PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus DUG2 SAS10 11283351 biogrid,i2d,mint,intact,dip exp DUG2 VTH1 16554755 biogrid,i2d,mint,intact exp SSB1 DUG2 22940862 biogrid exp DUG2 ARG5,6 i2d exp SSA1 DUG2 23217712 intact exp URA2 DUG2 i2d exp DUG2 SSB2 23332755 biogrid exp YDJ1 DUG2 19536198 intact exp DUG2 ACC1 i2d exp DUG2 NCS2 20826334 biogrid exp ARG3 DUG2 i2d exp DUG2 PPT2 i2d exp SBP1 DUG2 23222640 biogrid exp DUR1,2 DUG2 i2d exp AAP1 DUG2 22034500 intact exp DUG2 AGX1 i2d exp DAL1 DUG2 i2d exp HSP82 DUG2 19536198 intact exp DUG2 CEM1 i2d exp DUG2 BIO3 i2d exp FAS2 DUG2 i2d exp SEC21 DUG2 10688190 biogrid,i2d,mint,intact,dip exp HSP104 DUG2 19536198 intact exp DUG2 UTP15 11805837 biogrid,mint,intact,dip exp DUG2 DUG1 17179087, 23023127 biogrid exp, pred DUG2 TEM1 11805837, 23023127 biogrid,mint,intact,dip exp, pred DUG2 DUG2 22277648, 23023127 biogrid exp, pred DUG2 DUG3 20826334,16429126,22277648,17179087,11283351, 23023127 biogrid,i2d,mint,intact,dip exp, pred CPS1 DUG2 23023127 pred Putative carboxypeptidase YOL153C DUG2 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P38149 - 11805837 - C 8 P38149 P32074 - 10688190 - X 2 P38149 - 11805837 - C 5 P38149 - 11805837 - C 11 P38149 - 11805837 - C 3 P38149 - 11805837 - C 3 P38149 - 11805837 - C 6 P38149 - 11805837 - C 18 P38149 - 11805837 - C 10 P53871 P38149 - 11283351 - X 2 P38149 Q12136 - 11283351 - X 2 P53923 P38149 affinity chromatography technology 20826334 physical association X 2 P0CG63 P38149 affinity chromatography technology 23793018 physical association X 2 P38987 P38149 affinity chromatography technology 11805837 physical association X 2 P43616 P38149 two hybrid 17179087 direct interaction X 2 P43616 P38149 affinity chromatography technology 17179087 physical association X 2 P38149 P32074 two hybrid 10688190 direct interaction X 2 P11484 P38149 affinity chromatography technology 22940862 physical association X 2 Q04305 P38149 affinity chromatography technology 11805837 physical association X 2 P53871 P38149 two hybrid 17179087 direct interaction X 2 P53871 P38149 affinity chromatography technology 17179087 physical association X 2 P53871 P38149 affinity chromatography technology 17179087 physical association X 2 P53871 P38149 affinity chromatography technology 20826334 physical association X 2 P53871 P38149 pull down 22277648 direct interaction X 2 P53871 P38149 two hybrid 22277648 direct interaction X 2 P40150 P38149 biochemical 23332755 association X 2 P38149 P40438 affinity chromatography technology 16554755 physical association X 2 P38149 Q12136 two hybrid 11283351 direct interaction X 2 P38149 P38149 pull down 22277648 direct interaction X 2 P38149 P38149 two hybrid 22277648 direct interaction X 2 P38149 anti tag coimmunoprecipitation 11805837 - C 34 P38149 anti tag coimmunoprecipitation 11805837 - C 5 P38149 anti tag coimmunoprecipitation 11805837 - C 7 P38149 anti tag coimmunoprecipitation 11805837 - C 78 P38987 P38149 anti tag coimmunoprecipitation 11805837 physical association X 2 P38987 P38149 anti tag coimmunoprecipitation 11805837 physical association X 2 P38987 P38149 anti tag coimmunoprecipitation 11805837 physical association X 2 P38987 P38149 anti tag coimmunoprecipitation 11805837 physical association X 2 P38149 P32074 two hybrid 10688190 physical association X 2 P38149 anti tag coimmunoprecipitation 11805837 - C 11 P38149 anti tag coimmunoprecipitation 11805837 - C 10 P38149 anti tag coimmunoprecipitation 11805837 - C 3 P38149 anti tag coimmunoprecipitation 11805837 - C 3 P38149 anti tag coimmunoprecipitation 11805837 - C 25 P38149 anti tag coimmunoprecipitation 11805837 - C 6 Q04305 P38149 anti tag coimmunoprecipitation 11805837 physical association X 2 P53871 P38149 two hybrid pooling approach 11283351 physical association X 2 P38149 Q12136 two hybrid pooling approach 11283351 physical association X 2 P38149 pull down 23217712 association C 317 P38149 anti tag coimmunoprecipitation 11805837 association C 18 P38149 anti tag coimmunoprecipitation 11805837 association C 13 P38149 anti tag coimmunoprecipitation 11805837 association C 8 P38149 anti tag coimmunoprecipitation 11805837 association C 10 P38149 P32074 two hybrid 10688190 physical association X 2 P38149 anti tag coimmunoprecipitation 11805837 association C 5 P38149 tandem affinity purification 16429126 association C 5 P38149 anti tag coimmunoprecipitation 11805837 association C 6 P02829 P38149 tandem affinity purification 19536198 association X 2 P53871 P38149 two hybrid fragment pooling approach 11283351 physical association X 2 P38149 Q12136 two hybrid fragment pooling approach 11283351 physical association X 2 P38149 P40438 inferred by author 16554755 association X 2 P38149 P40438 tandem affinity purification 16554755 physical association X 2 P38149 P25491 tandem affinity purification 19536198 association X 2 P38149 P31539 tandem affinity purification 19536198 association X 2 P38149 mass spectrometry studies of complexes 11805837 - C 12 P38149 mass spectrometry studies of complexes 11805837 - C 4 P38149 mass spectrometry studies of complexes 11805837 - C 4 P38149 P32074 two hybrid 10688190 - X 2 P38149 mass spectrometry studies of complexes 11805837 - C 7 P38149 mass spectrometry studies of complexes 11805837 - C 35 P53871 P38149 two hybrid 11283351 - X 2 P38149 Q12136 two hybrid 11283351 - X 2

PPI - HINT Gene A Gene B PMID Method Quality SEC21 DUG2 10688190,10688190 0397,0018 HT AAP1 DUG2 22034500 0276 LC DUG2 DUG2 22277648,22277648 0096,0018 LC DUG2 SSB2 23332755 0401 LC DUG2 DUG1 17179087,17179087 0018,0004 LC DUG2 DUG3 22277648,17179087,17179087,11283351,22277648,11283351,11283351 0018,0018,0004,0398,0096,0018,0399 LC,HT DUG2 SAS10 11283351,11283351,11283351 0018,0399,0398 HT HSP82 DUG2 19536198 0676 HT SSA1 DUG2 23217712 0096 LC SSB1 DUG2 22940862 0004 HT YDJ1 DUG2 19536198 0676 HT HSP104 DUG2 19536198 0676 HT DUG2 DUG2 22277648,22277648 0096,0018 LC DUG2 TEM1 11805837,11805837 0004,0007 HT DUG2 SSB2 23332755 0401 LC DUG2 VTH1 16554755,16554755,16554755 0363,0676,0004 HT DUG2 DUG1 17179087,17179087 0018,0004 LC DUG2 DUG3 22277648,17179087,16429126,17179087,22277648,20826334 0018,0018,0676,0004,0096,0004 LC,HT DUG2 NCS2 20826334 0004 LC DUG2 UTP15 11805837,11805837 0004,0007 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P38149 P10080 DUG2 SBP1 0.126 23222640 P38149 P10591 DUG2 SSA1 0.126 23217712 P38149 P02829 DUG2 HSP82 0.126 19536198 P38149 P38149 DUG2 DUG2 0.554 22277648 P40438 P38149 VTH1 DUG2 0.332 16554755 P38149 P37898 DUG2 AAP1 0.126 22034500 P38149 P25491 DUG2 YDJ1 0.126 19536198 P38149 P31539 DUG2 HSP104 0.126 19536198 P38149 P32074 DUG2 SEC21 0.332 10688190 P53871 P38149 DUG3 DUG2 0.712 22277648,16429126,11283351,20826334 Q04305 P38149 UTP15 DUG2 0.236 11805837 Q12136 P38149 SAS10 DUG2 0.354 11283351 P38987 P38149 TEM1 DUG2 0.286 11805837 P53923 P38149 NCS2 DUG2 0.126 20826334