PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Hypoxia-inducible factor 1 dpff-1 23791784 intact exp dpff-1 R06C7.9a 23791784 intact exp dpff-1 F49H12.1a 23791784 intact exp G dpff-1 dpff-1 14704431 intact exp G C34F11.9b dpff-1 14704431 biogrid exp G dpff-1 Y39B6A.19a i2d exp dpff-1 Uncharacterized protein F36G3.1 14704431 biogrid,i2d,mint,intact exp G lin-11 dpff-1 23791784 intact exp G dpff-1 F13G3.1 23791784 intact exp dpff-1 C44C10.4 14704431 biogrid,i2d,mint,intact exp dpff-1 Y39B6A.1 14704431 biogrid,mint,intact exp G dpff-1 F40F9.7a 23791784 intact exp G F52F12.4 dpff-1 23791784 intact exp dpff-1 T05C12.6a 23791784,14704431 biogrid,mint,intact exp G M04G12.1a dpff-1 14704431 biogrid,i2d,mint,intact exp G ceh-9 dpff-1 23791784 intact exp cpr-5 dpff-1 14704431 biogrid,i2d,mint,intact exp G psa-4 dpff-1 ortho G C26C6.1a dpff-1 ortho G dpff-1 Y71H2AM.17 ortho G dpff-1 R07E5.3 ortho G dpff-1 ZK616.4 ortho G dpff-1 C01H6.7a ortho G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q09477 G5EC49 - 14704431 - X 2 Q18616 Q09477 - 14704431 - X 2 Q09477 P43509 - 14704431 - X 2 Q09477 Q9XVK9 - 14704431 - X 2 Q09477 - 14704431 - X 2 Q09477 - 14704431 - X 2 Q09560 Q09477 - 14704431 - X 2 Q09477 Q22227 two hybrid 14704431 physical association X 2 Q18616 Q09477 two hybrid 14704431 physical association X 2 Q9NES7 Q09477 two hybrid 14704431 physical association X 2 Q09477 P43509 two hybrid 14704431 physical association X 2 B7WN58 Q09477 two hybrid 14704431 physical association X 2 P92004 Q09477 two hybrid 14704431 physical association X 2 Q09560 Q09477 two hybrid 14704431 physical association X 2 Q09477 Q22227 two hybrid pooling approach 14704431 physical association X 2 Q09477 G5EGD2 two hybrid 23791784 physical association X 2 Q09477 P56407 two hybrid 23791784 physical association X 2 Q09477 Q22227 two hybrid 23791784 physical association X 2 Q18616 Q09477 two hybrid pooling approach 14704431 physical association X 2 Q9NES7 Q09477 two hybrid pooling approach 14704431 physical association X 2 Q9N5S3 Q09477 two hybrid 23791784 physical association X 2 Q20237 Q09477 two hybrid 23791784 physical association X 2 Q09477 P43509 two hybrid pooling approach 14704431 physical association X 2 Q09477 P20154 two hybrid 23791784 physical association X 2 Q09477 Q21777 two hybrid 23791784 physical association X 2 Q19418 Q09477 two hybrid 23791784 physical association X 2 P92004 Q09477 two hybrid pooling approach 14704431 physical association X 2 O02273 Q09477 two hybrid 23791784 physical association X 2 Q09560 Q09477 two hybrid pooling approach 14704431 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B tag-260 C28H8.9/C28H8.10 MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0007(anti tag coimmunoprecipitation) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0465(dip)|MI:0471(mint)|(intact) DIP_1485|MINT_7062|UniProt_29868 -|prey|prey -|bait|bait C28H8.9/C28H8.10 Y39B6A.1 MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|MI:0465(dip)|MI:0471(mint)|(biogrid) UniProt_29871|DIP_1488|MINT_7065|BIOGRID_21745 bait|-|bait|bait prey|-|prey|prey cpr-5 C28H8.9/C28H8.10 MI:0007(anti tag coimmunoprecipitation)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|MI:0471(mint)|MI:0465(dip)|(biogrid) UniProt_29870|MINT_7064|DIP_1487|BIOGRID_21744 prey|prey|-|prey bait|bait|-|bait C28H8.9/C28H8.10 Q95ZX3 MI:0398(two hybrid pooling approach)|MI:0007(anti tag coimmunoprecipitation) 14704431 taxid:6239(Caenorhabditis elegans) taxid:0() MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(intact) MINT_7059|UniProt_29865 bait|bait prey|prey C28H8.9/C28H8.10 hif-1 MI:0018(two hybrid) 23791784 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_32474 bait prey C28H8.9/C28H8.10 mig-5 MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction) (biogrid) BIOGRID_21743 bait prey C28H8.9/C28H8.10 C44C10.4 MI:0007(anti tag coimmunoprecipitation)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|MI:0471(mint)|MI:0465(dip)|(biogrid) UniProt_29866|MINT_7060|DIP_1483|BIOGRID_21740 bait|bait|-|bait prey|prey|-|prey C28H8.9/C28H8.10 F36G3.1 MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) MI:0465(dip)|(intact)|MI:0471(mint)|(biogrid) DIP_1484|UniProt_29867|MINT_7061|BIOGRID_21741 -|bait|bait|bait -|prey|prey|prey lsl-1 C28H8.9/C28H8.10 MI:0018(two hybrid) 23791784 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_32475 prey bait ceh-9 C28H8.9/C28H8.10 MI:0018(two hybrid) 23791784 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_32477 prey bait C28H8.9/C28H8.10 mig-5 MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14704431,23791784 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0465(dip)|(intact)|MI:0471(mint)|(intact) DIP_1486|UniProt_29869|MINT_7063|UniProt_32481 -|bait|bait|bait -|prey|prey|prey C28H8.9/C28H8.10 lsy-2 MI:0018(two hybrid) 23791784 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_32482 bait prey C28H8.9/C28H8.10 dsh-1 MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) MI:0465(dip) DIP_1482 - - C28H8.9/C28H8.10 ztf-2 MI:0018(two hybrid) 23791784 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_32478 bait prey C28H8.9/C28H8.10 ztf-15 MI:0018(two hybrid) 23791784 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_32480 bait prey C28H8.9/C28H8.10 drap-1 MI:0018(two hybrid) 23791784 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_32479 bait prey lin-11 C28H8.9/C28H8.10 MI:0018(two hybrid) 23791784 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_32476 prey bait

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q09477 O02273 Q09477 LSL-1 0.183 23791784 Q09477 P20154 Q09477 LIN-11 0.183 23791784 Q09477 P43509 Q09477 CPR-5 0.309 14704431 Q09477 P56407 Q09477 CEH-9 0.183 23791784 Q09560 Q09477 Q09560 Q09477 0.309 14704431 Q18616 Q09477 Q18616 Q09477 0.155 14704431 Q9NES7 Q09477 Q9NES7 Q09477 0.155 14704431 Q19418 Q09477 ZTF-2 Q09477 0.183 23791784 Q21777 Q09477 ZTF-15 Q09477 0.183 23791784 Q20237 Q09477 DRAP-1 Q09477 0.183 23791784 Q9N5S3 Q09477 LSY-2 Q09477 0.183 23791784 Q09477 P92004 Q09477 TAG-260 0.155 14704431 Q22227 Q09477 MIG-5 Q09477 0.436 23791784,14704431 Q95ZX3 Q09477 Q95ZX3 Q09477 0.033 14704431 Q09477 G5EGD2 Q09477 HIF-1 0.183 23791784