PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus RSA4 RPF2 23874617 biogrid exp SSC1 RSA4 19536198 intact exp RSA4 NOP53 23874617 biogrid exp TEF1, TEF2 RSA4 16429126 intact exp URA2 RSA4 16429126 intact exp RSA4 NOP7 23874617 biogrid exp RSA4 SER3 11283351 i2d,mint,intact,dip exp RSA4 SPB4 21825077 biogrid exp RSA4 RRS1 23874617 biogrid exp RSA4 HSP78 19536198 intact exp RSA4 EFM1 16554755 intact exp RPL4A RSA4 16429126 intact exp RSA4 AFG2 23874617 biogrid exp RSA4 HAS1 23874617 biogrid exp RSA4 SER33 i2d exp RPL35A RSA4 19737519 intact exp RSA4 NOP15 23874617 biogrid exp RSA4 SSB2 23332755,19536198 biogrid,intact exp RPL35B RSA4 19737519 biogrid exp RSA4 GTS1 11283351 i2d,mint,intact,dip exp RSA4 MIP18 family protein YHR122W 14690591 intact exp RSA4 ERB1 23874617 biogrid exp RSA4 RLP7 23945946,23874617 biogrid exp RSA4 UTP4 i2d exp RSA4 UBP10 16554755 biogrid,i2d,mint,intact exp PHO85 RSA4 16319894 biogrid,i2d exp SNF1 RSA4 21460040 biogrid exp RSA4 SBA1 21777812 biogrid exp RSA4 IPL1 16319894 biogrid,i2d exp RSA4 NSA2 11805826,16429126,25877921,19737519,23874617, 23023127 biogrid,mint,intact,dip exp, ortho, pred RSA4 PRP43 16227579, 23023127 biogrid exp, pred RSA4 NOG2 16429126,19737519,24240281,23874617, 23023127 biogrid,intact exp, pred RSA4 TIF6 16095611,23874617, 23023127 biogrid exp, pred RSA4 NUG1 16429126,12374754,11583615,23874617, 23023127 biogrid,i2d,intact exp, pred RSA4 NSA1 19737519, 23023127 biogrid exp, pred RSA4 MRT4 19789271,19797079,23874617, 23023127 biogrid exp, pred RSA4 ARX1 17803941,16429126,23045392,19737519,12374754,23874617, 23023127 biogrid,intact exp, pred RSA4 RIX1 16429126,12374754,18559667,23142978,11805826,21777812,23045392,19737519,20542003, 23023127 biogrid,mint,intact,dip exp, pred RSA4 IPI3 11805826,16429126,19737519, 23023127 biogrid,mint,intact,dip exp, pred RSA4 CGR1 16429126, 23023127 intact exp, pred RSA4 RPL5 19737519, 23023127 biogrid exp, pred RSA4 MDN1 11805826,16429126,20542003,19737519,23874617, 23023127 biogrid,mint,intact,dip exp, pred RSA4 RSA4 11805826,19737519,23874617, 23023127 biogrid,mint,intact exp, pred RSA4 ALB1 17803941,23045392,23874617, 23023127 biogrid,intact exp, pred RSA4 NOG1 19737519,12808088,23874617, 23023127 biogrid,intact exp, pred RSA4 LSG1 23045392,12374754, 23023127 biogrid exp, pred RSA4 CIC1 12374754,23874617, 23023127 biogrid exp, pred RSA4 UTP14 16554755, 23023127 biogrid,i2d,mint,intact exp, pred RSA4 SDA1 23142978,11805826,16429126,12374754, 23023127 biogrid,mint,intact,dip exp, pred RSA4 DRS1 23874617, 23023127 biogrid exp, pred RSA4 RLP24 19737519,12808088,23874617, 23023127 biogrid,intact exp, pred RSA4 IPI1 19737519,23874617, 23023127 biogrid exp, pred RSA4 BUD20 11805826,16429126,23045392, 23023127 biogrid,mint,intact,dip exp, pred RSA4 GLC3 ortho RSA4 SNF7 ortho ADE3 RSA4 ortho RSA4 NOP9 ortho RPS31 RSA4 ortho RSA4 MTR4 ortho CYC1 RSA4 ortho RSA4 MAK5 23023127 pred RSA4 ARP4 23023127 pred MAK11 RSA4 23023127 pred RSA4 BRX1 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P25382 - 11805826 - C 15 P25382 - 11805826 - C 20 P40956 P25382 - 11283351 - X 2 P25382 P40010 - 11583615 - X 2 P25382 - 11805826 - C 14 P25382 - 11805826 - C 4 P25382 P40054 - 11283351 - X 2 P40693 P25382 affinity chromatography technology 23945946 physical association X 2 P40693 P25382 affinity chromatography technology 23874617 physical association X 2 P47019 P25382 affinity chromatography technology 23045392 physical association X 2 P47019 P25382 affinity chromatography technology 23874617 physical association X 2 P47019 P25382 affinity chromatography technology 17803941 physical association X 2 P17157 P25382 enzymatic study 16319894 direct interaction X 2 P33201 P25382 affinity chromatography technology 23874617 physical association X 2 P33201 P25382 affinity chromatography technology 17200106 physical association X 2 P33201 P25382 affinity chromatography technology 19789271 physical association X 2 P33201 P25382 affinity chromatography technology 19797079 physical association X 2 P53145 P25382 affinity chromatography technology 12374754 physical association X 2 P53145 P25382 affinity chromatography technology 23045392 physical association X 2 P53927 P25382 affinity chromatography technology 23874617 physical association X 2 P49167 P25382 affinity chromatography technology 17200106 physical association X 2 P25382 Q03862 affinity chromatography technology 12374754 physical association X 2 P25382 P38779 affinity chromatography technology 12374754 physical association X 2 P25382 P40010 affinity chromatography technology 12374754 physical association X 2 P25382 Q03862 affinity chromatography technology 23045392 physical association X 2 P25382 Q03862 affinity chromatography technology 23045392 physical association X 2 P25382 P53742 affinity chromatography technology 23874617 physical association X 2 P25382 P32794 affinity chromatography technology 23874617 physical association X 2 P25382 P40010 affinity chromatography technology 23874617 physical association X 2 P25382 P40078 affinity chromatography technology 23874617 physical association X 2 P25382 P25382 affinity chromatography technology 23874617 physical association X 2 P25382 P38779 affinity chromatography technology 23874617 physical association X 2 P25382 P38803 affinity chromatography technology 23874617 physical association X 2 P25382 Q03862 affinity chromatography technology 23874617 physical association X 2 P25382 P53742 affinity chromatography technology 24240281 physical association X 2 P25382 Q04500 affinity chromatography technology 16554755 physical association X 2 P25382 Q03862 affinity chromatography technology 16429126 physical association X 2 P25382 P40010 affinity chromatography technology 16429126 physical association X 2 P25382 P40078 affinity chromatography technology 16429126 physical association X 2 P25382 P53742 affinity chromatography technology 16429126 physical association X 2 P25382 Q03862 affinity chromatography technology 17200106 physical association X 2 P25382 P40010 affinity chromatography technology 17200106 physical association X 2 P25382 P40078 affinity chromatography technology 17200106 physical association X 2 P25382 P53742 affinity chromatography technology 17200106 physical association X 2 P25382 Q03862 affinity chromatography technology 19737519 physical association X 2 P25382 P53742 affinity chromatography technology 19737519 physical association X 2 P25382 P25382 affinity chromatography technology 19737519 physical association X 2 P25382 P38803 affinity chromatography technology 19737519 physical association X 2 P25382 Q03862 affinity chromatography technology 17803941 physical association X 2 P25382 P40078 affinity chromatography technology 11805826 physical association X 2 P25382 P40010 affinity chromatography technology 11583615 physical association X 2 P32892 P25382 affinity chromatography technology 23874617 physical association X 2 P25808 P25382 affinity chromatography technology 21825077 physical association X 2 Q03532 P25382 affinity chromatography technology 23874617 physical association X 2 P06782 P25382 pull down 21460040 direct interaction X 2 Q08004 P25382 affinity chromatography technology 23045392 physical association X 2 Q08004 P25382 affinity chromatography technology 16429126 physical association X 2 P38991 P25382 enzymatic study 16319894 direct interaction X 2 Q08004 P25382 affinity chromatography technology 17200106 physical association X 2 Q08004 P25382 affinity chromatography technology 11805826 physical association X 2 P0CG63 P25382 affinity chromatography technology 23749301 physical association X 2 P53874 P25382 affinity chromatography technology 16554755 physical association X 2 Q12080 P25382 affinity chromatography technology 23874617 physical association X 2 Q07915 P25382 affinity chromatography technology 12808088 physical association X 2 Q07915 P25382 affinity chromatography technology 23874617 physical association X 2 P53261 P25382 affinity chromatography technology 23874617 physical association X 2 P36160 P25382 affinity chromatography technology 23874617 physical association X 2 P53136 P25382 affinity chromatography technology 19737519 physical association X 2 P53877 P25382 affinity chromatography technology 16429126 physical association X 2 P53877 P25382 affinity chromatography technology 16429126 physical association X 2 P53877 P25382 affinity chromatography technology 17200106 physical association X 2 P53877 P25382 affinity chromatography technology 19737519 physical association X 2 P53877 P25382 affinity chromatography technology 11805826 physical association X 2 Q12522 P25382 affinity chromatography technology 23874617 physical association X 2 Q08746 P25382 affinity chromatography technology 23874617 physical association X 2 Q12522 P25382 affinity chromatography technology 16095611 physical association X 2 Q12522 P25382 affinity chromatography technology 17200106 physical association X 2 P40150 P25382 biochemical 23332755 association X 2 P25382 Q02892 affinity chromatography technology 12808088 physical association X 2 P25382 P53313 affinity chromatography technology 12374754 physical association X 2 P25382 P53313 biochemical 23142978 association X 2 P25382 Q02892 affinity chromatography technology 23874617 physical association X 2 P25382 Q04660 affinity chromatography technology 23874617 physical association X 2 P25382 Q02892 affinity chromatography technology 23874617 physical association X 2 P25382 P53313 affinity chromatography technology 16429126 physical association X 2 P25382 P53313 affinity chromatography technology 17200106 physical association X 2 P25382 Q02892 affinity chromatography technology 17200106 physical association X 2 P25382 P26321 affinity chromatography technology 19737519 physical association X 2 P25382 P53313 affinity chromatography technology 11805826 physical association X 2 P38883 P25382 affinity chromatography technology 12374754 physical association X 2 P38883 P25382 biochemical 23142978 association X 2 P38883 P25382 affinity chromatography technology 23045392 physical association X 2 P38883 P25382 affinity chromatography technology 16429126 physical association X 2 P38883 P25382 affinity chromatography technology 17200106 physical association X 2 P38883 P25382 affinity chromatography technology 18559667 physical association X 2 P38883 P25382 affinity chromatography technology 19737519 physical association X 2 P38883 P25382 affinity chromatography technology 19737519 physical association X 2 P38883 P25382 affinity chromatography technology 20542003 physical association X 2 P38883 P25382 affinity chromatography technology 11805826 physical association X 2 P38883 P25382 affinity chromatography technology 21777812 physical association X 2 P0CX84 P25382 affinity chromatography technology 19737519 physical association X 2 P53131 P25382 affinity chromatography technology 16227579 physical association X 2 P28707 P25382 pull down 21777812 direct interaction X 2 P28707 P25382 two hybrid 21777812 direct interaction X 2 Q12019 P25382 affinity chromatography technology 23874617 physical association X 2 Q12019 P25382 affinity chromatography technology 16429126 physical association X 2 Q12019 P25382 affinity chromatography technology 17200106 physical association X 2 Q12019 P25382 affinity chromatography technology 19737519 physical association X 2 Q12019 P25382 two hybrid 19737519 direct interaction X 2 Q12019 P25382 two hybrid 20542003 direct interaction X 2 Q12019 P25382 affinity chromatography technology 11805826 physical association X 2 P25382 inferred by author 11805826 physical association C 88 P25382 tandem affinity purification 11805826 - C 15 P25382 tandem affinity purification 11805826 - C 20 P40956 P25382 two hybrid pooling approach 11283351 physical association X 2 P25382 P40078 tandem affinity purification 11805826 physical association X 2 P25382 tandem affinity purification 11805826 - C 14 P25382 tandem affinity purification 11805826 - C 4 Q08004 P25382 tandem affinity purification 11805826 physical association X 2 P25382 tandem affinity purification 11805826 physical association X 2 P53877 P25382 tandem affinity purification 11805826 physical association X 2 P25382 P40054 two hybrid pooling approach 11283351 physical association X 2 P25382 P53313 tandem affinity purification 11805826 physical association X 2 Q12019 P25382 tandem affinity purification 11805826 physical association X 2 P25382 inferred by author 16429126 physical association C 54 P25382 tandem affinity purification 19737519 association C 27 P25382 tandem affinity purification 16429126 association C 36 P25382 tandem affinity purification 19737519 association C 8 P25382 tandem affinity purification 19737519 association C 6 P25382 tandem affinity purification 16429126 association C 35 P25382 tandem affinity purification 11805826 association C 15 P25382 inferred by author 16554755 association C 5 P25382 inferred by author 16429126 physical association C 28 P25382 tandem affinity purification 16429126 association C 18 P25382 tandem affinity purification 16429126 association C 7 P25382 cosedimentation in solution 19737519 association C 6 P40956 P25382 two hybrid fragment pooling approach 11283351 physical association X 2 P25382 P38829 two hybrid array 14690591 physical association X 2 P25382 Q04500 tandem affinity purification 16554755 physical association X 2 P25382 Q04500 tandem affinity purification 16554755 physical association X 2 P25382 Q04500 tandem affinity purification 16554755 physical association X 2 P25382 tandem affinity purification 16429126 association C 34 P25382 tandem affinity purification 16429126 association C 33 P25382 tandem affinity purification 11805826 association C 21 P25382 inferred by author 16429126 physical association C 91 P25382 tandem affinity purification 11805826 association C 5 P25382 tandem affinity purification 11805826 association C 5 P25382 tandem affinity purification 16429126 association C 37 P25382 tandem affinity purification 11805826 association C 16 P25382 tandem affinity purification 16429126 association C 37 P25382 tandem affinity purification 19737519 physical association C 4 P25382 inferred by author 16429126 physical association C 30 P25382 tandem affinity purification 16429126 association C 3 P53874 P25382 tandem affinity purification 16554755 physical association X 2 P53874 P25382 tandem affinity purification 16554755 physical association X 2 P40150 P25382 tandem affinity purification 19536198 association X 2 P25382 P40054 two hybrid fragment pooling approach 11283351 physical association X 2 P25382 P0CS90 tandem affinity purification 19536198 association X 2 P25382 P33416 tandem affinity purification 19536198 association X 2 Q12019 P25382 two hybrid 19737519 physical association X 2 Q12019 P25382 two hybrid 19737519 physical association X 2 Q12019 P25382 pull down 19737519 physical association X 2 Q12019 P25382 pull down 19737519 physical association X 2 P25382 mass spectrometry studies of complexes 11805826 - C 106 P25382 mass spectrometry studies of complexes 11805826 - C 106 P40956 P25382 two hybrid 11283351 - X 2 P25382 P40010 affinity chromatography technology 11583615 - X 2 P25382 P40054 two hybrid 11283351 - X 2

PPI - HINT Gene A Gene B PMID Method Quality RPL35A RSA4 19737519,19737519 0004,0028 LC PHO85 RSA4 16319894 0415 LC RSA4 RSA4 25404745 0114 LC RSA4 SBA1 21777812,21777812 0018,0096 LC RSA4 P38829 14690591 0397 LC RSA4 RIX1 23142978 0401 LC RSA4 IPL1 16319894 0415 LC RSA4 SER3 11283351,11283351,11283351 0018,0399,0398 HT RSA4 NSA2 25877921,25877921,25877921,19737519 1356,0397,0018,0028 LC RSA4 SSB2 23332755 0401 LC RSA4 GTS1 11283351,11283351,11283351 0018,0399,0398 HT RSA4 SDA1 23142978 0401 LC RSA4 NOG2 19737519,19737519 0028,0004 LC RSA4 NOG1 19737519 0028 LC RSA4 RLP24 19737519 0028 LC RSA4 MDN1 19737519,19737519,20542003,19737519 0096,0004,0018,0018 LC TEF1|TEF2 RSA4 16429126 0676 HT SNF1 RSA4 21460040 0096 LC URA2 RSA4 16429126 0676 HT SSC1 RSA4 19536198 0676 HT RPL35A RSA4 19737519,19737519 0004,0028 LC RPL35B RSA4 19737519 0004 LC RPL4A RSA4 16429126 0676 HT RSA4 RSA4 11805826,23874617,19737519,11805826 0676,0004,0004,0007 HT,LC RSA4 SPB4 21825077 0004 LC RSA4 RPL5 19737519 0004 LC RSA4 SBA1 21777812,21777812 0018,0096 LC RSA4 AFG2 23874617 0004 LC RSA4 DRS1 23874617 0004 LC RSA4 MRT4 17200106,23874617,19797079,19789271 0004,0004,0004,0004 HT,LC RSA4 HSP78 19536198 0676 HT RSA4 RPF2 23874617 0004 LC RSA4 EFM1 16554755 0363 HT RSA4 CIC1 12374754,23874617 0004,0004 LC RSA4 IPI1 23874617,19737519 0004,0004 LC RSA4 WSS1 26349035 0004 LC RSA4 RIX1 23142978,16429126,20542003,18559667,23045392,11805826,12374754,11805826,23045392,19737519,17200106,21777812,11805826,16429126,19737519 0401,0004,0004,0004,0004,0004,0004,0676,0676,0676,0004,0004,0007,0676,0004 LC,HT RSA4 NUG1 23874617,16429126,12374754,17200106,11583615,16429126 0004,0004,0004,0004,0004,0676 LC,HT RSA4 NSA2 23874617,16429126,11805826,11805826,17200106,11805826,16429126 0004,0676,0004,0676,0004,0007,0004 LC,HT RSA4 SSB2 19536198,23332755 0676,0401 HT,LC RSA4 RLP7 23945946,23874617 0004,0004 LC RSA4 ALB1 23874617,23045392,17803941,23045392 0004,0004,0004,0676 LC RSA4 RPL38 17200106 0004 HT RSA4 PRP43 16227579,16227579 0676,0004 LC RSA4 NSA1 19737519 0004 LC RSA4 LSG1 12374754,23045392 0004,0004 LC RSA4 CGR1 16429126 0676 HT RSA4 NOP7 23874617 0004 LC RSA4 SDA1 23142978,16429126,11805826,12374754,11805826,17200106,11805826,16429126 0401,0676,0004,0004,0676,0004,0007,0004 LC,HT RSA4 NOG2 23874617,24240281,16429126,19737519,19737519,17200106,16429126 0004,0004,0004,0028,0004,0004,0676 LC,HT RSA4 UBP10 16554755,16554755 0676,0004 HT RSA4 IPI3 16429126,11805826,11805826,19737519,17200106,11805826,16429126 0004,0676,0004,0004,0004,0007,0676 HT,LC RSA4 NOP15 23874617 0004 LC RSA4 NOG1 17200106,23874617,12808088 0004,0004,0004 HT,LC RSA4 HAS1 23874617 0004 LC RSA4 ARX1 23874617,17803941,16429126,12374754,23045392,19737519,17200106,16429126,16429126 0004,0004,0004,0004,0004,0004,0004,0676,0363 LC,HT RSA4 UTP14 16554755,16554755 0676,0004 HT RSA4 ERB1 23874617 0004 LC RSA4 MMS22 26849847 0004 LC RSA4 RLP24 23874617,12808088 0004,0004 LC RSA4 BUD20 16429126,11805826,23045392,11805826,23045392,17200106,11805826,16429126 0676,0676,0004,0004,0676,0004,0007,0004 HT,LC RSA4 RRS1 23874617 0004 LC RSA4 MDN1 23874617,19737519,16429126,16429126,11805826,11805826,19737519,17200106,11805826,19737519 0004,0096,0004,0676,0004,0676,0004,0004,0007,0018 LC,HT RSA4 NOP53 23874617 0004 LC RSA4 TIF6 17200106,23874617,16095611 0004,0004,0004 HT,LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P53136 P25382 NSA1 RSA4 0.126 19737519 P53145 P25382 LSG1 RSA4 0.126 23045392 P53188 P25382 CGR1 RSA4 0.126 16429126 P25382 P02994 RSA4 TEF2 0.126 16429126 P25382 P05317 RSA4 RPP0 0.126 27775710 P25382 P07259 RSA4 URA2 0.126 16429126 P25382 P0CX84 RSA4 RPL35A 0.126 19737519 P25382 P0CX85 RSA4 RPL35B 0.126 19737519 P25382 P10664 RSA4 RPL4A 0.126 16429126 P26321 P25382 RPL5 RSA4 0.126 19737519 P32794 P25382 AFG2 RSA4 0.126 23874617 P32892 P25382 DRS1 RSA4 0.126 23874617 P36160 P25382 RPF2 RSA4 0.126 23874617 P38779 P25382 CIC1 RSA4 0.126 23874617 P38829 P25382 P38829 RSA4 0.126 14690591 P39741 P25382 RPL35A RSA4 0.126 19737519 P40010 P25382 NUG1 RSA4 0.396 11583615,23874617,16429126 P40054 P25382 SER3 RSA4 0.21 11283351 P40078 P25382 NSA2 RSA4 0.681 11805826,19737519,25877921,16429126,23874617 P47019 P25382 ALB1 RSA4 0.472 17803941,23874617,23045392 P53313 P25382 SDA1 RSA4 0.416 11805826,23142978,16429126 P53874 P25382 UBP10 RSA4 0.126 16554755 P53927 P25382 NOP15 RSA4 0.126 23874617 Q03532 P25382 HAS1 RSA4 0.126 23874617 Q03862 P25382 ARX1 RSA4 0.722 12374754,19737519,27775710,16429126,23874617,17803941,23045392 Q04500 P25382 UTP14 RSA4 0.332 16554755 Q04660 P25382 ERB1 RSA4 0.126 23874617 Q08746 P25382 RRS1 RSA4 0.126 23874617 Q12019 P25382 MDN1 RSA4 0.748 11805826,19737519,16429126,20542003,23874617 Q12080 P25382 NOP53 RSA4 0.126 23874617 P25382 P0CS90 RSA4 SSC1 0.126 19536198 P25382 P06782 RSA4 SNF1 0.183 21460040 Q02892 P25382 NOG1 RSA4 0.472 12808088,19737519,23874617 P38803 P25382 IPI1 RSA4 0.236 19737519,23874617 P33201 P25382 MRT4 RSA4 0.416 19789271,27775710,19797079,23874617 Q07915 P25382 RLP24 RSA4 0.236 19737519,23874617 P53261 P25382 NOP7 RSA4 0.236 23874617,27775710 P53742 P25382 NOG2 RSA4 0.539 19737519,24240281,16429126,23874617 P28707 P25382 SBA1 RSA4 0.332 21777812 P53131 P25382 PRP43 RSA4 0.236 16227579 P25382 P25382 RSA4 RSA4 0.396 11805826,19737519,23874617 P25808 P25382 SPB4 RSA4 0.126 21825077 P38732 P25382 EFM1 RSA4 0.126 16554755 P38838 P25382 WSS1 RSA4 0.126 26349035 P38883 P25382 RIX1 RSA4 0.787 11805826,23142978,19737519,16429126,20542003,18559667,23045392,21777812 P38991 P25382 IPL1 RSA4 0.183 16319894 P33416 P25382 HSP78 RSA4 0.126 19536198 P40150 P25382 SSB2 RSA4 0.236 23332755,19536198 P40693 P25382 RLP7 RSA4 0.236 23874617,23945946 P40956 P25382 GTS1 RSA4 0.236 11283351 Q12522 P25382 TIF6 RSA4 0.396 16095611,23874617,27775710 P53877 P25382 IPI3 RSA4 0.436 11805826,19737519,16429126 P25382 P17157 RSA4 PHO85 0.183 16319894 Q08004 P25382 BUD20 RSA4 0.416 11805826,23045392,16429126