PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus STP22 Uncharacterized protein YGR130C 22875988 biogrid exp NOT3 STP22 22875988 biogrid exp STP22 HSK3 22875988 biogrid exp STP22 PSA1 i2d exp STP22 VPS20 22875988 biogrid exp REC107 STP22 22875988 biogrid exp STP22 SNN1 22875988 biogrid exp STP22 CTR9 22875988 biogrid exp TUP1 STP22 22875988 biogrid exp STP22 MPD2 22875988 biogrid exp YCK2 STP22 16319894 biogrid,i2d exp STP22 LNP1 22875988 biogrid exp STP22 STP22 17513562,22875988 biogrid exp STP22 GON7 22875988 biogrid exp STP22 ARR1 22875988 biogrid exp UBI4 STP22 19380877,14581452,12900393 biogrid,i2d exp STP22 SMY1 22875988 biogrid exp RPL40B STP22 i2d exp STP22 TMA17 22875988 biogrid exp STP22 RIM8 23645667,20028738 biogrid exp STP22 SED5 22875988 biogrid exp STP22 RPT5 22875988 biogrid exp STP22 CDC3 22875988 biogrid exp STP22 HOF1 19841731 biogrid,mint,intact exp RPL40A STP22 11511343 i2d,dip exp STP22 FMP27 22875988 biogrid exp STP22 PDS5 22875988 biogrid exp STP22 TSC11 22875988 biogrid exp STP22 PGD1 22875988 biogrid exp STP22 Putative ISWI chromatin-remodeling complex subunit YPL216W 22875988 biogrid exp STP22 KEL1 22875988 biogrid exp STP22 EBP2 22875988 biogrid exp MYO2 STP22 22875988 biogrid exp STP22 VPS51 22875988 biogrid exp STP22 SSB2 23332755 biogrid exp STP22 NAT5 i2d exp STP22 GRH1 22144692 biogrid exp STP22 SNX41 22875988 biogrid exp STP22 DYN1 22875988 biogrid exp STP22 NCA2 22875988 biogrid exp RPS31 STP22 i2d exp STP22 MYO3 11743162 mint exp STP22 NUF2 22875988 biogrid exp STP22 MYO5 11743162 mint exp STP22 VPS64 22875988 biogrid exp STP22 SPC25 22875988 biogrid exp STP22 VPS28 16615894,16429126,11208108,11511343, 23023127 biogrid,mint,intact,dip exp, pred STP22 BRO1 17513562, 23023127 biogrid exp, pred STP22 VPS36 17145965, 23023127 biogrid exp, pred STP22 DOA4 17513562, 23023127 biogrid exp, pred STP22 MVB12 17135292,16429126,22940862,22579254,17145965,16554755,17442384, 23023127 biogrid,i2d,mint,intact,dip exp, pred STP22 LSB3 19841731,14737190, 23023127 biogrid,i2d,mint,intact exp, pred STP22 PEX13 19841731, 23023127 biogrid,mint,intact exp, pred STP22 SRN2 16615894,16429126,11511343,16554755,21596998,17442384, 23023127 biogrid,i2d,mint,intact,dip exp, pred STP22 YSC84 19841731, 23023127 biogrid,mint,intact exp, pred STP22 CPS1 11511343, 23023127 biogrid,dip exp, pred STP22 BZZ1 19841731, 23023127 mint,intact exp, pred STP22 SLA1 19841731, 23023127 biogrid,mint,intact exp, pred STP22 VPS27 15086794,14581452,12900393,21505419,17513562,22918958, 23023127 biogrid,i2d,mint,intact exp, pred STP22 HSE1 15086794,19841731,11743162, 23023127 biogrid,i2d,mint,intact,dip exp, pred STP22 HEK2 18805955, 23023127 biogrid exp, pred STP22 GGA1 23023127 pred STP22 UBI4 23023127 pred STP22 SEC61 23023127 pred STP22 VPS24 23023127 pred STP22 RVS167 23023127 pred STP22 CUE5 23023127 pred STP22 VPS8 23023127 pred YDJ1 STP22 23023127 pred STP22 GGA2 23023127 pred STP22 VPS4 23023127 pred SEM1 STP22 23023127 pred STP22 VPS30 23023127 pred STP22 VID24 23023127 pred STP22 PAN1 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P0CH08 P25604 - 15044434 - X 2 P25604 P38753 - 11489916,11743162 - X 2 P25604 - 14737190 - X 2 P25604 P38753 - 15086794 - X 2 P40343 P25604 - 15086794 - X 2 P25604 P25604 two hybrid 22875988 direct interaction X 2 P25604 P16649 two hybrid 22875988 direct interaction X 2 P25604 P40014 two hybrid 22875988 direct interaction X 2 P25604 P38853 two hybrid 22875988 direct interaction X 2 P25604 P38878 two hybrid 22875988 direct interaction X 2 P25604 P21651 two hybrid 22875988 direct interaction X 2 P25604 P69852 two hybrid 22875988 direct interaction X 2 P25604 P36022 two hybrid 22875988 direct interaction X 2 P25604 P33895 two hybrid 22875988 direct interaction X 2 P25604 Q99316 two hybrid 22875988 direct interaction X 2 P25604 Q12374 two hybrid 22875988 direct interaction X 2 P25604 P40061 two hybrid 22875988 direct interaction X 2 P25604 P53278 two hybrid 22875988 direct interaction X 2 P25604 Q04264 two hybrid 22875988 direct interaction X 2 P25604 P33297 two hybrid 22875988 direct interaction X 2 P25604 Q04264 two hybrid 22875988 direct interaction X 2 P25604 P38753 two hybrid 15086794 direct interaction X 2 P25604 P38753 two hybrid 11743162 direct interaction X 2 P25604 P27614 affinity chromatography technology 11511343 physical association X 2 P25604 P0CH28 x-ray crystallography 15044434 association X 2 P25604 P40150 biochemical 23332755 association X 2 P25604 P32571 protein complementation assay 17513562 direct interaction X 2 P25604 P25604 protein complementation assay 17513562 direct interaction X 2 P25604 P38753 two hybrid 19841731 direct interaction X 2 P25604 P32793 two hybrid 19841731 direct interaction X 2 P53179 P25604 pull down 23645667 direct interaction X 2 P53179 P25604 affinity chromatography technology 20028738 physical association X 2 P53179 P25604 two hybrid 20028738 direct interaction X 2 P53179 P25604 pull down 20028738 direct interaction X 2 P40343 P25604 affinity chromatography technology 22918958 physical association X 2 P40343 P25604 affinity chromatography technology 14581452 physical association X 2 P40343 P25604 two hybrid 15086794 direct interaction X 2 P40343 P25604 two hybrid 15086794 direct interaction X 2 P40343 P25604 affinity chromatography technology 12900393 physical association X 2 P40343 P25604 affinity chromatography technology 12900393 physical association X 2 P40343 P25604 pull down 14581452 direct interaction X 2 P40343 P25604 x-ray crystallography 21505419 association X 2 P40343 P25604 pull down 21505419 direct interaction X 2 P40343 P25604 pull down 21505419 direct interaction X 2 P40343 P25604 protein complementation assay 17513562 direct interaction X 2 P23292 P25604 enzymatic study 16319894 direct interaction X 2 P36116 P25604 two hybrid 22875988 direct interaction X 2 P0CG63 P25604 pull down 12900393 direct interaction X 2 P0CG63 P25604 pull down 14581452 direct interaction X 2 P0CG63 P25604 pull down 19380877 direct interaction X 2 Q06596 P25604 two hybrid 22875988 direct interaction X 2 Q06696 P25604 affinity chromatography technology 17145965 physical association X 2 P25604 P42939 affinity chromatography technology 22940862 physical association X 2 P25604 Q12513 two hybrid 22875988 direct interaction X 2 P25604 P40356 two hybrid 22875988 direct interaction X 2 P25604 P46984 two hybrid 22875988 direct interaction X 2 P25604 P36049 two hybrid 22875988 direct interaction X 2 P25604 Q01590 two hybrid 22875988 direct interaction X 2 P25604 Q06179 two hybrid 22875988 direct interaction X 2 P25604 Q04272 two hybrid 22875988 direct interaction X 2 P25604 P48232 two hybrid 22875988 direct interaction X 2 P25604 Q08964 two hybrid 22875988 direct interaction X 2 P25604 Q04053 two hybrid 22875988 direct interaction X 2 P25604 P06102 two hybrid 22875988 direct interaction X 2 P25604 P32364 two hybrid 22875988 direct interaction X 2 P25604 P32457 two hybrid 22875988 direct interaction X 2 P25604 P19524 two hybrid 22875988 direct interaction X 2 P25604 Q04053 two hybrid 22875988 direct interaction X 2 P25604 P06102 two hybrid 22875988 direct interaction X 2 P25604 Q02767 affinity chromatography technology 11511343 physical association X 2 P25604 Q99176 affinity chromatography technology 11511343 physical association X 2 P25604 Q02767 biochemical 11511343 colocalization X 2 P25604 Q02767 biochemical 11208108 colocalization X 2 P25604 P42939 affinity chromatography technology 17135292 physical association X 2 P25604 P42939 affinity chromatography technology 17135292 physical association X 2 P25604 P42939 affinity chromatography technology 17442384 physical association X 2 P25604 Q99176 affinity chromatography technology 17442384 physical association X 2 P25604 Q99176 affinity chromatography technology 17442384 physical association X 2 P25604 P42939 affinity chromatography technology 16554755 physical association X 2 P25604 Q99176 affinity chromatography technology 16554755 physical association X 2 P25604 Q02767 x-ray crystallography 16615894 association X 2 P25604 Q99176 x-ray crystallography 16615894 association X 2 P25604 Q99176 biochemical 16615894 association X 2 P25604 Q02767 biochemical 16615894 association X 2 P25604 P42939 affinity chromatography technology 17200106 physical association X 2 P25604 Q99176 affinity chromatography technology 17200106 physical association X 2 P25604 Q02767 affinity chromatography technology 17200106 physical association X 2 P25604 P48582 protein complementation assay 17513562 direct interaction X 2 P25604 P48582 affinity chromatography technology 17513562 physical association X 2 P25604 P42939 affinity chromatography technology 17145965 physical association X 2 P25604 Q05080 two hybrid 19841731 direct interaction X 2 P25604 P43603 two hybrid 19841731 direct interaction X 2 P25604 P80667 two hybrid 19841731 direct interaction X 2 P25604 P32790 two hybrid 19841731 direct interaction X 2 P25604 Q04410 biochemical 22144692 colocalization X 2 P89105 P25604 two hybrid 22875988 direct interaction X 2 Q03944 P25604 two hybrid 22875988 direct interaction X 2 P25604 P27614 affinity chromatography technology 11511343 physical association X 2 P25604 P05759 affinity chromatography technology 11511343 physical association X 2 P25604 P38753 two hybrid 11743162 physical association X 2 P25604 molecular sieving 22579254 physical association C 4 P25604 pull down 20305637 physical association C 4 P25604 pull down 22579254 physical association C 4 P25604 x ray scattering 21596998 physical association C 4 P25604 molecular sieving 20305637 physical association C 4 P25604 x ray scattering 22579254 physical association C 7 P25604 P42939 pull down 20305637 physical association X 2 P25604 P42939 pull down 22579254 physical association X 2 P25604 Q99176 electron paramagnetic resonance 21596998 direct interaction X 2 P25604 Q99176 electron paramagnetic resonance 22579254 direct interaction X 2 P25604 Q99176 pull down 20305637 direct interaction X 2 P25604 Q99176 pull down 22579254 direct interaction X 2 P25604 Q99176 affinity chromatography technology 11511343 direct interaction X 2 P25604 Q02767 pull down 22579254 physical association X 2 P25604 Q02767 pull down 20305637 physical association X 2 P25604 Q02767 affinity chromatography technology 11511343 physical association X 2 P25604 P52917 anti tag coimmunoprecipitation 11208108 physical association X 2 P25604 P38753 two hybrid array 11743162 physical association X 2 P25604 P38753 inferred by author 19841731 direct interaction X 2 P25604 P32793 inferred by author 19841731 direct interaction X 2 P25604 P32793 peptide array 19841731 direct interaction X 2 P25604 P38753 peptide array 19841731 direct interaction X 2 P25604 P38753 two hybrid pooling approach 19841731 physical association X 2 P25604 P32793 two hybrid pooling approach 19841731 physical association X 2 P40343 P25604 isothermal titration calorimetry 21505419 direct interaction X 2 P40343 P25604 isothermal titration calorimetry 21505419 direct interaction X 2 P40343 P25604 isothermal titration calorimetry 21505419 direct interaction X 2 P40343 P25604 isothermal titration calorimetry 21505419 direct interaction X 2 P40343 P25604 x-ray crystallography 21505419 direct interaction X 2 P40343 P25604 isothermal titration calorimetry 21505419 direct interaction X 2 P40343 P25604 isothermal titration calorimetry 21505419 direct interaction X 2 P25604 tandem affinity purification 16429126 association C 4 P25604 inferred by author 16554755 association C 4 P25604 x-ray crystallography 17442384 physical association C 4 P25604 molecular sieving 17442384 physical association C 4 P25604 cosedimentation in solution 17442384 physical association C 4 P25604 x-ray crystallography 16615894 physical association C 3 P25604 molecular sieving 16615894 physical association C 3 P25604 cosedimentation in solution 16615894 physical association C 3 P25604 Q02767 - - physical association X 2 P25604 Q02767 affinity chromatography technology 11208108 physical association X 2 P25604 P36095 anti tag coimmunoprecipitation 11208108 physical association X 2 P25604 Q9P7F7 anti tag coimmunoprecipitation 11208108 physical association X 2 P25604 P43603 peptide array 14737190 direct interaction X 2 P25604 Q99176 tandem affinity purification 16554755 physical association X 2 P25604 P42939 tandem affinity purification 16554755 physical association X 2 P25604 Q02767 x-ray crystallography 16615894 direct interaction X 2 P25604 P42939 anti bait coimmunoprecipitation 17442384 physical association X 2 P25604 Q99176 anti bait coimmunoprecipitation 17442384 physical association X 2 P25604 P42939 anti bait coimmunoprecipitation 17442384 physical association X 2 P25604 P43603 inferred by author 19841731 direct interaction X 2 P25604 P38822 inferred by author 19841731 direct interaction X 2 P25604 P80667 inferred by author 19841731 direct interaction X 2 P25604 P43603 peptide array 19841731 direct interaction X 2 P25604 P80667 peptide array 19841731 direct interaction X 2 P25604 Q05080 peptide array 19841731 direct interaction X 2 P25604 P32790 two hybrid array 19841731 physical association X 2 P25604 Q05080 two hybrid pooling approach 19841731 physical association X 2 P25604 P43603 two hybrid pooling approach 19841731 physical association X 2 P25604 P80667 two hybrid pooling approach 19841731 physical association X 2 P25604 P38753 two hybrid 11743162 - X 2

PPI - HINT Gene A Gene B PMID Method Quality NOT3 STP22 22875988 0018 HT RPL40A STP22 15044434 0114 LC TUP1 STP22 22875988 0018 HT MYO2 STP22 22875988 0018 HT REC107 STP22 22875988 0018 HT YCK2 STP22 16319894 0415 LC STP22 STP22 16615894,22875988,17513562 0114,0018,0090 LC,HT STP22 SMY1 22875988 0018 HT STP22 CDC3 22875988 0018 HT STP22 DOA4 17513562 0090 LC STP22 SLA1 19841731,19841731 0397,0018 HT STP22 YSC84 19841731,19841731,19841731,19841731 0398,0363,0081,0018 HT STP22 RPT5 22875988 0018 HT STP22 NUF2 22875988 0018 HT STP22 DYN1 22875988 0018 HT STP22 EBP2 22875988 0018 HT STP22 VPS51 22875988 0018 HT STP22 HSE1 15086794,19841731,11743162,19841731,11743162,19841731,19841731 0018,0018,0397,0363,0018,0398,0081 LC,HT STP22 KEL1 22875988 0018 HT STP22 LNP1 22875988 0018 HT STP22 SPC25 22875988 0018 HT STP22 TSC11 22875988 0018 HT STP22 SSB2 23332755 0401 LC STP22 VPS27 21505419,15086794,21505419,21505419,17513562 0114,0018,0096,0065,0090 LC STP22 PGD1 22875988 0018 HT STP22 MVB12 17442384,17442384,17442384,17442384,17442384 0071,0006,0028,0114,0004 LC STP22 LSB3 19841731,19841731,14737190,19841731,19841731,14737190 0018,0363,0081,0081,0398,0045 HT STP22 GON7 22875988 0018 HT STP22 SNN1 22875988 0018 HT STP22 BRO1 17513562,17513562 0004,0090 LC STP22 RIM8 20028738,20028738,20028738 0004,0018,0096 LC STP22 P53278 22875988 0018 HT STP22 HSK3 22875988 0018 HT STP22 PEX13 19841731,19841731,19841731,19841731 0398,0363,0081,0018 HT STP22 CTR9 22875988 0018 HT STP22 SED5 22875988 0018 HT STP22 VPS28 11208108,11208108,11511343,11511343,17442384,16615894,11208108,16615894 0007,0401,0004,0401,0114,0401,0004,0114 LC STP22 VPS64 22875988 0018 HT STP22 SNX41 22875988 0018 HT STP22 PDS5 22875988 0018 HT STP22 VPS20 22875988 0018 HT STP22 GRH1 22144692 0401 LC STP22 HOF1 19841731,19841731,19841731 0398,0081,0018 HT STP22 FMP27 22875988 0018 HT STP22 ARR1 22875988 0018 HT STP22 Q08964 22875988 0018 HT STP22 NCA2 22875988 0018 HT STP22 TMA17 22875988 0018 HT STP22 SRN2 21596998,16615894,22579254,17442384,22579254,17442384,16615894,16615894,16615894,17442384 0042,0028,0042,0006,0096,0114,0401,0071,0114,0004 LC STP22 MPD2 22875988 0018 HT RPS31 STP22 11511343 0004 LC UBI4 STP22 15039776,19380877,14581452,14581452,19380877,12900393 0004,0004,0004,0096,0096,0096 LC STP22 CPS1 11511343 0004 LC STP22 YSC84 19841731,19841731,19841731,19841731 0398,0363,0081,0018 LC STP22 VPS24 11208108 0007 LC STP22 HSE1 19841731,19841731,19841731,19841731 0018,0363,0398,0081 LC STP22 BZZ1 19841731 0363 LC STP22 SSB2 23332755 0401 LC STP22 VPS27 21505419,21505419,21505419,12900393,22918958,14581452,14581452 0114,0096,0065,0004,0004,0096,0004 LC STP22 MVB12 16554755,16554755,17442384,22940862,17145965,16429126,17442384,22579254,17442384,20305637,17442384,17200106,17135292,17442384,16554755 0363,0676,0071,0004,0004,0676,0006,0096,0028,0096,0114,0004,0004,0004,0004 HT,LC STP22 LSB3 19841731,19841731,19841731,19841731 0018,0363,0081,0398 LC STP22 BRO1 17513562,17513562 0004,0090 LC STP22 VPS4 11208108 0007 LC STP22 RIM8 23645667,20028738,20028738,20028738 0096,0004,0018,0096 LC STP22 PEX13 19841731,19841731,19841731,19841731 0398,0363,0081,0018 LC STP22 VPS28 11208108,11208108,11511343,16429126,11511343,22579254,20305637,16615894,17200106,11208108,16615894 0007,0401,0004,0676,0401,0096,0096,0401,0004,0004,0114 LC,HT STP22 GRH1 22144692 0401 LC STP22 VPS36 17145965 0004 LC STP22 SRN2 16554755,11511343,16429126,16615894,22579254,17442384,22579254,20305637,17442384,16615894,16615894,17200106,16615894,17442384,16554755 0676,0004,0676,0028,0042,0006,0096,0096,0114,0401,0071,0004,0114,0004,0004 HT,LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q04410 P25604 GRH1 STP22 0.126 22144692 P25604 P23292 STP22 YCK2 0.183 16319894 P61864 P25604 RPL40A STP22 0.033 11511343 P25604 P06102 STP22 NOT3 0.183 22875988 P25604 P0CG63 STP22 UBI4 0.671 14581452,19380877,12900393 P25604 P0CH28 STP22 UBC 0.309 15044434 P32793 P25604 YSC84 STP22 0.659 19841731 P38822 P25604 BZZ1 STP22 0.183 19841731 P80667 P25604 PEX13 STP22 0.659 19841731 Q04264 P25604 PDS5 STP22 0.183 22875988 Q99176 P25604 SRN2 STP22 0.843 16429126,11511343,16615894,16554755,17442384 P38753 P25604 HSE1 STP22 0.681 11743162,19841731 P53179 P25604 RIM8 STP22 0.74 23645667,20028738 P42939 P25604 MVB12 STP22 0.911 16429126,17135292,16554755,17442384 P40343 P25604 VPS27 STP22 0.971 14581452,21505419,22918958,12900393 P38199 P25604 HEK2 STP22 0.126 18805955 P32790 P25604 SLA1 STP22 0.286 19841731 P27614 P25604 CPS1 STP22 0.236 11511343 P43603 P25604 LSB3 STP22 0.648 14737190,19841731 Q02767 P25604 VPS28 STP22 0.731 16429126,11511343,11208108,16615894 Q05080 P25604 HOF1 STP22 0.454 19841731