PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus HIR1 PUF3 26493364 biogrid exp CLB2 HIR1 21978826 biogrid exp HIR1 CMR1 22199229 biogrid exp HIR1 ARP8 21179020 intact exp HIR1 TAF4 12052880 biogrid exp HIR1 VID30 i2d exp HIR1 NET1 21179020 intact exp SSA1 HIR1 19536198 intact exp SAM35 HIR1 14690591 intact exp HIR1 SIZ1 23712011 biogrid exp HIR1 ACT1 21179020 intact exp HIR1 RNR4 11805837 dip exp SSB1 HIR1 19536198 intact exp HIR1 TFC4 21179020 intact exp HIR1 RVB1 21179020 intact exp HIR1 SPT10 25228766 biogrid exp HIR1 IES4 21179020 intact exp HIR1 RVB2 21179020 intact exp HIR1 DPB4 21179020 intact exp HIR1 CDC14 21179020 intact exp HIR1 SSB2 23332755 biogrid exp TEF1, TEF2 HIR1 16429126 intact exp LEU2 HIR1 11805837 dip exp HIR1 ITC1 21179020 intact exp HIR1 LIA1 i2d exp SNF2 HIR1 10445029, 23023127 biogrid,dip exp, pred HTB1 HIR1 21179020, 23023127 intact exp, pred HTA2 HIR1 21179020, 23023127 intact exp, pred HIR1 UTP7 11805837, 23023127 biogrid,mint,intact,dip exp, pred HIR1 ARP9 21179020, 23023127 intact exp, pred HIR1 ISW2 21179020, 23023127 intact exp, pred HIR1 ARP5 21179020, 23023127 intact exp, pred HIR1 SPT4 9504914, 23023127 biogrid,i2d,intact exp, pred HHF1, HHF2 HIR1 21179020,22199229,14651846, 23023127 biogrid,intact exp, pred HIR1 RLF2 21179020, 23023127 intact exp, pred HIR1 SET3 21179020, 23023127 intact exp, pred HIR1 HPC2 21782987,19029251,16264190,21179020,16554755, 23023127 biogrid,i2d,mint,intact exp, pred ASF1 HIR1 11412995,11404324,21179020,20048053,16303565,16554755, 23023127 biogrid,i2d,mint,intact,dip exp, pred HTB2 HIR1 21179020, 23023127 intact exp, pred HIR1 INO80 21179020, 23023127 intact exp, pred HIR1 SWI3 21179020,10445029, 23023127 biogrid,intact,dip exp, pred HIR1 HIR3 21782987,16264190,21179020, 23023127 biogrid,i2d,intact exp, pred HIR1 HIR1 21179020,9001207,9504914, 23023127 biogrid,i2d,intact,dip exp, pred HIR1 RSC8 21179020, 23023127 intact exp, pred SNF5 HIR1 10445029, 23023127 biogrid,dip exp, pred HIR1 HHT1, HHT2 21179020,22922743,22199229,14651846, 23023127 biogrid,intact exp, pred HIR1 RTT106 19683497,21179020, 23023127 biogrid,intact exp, pred HIR1 HIR2 21782987,16264190,21179020,9001207,9504914, 23023127 biogrid,i2d,intact,dip exp, pred HIR1 HAT2 23023127 pred SPT5 HIR1 23023127 pred HIR1 ATG26 23023127 pred HIR1 SPT8 23023127 pred MSI1 HIR1 23023127 pred HIR1 TAF5 23023127 pred HIR1 SWD2 23023127 pred HIR1 CAC2 23023127 pred TUP1 HIR1 23023127 pred HIR1 SKI8 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P40161 P32479 affinity chromatography technology 19683497 physical association X 2 P22082 P32479 affinity chromatography technology 10445029 physical association X 2 P0CG63 P32479 affinity chromatography technology 23749301 physical association X 2 P35208 P32479 affinity chromatography technology 25228766 physical association X 2 P40150 P32479 biochemical 23332755 association X 2 P50105 P32479 affinity chromatography technology 12052880 physical association X 2 P02309 P32479 affinity chromatography technology 14651846 physical association X 2 P02309 P32479 affinity chromatography technology 22199229 physical association X 2 P02309 P32479 affinity chromatography technology 22199229 physical association X 2 P32914 P32479 affinity chromatography technology 9504914 physical association X 2 P32914 P32479 affinity chromatography technology 9504914 physical association X 2 Q01448 P32479 affinity chromatography technology 16554755 physical association X 2 Q01448 P32479 affinity chromatography technology 16264190 physical association X 2 Q01448 P32479 affinity chromatography technology 16264190 physical association X 2 Q01448 P32479 affinity chromatography technology 17200106 physical association X 2 Q01448 P32479 affinity chromatography technology 21782987 physical association X 2 P32447 P32479 affinity chromatography technology 11412995 physical association X 2 P32447 P32479 pull down 11412995 direct interaction X 2 P32447 P32479 two hybrid 11404324 direct interaction X 2 P32447 P32479 affinity chromatography technology 16554755 physical association X 2 P32447 P32479 affinity chromatography technology 16303565 physical association X 2 P32447 P32479 affinity chromatography technology 20048053 physical association X 2 P24869 P32479 affinity chromatography technology 21978826 physical association X 2 P24869 P32479 affinity chromatography technology 21978826 physical association X 2 P32591 P32479 affinity chromatography technology 10445029 physical association X 2 P32479 P32479 affinity chromatography technology 9504914 physical association X 2 P32479 P32479 affinity chromatography technology 9001207 physical association X 2 P18480 P32479 affinity chromatography technology 10445029 physical association X 2 P40055 P32479 affinity chromatography technology 11805837 physical association X 2 P47171 P32479 affinity chromatography technology 16264190 physical association X 2 P47171 P32479 affinity chromatography technology 16264190 physical association X 2 P47171 P32479 affinity chromatography technology 21782987 physical association X 2 P61830 P32479 affinity chromatography technology 22922743 physical association X 2 P61830 P32479 affinity chromatography technology 14651846 physical association X 2 P61830 P32479 affinity chromatography technology 22199229 physical association X 2 P61830 P32479 affinity chromatography technology 22199229 physical association X 2 Q12510 P32479 affinity chromatography technology 22199229 physical association X 2 P32480 P32479 affinity chromatography technology 9504914 physical association X 2 P32480 P32479 affinity chromatography technology 9001207 physical association X 2 P32480 P32479 affinity chromatography technology 16264190 physical association X 2 P32480 P32479 affinity chromatography technology 16264190 physical association X 2 P32480 P32479 affinity chromatography technology 17200106 physical association X 2 P32480 P32479 affinity chromatography technology 21782987 physical association X 2 P32480 P32479 affinity chromatography technology 21782987 physical association X 2 Q04195 P32479 affinity chromatography technology 23712011 physical association X 2 P32479 anti tag coimmunoprecipitation 11805837 - C 22 P32479 anti tag coimmunoprecipitation 11805837 - C 31 P22082 P32479 coimmunoprecipitation 10445029 physical association X 2 P32479 P32479 coimmunoprecipitation 9504914 physical association Y 1 P49723 P32479 anti tag coimmunoprecipitation 11805837 physical association X 2 P32479 anti tag coimmunoprecipitation 11805837 - C 3 P32447 P32479 two hybrid 11404324 physical association X 2 P32591 P32479 coimmunoprecipitation 10445029 physical association X 2 P18480 P32479 coimmunoprecipitation 10445029 physical association X 2 P40055 P32479 anti tag coimmunoprecipitation 11805837 physical association X 2 P04173 P32479 anti tag coimmunoprecipitation 11805837 physical association X 2 P32480 P32479 coimmunoprecipitation 9504914 physical association X 2 P32479 tandem affinity purification 21179020 association C 46 P32479 tandem affinity purification 21179020 association C 140 P32479 tandem affinity purification 21179020 association C 106 P32479 inferred by author 16554755 association C 7 P32479 tandem affinity purification 21179020 association C 9 P32479 tandem affinity purification 21179020 association C 9 P32479 anti tag coimmunoprecipitation 11805837 association C 22 P32479 tandem affinity purification 21179020 association C 193 P32479 tandem affinity purification 21179020 association C 45 P32479 tandem affinity purification 21179020 association C 90 P32479 tandem affinity purification 21179020 association C 26 P32479 tandem affinity purification 21179020 association C 26 P32479 tandem affinity purification 21179020 association C 121 P02994 P32479 tandem affinity purification 16429126 physical association X 2 P11484 P32479 tandem affinity purification 19536198 association X 2 P14693 P32479 two hybrid array 14690591 physical association X 2 P10591 P32479 tandem affinity purification 19536198 association X 2 P32914 P32479 anti tag coimmunoprecipitation 9504914 physical association X 2 P32914 P32479 anti tag coimmunoprecipitation 9504914 physical association X 2 P32479 tandem affinity purification 21179020 association C 78 P32479 tandem affinity purification 21179020 physical association C 3 P32479 tandem affinity purification 21179020 association C 16 Q01448 P32479 tandem affinity purification 16554755 physical association X 2 Q01448 P32479 tandem affinity purification 16554755 physical association X 2 P32447 P32479 two hybrid 11404324 physical association X 2 P32447 P32479 two hybrid 11404324 physical association X 2 P32447 P32479 tandem affinity purification 16554755 physical association X 2 P32447 P32479 tandem affinity purification 16554755 physical association X 2 P32447 P32479 tandem affinity purification 16554755 physical association X 2 P32447 P32479 tandem affinity purification 16554755 physical association X 2 P32447 P32479 tandem affinity purification 16554755 physical association X 2 P32447 P32479 tandem affinity purification 16554755 physical association X 2 P32447 P32479 tandem affinity purification 16554755 physical association X 2 P32447 P32479 tandem affinity purification 16554755 physical association X 2 P32447 P32479 tandem affinity purification 16554755 physical association X 2 P32447 P32479 tandem affinity purification 21179020 physical association X 2 P32479 P32479 anti tag coimmunoprecipitation 9001207 physical association X 2 P32479 P32479 anti tag coimmunoprecipitation 9504914 physical association X 2 P32480 P32479 anti tag coimmunoprecipitation 9001207 physical association X 2 P32480 P32479 anti tag coimmunoprecipitation 9001207 physical association X 2 P32480 P32479 anti tag coimmunoprecipitation 9504914 physical association X 2 P31385 P32479 interaction detection method 14764870 - X 2 P32914 P32479 coimmunoprecipitation 9504914 - X 2 P32479 mass spectrometry studies of complexes 11805837 - C 23 Q08032 P32479 interaction detection method 14764870 - X 2 P06243 P32479 interaction detection method 14764870 - X 2 P32479 P32479 coimmunoprecipitation 9504914 - X 2 P32325 P32479 interaction detection method 14764870 - X 2 P32480 P32479 coimmunoprecipitation 9504914 - X 2

PPI - HINT Gene A Gene B PMID Method Quality SAM35 HIR1 14690591 0397 LC SNF5 HIR1 10445029,10445029 0004,0019 LC SNF2 HIR1 10445029,10445029 0004,0019 LC ASF1 HIR1 11412995,11412995,11404324,11412995 0004,0019,0018,0096 LC HIR1 HIR1 9504914,9504914,9504914 0007,0004,0019 LC HIR1 HIR2 16264190,16264190,9504914,9504914,16264190,9504914 0676,0029,0007,0004,0004,0019 LC HIR1 SWI3 10445029,10445029 0004,0019 LC HIR1 SPT4 9504914,9504914,9504914,9504914 0007,0019,0004,0045 LC HIR1 SSB2 23332755 0401 LC HIR1 HIR3 16264190,16264190,16264190 0004,0029,0676 LC HIR1 HPC2 16264190,16264190,16264190 0676,0029,0004 LC HTB1 HIR1 21179020 0676 HT HTB2 HIR1 21179020 0676 HT HHF1|HHF2 HIR1 21179020,14651846,22199229 0676,0004,0004 HT,LC TEF1|TEF2 HIR1 16429126 0676 HT LEU2 HIR1 11805837 0007 HT HTA2 HIR1 21179020 0676 HT SSA1 HIR1 19536198 0676 HT SSB1 HIR1 19536198 0676 HT SNF5 HIR1 10445029,10445029 0004,0019 LC SNF2 HIR1 10445029,10445029 0004,0019 LC CLB2 HIR1 21978826 0004 LC ASF1 HIR1 16303565,21179020,16554755,11412995,11412995,16554755,20048053,11412995,16554755 0004,0676,0363,0004,0019,0676,0004,0096,0004 LC,HT HIR1 HIR1 21179020,9001207,9504914,9504914,9504914,9001207 0676,0007,0007,0004,0019,0004 HT,LC HIR1 HIR2 16264190,21179020,9001207,16264190,9504914,9504914,21782987,9001207,16264190,9504914,17200106 0676,0676,0007,0029,0007,0004,0004,0004,0004,0019,0004 LC,HT HIR1 SWI3 21179020,10445029,10445029 0676,0004,0019 HT,LC HIR1 SPT4 9504914,9504914,9504914,9504914 0007,0019,0004,0045 LC HIR1 TFC4 21179020 0676 HT HIR1 SPT10 25228766 0004 HT HIR1 SET3 21179020 0676 HT HIR1 UTP7 11805837,11805837 0004,0007 HT HIR1 SSB2 23332755 0401 LC HIR1 RTT106 21179020,19683497 0676,0004 HT,LC HIR1 RSC8 21179020 0676 HT HIR1 NET1 21179020 0676 HT HIR1 HIR3 16264190,21782987,16264190,16264190,21179020 0004,0004,0029,0676,0676 LC,HT HIR1 RNR4 11805837 0007 HT HIR1 TAF4 12052880 0004 LC HIR1 INO80 21179020 0676 HT HIR1 ITC1 21179020 0676 HT HIR1 ARP5 21179020 0676 HT HIR1 ACT1 21179020 0676 HT HIR1 HHT1|HHT2 21179020,22922743,14651846,22199229 0676,0004,0004,0004 HT,LC HIR1 CDC14 21179020 0676 HT HIR1 HPC2 19029251,16264190,16554755,21179020,21782987,16264190,16264190,17200106,16554755 0096,0676,0004,0676,0004,0029,0004,0004,0676 LC,HT HIR1 RVB1 21179020 0676 HT HIR1 SIZ1 23712011 0004 LC HIR1 DPB4 21179020 0676 HT HIR1 ARP9 21179020 0676 HT HIR1 IES4 21179020 0676 HT HIR1 ISW2 21179020 0676 HT HIR1 ARP8 21179020 0676 HT HIR1 RVB2 21179020 0676 HT HIR1 RLF2 21179020 0676 HT HIR1 CMR1 22199229 0004 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q12495 P32479 RLF2 HIR1 0.126 21179020 P32479 P10591 HIR1 SSA1 0.126 19536198 P32479 P02293 HIR1 HTB1 0.126 21179020 P32479 P11484 HIR1 SSB1 0.126 19536198 P32479 P02994 HIR1 TEF2 0.126 16429126 P32479 P04173 HIR1 LEU2 0.126 11805837 P47171 P32479 HIR3 HIR1 0.787 21179020,21782987,16264190 Q01448 P32479 HPC2 HIR1 0.888 21782987,16264190,16554755,19029251,21179020 P35208 P32479 SPT10 HIR1 0.126 25228766 P32479 P02294 HIR1 HTB2 0.126 21179020 P32479 P02309 HIR1 HHF2 0.236 21179020 P32479 P04912 HIR1 HTA2 0.126 21179020 P32479 P14693 HIR1 SAM35 0.126 14690591 P32479 P24869 HIR1 CLB2 0.376 21978826 P32479 P32447 HIR1 ASF1 0.722 11404324,16303565,20048053,16554755,21179020 P32479 P32479 HIR1 HIR1 0.155 9504914,21179020 P32591 P32479 SWI3 HIR1 0.155 21179020,10445029 P33339 P32479 TFC4 HIR1 0.126 21179020 P40055 P32479 UTP7 HIR1 0.332 11805837 P40161 P32479 RTT106 HIR1 0.472 21179020,19683497 P43609 P32479 RSC8 HIR1 0.126 21179020 P47035 P32479 NET1 HIR1 0.126 21179020 P53115 P32479 INO80 HIR1 0.126 21179020 P53125 P32479 ITC1 HIR1 0.126 21179020 P53946 P32479 ARP5 HIR1 0.126 21179020 P60010 P32479 ACT1 HIR1 0.126 21179020 P61830 P32479 HHT2 HIR1 0.309 21179020,22922743 Q00684 P32479 CDC14 HIR1 0.126 21179020 Q03940 P32479 RVB1 HIR1 0.126 21179020 Q04603 P32479 DPB4 HIR1 0.126 21179020 Q05123 P32479 ARP9 HIR1 0.126 21179020 Q08561 P32479 IES4 HIR1 0.126 21179020 Q08773 P32479 ISW2 HIR1 0.126 21179020 Q12386 P32479 ARP8 HIR1 0.126 21179020 Q12464 P32479 RVB2 HIR1 0.126 21179020 P32480 P32479 HIR2 HIR1 0.82 9504914,21782987,16264190,21179020 P36124 P32479 SET3 HIR1 0.126 21179020 P40150 P32479 SSB2 HIR1 0.126 23332755 P32479 P18480 HIR1 SNF5 0.033 10445029 P49723 P32479 RNR4 HIR1 0.126 11805837 Q04195 P32479 SIZ1 HIR1 0.126 23712011 P32479 P22082 HIR1 SNF2 0.033 10445029