PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus FUN30 MDM1 i2d exp FUN30 CRN1 i2d exp FUN30 ZUO1 19536198 intact exp SEM1 FUN30 i2d exp SBP1 FUN30 23222640 biogrid exp FUN30 SSZ1 19536198 intact exp RFA1 FUN30 22960743 biogrid exp FUN30 DRE2 i2d exp FUN30 RPN12 16554755 biogrid,i2d,mint,intact exp FUN30 TEL1 11805826 biogrid,mint,intact,dip exp FUN30 CYK3 19841731 mint,intact exp FUN30 HSP78 19536198 intact exp SSA2 FUN30 16429126,19536198 intact exp FUN30 EXO1 22960743 biogrid exp HTA1 FUN30 23007155 biogrid exp FUN30 ADA2 i2d exp CKA2 FUN30 i2d exp FUN30 LSM1 10900456 biogrid,i2d,mint,intact,dip exp SSA3 FUN30 19536198 intact exp HTA2 FUN30 23007155 biogrid exp FUN30 RPN5 16554755 biogrid,i2d,mint,intact exp FUN30 DRS2 16554755 biogrid,i2d,mint,intact exp FUN30 RPN6 16554755 biogrid,i2d,mint,intact exp MIS1 FUN30 11805826,16429126 biogrid,mint,intact,dip exp FUN30 PAC10 i2d exp CAM1 FUN30 i2d exp HSP82 FUN30 19536198 intact exp URA2 FUN30 16429126 intact exp FUN30 ESF1 i2d exp FUN30 PSK2 11805837 biogrid,mint,intact,dip exp SSB1 FUN30 16429126,19536198 intact exp YDJ1 FUN30 19536198 intact exp RPL4A FUN30 16429126 intact exp FUN30 DNA2 22960743 biogrid exp FUN30 RPL7B 16429126 intact exp FUN30 SSE1 19536198 intact exp SSA1 FUN30 16429126,19536198 intact exp FUN30 CDC73 i2d exp FUN30 UTP22 i2d exp CDC28 FUN30 14574415 biogrid,dip exp FUN30 JHD2 16554755 biogrid,i2d,mint,intact exp FUN30 PUS9 i2d exp FUN30 HHT1, HHT2 22199229 biogrid exp FUN30 TSR2 i2d exp FUN30 RPG1 i2d exp AAT2 FUN30 16554755 biogrid,i2d,mint,intact exp FUN30 RPN2 16429126 intact exp FUN30 SSB2 19536198 intact exp FUN30 MMT2 i2d exp CKA1 FUN30 16554755, 23023127 biogrid,i2d,mint,intact exp, pred FUN30 FUN30 11805826,20075079, 23023127 biogrid,mint,intact exp, pred FUN30 RAD54 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P31380 - 11805837 - C 3 P31380 - 11805826 - C 3 P47017 P31380 - 10900456 - X 2 P0CG63 P31380 affinity chromatography technology 23793018 physical association X 2 P32496 P31380 affinity chromatography technology 16554755 physical association X 2 P31380 P04911 far western blotting 23007155 direct interaction X 2 P31380 P22336 affinity chromatography technology 22960743 physical association X 2 P31380 P22336 affinity chromatography technology 22960743 physical association X 2 P31380 P31380 affinity chromatography technology 20075079 physical association X 2 P31380 P09440 affinity chromatography technology 11805826 physical association X 2 P31380 P61830 affinity chromatography technology 22199229 physical association X 2 P31380 P61830 affinity chromatography technology 22199229 physical association X 2 Q12250 P31380 affinity chromatography technology 16554755 physical association X 2 P38110 P31380 affinity chromatography technology 11805826 physical association X 2 P47156 P31380 affinity chromatography technology 16554755 physical association X 2 P31380 P39875 affinity chromatography technology 22960743 physical association X 2 P31380 P39875 affinity chromatography technology 22960743 physical association X 2 P31380 P00546 enzymatic study 14574415 direct interaction X 2 P31380 P39524 affinity chromatography technology 16554755 physical association X 2 P31380 P15790 affinity chromatography technology 16554755 physical association X 2 P31380 Q12377 affinity chromatography technology 16554755 physical association X 2 P31380 P23542 affinity chromatography technology 16554755 physical association X 2 P31380 Q08217 affinity chromatography technology 11805837 physical association X 2 P47017 P31380 two hybrid 10900456 direct interaction X 2 P04912 P31380 far western blotting 23007155 direct interaction X 2 P38859 P31380 affinity chromatography technology 22960743 physical association X 2 P38859 P31380 affinity chromatography technology 22960743 physical association X 2 P31380 P09440 tandem affinity purification 11805826 physical association X 2 P31380 anti tag coimmunoprecipitation 11805837 - C 5 P31380 tandem affinity purification 11805826 physical association C 3 P31380 inferred by author 11805826 physical association C 3 P31380 anti tag coimmunoprecipitation 11805837 - C 3 P31380 Q08217 anti tag coimmunoprecipitation 11805837 physical association X 2 P31380 tandem affinity purification 11805826 physical association X 2 P31380 P00546 biochemical 14574415 physical association X 2 P31380 P00546 protein kinase assay 14574415 physical association X 2 P47017 P31380 two hybrid 10900456 physical association X 2 P31380 tandem affinity purification 16429126 association C 9 P31380 tandem affinity purification 11805826 association C 4 P31380 tandem affinity purification 11805826 association C 4 P10592 P31380 tandem affinity purification 19536198 association X 2 P32589 P31380 tandem affinity purification 19536198 association X 2 P32496 P31380 tandem affinity purification 16554755 physical association X 2 P31380 P11484 tandem affinity purification 19536198 association X 2 P31380 P31380 anti tag coimmunoprecipitation 20075079 physical association X 2 P31380 P31380 anti tag coimmunoprecipitation 20075079 physical association X 2 P31380 P31380 molecular sieving 20075079 physical association Y 1 P31380 P31380 cosedimentation through density gradient 20075079 physical association Y 1 P31380 P31380 pull down 20075079 physical association X 2 Q07533 P31380 inferred by author 19841731 direct interaction X 2 Q12250 P31380 tandem affinity purification 16554755 physical association X 2 Q12250 P31380 tandem affinity purification 16554755 physical association X 2 P31380 anti tag coimmunoprecipitation 11805837 association C 3 P47156 P31380 tandem affinity purification 16554755 physical association X 2 P31380 P23542 inferred by author 16554755 association X 2 P31380 P15790 tandem affinity purification 16554755 physical association X 2 P31380 Q12377 tandem affinity purification 16554755 physical association X 2 P31380 P23542 tandem affinity purification 16554755 physical association X 2 P31380 P15790 tandem affinity purification 16554755 physical association X 2 P31380 P15790 tandem affinity purification 16554755 physical association X 2 P31380 P39524 tandem affinity purification 16554755 physical association X 2 P31380 P32527 tandem affinity purification 19536198 association X 2 P31380 P09435 tandem affinity purification 19536198 association X 2 P31380 P38788 tandem affinity purification 19536198 association X 2 P31380 P33416 tandem affinity purification 19536198 association X 2 P31380 P25491 tandem affinity purification 19536198 association X 2 P31380 P02829 tandem affinity purification 19536198 association X 2 P47017 P31380 two hybrid 10900456 physical association X 2 P40150 P31380 tandem affinity purification 19536198 association X 2 P10591 P31380 tandem affinity purification 19536198 association X 2 P31380 mass spectrometry studies of complexes 11805826 - C 4 P31380 mass spectrometry studies of complexes 11805826 - C 4 P31380 mass spectrometry studies of complexes 11805837 - C 4 P31380 P40395 interaction detection method 14764870 - X 2 P31380 Q99260 interaction detection method 14764870 - X 2 P47017 P31380 two hybrid 10900456 - X 2

PPI - HINT Gene A Gene B PMID Method Quality CDC28 FUN30 14574415,14574415,14574415 0424,0401,0415 HT HTA1 FUN30 23007155 0047 LC HTA2 FUN30 23007155 0047 LC FUN30 FUN30 20075079,20075079,20075079,20075079,20075079 0071,0007,0029,0096,0004 LC FUN30 LSM1 10900456 0018 HT CDC28 FUN30 14574415,14574415,14574415 0424,0401,0415 LC HSP82 FUN30 19536198 0676 HT URA2 FUN30 16429126 0676 HT SSA3 FUN30 19536198 0676 HT MIS1 FUN30 11805826,16429126,11805826,11805826 0004,0676,0007,0676 HT SSA1 FUN30 19536198,16429126 0676,0676 HT SSA2 FUN30 19536198,16429126 0676,0676 HT RPL4A FUN30 16429126 0676 HT SSB1 FUN30 19536198,16429126 0676,0676 HT CKA1 FUN30 16554755,16554755 0676,0004 HT RFA1 FUN30 22960743 0004 LC AAT2 FUN30 16554755,16554755,16554755 0363,0676,0004 HT YDJ1 FUN30 19536198 0676 HT FUN30 FUN30 20075079,20075079,20075079,20075079,11805826,11805826,20075079 0071,0007,0029,0096,0676,0007,0004 LC,HT FUN30 RPN12 16554755,16554755 0676,0004 HT FUN30 ZUO1 19536198 0676 HT FUN30 RPN2 16429126 0676 HT FUN30 SSE1 19536198 0676 HT FUN30 HSP78 19536198 0676 HT FUN30 TEL1 11805826,11805826,11805826 0676,0007,0004 HT FUN30 SSZ1 19536198 0676 HT FUN30 DNA2 22960743 0004 LC FUN30 DRS2 16554755,16554755 0676,0004 HT FUN30 EXO1 22960743 0004 LC FUN30 SSB2 19536198 0676 HT FUN30 JHD2 16554755,16554755 0676,0004 HT FUN30 HHT1|HHT2 22199229 0004 HT FUN30 CYK3 19841731 0363 LC FUN30 PSK2 11805837,11805837 0004,0007 HT FUN30 RPL7B 16429126 0676 HT FUN30 RPN5 16554755,16554755 0676,0004 HT FUN30 RPN6 16554755,16554755 0676,0004 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P31380 P15790 FUN30 CKA1 0.332 16554755 P31380 P10080 FUN30 SBP1 0.126 23222640 P31380 P02829 FUN30 HSP82 0.126 19536198 P31380 P04911 FUN30 HTA1 0.309 23007155 P31380 P04912 FUN30 HTA2 0.309 23007155 P31380 P00546 FUN30 CDC28 0.236 14574415 P31380 P23542 FUN30 AAT2 0.236 16554755 Q12250 P31380 RPN5 FUN30 0.236 16554755 P31380 P10592 FUN30 SSA2 0.236 16429126,19536198 P39524 P31380 DRS2 FUN30 0.236 16554755 P31380 P31380 FUN30 FUN30 0.78 11805826,20075079 P31380 P07259 FUN30 URA2 0.126 16429126 P31380 P09435 FUN30 SSA3 0.126 19536198 P31380 P09440 FUN30 MIS1 0.286 11805826,16429126 P31380 P10591 FUN30 SSA1 0.236 16429126,19536198 P31380 P10664 FUN30 RPL4A 0.126 16429126 P31380 P11484 FUN30 SSB1 0.236 16429126,19536198 P31380 P22336 FUN30 RFA1 0.376 22960743 P31380 P25491 FUN30 YDJ1 0.126 19536198 P32496 P31380 RPN12 FUN30 0.236 16554755 P32527 P31380 ZUO1 FUN30 0.126 19536198 P32565 P31380 RPN2 FUN30 0.126 16429126 P32589 P31380 SSE1 FUN30 0.126 19536198 P38110 P31380 TEL1 FUN30 0.21 11805826 P38859 P31380 DNA2 FUN30 0.376 22960743 P39875 P31380 EXO1 FUN30 0.376 22960743 P47017 P31380 LSM1 FUN30 0.332 10900456 Q07533 P31380 CYK3 FUN30 0.183 19841731 Q12213 P31380 RPL7B FUN30 0.126 16429126 Q12377 P31380 RPN6 FUN30 0.236 16554755 P38788 P31380 SSZ1 FUN30 0.126 19536198 P33416 P31380 HSP78 FUN30 0.126 19536198 P40150 P31380 SSB2 FUN30 0.126 19536198 P47156 P31380 JHD2 FUN30 0.126 16554755 Q08217 P31380 PSK2 FUN30 0.21 11805837