PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus GIS2 APC11 21232131 biogrid exp SSA2 APC11 19536198 intact exp UBC5 APC11 17632060 biogrid exp HSP82 APC11 19536198 intact exp PUF3 APC11 26493364 biogrid exp SSB1 APC11 19536198 intact exp SSB2 APC11 23332755,19536198 biogrid,intact exp SSC1 APC11 19536198 intact exp SSE1 APC11 19536198 intact exp APC11 APC11 10888670 biogrid exp, ortho UBC4 APC11 19475395,23078409,16364911,22079111,10888670,21460798,25217616,15797379,22940250,25877870,21562221,23707760,18498748,23049888,17632060,12574115,23751495,17018280 biogrid,i2d exp, ortho UBC11 APC11 17632060 biogrid exp, ortho UBC1 APC11 17632060,23751495 biogrid exp, ortho CDC23 APC11 16481473,9469814, 23023127 biogrid,i2d,intact,dip exp, ortho, pred CDC16 APC11 10318877,21186364,9469814,16364911,15649358,15060174,16275330,10888670,17406682,12574115,15797379, 23023127 biogrid,i2d,intact,dip exp, ortho, pred APC11 APC2 24225956,15060174,17634282,9469814,15797379, 23023127 biogrid,i2d,intact,dip exp, pred APC5 APC11 9469814, 23023127 biogrid,i2d,intact,dip exp, pred CDC27 APC11 10888670,12609981,9469814, 23023127 biogrid,i2d,intact,dip exp, pred DOC1 APC11 9469814, 23023127 biogrid,i2d,intact,dip exp, pred CDC26 APC11 9469814, 23023127 i2d,intact,dip exp, pred MND2 APC11 12477395, 23023127 biogrid,intact exp, pred CDC5 APC11 19013276, 23023127 biogrid,intact exp, pred APC11 SWM1 12477395,15060174,12574115, 23023127 biogrid,intact exp, pred SMY1 APC11 18467557, 23023127 biogrid,i2d,mint,intact exp, pred SAP1 APC11 16554755, 23023127 biogrid,i2d,mint,intact exp, pred APC1 APC11 16481473,9469814, 23023127 biogrid,i2d,intact,dip exp, pred APC4 APC11 12477395,15060174,21186364,9469814, 23023127 biogrid,i2d,intact,dip exp, pred DCC1 APC11 18467557, 23023127 biogrid,i2d,mint,intact exp, pred APC9 APC11 9469814, 23023127 biogrid,i2d,intact,dip exp, pred CLB3 APC11 ortho CDC19 APC11 ortho CDH1 APC11 23023127 ortho, pred CDC20 APC11 23023127 ortho, pred SDS22 APC11 23023127 pred RPN12 APC11 23023127 pred UBC9 APC11 23023127 pred MET30 APC11 23023127 pred RSP5 APC11 23023127 pred GLC7 APC11 23023127 pred CDC48 APC11 23023127 pred PDS1 APC11 23023127 pred PRE1 APC11 23023127 pred MNS1 APC11 23023127 pred UBA1 APC11 23023127 pred CDC53 APC11 23023127 pred RPT4 APC11 23023127 pred RAD6 APC11 23023127 pred ESP1 APC11 23023127 pred UBA2 APC11 23023127 pred UBI4 APC11 23023127 pred SKP1 APC11 23023127 pred CDC34 APC11 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q12157 - 15797379 - C 13 Q12157 - 15649358 - C 13 Q12157 - 9469814 - C 12 Q12157 - 10888670 - C 3 Q12157 P09798 - 9469814 - X 2 Q12157 P16522 - 9469814 - X 2 Q12157 - 9469814 - X 2 Q12157 P53068 - 9469814 - X 2 Q12107 Q12157 - 9469814 - X 2 Q04601 Q12157 - 9469814 - X 2 Q12157 - 15797379 - C 6 Q12157 - 15044803 - C 11 Q12157 P15731 - 10888670 - X 2 Q12157 Q08683 - 9469814 - X 2 Q12157 Q12440 - 9469814 - X 2 P14724 Q12157 - 9469814 - X 2 Q12157 P09798 affinity chromatography technology 12574115 physical association X 2 Q12157 P09798 affinity chromatography technology 10318877 physical association X 2 Q12157 P38042 affinity chromatography technology 12609981 physical association X 2 Q12157 Q12379 affinity chromatography technology 12574115 physical association X 2 Q12157 P09798 affinity chromatography technology 15060174 physical association X 2 Q12157 Q12379 affinity chromatography technology 15060174 physical association X 2 Q12157 P09798 affinity chromatography technology 9469814 physical association X 2 Q12157 P16522 affinity chromatography technology 9469814 physical association X 2 Q12157 Q12379 affinity chromatography technology 12477395 physical association X 2 Q12157 P40577 affinity chromatography technology 12477395 physical association X 2 Q12157 P38042 affinity chromatography technology 10888670 physical association X 2 Q12157 P09798 affinity chromatography technology 10888670 physical association X 2 Q12157 P53886 affinity chromatography technology 9469814 physical association X 2 Q12157 P38042 affinity chromatography technology 9469814 physical association X 2 Q12157 P53068 affinity chromatography technology 9469814 physical association X 2 Q12157 P09798 affinity chromatography technology 15649358 physical association X 2 Q12157 P53886 affinity chromatography technology 16481473 physical association X 2 Q12157 P16522 affinity chromatography technology 16481473 physical association X 2 Q12157 P15732 pull down 17632060 direct interaction X 2 Q12157 P39955 affinity chromatography technology 16554755 physical association X 2 Q12157 P09798 affinity chromatography technology 16275330 physical association X 2 Q12157 P53886 affinity chromatography technology 16481473 physical association X 2 Q12157 P32364 protein complementation assay 18467557 direct interaction X 2 Q12157 P09798 affinity chromatography technology 17406682 physical association X 2 Q12157 P09798 affinity chromatography technology 15797379 physical association X 2 Q12157 P09798 affinity chromatography technology 21186364 physical association X 2 Q12157 P09798 affinity chromatography technology 16364911 physical association X 2 P52492 Q12157 pull down 17632060 direct interaction X 2 P21734 Q12157 pull down 17632060 direct interaction X 2 P21734 Q12157 pull down 23751495 direct interaction X 2 Q12107 Q12157 affinity chromatography technology 9469814 physical association X 2 Q04601 Q12157 affinity chromatography technology 15060174 physical association X 2 Q04601 Q12157 affinity chromatography technology 12477395 physical association X 2 Q04601 Q12157 affinity chromatography technology 9469814 physical association X 2 Q04601 Q12157 affinity chromatography technology 21186364 physical association X 2 Q12157 P15731 pull down 21562221 direct interaction X 2 Q12157 P15731 pull down 18498748 direct interaction X 2 Q12157 P15731 pull down 22079111 direct interaction X 2 Q12157 P34244 enzymatic study 23078409 direct interaction X 2 Q12157 P15731 pull down 23078409 direct interaction X 2 Q12157 P15731 pull down 22940250 direct interaction X 2 Q12157 P40316 enzymatic study 22940250 direct interaction X 2 Q12157 Q12440 affinity chromatography technology 15060174 physical association X 2 Q12157 Q12440 affinity chromatography technology 9469814 physical association X 2 Q12157 Q08683 affinity chromatography technology 9469814 physical association X 2 Q12157 Q12440 pull down 24225956 direct interaction X 2 Q12157 P24868 enzymatic study 17018280 direct interaction X 2 Q12157 P15731 pull down 17018280 direct interaction X 2 Q12157 Q12157 enzymatic study 10888670 direct interaction X 2 Q12157 P15731 pull down 10888670 direct interaction X 2 Q12157 P15731 pull down 19475395 direct interaction X 2 Q12157 P15731 pull down 12574115 direct interaction X 2 Q12157 P15731 pull down 16364911 direct interaction X 2 Q12157 P15731 pull down 23707760 direct interaction X 2 Q12157 P15731 pull down 17632060 direct interaction X 2 Q12157 P15731 pull down 25217616 direct interaction X 2 Q12157 P15731 pull down 23049888 direct interaction X 2 Q12157 P15731 pull down 15797379 direct interaction X 2 Q12157 P15731 pull down 23751495 direct interaction X 2 Q12157 P62837 pull down 18519589 direct interaction X 2 Q12157 P15731 pull down 21460798 direct interaction X 2 Q12157 P40150 biochemical 23332755 association X 2 Q12157 Q12440 two hybrid 17634282 direct interaction X 2 Q12157 P25559 protein complementation assay 18467557 direct interaction X 2 Q12157 P62837 pull down 10888670 direct interaction X 2 Q12157 P32562 affinity chromatography technology 19013276 physical association X 2 Q12157 Q12440 affinity chromatography technology 15797379 physical association X 2 Q12157 pull down 21107322 - C 13 Q12157 tandem affinity purification 21107322 - C 12 Q12157 tandem affinity purification 21107322 - C 13 Q12157 coimmunoprecipitation 9469814 physical association X 2 Q12157 P09798 coimmunoprecipitation 10888670 physical association X 2 Q12157 P09798 coimmunoprecipitation 10318877 physical association X 2 Q12157 P09798 pull down 21107322 physical association X 2 Q12157 P09798 coimmunoprecipitation 9469814 physical association X 2 Q12157 P09798 tandem affinity purification 21107322 physical association X 2 Q12157 P09798 tandem affinity purification 21186364 physical association X 2 Q12157 P09798 tandem affinity purification 21107322 physical association X 2 Q12157 P09798 tandem affinity purification 21186364 physical association X 2 Q12157 P09798 tandem affinity purification 21186364 physical association X 2 Q12157 P09798 pull down 21107322 physical association X 2 Q12157 P09798 anti tag coimmunoprecipitation 21186364 physical association X 2 Q12157 P16522 coimmunoprecipitation 9469814 physical association X 2 Q12157 P38042 coimmunoprecipitation 9469814 physical association X 2 Q12157 P38042 coimmunoprecipitation 10888670 physical association X 2 Q12157 coimmunoprecipitation 9469814 physical association X 2 Q12107 Q12157 coimmunoprecipitation 9469814 physical association X 2 Q04601 Q12157 coimmunoprecipitation 9469814 physical association X 2 Q12157 tandem affinity purification 21186364 - C 3 Q12157 tandem affinity purification 21186364 - C 3 Q12157 tandem affinity purification 21186364 physical association C 11 Q12157 electron tomography 21186364 physical association C 11 Q12157 pull down 21107322 - C 14 Q12157 anti tag coimmunoprecipitation 21186364 - C 3 Q12157 Q08683 coimmunoprecipitation 9469814 physical association X 2 Q12157 Q12440 coimmunoprecipitation 10230406 physical association X 2 Q12157 Q12440 coimmunoprecipitation 9469814 physical association X 2 P14724 Q12157 coimmunoprecipitation 9469814 physical association X 2 Q12157 tandem affinity purification 12477395 association C 13 Q12157 tandem affinity purification 12477395 association C 13 Q12157 tandem affinity purification 12477395 association C 13 Q12157 affinity chromatography technology 12609981 association C 13 Q12157 anti tag coimmunoprecipitation 9469814 association C 10 Q12157 anti tag coimmunoprecipitation 9469814 association C 10 Q12157 anti tag coimmunoprecipitation 9469814 association C 10 Q12157 anti tag coimmunoprecipitation 9469814 association C 12 Q12157 anti tag coimmunoprecipitation 9469814 association C 12 Q12157 anti tag coimmunoprecipitation 9469814 association C 12 Q12157 anti tag coimmunoprecipitation 9469814 association C 12 Q12157 anti tag coimmunoprecipitation 9469814 association C 12 Q12157 P39955 inferred by author 16554755 association X 2 Q12157 P39955 tandem affinity purification 16554755 physical association X 2 Q12157 P32364 dihydrofolate reductase reconstruction 18467557 physical association X 2 Q12157 P02829 tandem affinity purification 19536198 association X 2 Q12157 tandem affinity purification 19013276 association C 41 P32589 Q12157 tandem affinity purification 19536198 association X 2 Q12157 P25559 dihydrofolate reductase reconstruction 18467557 physical association X 2 Q12157 P11484 tandem affinity purification 19536198 association X 2 Q12157 P0CS90 tandem affinity purification 19536198 association X 2 Q12157 P10592 tandem affinity purification 19536198 association X 2 Q12157 P40150 tandem affinity purification 19536198 association X 2 Q12157 P53068 coimmunoprecipitation 9469814 - X 2 Q12157 P16522 coimmunoprecipitation 9469814 - X 2 Q12157 P09798 coimmunoprecipitation 9469814 - X 2 Q12157 P53886 coimmunoprecipitation 9469814 - X 2 Q12157 P38042 coimmunoprecipitation 10888670 - X 2 Q12157 P38042 coimmunoprecipitation 9469814 - X 2 Q12107 Q12157 coimmunoprecipitation 9469814 - X 2 Q04601 Q12157 coimmunoprecipitation 9469814 - X 2 Q12157 confirmational text mining - - C 11 Q12157 Q12440 coimmunoprecipitation 9469814 - X 2 Q12157 Q08683 coimmunoprecipitation 9469814 - X 2 P14724 Q12157 coimmunoprecipitation 9469814 - X 2

PPI - HINT Gene A Gene B PMID Method Quality CDC16 APC11 10888670,9469814,10888670,10318877,9469814,10318877,9469814 0019,0004,0004,0004,0019,0019,0007 LC UBI4 APC11 26306044 0415 LC CDC26 APC11 9469814,9469814 0019,0007 LC UBC4 APC11 10888670,10888670,10888670 0096,0004,0045 LC CDC23 APC11 9469814,9469814,9469814 0019,0004,0007 LC DCC1 APC11 18467557,18467557 0111,0090 HT SMY1 APC11 18467557,18467557 0111,0090 HT CDC27 APC11 10888670,9469814,10888670,9469814,9469814 0019,0004,0004,0019,0007 LC SSB2 APC11 23332755 0401 LC PDS1 APC11 16364911 0415 LC DOC1 APC11 9469814,9469814,9469814 0019,0007,0004 LC NRM1 APC11 21562221 0415 LC APC1 APC11 9469814,9469814,9469814 0019,0004,0007 LC YHP1 APC11 21562221 0415 LC APC4 APC11 9469814,9469814,9469814 0004,0019,0007 LC APC5 APC11 9469814,9469814,9469814 0019,0007,0004 LC APC9 APC11 9469814,9469814,9469814 0019,0007,0004 LC APC11 APC11 10888670 0415 LC APC11 APC2 9469814,21107322,17634282,10230406,9469814,9469814 0004,0114,0018,0019,0019,0007 LC,HT HSP82 APC11 19536198 0676 HT CDC16 APC11 21107322,10888670,21107322,9469814,17406682,16364911,15060174,21186364,10888670,21186364,21186364,10318877,12574115,15649358,9469814,10318877,16275330,9469814,15797379 0676,0019,0096,0004,0004,0004,0004,0004,0004,0676,0007,0004,0004,0004,0019,0019,0004,0007,0004 LC SSC1 APC11 19536198 0676 HT SSA2 APC11 19536198 0676 HT SSB1 APC11 19536198 0676 HT CDC26 APC11 9469814,9469814 0019,0007 LC UBC4 APC11 19475395,17632060,23751495,10888670,23049888,22940250,15797379,17018280,25217616,10888670,23078409,21562221,25877870,23707760,12574115,21460798,26573515,26306044,10888670,22079111,18498748,16364911 0096,0096,0096,0096,0096,0096,0096,0096,0096,0004,0096,0096,0096,0096,0096,0096,0096,0096,0045,0096,0096,0096 LC UBC5 APC11 17632060 0096 LC CDC23 APC11 9469814,9469814,9469814,16481473 0019,0004,0007,0004 LC UBC1 APC11 17632060,26306044,23751495 0096,0096,0096 LC CDC5 APC11 19013276,19013276 0004,0676 LC SSE1 APC11 19536198 0676 HT CDC27 APC11 10888670,12609981,9469814,10888670,9469814,9469814 0019,0004,0004,0004,0019,0007 LC SAP1 APC11 16554755,16554755,16554755 0363,0676,0004 HT SSB2 APC11 19536198,23332755 0676,0401 HT,LC MND2 APC11 12477395,12477395 0004,0676 LC UBC11 APC11 17632060 0096 LC DOC1 APC11 9469814,9469814,9469814 0019,0007,0004 LC CDH1 APC11 21107322 0004 LC APC1 APC11 9469814,9469814,9469814,16481473 0019,0004,0007,0004 LC APC4 APC11 12477395,9469814,15060174,12477395,21186364,9469814,9469814 0676,0004,0004,0004,0004,0019,0007 LC APC5 APC11 9469814,9469814,9469814 0019,0007,0004 LC APC9 APC11 9469814,9469814,9469814 0019,0007,0004 LC APC11 SWM1 12477395,12574115,12477395,15060174 0676,0004,0004,0004 LC APC11 APC2 15060174,24225956,9469814,9469814,9469814,15797379 0004,0096,0004,0019,0007,0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q12157 P53068 APC11 DOC1 0.261 9469814 Q12157 Q12107 APC11 APC9 0.261 9469814 Q12157 P02829 APC11 HSP82 0.126 19536198 Q12157 P0CG63 APC11 UBI4 0.309 26306044 Q12157 P10592 APC11 SSA2 0.126 19536198 Q12157 P11484 APC11 SSB1 0.126 19536198 Q12157 P15732 APC11 UBC5 0.309 17632060 Q12157 P16522 APC11 CDC23 0.472 9469814,16481473 Q12157 P25559 APC11 DCC1 0.286 18467557 Q12157 P32562 APC11 CDC5 0.332 19013276 Q12157 P32589 APC11 SSE1 0.126 19536198 Q12157 P52492 APC11 UBC11 0.309 17632060 Q12157 Q04601 APC11 APC4 0.523 9469814,21186364,12477395 Q12157 Q08683 APC11 APC5 0.21 9469814 Q12157 Q12157 APC11 APC11 0.332 10888670 Q12157 P0CS90 APC11 SSC1 0.126 19536198 Q12157 P09798 APC11 CDC16 0.872 16275330,17406682,15649358,9469814,15797379,21186364,16364911,10888670,10318877 Q12157 P62837 APC11 UBE2D2 0.523 10888670,18519589 Q12379 Q12157 SWM1 APC11 0.236 12477395 Q12440 Q12157 APC2 APC11 0.659 10230406,24225956,17634282,9469814,15797379 Q12157 P40577 APC11 MND2 0.236 12477395 Q12157 P39955 APC11 SAP1 0.236 16554755 Q12157 P21734 APC11 UBC1 0.671 17632060,26306044,23751495 Q12157 P15731 APC11 UBC4 0.999 23078409,23049888,16364911,22079111,10888670,25877870,18498748,19475395,26306044,21460798,15797379,26573515,17632060,21562221,23751495,22940250,23707760,17018280,25217616,12574115 Q12157 P38042 APC11 CDC27 0.332 9469814,10888670 Q12157 P32364 APC11 SMY1 0.286 18467557 Q12157 P40150 APC11 SSB2 0.236 23332755,19536198 Q12157 P14724 APC11 CDC26 0.126 9469814 Q12157 P53849 APC11 GIS2 0.126 21232131 Q12157 P53886 APC11 APC1 0.436 9469814,16481473 Q12157 Q07807 APC11 PUF3 0.126 26493364