PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus RAD18 SMT3 23034805 biogrid exp TUB1 RAD18 i2d exp SSA1 RAD18 19536198 intact exp RAD18 NAB2 19840948 biogrid exp RAD18 HEK2 18805955 biogrid exp SSA2 RAD18 19536198 intact exp RAD18 ADE2 10688190 biogrid,i2d,mint,intact,dip exp RAD18 NPA3 14690591 intact exp RAD18 CIA1 14690591 intact exp UBI4 RAD18 19396164 biogrid exp RAD18 SSE1 19536198 intact exp RAD18 CUE4 16554755 intact exp RAD18 PUF3 26493364 biogrid exp RAD18 SSB1 19536198 intact exp TDH2 RAD18 i2d exp RAD18 APM4 25346786 biogrid exp GAL1 RAD18 11805837 dip exp RAD18 PFK2 i2d exp RAD18 CMK2 i2d exp RAD18 MRE11 25343618 biogrid exp RAD18 UBC9 24224485,23034805,12226657, 23023127 biogrid exp, pred RAD18 LSM3 10900456, 23023127 biogrid,i2d,mint,intact,dip exp, pred RAD6 RAD18 10880451,19851286,9287349,16957771,21179020,23034805,11805837,10688190,18485869,7926769,9234711,16611731,24224485,12535539,16554755,18385374, 23023127 biogrid,i2d,mint,intact,dip exp, pred RAD18 RFA1 18342608, 23023127 biogrid exp, pred RAD18 RAD17 18485869, 23023127 biogrid,intact exp, pred RAD18 RAD5 10880451,18342608,16224103, 23023127 biogrid,dip exp, pred RAD18 UBC13 10880451,19396164,11805837, 23023127 biogrid,mint,intact,dip exp, pred RAD18 SRS2 15964827,15931174, 23023127 biogrid,i2d exp, pred RAD18 HMT1 14690591, 23023127 intact exp, pred RAD18 POL30 16611731,19851286,16957771,24224485,18485869,23034805,18385374, 23023127 biogrid,intact exp, pred RAD18 ATG12 14690591, 23023127 intact exp, pred RAD18 RFA2 18342608, 23023127 biogrid exp, pred RAD18 RAD18 10880451,23034805,18342608, 23023127 biogrid,dip exp, pred RAD18 LSM2 10900456, 23023127 biogrid,i2d,mint,intact,dip exp, pred RAD18 UBI4 23023127 pred RAD18 TUL1 23023127 pred CDC16 RAD18 23023127 pred RAD18 RAD30 23023127 pred RAD18 UBC12 23023127 pred RAD18 REV1 23023127 pred RAD18 UBC1 23023127 pred RAD18 PEX4 23023127 pred RAD18 APC1 23023127 pred RAD18 UBA1 23023127 pred RAD18 POL3 23023127 pred RAD18 GRR1 23023127 pred RAD18 UBC4 23023127 pred RAD18 UBC5 23023127 pred RAD18 UBA2 23023127 pred RAD18 MPE1 23023127 pred RAD18 SKP1 23023127 pred RAD18 REV3 23023127 pred RAD18 RSP5 23023127 pred RAD18 CDH1 23023127 pred RAD18 APC2 23023127 pred RAD18 UBC7 23023127 pred RAD18 PRP19 23023127 pred RAD18 TFB3 23023127 pred RAD18 UBC11 23023127 pred RAD18 DOA4 23023127 pred RAD18 UBC6 23023127 pred RAD18 PEX10 23023127 pred RAD18 UBC8 23023127 pred RAD18 MMS2 23023127 pred RAD18 POL32 23023127 pred RAD52 RAD18 23023127 pred RAD18 CDC34 23023127 pred RAD18 HRT1 23023127 pred RAD18 POL31 23023127 pred RAD18 REV7 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P10862 - 11805837 - C 6 P10862 P38203 - 10900456 - X 2 P10862 - 11805837 - C 3 P10862 P06104 - 7926769 - X 2 P10862 P57743 - 10900456 - X 2 P10862 P21264 - 10688190 - X 2 P10862 P06104 - 10688190 - X 2 P10862 P06104 - 9287349 - X 2 P10862 P12954 - 15931174 - X 2 P10862 P50623 two hybrid 23034805 direct interaction X 2 P10862 P50623 two hybrid 23034805 direct interaction X 2 P10862 P50623 enzymatic study 23034805 direct interaction X 2 P10862 P50623 affinity chromatography technology 12226657 physical association X 2 P10862 P52490 affinity chromatography technology 10880451 physical association X 2 P10862 P38203 two hybrid 10900456 direct interaction X 2 P10862 P50623 two hybrid 24224485 direct interaction X 2 P10862 Q99186 two hybrid 25346786 direct interaction X 2 P10862 P50623 pull down 23034805 direct interaction X 2 P10862 P48581 two hybrid 18485869 direct interaction X 2 P10862 P22336 two hybrid 18342608 direct interaction X 2 P10862 P26754 two hybrid 18342608 direct interaction X 2 P10862 P22336 two hybrid 18342608 direct interaction X 2 P10862 P26754 two hybrid 18342608 direct interaction X 2 P10862 P22336 pull down 18342608 direct interaction X 2 P10862 P26754 pull down 18342608 direct interaction X 2 P10862 P22336 affinity chromatography technology 18342608 physical association X 2 P10862 P22336 affinity chromatography technology 18342608 physical association X 2 P10862 P52490 imaging technique 19396164 colocalization X 2 P10862 P52490 affinity chromatography technology 11805837 physical association X 2 P0CG63 P10862 affinity chromatography technology 23749301 physical association X 2 P0CG63 P10862 pull down 19396164 direct interaction X 2 P0CG63 P10862 affinity chromatography technology 22106047 physical association X 2 P10862 P06104 affinity chromatography technology 7926769 physical association X 2 P10862 P06104 affinity chromatography technology 7926769 physical association X 2 P10862 P06104 far western blotting 7926769 direct interaction X 2 P10862 P10862 two hybrid 23034805 direct interaction X 2 P10862 Q12306 two hybrid 23034805 direct interaction X 2 P10862 Q12306 two hybrid 23034805 direct interaction X 2 P10862 P10862 affinity chromatography technology 10880451 physical association X 2 P10862 P32849 affinity chromatography technology 10880451 physical association X 2 P10862 P06104 affinity chromatography technology 10880451 physical association X 2 P10862 P06104 affinity chromatography technology 9287349 physical association X 2 P10862 P06104 affinity chromatography technology 9234711 physical association X 2 P10862 P06104 pull down 19851286 direct interaction X 2 P10862 P06104 far western blotting 9234711 direct interaction X 2 P10862 P06104 far western blotting 9234711 direct interaction X 2 P10862 P06104 pull down 9287349 direct interaction X 2 P10862 P57743 two hybrid 10900456 direct interaction X 2 P10862 P10862 two hybrid 10880451 direct interaction X 2 P10862 P32849 two hybrid 10880451 direct interaction X 2 P10862 P32849 two hybrid 10880451 direct interaction X 2 P10862 P06104 two hybrid 10880451 direct interaction X 2 P10862 P06104 two hybrid 10880451 direct interaction X 2 P10862 P06104 affinity chromatography technology 12535539 physical association X 2 P10862 P12954 two hybrid 15964827 direct interaction X 2 P10862 P12954 two hybrid 15931174 direct interaction X 2 P10862 P32849 two hybrid 16224103 direct interaction X 2 P10862 P06104 pull down 24224485 direct interaction X 2 P10862 P06104 two hybrid 24224485 direct interaction X 2 P10862 P06104 affinity chromatography technology 9234711 physical association X 2 P10862 P06104 biochemical 9287349 association X 2 P10862 P06104 pull down 23034805 direct interaction X 2 P10862 P06104 pull down 16611731 direct interaction X 2 P10862 P06104 pull down 16957771 direct interaction X 2 P10862 P32829 affinity chromatography technology 25343618 physical association X 2 P10862 P32829 affinity chromatography technology 25343618 physical association X 2 P10862 P06104 pull down 18385374 direct interaction X 2 P10862 Q12306 pull down 23034805 direct interaction X 2 P10862 Q12306 affinity chromatography technology 23034805 physical association X 2 P10862 P06104 affinity chromatography technology 16554755 physical association X 2 P10862 P06104 affinity chromatography technology 17200106 physical association X 2 P10862 P06104 two hybrid 18485869 direct interaction X 2 P10862 P10862 two hybrid 18342608 direct interaction X 2 P10862 P32849 two hybrid 18342608 direct interaction X 2 P10862 P06104 affinity chromatography technology 11805837 physical association X 2 P10862 P21264 two hybrid 10688190 direct interaction X 2 P10862 P06104 two hybrid 10688190 direct interaction X 2 P15873 P10862 two hybrid 23034805 direct interaction X 2 P15873 P10862 enzymatic study 23034805 direct interaction X 2 P15873 P10862 enzymatic study 24224485 direct interaction X 2 P15873 P10862 enzymatic study 16611731 direct interaction X 2 P15873 P10862 enzymatic study 16957771 direct interaction X 2 P15873 P10862 enzymatic study 18385374 direct interaction X 2 P15873 P10862 pull down 23034805 direct interaction X 2 P15873 P10862 two hybrid 18485869 direct interaction X 2 P15873 P10862 enzymatic study 19851286 direct interaction X 2 P10862 anti tag coimmunoprecipitation 11805837 - C 6 P10862 anti tag coimmunoprecipitation 11805837 - C 7 P10862 P04385 anti tag coimmunoprecipitation 11805837 physical association X 2 P10862 P10862 coimmunoprecipitation 10880451 physical association Y 1 P10862 P10862 two hybrid 10880451 physical association Y 1 P10862 P52490 anti tag coimmunoprecipitation 11805837 physical association X 2 P10862 P52490 coimmunoprecipitation 10880451 physical association X 2 P10862 P38203 two hybrid 10900456 physical association X 2 P10862 anti tag coimmunoprecipitation 11805837 - C 11 P10862 P32849 two hybrid 10880451 physical association X 2 P10862 P32849 coimmunoprecipitation 10880451 physical association X 2 P10862 P21264 two hybrid 10688190 physical association X 2 P10862 P06104 coimmunoprecipitation 10880451 physical association X 2 P10862 P06104 two hybrid 10688190 physical association X 2 P10862 P06104 coimmunoprecipitation 9234711 physical association X 2 P10862 P06104 filter binding 9234711 physical association X 2 P10862 P06104 two hybrid 10880451 physical association X 2 P10862 P06104 biochemical 9287349 physical association X 2 P10862 P57743 two hybrid 10900456 physical association X 2 P10862 tandem affinity purification 21179020 association C 10 P10862 anti tag coimmunoprecipitation 11805837 association C 6 P10862 inferred by author 16554755 association C 4 P32589 P10862 tandem affinity purification 19536198 association X 2 P10862 P38203 two hybrid 10900456 physical association X 2 P10862 P38074 two hybrid array 14690591 physical association X 2 P10862 P47122 two hybrid array 14690591 physical association X 2 P10862 P48581 two hybrid 18485869 physical association X 2 P10862 P11484 tandem affinity purification 19536198 association X 2 P10862 P10592 tandem affinity purification 19536198 association X 2 P38316 P10862 two hybrid array 14690591 physical association X 2 P10862 anti tag coimmunoprecipitation 11805837 association C 3 P10862 tandem affinity purification 21179020 association C 8 P10862 P21264 two hybrid 10688190 physical association X 2 P10862 P06104 two hybrid 10688190 physical association X 2 P10862 P57743 two hybrid 10900456 physical association X 2 P10862 Q05583 two hybrid array 14690591 physical association X 2 P10862 P06104 tandem affinity purification 16554755 physical association X 2 P10862 P06104 tandem affinity purification 16554755 physical association X 2 P10862 P06104 tandem affinity purification 16554755 physical association X 2 P10862 P06104 tandem affinity purification 16554755 physical association X 2 P10862 P06104 tandem affinity purification 16554755 physical association X 2 P10862 P06104 tandem affinity purification 16554755 physical association X 2 P10862 P06104 two hybrid 18485869 physical association X 2 P10862 P10591 tandem affinity purification 19536198 association X 2 P15873 P10862 two hybrid 18485869 physical association X 2 P10862 mass spectrometry studies of complexes 11805837 - C 7 P10862 mass spectrometry studies of complexes 11805837 - C 4 P10862 P38203 two hybrid 10900456 - X 2 P10862 P31383 interaction detection method - - X 2 P10862 P57743 two hybrid 10900456 - X 2 P10862 Q99260 interaction detection method 14764870 - X 2 P10862 P06104 two hybrid 10688190 - X 2 P10862 P06104 coimmunoprecipitation 9234711 - X 2 P10862 P06104 coimmunoprecipitation 9287349 - X 2 P10862 P12954 interaction detection method 1849857 - X 2 P10862 P21264 two hybrid 10688190 - X 2

PPI - HINT Gene A Gene B PMID Method Quality RAD6 RAD18 24224485,9234711,24224485,10880451,10880451,9287349,9287349,7926769,10688190,10688190,10880451,7926769,18485869,9287349,9234711,9234711,9234711,9287349 0096,0019,0018,0004,0019,0096,0019,0047,0397,0018,0018,0004,0018,0004,0047,0049,0004,0401 LC,HT RAD18 RAD18 10880451,10880451,23034805,10880451,18342608 0018,0019,0018,0004,0018 LC RAD18 SRS2 15931174,15964827 0018,0018 LC RAD18 POL30 16957771,23034805,18385374,24224485,23034805,12226657,16611731,18485869,23034805,19851286 0415,0018,0415,0415,0415,0018,0415,0018,0096,0415 LC RAD18 ADE2 10688190,10688190 0397,0018 HT RAD18 RFA1 18342608,18342608,18342608 0096,0004,0018 LC RAD18 RFA2 18342608,18342608 0096,0018 LC RAD18 RAD5 10880451,10880451,10880451,16224103,18342608 0004,0018,0019,0018,0018 LC RAD18 HMT1 14690591 0397 LC RAD18 LSM2 10900456 0018 HT RAD18 ATG12 14690591 0397 LC RAD18 NPA3 14690591 0397 LC RAD18 RAD17 18485869 0018 LC RAD18 UBC9 23034805,12226657,24224485,12226657,24224485,23034805,23034805 0018,0018,0096,0004,0018,0096,0415 LC RAD18 UBC13 10880451,10880451 0019,0004 LC RAD18 LSM3 10900456 0018 HT RAD18 CIA1 14690591 0397 LC RAD18 SMT3 23034805,23034805 0096,0018 LC RAD18 APM4 25346786 0018 LC GAL1 RAD18 11805837 0007 HT RAD6 RAD18 21179020,16611731,24224485,9234711,17200106,19851286,24224485,10880451,23034805,10880451,9287349,9287349,16957771,7926769,11805837,16554755,10880451,18385374,7926769,9287349,11805837,9234711,16554755,9234711,9234711,9287349,12535539 0676,0096,0096,0019,0004,0096,0018,0004,0096,0019,0096,0019,0096,0047,0004,0676,0018,0096,0004,0004,0007,0047,0004,0049,0004,0401,0004 HT,LC UBI4 RAD18 19396164,22106047 0096,0004 LC SSA1 RAD18 19536198 0676 HT SSA2 RAD18 19536198 0676 HT RAD18 RAD18 10880451,10880451,10880451 0018,0019,0004 LC RAD18 SSB1 19536198 0676 HT RAD18 POL30 23034805,23034805,23034805 0018,0415,0096 LC RAD18 RFA1 18342608,18342608,18342608 0096,0004,0018 LC RAD18 RFA2 18342608,18342608 0096,0018 LC RAD18 NAB2 19840948 0004 LC RAD18 SSE1 19536198 0676 HT RAD18 MRE11 25343618 0004 LC RAD18 RAD5 10880451,10880451,10880451 0004,0018,0019 LC RAD18 UBC9 23034805,12226657,24224485,12226657,24224485,23034805,23034805 0018,0018,0096,0004,0018,0096,0415 LC RAD18 UBC13 19396164,11805837,10880451,11805837,10880451 0428,0004,0019,0007,0004 LC,HT RAD18 CUE4 16554755 0363 HT RAD18 SMT3 23034805,23034805 0096,0018 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P57743 P10862 LSM3 RAD18 0.332 10900456 Q12221 P10862 PUF2 RAD18 0.126 26668354 P10862 P0CG63 RAD18 UBI4 0.309 19396164 P10862 P10591 RAD18 SSA1 0.126 19536198 P10862 P10592 RAD18 SSA2 0.126 19536198 P10862 P04385 RAD18 GAL1 0.126 11805837 P26754 P10862 RFA2 RAD18 0.671 18342608 P32589 P10862 SSE1 RAD18 0.126 19536198 P38074 P10862 HMT1 RAD18 0.126 14690591 P38316 P10862 ATG12 RAD18 0.126 14690591 P47122 P10862 NPA3 RAD18 0.126 14690591 Q05583 P10862 CIA1 RAD18 0.126 14690591 Q12306 P10862 SMT3 RAD18 0.671 23034805 Q9M7Q7 P10862 PCNA RAD18 0.309 25728088 Q9ZW35 P10862 PCNA2 RAD18 0.309 25728088 P11484 P10862 SSB1 RAD18 0.126 19536198 P12954 P10862 SRS2 RAD18 0.183 15964827 P50623 P10862 UBC9 RAD18 0.843 24224485,23034805 P32849 P10862 RAD5 RAD18 0.554 16224103,18342608,10880451 P10862 P10862 RAD18 RAD18 0.554 18342608,10880451,23034805 P22336 P10862 RFA1 RAD18 0.794 18342608 P15873 P10862 POL30 RAD18 0.975 24224485,16957771,23034805,18385374,18485869,16611731,19851286 P10862 P06104 RAD18 RAD6 0.998 10688190,16957771,23034805,18385374,16611731,16554755,11805837,21179020,10880451,9287349,24224485,9234711,19851286,7926769,18485869 P38199 P10862 HEK2 RAD18 0.126 18805955 P38203 P10862 LSM2 RAD18 0.332 10900456 P32505 P10862 NAB2 RAD18 0.126 19840948 Q99186 P10862 APM4 RAD18 0.309 25346786 P32829 P10862 MRE11 RAD18 0.376 25343618 P48581 P10862 RAD17 RAD18 0.523 18485869 P52490 P10862 UBC13 RAD18 0.309 11805837,19396164,10880451 P21264 P10862 ADE2 RAD18 0.332 10688190 Q04201 P10862 CUE4 RAD18 0.126 16554755