6 F41B4.1 23549480,19447967 biogrid,intact exp G B0336.6 prx-13 23549480 intact exp B0336.6 dyb-1 14704431 biogrid,i2d,mint,intact,dip exp G B0336.6 Y38C1BA.2b 23549480 intact exp G T22A3.3a B0336.6 23549480 intact exp F14F3.1a, Variable abnormal-3 B0336.6 19447967 biogrid,intact exp G B0336.6 M57.1 19447967 biogrid,intact exp rpy-1 B0336.6 14704431 biogrid,i2d,mint,intact,dip exp G mig-10 B0336.6 23022657,23549480,19447967 biogrid,intact exp G T17H7.4d B0336.6 14704431 biogrid,intact,dip exp G F35G12.3a, SEL-5A serine/threonine kinase B0336.6 23549480 intact exp G abl-1 B0336.6 19402756 dip exp G B0336.6 sqv-4 23549480 intact exp G Y43F8C.6b B0336.6 23549480 intact exp Uncharacterized protein B0303.7 B0336.6 23549480 intact exp G JC8.10b, Synaptojanin UNC-26A B0336.6 23549480 intact exp F32B4.4a B0336.6 23549480,19447967 biogrid,intact exp G M01E11.7a B0336.6 23549480 intact exp G B0336.6 M04F3.5 23549480,19447967 biogrid,intact exp G F47B10.8b B0336.6 23549480 intact exp G B0336.6 C49H3.6a 23549480 intact exp G B0336.6 Y50D4A.4 19447967 biogrid,intact exp CEH-17, D1007.1 B0336.6 19447967 biogrid,intact exp G B0336.6 jac-1 unassigned1274 intact exp Epidermal growth factor receptor pathway substrate 8 splice variant A, Y57G11C.24g B0336.6 23549480 intact exp G figl-1 B0336.6 23549480 intact exp G T11B7.4d B0336.6 14704431 biogrid,intact exp G sap-49 B0336.6 23549480 intact exp

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants H2KYY3 Q10929 - 14704431 - X 2 G5EFL5 Q10929 - 14704431 - X 2 Q10929 Q09485 - 14704431 - X 2 Q10929 Q9Y048 - 14704431 - X 2 Q9TYX9 Q10929 two hybrid 19447967 direct interaction X 2 Q95Y95 Q10929 two hybrid 19447967 direct interaction X 2 Q966J6 Q10929 two hybrid 19447967 direct interaction X 2 G5EEL1 Q10929 two hybrid 14704431 direct interaction X 2 Q10929 P34400-2 two hybrid 23022657 direct interaction X 2 Q10929 P34400-2 affinity chromatography technology 23022657 physical association X 2 Q10929 G5EE71 two hybrid 19447967 direct interaction X 2 Q10929 P34400-2 two hybrid 19447967 direct interaction X 2 Q10929 H2KYY9 two hybrid 14704431 direct interaction X 2 G5EC89 Q10929 two hybrid 19447967 direct interaction X 2 Q95Y58 Q10929 two hybrid 19447967 direct interaction X 2 F5GUF6 Q10929 two hybrid 19447967 direct interaction X 2 Q10929 Q09485 two hybrid 14704431 direct interaction X 2 Q10929 Q9Y048 two hybrid 14704431 direct interaction X 2 Q95QA6 Q10929 two hybrid 14704431 physical association X 2 P03949 Q10929 pull down 19402756 direct interaction X 2 G5EFL5 Q10929 two hybrid 14704431 physical association X 2 Q10929 Q09485 two hybrid 14704431 physical association X 2 Q10929 Q9Y048 two hybrid 14704431 physical association X 2 Q9TYX9 Q10929 two hybrid pooling approach 19447967 physical association X 2 Q9TYX9 Q10929 two hybrid pooling approach 19447967 physical association X 2 Q9TYX9 Q10929 two hybrid pooling approach 19447967 physical association X 2 G5ED33 Q10929 two hybrid 23549480 physical association X 2 B3CJ53 Q10929 two hybrid 23549480 physical association X 2 Q9XWN1 Q10929 two hybrid 23549480 physical association X 2 G5EGI2 Q10929 two hybrid 23549480 physical association X 2 Q95Y95 Q10929 two hybrid 19447967 physical association X 2 Q95Y95 Q10929 two hybrid pooling approach 19447967 physical association X 2 Q95Y95 Q10929 two hybrid 23549480 physical association X 2 Q95Y95 Q10929 two hybrid 23549480 physical association X 2 Q966J6 Q10929 two hybrid 19447967 physical association X 2 Q966J6 Q10929 two hybrid pooling approach 19447967 physical association X 2 Q966J6 Q10929 two hybrid pooling approach 19447967 physical association X 2 Q966J6 Q10929 two hybrid 23549480 physical association X 2 Q966J6 Q10929 two hybrid 23549480 physical association X 2 O62203 Q10929 two hybrid 19447967 physical association X 2 O62203 Q10929 two hybrid pooling approach 19447967 physical association X 2 O62203 Q10929 two hybrid pooling approach 19447967 physical association X 2 O62203 Q10929 two hybrid pooling approach 19447967 physical association X 2 Q10929 G5EE71 two hybrid pooling approach 19447967 physical association X 2 Q10929 G5EE71 two hybrid pooling approach 19447967 physical association X 2 Q10929 P34258 two hybrid 23549480 physical association X 2 Q10929 Q09442 two hybrid 23549480 physical association X 2 Q10929 G5ECQ3 two hybrid 23549480 physical association X 2 Q10929 B6VQ68 two hybrid 23549480 physical association X 2 H2KYY5 Q10929 two hybrid pooling approach 14704431 physical association X 2 Q19951 Q10929 two hybrid 23549480 physical association X 2 P92160 Q10929 two hybrid 23549480 physical association X 2 Q95QQ9 Q10929 two hybrid 23549480 physical association X 2 P91820 Q10929 two hybrid 23549480 physical association X 2 G5EC89 Q10929 two hybrid pooling approach 19447967 physical association X 2 G5EC89 Q10929 two hybrid pooling approach 19447967 physical association X 2 Q95Y58 Q10929 two hybrid pooling approach 19447967 physical association X 2 Q95Y58 Q10929 two hybrid pooling approach 19447967 physical association X 2 O16299 Q10929 two hybrid 23549480 physical association X 2 F5GUF6 Q10929 two hybrid 23549480 physical association X 2 F5GUF6 Q10929 two hybrid 23549480 physical association X 2 G5EFL5 Q10929 two hybrid pooling approach 14704431 physical association X 2 Q10929 Q9Y048 two hybrid pooling approach 14704431 physical association X 2 Q10929 Q09485 two hybrid pooling approach 14704431 physical association X 2 Q10929 G5EDS1 two hybrid 19447967 physical association X 2 Q10929 P34400 two hybrid 19447967 physical association X 2 Q10929 G5EDS1 two hybrid pooling approach 19447967 physical association X 2 Q10929 P34400 two hybrid pooling approach 19447967 physical association X 2 Q10929 G5EDS1 two hybrid pooling approach 19447967 physical association X 2 Q10929 G5EDS1 two hybrid pooling approach 19447967 physical association X 2 Q10929 P34400 two hybrid pooling approach 19447967 physical association X 2 Q10929 P34400 two hybrid pooling approach 19447967 physical association X 2 Q10929 P34400 two hybrid 23549480 physical association X 2 Q10929 P34400 two hybrid 23549480 physical association X 2 Q10929 Q19905 two hybrid 23549480 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B abl-1 abi-1 MI:0096(pull down) 19402756 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction) MI:0465(dip) DIP_5029 - - abi-1 pat-12 MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) MI:0465(dip) DIP_3627 - - abi-1 C49H3.6 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_24075 bait prey abi-1 dyb-1 MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) MI:0465(dip)|MI:0471(mint)|(intact)|(biogrid) DIP_2484|MINT_876|UniProt_30868|BIOGRID_22925 -|prey|prey|prey -|bait|bait|bait sap-49 abi-1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23494 prey bait abi-1 Q22534 MI:0398(two hybrid pooling approach) 14704431 taxid:6239(Caenorhabditis elegans) taxid:0() MI:0915(physical association) MI:0471(mint) MINT_2110 prey bait abi-1 pat-12 MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction) (biogrid) BIOGRID_24120 prey bait lst-1 abi-1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23505 prey bait abi-1 sel-5 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23497 bait prey abi-1 eps-8 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23507 bait prey abi-1 alp-1 MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction) (biogrid) BIOGRID_24019 prey bait abi-1 ceh-17 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 19447967 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact)|(intact) BIOGRID_29439|UniProt_22733|UniProt_22975 bait|bait|bait prey|prey|prey abi-1 vab-3 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 19447967 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|(intact)|(intact)|(intact)|(biogrid) UniProt_22817|UniProt_22736|UniProt_22979|UniProt_22606|BIOGRID_29443 bait|bait|bait|bait|bait prey|prey|prey|prey|prey abi-1 vab-3 MI:0018(two hybrid)|MI:0018(two hybrid) 19447967 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_22737|UniProt_22980 bait|bait prey|prey abi-1 Q17878 MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:0() MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|MI:0465(dip) MINT_2006|DIP_3524 prey|- bait|- abi-1 alp-1 MI:0007(anti tag coimmunoprecipitation) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_27913 prey bait abi-1 snn-1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_24080 bait prey abi-1 Y50D4A.4 MI:0018(two hybrid)|MI:0018(two hybrid) 19447967 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_22818|UniProt_22982 bait|bait prey|prey abi-1 M04F3.5 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 19447967,23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|(intact)|(intact)|(intact)|(biogrid) UniProt_22976|UniProt_24079|UniProt_22604|UniProt_23504|BIOGRID_29440 bait|bait|bait|bait|bait prey|prey|prey|prey|prey abi-1 F32B4.4 MI:0018(two hybrid) 19447967 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction) (biogrid) BIOGRID_29441 bait prey abi-1 M57.1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 19447967 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|(intact)|(intact)|(biogrid) UniProt_22816|UniProt_22978|UniProt_22735|BIOGRID_29442 bait|bait|bait|bait prey|prey|prey|prey abi-1 CELE_F41B4.1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 19447967,23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact)|(intact)|(intact) UniProt_22738|UniProt_23500|UniProt_24078|UniProt_22607|UniProt_22981 bait|bait|bait|bait|bait prey|prey|prey|prey|prey abi-1 CELE_F32B4.4 MI:0018(two hybrid)|MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_23499|UniProt_24077 bait|bait prey|prey abi-1 sqv-4 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23496 bait prey abi-1 prx-13 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23589 prey bait B0303.7 abi-1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23495 prey bait abi-1 pat-12 MI:0007(anti tag coimmunoprecipitation) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_28015 prey bait rpy-1 abi-1 MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|MI:0465(dip)|MI:0471(mint) UniProt_29779|DIP_1396|MINT_6961 bait|-|bait prey|-|prey tag-163 abi-1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23501 prey bait figl-1 abi-1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23498 prey bait abi-1 CELE_F47B10.8 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23503 bait prey abi-1 unc-26 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23502 bait prey abi-1 Y43F8C.6 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23508 bait prey F32B4.4 abi-1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 19447967 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact)|(intact) UniProt_22815|UniProt_22977|UniProt_22734|UniProt_22605 prey|prey|prey|prey bait|bait|bait|bait mig-10 abi-1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 19447967,23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(biogrid)|(intact)|(intact)|(intact)|(intact) UniProt_24076|UniProt_22739|BIOGRID_29446|UniProt_22608|UniProt_22983|UniProt_22819|UniProt_23493 prey|prey|prey|prey|prey|prey|prey bait|bait|bait|bait|bait|bait|bait

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q10929 Q09442 ABI-1 SAP-49 0.183 23549480 Q19951 Q10929 PRX-13 ABI-1 0.183 23549480 Q10929 B6VQ68 ABI-1 B6VQ68 0.183 23549480 Q10929 F5GUF6 ABI-1 F5GUF6 0.183 23549480 Q10929 G5ECQ3 ABI-1 SEL-5 0.183 23549480 Q10929 G5ED33 ABI-1 EPS-8 0.183 23549480 Q10929 G5EFL5 ABI-1 ALP-1 0.126 14704431 Q10929 G5EGI2 ABI-1 SNN-1 0.183 23549480 Q10929 O01874 ABI-1 O01874 0.126 19447967 Q10929 O16299 ABI-1 FIGL-1 0.183 23549480 Q10929 P34258 ABI-1 P34258 0.183 23549480 Q10929 P92160 ABI-1 TAG-163 0.183 23549480 Q17878 Q10929 Q17878 ABI-1 0.033 14704431 Q19905 Q10929 SQV-4 ABI-1 0.183 23549480 Q9U308 Q10929 JAC-1 ABI-1 0.183 26780296 Q9XWN1 Q10929 Q9XWN1 ABI-1 0.183 23549480 Q10929 P03949 ABI-1 ABL-1 0.309 19402756 Q95QA6 Q10929 PAT-12 ABI-1 0.155 14704431 Q17359 Q10929 Q17359 ABI-1 0.286 19447967 Q10929 G5EDS1 ABI-1 VAB-3 0.286 19447967 Q10929 Q09485 ABI-1 RPY-1 0.155 14704431 Q10929 O62203 ABI-1 O62203 0.286 19447967 Q9Y048 Q10929 DYB-1 ABI-1 0.155 14704431 Q95Y95 Q10929 Q95Y95 ABI-1 0.416 23549480,19447967 Q10929 P34400 ABI-1 MIG-10 0.416 23549480,19447967 Q966J6 Q10929 Q966J6 ABI-1 0.659 23549480,19447967 Q95QQ9 Q10929 Q95QQ9 ABI-1 0.183 23549480 Q95Y58 Q10929 Q95Y58 ABI-1 0.236 19447967 Q9TYX9 Q10929 Q9TYX9 ABI-1 0.236 19447967 Q10929 P91820 ABI-1 LST-1 0.183 23549480 Q10929 G5EC89 ABI-1 CEH-17 0.126 19447967 Q10929 G5ECL2 ABI-1 UNC-26 {ECO:0000312|WORMBASE:JC8.10B} 0.183 23549480 Q10929 G5EE71 ABI-1 VAB-3 0.126 19447967 Q21227 Q10929 APR-1 ABI-1 0.183 26780296 Q17357 Q10929 Q17357 ABI-1 0.126 19447967