PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus C34C6.6a F23C8.4 14704431 biogrid,i2d,mint,intact,dip exp Uncharacterized protein C13G5.2 F23C8.4 14704431 biogrid,i2d,mint,intact exp ero-1 F23C8.4 14704431 biogrid,mint,intact,dip exp G cdc-48.2 F23C8.4 20977550,14704431 biogrid,i2d,mint,intact,dip exp G C25E10.8 F23C8.4 14704431 biogrid,i2d,mint,intact,dip exp G cdc-48.1 F23C8.4 20977550,19123269,14704431 biogrid,i2d,mint,intact,dip exp G ztf-17 F23C8.4 14704431 biogrid,i2d,mint,intact,dip exp G F23C8.4 K08E3.4 14704431 biogrid,i2d,mint,intact,dip exp G nhr-111 F23C8.4 14704431 biogrid,i2d,mint,intact,dip exp M02A10.3a, Sli-1 protein F23C8.4 14704431 biogrid,i2d,mint,intact,dip exp G gst-42 F23C8.4 14704431 biogrid,i2d,mint,intact,dip exp G W06A11.3 F23C8.4 14704431 biogrid,i2d,mint,intact,dip exp Transgelin F23C8.4 ortho C44E4.1a F23C8.4 ortho Y34D9A.10 F23C8.4 ortho G cul-3 F23C8.4 ortho G ufd-1 F23C8.4 ortho G F23C8.4 gsk-3 ortho G F55B12.4 F23C8.4 ortho G Proline synthase co-transcribed bacterial homolog protein F23C8.4 ortho G cul-2 F23C8.4 ortho G F23C8.4 vha-13 ortho G Density-regulated protein homolog F23C8.4 ortho F38H4.7 F23C8.4 ortho G hrdl-1 F23C8.4 ortho G png-1 F23C8.4 ortho G C05C8.6 F23C8.4 ortho G ubr-1 F23C8.4 ortho G B0205.3 F23C8.4 ortho G F23C8.4 F23C8.4 ortho G T23G11.7a F23C8.4 ortho F55A4.1 F23C8.4 ortho G dnj-20 F23C8.4 ortho G Zinc finger protein ZPR1 homolog F23C8.4 ortho G ZK328.1b F23C8.4 ortho G F38E9.5 F23C8.4 ortho G Y71H2B.3 F23C8.4 ortho G ubc-1 F23C8.4 ortho G ufd-2 F23C8.4 ortho C11D2.7 F23C8.4 ortho G Ubiquitin-fold modifier-conjugating enzyme 1, Ufm1-conjugating enzyme 1 F23C8.4 ortho G WD repeat-containing protein 20 homolog F23C8.4 ortho G D2045.8 F23C8.4 ortho cul-1 F23C8.4 ortho G Elongation factor Tu homologue, Y71H2AM.23 F23C8.4 ortho G F56H1.4 F23C8.4 ortho G hmp-2 F23C8.4 ortho G sma-6 F23C8.4 ortho G tag-277 F23C8.4 ortho G CTP synthase F23C8.4 ortho F09D1.1 F23C8.4 ortho G lis-1 F23C8.4 ortho G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9XUT0 Q9TXH9 - 14704431 - X 2 B7FAS8 Q9TXH9 - 14704431 - X 2 Q9TXH9 - 14704431 - X 2 Q9TXH9 Q18157 - 14704431 - X 2 Q19019 Q9TXH9 - 14704431 - X 2 P54811 Q9TXH9 - 14704431 - X 2 P34327 Q9TXH9 - 14704431 - X 2 Q9TXH9 - 14704431 - X 2 Q23182 Q9TXH9 - 14704431 - X 2 Q18938 Q9TXH9 - 14704431 - X 2 P54812 Q9TXH9 - 14704431 - X 2 Q18426 Q9TXH9 - 14704431 - X 2 Q9XUT0 Q9TXH9 two hybrid 14704431 direct interaction X 2 B7FAS8 Q9TXH9 two hybrid 14704431 direct interaction X 2 Q9TXH9 two hybrid 14704431 direct interaction X 2 Q9TXH9 Q18157 two hybrid 14704431 direct interaction X 2 Q6ABG8 Q9TXH9 two hybrid 14704431 direct interaction X 2 Q7JM90 Q9TXH9 two hybrid 14704431 direct interaction X 2 P54811 Q9TXH9 affinity chromatography technology 20977550 physical association X 2 P54811 Q9TXH9 two hybrid 20977550 direct interaction X 2 P54811 Q9TXH9 two hybrid 14704431 direct interaction X 2 P34327 Q9TXH9 two hybrid 14704431 direct interaction X 2 Q23182 Q9TXH9 two hybrid 14704431 direct interaction X 2 Q18938 Q9TXH9 two hybrid 14704431 direct interaction X 2 O45521 Q9TXH9 two hybrid 14704431 direct interaction X 2 P54812 Q9TXH9 affinity chromatography technology 20977550 physical association X 2 P54812 Q9TXH9 two hybrid 20977550 direct interaction X 2 P54812 Q9TXH9 two hybrid 14704431 direct interaction X 2 Q9XUT0 Q9TXH9 two hybrid 14704431 physical association X 2 Q9TXH9 two hybrid 14704431 physical association X 2 Q9TXH9 Q18157 two hybrid 14704431 physical association X 2 Q19019 Q9TXH9 two hybrid 14704431 physical association X 2 P54811 Q9TXH9 two hybrid 14704431 physical association X 2 P34327 Q9TXH9 two hybrid 14704431 physical association X 2 Q9TXH9 two hybrid 14704431 physical association X 2 Q23182 Q9TXH9 two hybrid 14704431 physical association X 2 Q7YTU4 Q9TXH9 two hybrid 14704431 physical association X 2 Q18938 Q9TXH9 two hybrid 14704431 physical association X 2 P54812 Q9TXH9 two hybrid 14704431 physical association X 2 Q18426 Q9TXH9 two hybrid 14704431 physical association X 2 Q9XUT0 Q9TXH9 two hybrid pooling approach 14704431 physical association X 2 Q9TXH9 Q18157 two hybrid pooling approach 14704431 physical association X 2 Q19019 Q9TXH9 two hybrid pooling approach 14704431 physical association X 2 P54811 Q9TXH9 two hybrid pooling approach 14704431 physical association X 2 P54811 Q9TXH9 two hybrid pooling approach 19123269 physical association X 2 P54811 Q9TXH9 two hybrid array 19123269 physical association X 2 P34327 Q9TXH9 two hybrid pooling approach 14704431 physical association X 2 Q23182 Q9TXH9 two hybrid pooling approach 14704431 physical association X 2 Q7YTU4 Q9TXH9 two hybrid pooling approach 14704431 physical association X 2 Q18938 Q9TXH9 two hybrid pooling approach 14704431 physical association X 2 O45521 Q9TXH9 two hybrid pooling approach 14704431 physical association X 2 P45972 Q9TXH9 two hybrid pooling approach 14704431 physical association X 2 P54812 Q9TXH9 two hybrid pooling approach 14704431 physical association X 2 Q18426 Q9TXH9 two hybrid pooling approach 14704431 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B gst-42 ubxn-1 MI:0398(two hybrid pooling approach)|MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid)|MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) MI:0471(mint)|(intact)|MI:0465(dip)|(biogrid) MINT_345|UniProt_30443|DIP_2059|BIOGRID_22407 prey|prey|-|prey bait|bait|-|bait ubxn-1 K08E3.4 MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) MI:0465(dip)|(intact)|(biogrid)|MI:0471(mint) DIP_2061|UniProt_30445|BIOGRID_22409|MINT_347 -|bait|bait|bait -|prey|prey|prey ero-1 ubxn-1 MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0007(anti tag coimmunoprecipitation) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|MI:0471(mint)|(intact) BIOGRID_22412|MINT_350|UniProt_30448 prey|prey|prey bait|bait|bait fbxb-118 ubxn-1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation)|MI:0398(two hybrid pooling approach) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|MI:0465(dip)|(intact)|MI:0471(mint) BIOGRID_22411|DIP_2063|UniProt_30447|MINT_349 prey|-|prey|prey bait|-|bait|bait C25E10.8 ubxn-1 MI:0007(anti tag coimmunoprecipitation)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|MI:0471(mint)|MI:0465(dip) UniProt_30440|MINT_342|DIP_2056 prey|prey|- bait|bait|- cdc-48.2 ubxn-1 MI:0398(two hybrid pooling approach)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid) 14704431,20977550 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(biogrid)|(biogrid)|(biogrid)|(intact)|MI:0465(dip) MINT_344|BIOGRID_28453|BIOGRID_22406|BIOGRID_28466|UniProt_30442|DIP_2058 prey|prey|prey|prey|prey|- bait|bait|bait|bait|bait|- sli-1 ubxn-1 MI:0398(two hybrid pooling approach)|MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid)|MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) MI:0471(mint)|(intact)|(biogrid)|MI:0465(dip) MINT_1398|UniProt_31340|BIOGRID_23429|DIP_2953 bait|bait|bait|- prey|prey|prey|- nhr-111 ubxn-1 MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (intact)|MI:0465(dip)|(biogrid)|MI:0471(mint) UniProt_30444|DIP_2060|BIOGRID_22408|MINT_346 prey|-|prey|prey bait|-|bait|bait prx-5 ubxn-1 MI:0398(two hybrid pooling approach)|MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(intact)|MI:0465(dip) MINT_343|UniProt_30441|DIP_2057 prey|prey|- bait|bait|- C13G5.2 ubxn-1 MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(biogrid)|(intact)|MI:0465(dip) MINT_341|BIOGRID_22403|UniProt_30439|DIP_2055 prey|prey|prey|- bait|bait|bait|- ztf-17 ubxn-1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation)|MI:0398(two hybrid pooling approach) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) MI:0465(dip)|(biogrid)|(intact)|MI:0471(mint) DIP_2062|BIOGRID_22410|UniProt_30446|MINT_348 -|prey|prey|prey -|bait|bait|bait cdc-48.1 ubxn-1 MI:0398(two hybrid pooling approach)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14704431,19123269,20977550 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid)|(biogrid)|MI:0471(mint)|(biogrid)|(intact)|(intact)|MI:0465(dip) UniProt_18021|BIOGRID_28460|BIOGRID_22402|MINT_340|BIOGRID_28448|UniProt_30438|UniProt_19934|DIP_2054 prey|prey|prey|prey|prey|prey|prey|- bait|bait|bait|bait|bait|bait|bait|-

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9TXH9 Q7YTU4 UBXN-1 ERO-1 0.126 14704431 Q9TXH9 Q19019 UBXN-1 SLI-1 0.155 14704431 Q9TXH9 Q23182 UBXN-1 FBXB-118 0.155 14704431 Q9TXH9 O45521 UBXN-1 NHR-111 0.155 14704431 Q9TXH9 P34327 UBXN-1 P34327 0.155 14704431 Q9TXH9 P45972 UBXN-1 ZTF-17 0.155 14704431 Q9TXH9 P54811 UBXN-1 CDC-48.1 0.354 19123269,14704431 Q9TXH9 P54812 UBXN-1 CDC-48.2 0.155 14704431 Q9TXH9 Q18157 UBXN-1 Q18157 0.155 14704431 Q9TXH9 Q18426 UBXN-1 PRX-5 0.155 14704431 Q9TXH9 Q18938 UBXN-1 GST-42 0.155 14704431 Q9TXH9 Q95Q33 UBXN-1 ERO-1 0.033 14704431 Q9XUT0 Q9TXH9 Q9XUT0 UBXN-1 0.155 14704431