PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus klp-6 C09G12.9 18692475,unassigned701 biogrid,mint,intact exp klc-1 C09G12.9 18692475,unassigned701 biogrid,mint,intact exp vps-37 C09G12.9 18692475,unassigned701,17895996,19123269 biogrid,mint,intact exp C09G12.9 Galectin 18692475,unassigned701 biogrid,intact exp C09G12.9 F35F10.12 19123269 intact exp C09G12.9 W04D2.1a 18692475,unassigned701 biogrid,intact exp, ortho C09G12.9 dnc-2 18692475,unassigned701 biogrid,mint,intact exp, ortho C09G12.9 C06A6.3 17895996 biogrid exp, ortho C09G12.9 C07G1.5 18692475,unassigned701,23818590 biogrid,mint,intact exp, ortho C09G12.9 sem-5 ortho C09G12.9 tag-345 ortho Heavy metal tolerance factor 1, W09D6.6 C09G12.9 ortho let-413 C09G12.9 ortho C09G12.9 sur-5 ortho C09G12.9 ubq-2 ortho C09G12.9 F01G4.5 ortho Y105E8A.17b C09G12.9 ortho K11C4.3c C09G12.9 ortho Talin, Y71G12B.11a C09G12.9 ortho C09G12.9 ZK742.1a ortho C09G12.9 vps-28 ortho C09G12.9 F28A10.6 ortho sma-1 C09G12.9 ortho C09G12.9 C09G12.9 ortho wrs-1 C09G12.9 ortho C09G12.9 B0379.4b ortho C09G12.9 F17C11.8 ortho C09G12.9 F09E5.2 ortho C09G12.9 C27F2.5 ortho C09G12.9 cgh-1 ortho C09G12.9 par-4 ortho C09G12.9 lin-40 ortho C09G12.9 Uncharacterized protein T27F2.1 ortho C09G12.9 arc-1 ortho C09G12.9 Y39H10A.6 ortho C09G12.9 srs-2 ortho C09G12.9 F32H2.5 ortho C09G12.9 Y116A8C.36a ortho D1081.8 C09G12.9 ortho C09G12.9 Y73E7A.2 ortho C09G12.9 ZC518.2 ortho cope-1 C09G12.9 ortho C09G12.9 rnr-2 ortho C09G12.9 Uncharacterized protein F07F6.4 ortho C09G12.9 smg-2 ortho C09G12.9 csn-6 ortho C09G12.9 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial ortho C09G12.9 M04F3.4a, M04F3.4b ortho C09G12.9 alx-1 ortho C09G12.9 lpd-7 ortho C09G12.9 mogs-1 ortho C09G12.9 Y62E10A.16 ortho C09G12.9 enol-1 ortho

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q21592 O76258 two hybrid 18692475 direct interaction X 2 O44158 O76258 affinity chromatography technology 17895996 physical association X 2 O44158 O76258 two hybrid 18692475 direct interaction X 2 O44158 O76258 two hybrid 18692475 direct interaction X 2 O76258 biochemical 17895996 colocalization X 2 O76258 affinity chromatography technology 17895996 physical association X 2 Q17796 O76258 two hybrid 18692475 direct interaction X 2 Q17796 O76258 affinity chromatography technology 23818590 physical association X 2 O76258 H2KZL0 two hybrid 18692475 direct interaction X 2 O76258 Q9XVU8 two hybrid 18692475 direct interaction X 2 Q8MQ04 O76258 two hybrid 18692475 direct interaction X 2 Q09248 O76258 two hybrid 18692475 direct interaction X 2 H9G2T2 O76258 two hybrid - physical association X 2 O44158 O76258 two hybrid pooling approach 19123269 physical association X 2 O44158 O76258 two hybrid array 19123269 physical association X 2 O44158 O76258 two hybrid - physical association X 2 O44158 O76258 two hybrid - physical association X 2 H2KZL1 O76258 two hybrid - physical association X 2 Q17796 O76258 two hybrid - physical association X 2 O76258 Q9XVU8 two hybrid - physical association X 2 Q8MQ04 O76258 two hybrid - physical association X 2 Q09248 O76258 two hybrid - physical association X 2 Q9GYT4 O76258 two hybrid pooling approach 19123269 physical association X 2 Q9GYT4 O76258 two hybrid array 19123269 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B tsg-101 Q8ITW2 MI:0018(two hybrid) 18692475 taxid:6239(Caenorhabditis elegans) taxid:0() MI:0915(physical association) MI:0471(mint) MINT_4047 bait prey tsg-101 atn-1 MI:0018(two hybrid) pubmed:unassigned701 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_24744 bait prey tsg-101 dnc-2 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 18692475 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(intact)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint) MINT_4021|UniProt_24587|MINT_4018|MINT_4019|MINT_4034|MINT_4020 bait|bait|bait|bait|bait|bait prey|prey|prey|prey|prey|prey tsg-101 klc-1 MI:0018(two hybrid) 18692475 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) MI:0471(mint) MINT_4046 bait prey tsg-101 hgrs-1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 18692475 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|MI:0471(mint)|(intact)|MI:0471(mint) MINT_4031|MINT_4032|UniProt_24845|MINT_4033 bait|bait|bait|bait prey|prey|prey|prey tsg-101 arrd-19 MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach) 19123269 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_18127|UniProt_20043 bait|bait prey|prey tsg-101 zen-4 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 18692475 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|(intact) MINT_4041|MINT_4042|MINT_4028|UniProt_24729 bait|bait|bait|bait prey|prey|prey|prey tsg-101 W04B5.3 MI:0018(two hybrid) pubmed:unassigned701 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_25232 bait prey tsg-101 klc-1 MI:0018(two hybrid) pubmed:unassigned701 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_24545 bait prey vps-37 tsg-101 MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 18692475,19123269 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|(intact)|(intact)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|(intact) UniProt_20044|MINT_4038|MINT_4039|MINT_4036|MINT_4037|MINT_4035|MINT_4401|MINT_4402|MINT_4400|UniProt_24929|UniProt_18129|MINT_4022|MINT_4040|MINT_4024|MINT_4399|MINT_4023|MINT_4398|MINT_4026|MINT_4025|MINT_4397|MINT_4027|MINT_4404|MINT_4403|MINT_4406|MINT_4405|MINT_4408|MINT_4407|MINT_4409|MINT_4410|UniProt_24939 prey|prey|prey|prey|prey|prey|bait|bait|bait|prey|prey|prey|prey|prey|bait|prey|bait|prey|prey|bait|prey|bait|bait|bait|bait|bait|bait|bait|bait|bait bait|bait|bait|bait|bait|bait|prey|prey|prey|bait|bait|bait|bait|bait|prey|bait|prey|bait|bait|prey|bait|prey|prey|prey|prey|prey|prey|prey|prey|prey

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8MQ04 O76258 ZEN-4 TSG-101 0.332 unassigned701,18692475 Q8ITW2 O76258 Q8ITW2 TSG-101 0.183 18692475 Q9XVU8 O76258 ATN-1 TSG-101 0.183 unassigned701 O76258 H9G2T2 TSG-101 KLC-1 0.183 unassigned701 Q21592 O76258 KLC-1 TSG-101 0.183 18692475 Q23158 O76258 ATN-1 TSG-101 0.183 18692475 Q17796 O76258 HGRS-1 TSG-101 0.332 unassigned701,18692475 Q09248 O76258 DNC-2 TSG-101 0.332 unassigned701,18692475 O76258 O44158 TSG-101 VPS-37 0.583 19123269,unassigned701,18692475 Q9GYT4 O76258 ARRD-19 TSG-101 0.236 19123269 O76258 H2KZL1 TSG-101 H2KZL1 0.183 unassigned701