PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus RPL25 SWD1 16429126 intact exp UGP1 SWD1 11805837 dip exp TEF1, TEF2 SWD1 16429126 intact exp RNR2 SWD1 11805837 biogrid,mint,intact,dip exp SUP35 SWD1 i2d exp SWD1 SSB2 23332755 biogrid exp SWD1 SER33 i2d exp RPL40A SWD1 11805837 intact,dip exp GLK1 SWD1 11805837 dip exp RPL27A SWD1 16429126 intact exp SWD1 LIA1 i2d exp SWD1 RSM7 11805826,16429126 biogrid,mint,intact,dip exp UBI4 SWD1 11805837 biogrid,mint exp SWD1 GPP2 i2d exp SSA2 SWD1 16429126 intact exp ATP1 SWD1 11805837 dip exp CDC28 SWD1 16319894 biogrid exp LSM2 SWD1 10900456 biogrid,i2d,mint,intact,dip exp SRP54 SWD1 21765803 biogrid exp SWD1 SER3 11283351 i2d,mint,intact,dip exp HXK1 SWD1 11805837 dip exp SWD1 PFS2 12453421 biogrid exp, ortho SWD1 HHT1, HHT2 20347846 biogrid exp, ortho SWD1 SWD1 11805826, 23023127 mint,intact exp, ortho, pred SWD2 SWD1 16429126,11742990, 23023127 biogrid,intact,dip exp, ortho, pred SWD1 SPP1 11805826,16429126,11742990,16921172,16554755, 23023127 biogrid,i2d,mint,intact,dip exp, pred SHG1 SWD1 11742990, 23023127 biogrid,intact,dip exp, pred YAK1 SWD1 20489023, 23023127 biogrid,mint,intact exp, pred SWD3 SWD1 11805826,16429126,18342605,10688190,21179020,11742990,16554755,22147691, 23023127 biogrid,i2d,mint,intact,dip exp, pred DOA4 SWD1 11805826,16429126, 23023127 biogrid,mint,intact,dip exp, pred SWD1 MTQ2 10688190, 23023127 biogrid,i2d,mint,intact,dip exp, pred SWD1 SDC1 11805826,16429126,11742990,16554755, 23023127 biogrid,i2d,mint,intact,dip exp, pred SWD1 BRE2 17392337,20498280,16429126,11687631,18083099,16554755,11805826,11742990,19398585, 23023127 biogrid,i2d,mint,intact,dip exp, pred SET1 SWD1 19713935,16429126,11687631,22158900,21179020,23453808,16554755,22147691,11805826,11742990,11752412,16921172, 23023127 biogrid,i2d,mint,intact,dip exp, pred SWD1 UBC9 ortho PRE10 SWD1 ortho SWD1 VPS36 ortho PRP16 SWD1 ortho ORC2 SWD1 23023127 pred SWD1 UBI4 23023127 pred MSI1 SWD1 23023127 pred SWD1 SAS2 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P39706 - 11805083 - C 8 P39706 - 11805837 - C 3 P39706 - 15775977 - C 7 P39706 - 15044803 - C 7 P39706 P40054 - 11283351 - X 2 P39706 Q03920 - 10688190 - X 2 P39706 P38123 - 10688190 - X 2 P39706 - 11805826 - C 8 P38203 P39706 - 10900456 - X 2 P0CG63 P39706 affinity chromatography technology 11805837 physical association X 2 P39706 P42841 affinity chromatography technology 12453421 physical association X 2 P39706 P43132 affinity chromatography technology 11742990 physical association X 2 P39706 P43132 affinity chromatography technology 11742990 physical association X 2 P39706 P36104 affinity chromatography technology 11742990 physical association X 2 P39706 P38123 affinity chromatography technology 11742990 physical association X 2 P39706 P38123 affinity chromatography technology 11742990 physical association X 2 P39706 P43132 affinity chromatography technology 11687631 physical association X 2 P39706 P43132 affinity chromatography technology 17392337 physical association X 2 P39706 P40150 biochemical 23332755 association X 2 P39706 P38123 affinity chromatography technology 16554755 physical association X 2 P39706 P43132 affinity chromatography technology 16554755 physical association X 2 P39706 P43132 affinity chromatography technology 16429126 physical association X 2 P39706 P32571 affinity chromatography technology 16429126 physical association X 2 P39706 P47150 affinity chromatography technology 16429126 physical association X 2 P39706 P36104 affinity chromatography technology 16429126 physical association X 2 P39706 P38123 affinity chromatography technology 16429126 physical association X 2 P39706 P43132 affinity chromatography technology 16429126 physical association X 2 P39706 P38123 affinity chromatography technology 17200106 physical association X 2 P39706 P36104 affinity chromatography technology 17200106 physical association X 2 P39706 P43132 affinity chromatography technology 17200106 physical association X 2 P39706 P43132 affinity chromatography technology 18083099 physical association X 2 P39706 P43132 affinity chromatography technology 18083099 physical association X 2 P39706 P38123 affinity chromatography technology 18342605 physical association X 2 P39706 P43132 affinity chromatography technology 19398585 physical association X 2 P39706 P14680 affinity chromatography technology 20489023 physical association X 2 P39706 P00546 enzymatic study 16319894 direct interaction X 2 P39706 P43132 affinity chromatography technology 20498280 physical association X 2 P39706 P43132 affinity chromatography technology 11805826 physical association X 2 P39706 P32571 affinity chromatography technology 11805826 physical association X 2 P39706 P47150 affinity chromatography technology 11805826 physical association X 2 P39706 P38123 affinity chromatography technology 11805826 physical association X 2 P39706 P09938 affinity chromatography technology 11805837 physical association X 2 P39706 P38123 affinity chromatography technology 22147691 physical association X 2 P39706 P38123 two hybrid 10688190 direct interaction X 2 P39706 Q03920 two hybrid 10688190 direct interaction X 2 P38203 P39706 two hybrid 10900456 direct interaction X 2 P39706 P38827 affinity chromatography technology 11742990 physical association X 2 P39706 P38827 affinity chromatography technology 11742990 physical association X 2 P39706 Q03012 affinity chromatography technology 11742990 physical association X 2 P39706 Q03012 affinity chromatography technology 11742990 physical association X 2 P39706 Q03323 affinity chromatography technology 11742990 physical association X 2 P39706 Q03323 affinity chromatography technology 11742990 physical association X 2 P39706 P38337 affinity chromatography technology 11742990 physical association X 2 P39706 P38337 affinity chromatography technology 11742990 physical association X 2 P39706 P38827 affinity chromatography technology 11687631 physical association X 2 P39706 P38827 affinity chromatography technology 11752412 physical association X 2 P39706 P38827 biochemical 11687631 association X 2 P39706 P38827 affinity chromatography technology 23453808 physical association X 2 P39706 Q03323 affinity chromatography technology 16554755 physical association X 2 P39706 Q03012 affinity chromatography technology 16554755 physical association X 2 P39706 P38827 affinity chromatography technology 16554755 physical association X 2 P39706 Q03323 affinity chromatography technology 16429126 physical association X 2 P39706 P38827 affinity chromatography technology 16429126 physical association X 2 P39706 Q03012 affinity chromatography technology 16429126 physical association X 2 P39706 P38827 affinity chromatography technology 16429126 physical association X 2 P39706 Q03012 affinity chromatography technology 16429126 physical association X 2 P39706 P61830 enzymatic study 16582434 direct interaction X 2 P39706 P61830 enzymatic study 16582434 direct interaction X 2 P39706 P38337 affinity chromatography technology 17200106 physical association X 2 P39706 Q03323 affinity chromatography technology 17200106 physical association X 2 P39706 P38827 affinity chromatography technology 17200106 physical association X 2 P39706 Q03012 affinity chromatography technology 17200106 physical association X 2 P39706 P38827 affinity chromatography technology 16921172 physical association X 2 P39706 Q03012 affinity chromatography technology 16921172 physical association X 2 P39706 P38827 pull down 19713935 direct interaction X 2 P39706 P61830 affinity chromatography technology 20347846 physical association X 2 P39706 P61830 affinity chromatography technology 20347846 physical association X 2 P39706 P38827 affinity chromatography technology 11805826 physical association X 2 P39706 Q03323 affinity chromatography technology 11805826 physical association X 2 P39706 Q03012 affinity chromatography technology 11805826 physical association X 2 P39706 P38827 pull down 22158900 direct interaction X 2 P39706 P61830 enzymatic study 22158900 direct interaction X 2 P39706 P61830 enzymatic study 22158900 direct interaction X 2 P39706 P38827 biochemical 22158900 association X 2 P39706 P38827 x-ray crystallography 22158900 association X 2 P39706 P38827 affinity chromatography technology 22147691 physical association X 2 P39706 P38827 pull down 22147691 direct interaction X 2 P39706 inferred by author 11805826 physical association C 9 P39706 anti tag coimmunoprecipitation 11805837 - C 3 P39706 affinity chromatography technology 11752412 - C 7 P39706 P07251 anti tag coimmunoprecipitation 11805837 physical association X 2 P39706 P40054 two hybrid pooling approach 11283351 physical association X 2 P39706 P05759 anti tag coimmunoprecipitation 11805837 physical association X 2 P39706 P09938 anti tag coimmunoprecipitation 11805837 physical association X 2 P39706 P43132 tandem affinity purification 11805826 physical association X 2 P39706 P43132 coimmunoprecipitation 11742990 physical association X 2 P39706 P32571 tandem affinity purification 11805826 physical association X 2 P39706 P47150 tandem affinity purification 11805826 physical association X 2 P39706 P36104 coimmunoprecipitation 11742990 physical association X 2 P39706 P38123 tandem affinity purification 11805826 physical association X 2 P39706 P38123 coimmunoprecipitation 11742990 physical association X 2 P39706 P38123 two hybrid 10688190 physical association X 2 P39706 Q03920 two hybrid 10688190 physical association X 2 P39706 anti tag coimmunoprecipitation 11805837 - C 7 P39706 tandem affinity purification 11805826 - C 8 P38203 P39706 two hybrid 10900456 physical association X 2 P39706 P17709 anti tag coimmunoprecipitation 11805837 physical association X 2 P39706 P04806 anti tag coimmunoprecipitation 11805837 physical association X 2 P39706 P38827 coimmunoprecipitation 11752412 physical association X 2 P39706 P38827 coimmunoprecipitation 11742990 physical association X 2 P39706 P38827 tandem affinity purification 11805826 physical association X 2 P39706 Q03323 coimmunoprecipitation 11742990 physical association X 2 P39706 Q03323 tandem affinity purification 11805826 physical association X 2 P39706 Q03012 tandem affinity purification 11805826 physical association X 2 P39706 Q03012 coimmunoprecipitation 11742990 physical association X 2 P39706 P38337 coimmunoprecipitation 11742990 physical association X 2 P32861 P39706 anti tag coimmunoprecipitation 11805837 physical association X 2 P39706 tandem affinity purification 21179020 association C 22 P39706 tandem affinity purification 16429126 association C 5 P39706 tandem affinity purification 11805826 association C 9 P39706 tandem affinity purification 11805826 association C 9 P39706 tandem affinity purification 11742990 association C 8 P39706 tandem affinity purification 11742990 association C 8 P39706 tandem affinity purification 11742990 association C 8 P39706 tandem affinity purification 11742990 association C 8 P39706 tandem affinity purification 11742990 association C 8 P39706 tandem affinity purification 11742990 association C 8 P39706 tandem affinity purification 18083099 association C 8 P39706 inferred by author 16554755 association C 10 P39706 tandem affinity purification 16429126 association C 6 P39706 anti tag coimmunoprecipitation 11805837 association C 3 P39706 tandem affinity purification 16429126 association C 7 P39706 tandem affinity purification 11742990 association C 7 P39706 tandem affinity purification 16429126 association C 3 P39706 P38123 two hybrid 10688190 physical association X 2 P39706 Q03920 two hybrid 10688190 physical association X 2 P39706 P40054 two hybrid fragment pooling approach 11283351 physical association X 2 P39706 P38123 tandem affinity purification 11742990 physical association X 2 P39706 P43132 tandem affinity purification 16554755 physical association X 2 P39706 P38123 tandem affinity purification 16554755 physical association X 2 P39706 P38123 tandem affinity purification 16554755 physical association X 2 P39706 P43132 tandem affinity purification 16554755 physical association X 2 P39706 P43132 tandem affinity purification 16554755 physical association X 2 P39706 P38123 tandem affinity purification 16554755 physical association X 2 P39706 P38123 tandem affinity purification 16554755 physical association X 2 P39706 P43132 tandem affinity purification 16554755 physical association X 2 P39706 P43132 tandem affinity purification 16554755 physical association X 2 P39706 pull down 19713935 association C 4 P39706 tandem affinity purification 21179020 association C 15 P39706 tandem affinity purification 16429126 association C 9 P39706 anti tag coimmunoprecipitation 20489023 association C 6 P39706 tandem affinity purification 16429126 association C 12 P39706 inferred by author 16429126 physical association C 9 P38203 P39706 two hybrid 10900456 physical association X 2 P39706 Q03012 tandem affinity purification 16554755 physical association X 2 P39706 Q03323 tandem affinity purification 16554755 physical association X 2 P39706 P38827 tandem affinity purification 16554755 physical association X 2 P39706 Q03012 tandem affinity purification 16554755 physical association X 2 P39706 Q03323 tandem affinity purification 16554755 physical association X 2 P39706 Q03012 tandem affinity purification 16554755 physical association X 2 P39706 Q01454 interaction detection method 14764870 - X 2 P39706 P38123 two hybrid 10688190 - X 2 P39706 Q03920 two hybrid 10688190 - X 2 P39706 P40054 two hybrid 11283351 - X 2 P39706 mass spectrometry studies of complexes 11805837 - C 4 P39706 mass spectrometry studies of complexes 11805837 - C 4 P39706 mass spectrometry studies of complexes 11805826 - C 11 P39706 mass spectrometry studies of complexes 11805826 - C 11 P12753 P39706 interaction detection method 14764870 - X 2 P38203 P39706 two hybrid 10900456 - X 2 P39706 Q06340 interaction detection method 14764870 - X 2

PPI - HINT Gene A Gene B PMID Method Quality CDC28 SWD1 16319894 0415 LC SRP54 SWD1 21765803 0401 LC SWD2 SWD1 11742990,11742990,11742990 0004,0676,0019 LC SWD3 SWD1 10688190,11742990,11742990,11742990,10688190 0397,0004,0676,0019,0018 HT,LC LSM2 SWD1 10900456 0018 HT SHG1 SWD1 11742990,11742990,11742990 0004,0019,0676 LC SET1 SWD1 22158900,22158900,22158900,11742990,11752412,11742990,11752412,11687631,11687631,11742990 0096,0114,0401,0019,0019,0004,0004,0004,0401,0676 LC SWD1 SER3 11283351,11283351,11283351 0018,0399,0398 HT SWD1 SSB2 23332755 0401 LC SWD1 BRE2 11742990,11742990,11742990 0676,0019,0004 LC SWD1 HHT1|HHT2 22158900,16582434 0415,0415 LC SWD1 SPP1 11742990,11742990,11742990 0004,0676,0019 LC SWD1 SDC1 11742990,11742990,11742990 0004,0676,0019 LC SWD1 MTQ2 10688190,10688190 0397,0018 HT TEF1|TEF2 SWD1 16429126 0676 HT RPL25 SWD1 16429126 0676 HT HXK1 SWD1 11805837 0007 HT RPS31 SWD1 11805837 0007 HT ATP1 SWD1 11805837 0007 HT RNR2 SWD1 11805837,11805837 0004,0007 HT RPL27B SWD1 16429126 0676 HT UBI4 SWD1 11805837,11805837 0004,0007 HT RPL40B SWD1 11805837 0007 HT SSA2 SWD1 16429126 0676 HT YAK1 SWD1 20489023,20489023 0007,0004 HT GLK1 SWD1 11805837 0007 HT SRP54 SWD1 21765803 0401 LC DOA4 SWD1 11805826,16429126,11805826,16429126,11805826 0004,0004,0007,0676,0676 HT UGP1 SWD1 11805837 0007 HT SWD2 SWD1 16429126,11742990,11742990,11742990,17200106,16429126 0676,0004,0676,0019,0004,0004 HT,LC SWD3 SWD1 18342605,21179020,16554755,22147691,16429126,11805826,11742990,11805826,11742990,17200106,11742990,11805826,16429126,16554755 0004,0676,0676,0004,0676,0676,0004,0004,0676,0004,0019,0007,0004,0004 LC,HT SHG1 SWD1 11742990,11742990,17200106,11742990 0004,0019,0004,0676 LC,HT SET1 SWD1 21179020,16921172,22158900,17200106,22158900,22158900,11742990,16554755,11752412,22147691,16429126,11805826,11742990,11752412,16554755,11687631,16429126,19713935,11687631,11805826,22147691,11742990,11805826,23453808 0676,0004,0096,0004,0114,0401,0019,0676,0019,0004,0676,0004,0004,0004,0004,0004,0004,0096,0401,0676,0096,0676,0007,0004 HT,LC SWD1 SWD1 11805826,11805826 0676,0007 HT SWD1 SSB2 23332755 0401 LC SWD1 PFS2 12453421 0004 LC SWD1 BRE2 16554755,16554755,18083099,11687631,16429126,16429126,18083099,11805826,20498280,17392337,11742990,11805826,11742990,11742990,19398585,17200106,11805826,16429126,16554755 0363,0676,0676,0004,0363,0676,0004,0676,0004,0004,0676,0004,0019,0004,0004,0004,0007,0004,0004 HT,LC SWD1 RSM7 11805826,16429126,11805826,16429126,11805826 0004,0004,0007,0676,0676 HT SWD1 HHT1|HHT2 20347846 0004 LC SWD1 SPP1 16554755,16921172,16429126,11805826,11742990,11805826,11742990,11742990,17200106,11805826,16429126,16554755 0676,0004,0676,0004,0004,0676,0676,0019,0004,0007,0004,0004 HT,LC SWD1 SDC1 16554755,16429126,11805826,11742990,11805826,11742990,11742990,17200106,11805826,16429126,16554755 0676,0676,0004,0004,0676,0676,0019,0004,0007,0004,0004 HT,LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P39706 P00546 SWD1 CDC28 0.183 16319894 Q03012 P39706 SPP1 SWD1 0.681 11805826,16429126,16554755,11742990 Q03323 P39706 SDC1 SWD1 0.597 11805826,16429126,16554755,11742990 P43132 P39706 BRE2 SWD1 0.905 11805826,17392337,18083099,16429126,19398585,16554755,11742990,20498280 P39706 P38123 SWD1 SWD3 0.867 11805826,10688190,16429126,16554755,21179020,11742990,18342605,22147691 P39706 P38827 SWD1 SET1 0.988 16554755,21179020,11742990,11687631,23453808,22147691,11805826,19713935,16429126,11752412,22158900 P39706 P38203 SWD1 LSM2 0.332 10900456 P39706 P38337 SWD1 SHG1 0.236 11742990 P39706 P32571 SWD1 DOA4 0.332 11805826,16429126 P39706 P32861 SWD1 UGP1 0.126 11805837 P39706 P02994 SWD1 TEF2 0.126 16429126 P39706 P04456 SWD1 RPL25 0.126 16429126 P39706 P04806 SWD1 HXK1 0.126 11805837 P39706 P07251 SWD1 ATP1 0.126 11805837 P39706 P09938 SWD1 RNR2 0.286 11805837 P39706 P0CG63 SWD1 UBI4 0.126 11805837 P39706 P10592 SWD1 SSA2 0.126 16429126 P39706 P14680 SWD1 YAK1 0.332 20489023 P39706 P17709 SWD1 GLK1 0.126 11805837 P39706 P36104 SWD1 SWD2 0.21 11742990,16429126 P39706 P38706 SWD1 RPL27B 0.126 16429126 P39706 P39706 SWD1 SWD1 0.155 11805826 P40054 P39706 SER3 SWD1 0.236 11283351 P47150 P39706 RSM7 SWD1 0.286 11805826,16429126 P61830 P39706 HHT2 SWD1 0.21 20347846 P61864 P39706 RPL40A SWD1 0.236 11805837 Q03920 P39706 MTQ2 SWD1 0.332 10688190 P40150 P39706 SSB2 SWD1 0.126 23332755 P39706 P20424 SWD1 SRP54 0.126 21765803