PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus F58E6.10a aak-2 14704431 biogrid,intact exp G nhr-6 aak-2 14704431 biogrid,i2d,mint,intact,dip exp G F54B11.7 aak-2 14704431 biogrid,i2d,mint,intact,dip exp C54D10.3 aak-2 14704431 biogrid,i2d,mint,intact,dip exp G aak-2 Y47D3A.15 19123269 intact exp G F49E8.7a aak-2 14704431 intact exp G nhr-2 aak-2 14704431 biogrid,mint,intact exp F49E8.6 aak-2 14704431 biogrid,i2d exp G icd-1 aak-2 14704431 biogrid,i2d,mint,intact,dip exp G aak-2 F55F3.1 11731503 intact exp G Nascent polypeptide-associated complex subunit alpha, NAC-alpha aak-2 14704431 biogrid,i2d,mint,intact,dip exp G ubq-1 aak-2 ortho G aak-2 par-4 ortho vps-52 aak-2 ortho G Y6B3A.1a aak-2 ortho G Stromal interaction molecule 1 aak-2 ortho unc-94 aak-2 ortho G paa-1 aak-2 ortho G Y92H12A.2a aak-2 ortho G C17G10.2 aak-2 ortho aak-2 aak-2 ortho G efk-1 aak-2 ortho G R06A4.8 aak-2 ortho G aak-2 spt-16 ortho G pph-6 aak-2 ortho G aak-2 Y65B4BR.4a ortho G Y105E8A.16 aak-2 ortho G aak-2 Y47G6A.6 ortho G tbb-4 aak-2 ortho G C05H8.1b aak-2 ortho G cct-6 aak-2 ortho G D2085.1 aak-2 ortho G him-1 aak-2 ortho G daf-21 aak-2 ortho G ZK742.1a aak-2 ortho G Stress-induced-phosphoprotein 1, CeSTI1, STI1 aak-2 ortho aak-2 Y111B2A.8 ortho G rpn-6.1 aak-2 ortho G trm-1 aak-2 ortho G gsp-2 aak-2 ortho G aak-2 gsy-1 ortho G T03F6.2 aak-2 ortho G F22D3.2c aak-2 ortho G M03A8.1 aak-2 ortho G Uncharacterized protein C30C11.4 aak-2 ortho G gsp-1 aak-2 ortho G T05C3.5 aak-2 ortho G aak-2 W07E6.2 ortho aak-2 Uncharacterized protein Y39B6A.33 ortho G Y81G3A.3b aak-2 ortho G Uncharacterized protein T27F2.1 aak-2 ortho G sds-22 aak-2 ortho G B0511.6 aak-2 ortho G T27F6.5a aak-2 ortho G unc-101 aak-2 ortho G aak-2 F54A5.1 ortho vdac-1 aak-2 ortho G usp-14 aak-2 ortho G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q86S66-2 Q95ZQ4 - 14704431 - X 2 Q10902 Q95ZQ4 - 14704431 - X 2 Q95ZQ4 Q20631 - 14704431 - X 2 Q18827 Q95ZQ4 - 14704431 - X 2 P41829 Q95ZQ4 - 14704431 - X 2 Q95ZQ4 - 14704431 - X 2 Q95ZQ4 Q20742 - 14704431 - X 2 Q95ZQ4 Q18885 - 14704431 - X 2 Q86S66 Q95ZQ4 two hybrid pooling approach 14704431 physical association X 2 Q10902 Q95ZQ4 two hybrid pooling approach 14704431 physical association X 2 Q95ZQ4 H2KZY3 two hybrid pooling approach 14704431 physical association X 2 Q18827 Q95ZQ4 two hybrid pooling approach 14704431 physical association X 2 P41829 Q95ZQ4 two hybrid pooling approach 14704431 physical association X 2 Q95ZQ4 Q9XUY2 two hybrid 11731503 physical association X 2 Q95ZQ4 Q18885 two hybrid pooling approach 14704431 physical association X 2 Q95ZQ4 Q20742 two hybrid pooling approach 14704431 physical association X 2 Q95ZQ4 G5EBS8 two hybrid pooling approach 14704431 physical association X 2 Q95ZQ4 Q9NAH7 two hybrid pooling approach 19123269 physical association X 2 Q95ZQ4 Q9NAH7 two hybrid pooling approach 19123269 physical association X 2 Q95ZQ4 Q9NAH7 two hybrid array 19123269 physical association X 2 Q95ZQ4 Q9NAH7 two hybrid array 19123269 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Q20455 aak-2 MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14704431 taxid:0() taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|MI:0465(dip) MINT_1694|DIP_3229 prey|- bait|- C54D10.3 aak-2 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0007(anti tag coimmunoprecipitation) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) MI:0465(dip)|(biogrid)|MI:0471(mint)|(intact) DIP_3225|BIOGRID_23712|MINT_1690|UniProt_27612 -|prey|prey|prey -|bait|bait|bait nhr-2 aak-2 MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation)|MI:0398(two hybrid pooling approach) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact)|MI:0471(mint) BIOGRID_23710|UniProt_27608|MINT_1688 prey|prey|prey bait|bait|bait aak-2 F49E8.7 MI:0007(anti tag coimmunoprecipitation) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_27613 bait prey aak-2 aakb-1 MI:0018(two hybrid) 11731503 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_853 bait prey aak-2 unc-42 MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_27614|BIOGRID_23716 bait|bait prey|prey aak-2 aakb-2 MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach) 19123269 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact)|(intact) UniProt_21366|UniProt_19454|UniProt_21365|UniProt_19452 bait|bait|prey|prey prey|prey|bait|bait icd-1 aak-2 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0007(anti tag coimmunoprecipitation) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) MI:0465(dip)|(biogrid)|MI:0471(mint)|(intact) DIP_3226|BIOGRID_23713|MINT_1691|UniProt_27611 -|prey|prey|prey -|bait|bait|bait Q20632 aak-2 MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14704431 taxid:0() taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|MI:0465(dip) MINT_1692|DIP_3227 prey|- bait|- F54B11.7 aak-2 MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(biogrid)|MI:0465(dip)|(intact) MINT_1693|BIOGRID_23715|DIP_3228|UniProt_27615 prey|prey|-|prey bait|bait|-|bait Y65B4BR.5 aak-2 MI:0398(two hybrid pooling approach)|MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) MI:0471(mint)|(intact)|(biogrid) MINT_1695|UniProt_27616|BIOGRID_23717 prey|prey|prey bait|bait|bait nhr-6 aak-2 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation)|MI:0398(two hybrid pooling approach) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|MI:0465(dip)|(intact)|MI:0471(mint) BIOGRID_23711|DIP_3224|UniProt_27610|MINT_1689 prey|-|prey|prey bait|-|bait|bait

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q95ZQ4 Q18827 AAK-2 Q18827 0.126 14704431 Q9XUY2 Q95ZQ4 AAKB-1 AAK-2 0.309 11731503 Q9NAH7 Q95ZQ4 AAKB-2 AAK-2 0.236 19123269 Q95ZQ4 P41829 AAK-2 NHR-6 0.286 14704431 Q95ZQ4 Q10902 AAK-2 NHR-2 0.286 14704431 Q95ZQ4 Q18885 AAK-2 ICD-1 0.286 14704431 Q95ZQ4 Q86S66 AAK-2 Q86S66 0.286 14704431 Q95ZQ4 G5EBS8 AAK-2 UNC-42 0.126 14704431 Q95ZQ4 H2KZY3 AAK-2 H2KZY3 0.126 14704431 Q95ZQ4 Q20742 AAK-2 Q20742 0.126 14704431