PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus MSI1 MEU1 18719252 biogrid,intact exp SSB1 MSI1 19536198 intact exp MSI1 NAM7 18087042 biogrid exp MSI1 HSP78 19536198 intact exp MSI1 RPF2 i2d exp MSI1 SNU66 11805837 biogrid,mint,intact,dip exp MSI1 SOV1 11805837 dip exp HHF1, HHF2 MSI1 22199229,23034810 biogrid exp MSI1 Uncharacterized protein YMR178W 17634282 biogrid exp SSA2 MSI1 19536198 intact exp MSI1 RVS167 i2d exp MSI1 NPR1 17321547,11238915 biogrid,i2d exp MSI1 POL30 i2d exp MSI1 CCT2 19536198 intact exp SSA1 MSI1 19536198 intact exp MSI1 HMO1 i2d exp MES1 MSI1 i2d exp MSI1 TSR4 14690591 intact exp MSI1 SSB2 23332755,19536198 biogrid,intact exp MSI1 CRC1 11805837 biogrid,mint,intact,dip exp HTA1 MSI1 i2d exp MSI1 HSP60 11805837 dip exp MSI1 UBC7 14690591, 23023127 intact exp, pred MSI1 BOI1 14737190, 23023127 i2d,mint,intact exp, pred MSI1 SSE1 19536198, 23023127 intact exp, pred MSI1 RTT106 19683497,21179020, 23023127 biogrid,intact exp, pred MSI1 RLF2 16429126,17321547,10975254,21179020,11283351,16554755,11756556,11805837,11731480,10688190,17634282,11238915, 23023127 biogrid,i2d,mint,intact,dip exp, pred MSI1 CAC2 16429126,8743889,16554755,18662540, 23023127 biogrid,i2d,mint,intact,dip exp, pred MSI1 CDC73 11283351, 23023127 i2d,mint,intact,dip exp, pred RAD1 MSI1 11805837, 23023127 biogrid,mint,intact,dip exp, pred MSI1 HHT1, HHT2 16015338,22199229,23034810, 23023127 biogrid exp, pred MSI1 SET3 11805837, 23023127 biogrid,intact,dip exp, pred MSI1 NEM1 11283351, 23023127 i2d,mint,intact,dip exp, pred MSI1 YPT32 23023127 pred MSI1 ORC5 23023127 pred MSI1 YPT53 23023127 pred MSI1 NAP1 23023127 pred MSI1 YPT52 23023127 pred SST2 MSI1 23023127 pred MSI1 RSC2 23023127 pred MSI1 RHO5 23023127 pred MSI1 RDI1 23023127 pred MSI1 RHB1 23023127 pred MSI1 CDC45 23023127 pred MSI1 ORC2 23023127 pred MSI1 BAG7 23023127 pred RAD6 MSI1 23023127 pred MSI1 CBF1 23023127 pred ARF1 MSI1 23023127 pred TOP1 MSI1 23023127 pred MSI1 ESA1 23023127 pred RAS2 MSI1 23023127 pred GPA1 MSI1 23023127 pred RHO1 MSI1 23023127 pred RAS1 MSI1 23023127 pred MSI1 ORC6 23023127 pred MSI1 ARF3 23023127 pred MSI1 ORC3 23023127 pred MSI1 HPC2 23023127 pred MSI1 CDC42 23023127 pred MSI1 FUS3 23023127 pred MSI1 SSK2 23023127 pred MSI1 HIR1 23023127 pred MSI1 STH1 23023127 pred MSI1 TFB3 23023127 pred MSI1 ORC1 23023127 pred MSI1 SPT16 23023127 pred MSI1 SPT6 23023127 pred MSI1 RSC8 23023127 pred MSI1 UME1 23023127 pred MSI1 Putative truncated guanine nucleotide exchange factor YLL017W 23023127 pred MSI1 SAS3 23023127 pred MSI1 CDC5 23023127 pred MSI1 SRO7 23023127 pred MSI1 ASF1 23023127 pred MSI1 ARF2 23023127 pred MSI1 CDC40 23023127 pred MSI1 RSC4 23023127 pred MSI1 RFA1 23023127 pred MSI1 ORC4 23023127 pred MSI1 HAT2 23023127 pred MSI1 ARP4 23023127 pred MSI1 RHO4 23023127 pred MSI1 ARL3 23023127 pred MSI1 TPD3 23023127 pred SEC4 MSI1 23023127 pred RHO2 MSI1 23023127 pred MSI1 SWD1 23023127 pred CDC6 MSI1 23023127 pred MSI1 SAS2 23023127 pred MSI1 ROM2 23023127 pred MSI1 CTF4 23023127 pred MSI1 SFH1 23023127 pred MSI1 ARL1 23023127 pred MSI1 SLA1 23023127 pred RAP1 MSI1 23023127 pred MSI1 PRP4 23023127 pred MSI1 CDH1 23023127 pred MSI1 STE4 23023127 pred SIR2 MSI1 23023127 pred MSI1 TEM1 23023127 pred CDC25 MSI1 23023127 pred MSI1 ASH1 23023127 pred MSI1 YPT6 23023127 pred MSI1 RSR1 23023127 pred MSI1 RSP5 23023127 pred MSI1 VPS21 23023127 pred MSI1 SET1 23023127 pred MSI1 SSN3 23023127 pred MSI1 TUP1 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P13712 - 15044803 - C 3 Q06697 P13712 - 11283351 - X 2 Q12495 P13712 - 11756556 - X 2 Q12495 P13712 - 11283351 - X 2 Q12495 P13712 - 10688190 - X 2 Q12495 P13712 - 11238915 - X 2 P13712 P36124 - 11805837 - X 2 P38757 P13712 - 11283351 - X 2 P13712 - 11805837 - C 3 P13712 - 11805837 - C 4 P13712 P22211 - 11238915 - X 2 P13712 P38041 - 14737190 - X 2 P40161 P13712 affinity chromatography technology 19683497 physical association X 2 P0CG63 P13712 affinity chromatography technology 17644757 physical association X 2 P06777 P13712 affinity chromatography technology 11805837 physical association X 2 Q12495 P13712 affinity chromatography technology 11731480 physical association X 2 Q12495 P13712 affinity chromatography technology 11756556 physical association X 2 Q12495 P13712 affinity chromatography technology 10975254 physical association X 2 Q12495 P13712 two hybrid 11238915 direct interaction X 2 Q12495 P13712 affinity chromatography technology 16554755 physical association X 2 Q12495 P13712 affinity chromatography technology 17200106 physical association X 2 Q12495 P13712 two hybrid 17321547 direct interaction X 2 Q12495 P13712 two hybrid 17634282 direct interaction X 2 Q12495 P13712 affinity chromatography technology 11805837 physical association X 2 Q12495 P13712 two hybrid 10688190 direct interaction X 2 P13712 P02309 pull down 23034810 direct interaction X 2 P13712 P36124 affinity chromatography technology 11805837 physical association X 2 P13712 P02309 affinity chromatography technology 22199229 physical association X 2 P13712 P02309 affinity chromatography technology 22199229 physical association X 2 Q12420 P13712 affinity chromatography technology 11805837 physical association X 2 Q12289 P13712 affinity chromatography technology 11805837 physical association X 2 Q03219 P13712 two hybrid 17634282 direct interaction X 2 P13712 P61830 pull down 23034810 direct interaction X 2 P13712 P22211 affinity chromatography technology 11238915 physical association X 2 P13712 P22211 two hybrid 11238915 direct interaction X 2 P13712 Q04199 affinity chromatography technology 16554755 physical association X 2 P13712 Q04199 affinity chromatography technology 16429126 physical association X 2 P13712 Q04199 affinity chromatography technology 17200106 physical association X 2 P13712 P22211 two hybrid 17321547 direct interaction X 2 P13712 Q07938 two hybrid 18719252 direct interaction X 2 P13712 Q04199 affinity chromatography technology 18662540 physical association X 2 P13712 P61830 affinity chromatography technology 16015338 physical association X 2 P13712 P61830 affinity chromatography technology 16015338 physical association X 2 P13712 P61830 affinity chromatography technology 22199229 physical association X 2 P13712 P61830 affinity chromatography technology 22199229 physical association X 2 P40150 P13712 biochemical 23332755 association X 2 P13712 anti tag coimmunoprecipitation 11805837 - C 28 P19882 P13712 anti tag coimmunoprecipitation 11805837 physical association X 2 P06777 P13712 anti tag coimmunoprecipitation 11805837 physical association X 2 Q06697 P13712 two hybrid pooling approach 11283351 physical association X 2 Q12495 P13712 experimental interaction detection 8743889 physical association X 2 Q12495 P13712 anti tag coimmunoprecipitation 11805837 physical association X 2 Q12495 P13712 coimmunoprecipitation 11731480 physical association X 2 Q12495 P13712 two hybrid 10688190 physical association X 2 Q12495 P13712 two hybrid pooling approach 11283351 physical association X 2 Q04748 P13712 anti tag coimmunoprecipitation 11805837 physical association X 2 P13712 P36124 anti tag coimmunoprecipitation 11805837 physical association X 2 P38757 P13712 two hybrid pooling approach 11283351 physical association X 2 P13712 anti tag coimmunoprecipitation 11805837 - C 7 P13712 anti tag coimmunoprecipitation 11805837 - C 5 P13712 anti tag coimmunoprecipitation 11805837 - C 19 P13712 tandem affinity purification 21256037 - C 7 P13712 tandem affinity purification 21256037 - C 7 Q12420 P13712 anti tag coimmunoprecipitation 11805837 physical association X 2 Q12289 P13712 anti tag coimmunoprecipitation 11805837 physical association X 2 P13712 Q04199 tandem affinity purification 21256037 physical association X 2 P13712 Q04199 tandem affinity purification 21256037 physical association X 2 P13712 Q04199 experimental interaction detection 8743889 physical association X 2 P13712 tandem affinity purification 21179020 association C 140 P13712 inferred by author 16554755 association C 4 P13712 tandem affinity purification 16429126 association C 5 P32589 P13712 tandem affinity purification 19536198 association X 2 P11484 P13712 tandem affinity purification 19536198 association X 2 Q06697 P13712 two hybrid fragment pooling approach 11283351 physical association X 2 Q12495 P13712 two hybrid 10688190 physical association X 2 Q12495 P13712 two hybrid fragment pooling approach 11283351 physical association X 2 Q12495 P13712 tandem affinity purification 16554755 physical association X 2 Q12495 P13712 tandem affinity purification 16554755 physical association X 2 Q12495 P13712 tandem affinity purification 16554755 physical association X 2 Q12495 P13712 tandem affinity purification 16554755 physical association X 2 Q12495 P13712 tandem affinity purification 16554755 physical association X 2 Q12495 P13712 tandem affinity purification 16554755 physical association X 2 Q12495 P13712 tandem affinity purification 16554755 physical association X 2 Q12495 P13712 tandem affinity purification 16554755 physical association X 2 Q12495 P13712 tandem affinity purification 16554755 physical association X 2 Q12495 P13712 tandem affinity purification 16554755 physical association X 2 P13712 P36124 anti tag coimmunoprecipitation 11805837 physical association X 2 P13712 Q02159 two hybrid array 14690591 physical association X 2 P13712 P25040 two hybrid array 14690591 physical association X 2 P38757 P13712 two hybrid fragment pooling approach 11283351 physical association X 2 P13712 anti tag coimmunoprecipitation 11805837 association C 3 P13712 tandem affinity purification 21179020 association C 16 P13712 anti tag coimmunoprecipitation 11805837 association C 4 P13712 tandem affinity purification 21179020 association C 40 P10592 P13712 tandem affinity purification 19536198 association X 2 P13712 P38041 peptide array 14737190 direct interaction X 2 P13712 Q04199 tandem affinity purification 16429126 physical association X 2 P13712 Q04199 inferred by author 16429126 physical association X 2 P13712 Q04199 tandem affinity purification 16554755 physical association X 2 P13712 Q04199 tandem affinity purification 16554755 physical association X 2 P13712 Q04199 tandem affinity purification 16554755 physical association X 2 P13712 Q04199 tandem affinity purification 16554755 physical association X 2 P13712 Q04199 tandem affinity purification 16554755 physical association X 2 P13712 Q04199 tandem affinity purification 16554755 physical association X 2 P13712 Q07938 two hybrid 18719252 physical association X 2 P13712 P33416 tandem affinity purification 19536198 association X 2 P40150 P13712 tandem affinity purification 19536198 association X 2 P39076 P13712 tandem affinity purification 19536198 association X 2 P10591 P13712 tandem affinity purification 19536198 association X 2 P13712 confirmational text mining - - C 3 P13712 mass spectrometry studies of complexes 11805837 - C 6 P13712 mass spectrometry studies of complexes 11805837 - C 6 Q08032 P13712 interaction detection method 14764870 - X 2 Q06697 P13712 two hybrid 11283351 - X 2 Q12495 P13712 two hybrid 11283351 - X 2 Q12495 P13712 two hybrid 10688190 - X 2 Q12495 P13712 two hybrid 11238915 - X 2 P13712 P18963 interaction detection method - - X 2 P38757 P13712 two hybrid 11283351 - X 2 P47110 P13712 interaction detection method 14764870 - X 2 P13712 mass spectrometry studies of complexes 11805837 - C 20 P13712 P22211 two hybrid 11238915 - X 2 P13712 P22211 copurification 11238915 - X 2

PPI - HINT Gene A Gene B PMID Method Quality MSI1 NPR1 11238915,11238915,11238915,17321547 0018,0004,0025,0018 LC MSI1 TSR4 14690591 0397 LC MSI1 BOI1 14737190,14737190 0081,0045 HT MSI1 NEM1 11283351,11283351,11283351 0018,0399,0398 HT MSI1 SSB2 23332755 0401 LC MSI1 UBC7 14690591 0397 LC MSI1 Q03219 17634282 0018 HT MSI1 CAC2 8743889 0045 LC MSI1 CDC73 11283351,11283351,11283351 0018,0399,0398 HT MSI1 MEU1 18719252 0018 HT MSI1 RLF2 8743889,11731480,17321547,11283351,11238915,10688190,11283351,10688190,11731480,17634282,11283351 0045,0004,0018,0398,0018,0397,0399,0018,0019,0018,0018 LC,HT HHF1|HHF2 MSI1 23034810,22199229 0096,0004 LC,HT RAD1 MSI1 11805837,11805837 0004,0007 HT SSA1 MSI1 19536198 0676 HT SSA2 MSI1 19536198 0676 HT SSB1 MSI1 19536198 0676 HT MSI1 HSP60 11805837 0007 HT MSI1 NPR1 11238915,11238915,11238915 0018,0004,0025 LC MSI1 SSE1 19536198 0676 HT MSI1 HSP78 19536198 0676 HT MSI1 SET3 11805837,11805837 0004,0007 HT MSI1 CCT2 19536198 0676 HT MSI1 SSB2 19536198,23332755 0676,0401 HT,LC MSI1 RTT106 21179020,19683497 0676,0004 HT,LC MSI1 HHT1|HHT2 23034810,16015338,22199229 0096,0004,0004 LC,HT MSI1 CAC2 16554755,16554755,21256037,16429126,18662540,17200106,16429126,16429126,16554755 0363,0004,0676,0676,0004,0004,0363,0004,0676 HT,LC MSI1 SOV1 11805837 0007 HT MSI1 CRC1 11805837,11805837 0004,0007 HT MSI1 SNU66 11805837,11805837 0004,0007 HT MSI1 RLF2 21179020,11731480,17200106,11756556,11805837,16554755,11731480,16429126,11805837,16554755,10975254 0676,0004,0004,0004,0004,0676,0019,0676,0007,0004,0004 HT,LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P61830 P13712 HHT2 MSI1 0.454 16015338,23034810 Q04748 P13712 SOV1 MSI1 0.126 11805837 Q12420 P13712 SNU66 MSI1 0.236 11805837 P13712 P02309 MSI1 HHF2 0.309 23034810 P13712 P06777 MSI1 RAD1 0.332 11805837 P13712 P10591 MSI1 SSA1 0.126 19536198 P13712 P10592 MSI1 SSA2 0.126 19536198 P13712 P11484 MSI1 SSB1 0.126 19536198 P22211 P13712 NPR1 MSI1 0.309 17321547 P25040 P13712 TSR4 MSI1 0.126 14690591 P32589 P13712 SSE1 MSI1 0.126 19536198 P33416 P13712 HSP78 MSI1 0.126 19536198 P38041 P13712 BOI1 MSI1 0.183 14737190 P39076 P13712 CCT2 MSI1 0.126 19536198 P40150 P13712 SSB2 MSI1 0.126 19536198 Q02159 P13712 UBC7 MSI1 0.126 14690591 Q04199 P13712 CAC2 MSI1 0.623 16429126,8743889,18662540,16554755 Q12289 P13712 CRC1 MSI1 0.21 11805837 P40161 P13712 RTT106 MSI1 0.309 21179020,19683497 Q12495 P13712 RLF2 MSI1 0.932 10688190,11731480,16554755,11805837,11283351,21179020,11756556,17321547,10975254,16429126,8743889,11238915 P30771 P13712 NAM7 MSI1 0.126 18087042 P38757 P13712 NEM1 MSI1 0.236 11283351 P36124 P13712 SET3 MSI1 0.126 11805837 P19882 P13712 HSP60 MSI1 0.126 11805837 Q06697 P13712 CDC73 MSI1 0.21 11283351 Q07938 P13712 MEU1 MSI1 0.332 18719252