PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus TEF1, TEF2 TSC13 16429126 intact exp NIP1 TSC13 16429126 intact exp TOP2 TSC13 16429126 intact exp TSC13 FRT1 18719252 biogrid,intact exp Probable transport protein YPL264C TSC13 16093310 biogrid,dip exp STE24 TSC13 16093310 biogrid,dip exp HSP60 TSC13 16429126 biogrid,intact exp RPP0 TSC13 16429126 intact exp Uncharacterized ABC transporter ATP-binding protein/permease YOL075C TSC13 23831759 biogrid exp RAD50 TSC13 16429126 intact exp AVT4 TSC13 16093310 biogrid,dip exp SSB1 TSC13 16429126,22940862,19536198 biogrid,intact exp PBY1 TSC13 16093310 biogrid,dip exp SAM2 TSC13 16429126 biogrid,intact exp SPC1 TSC13 16554755 biogrid,i2d,mint,intact exp TSC13 OST4 16093310 biogrid,dip exp KAP104 TSC13 16429126 biogrid,intact exp GAS3 TSC13 16093310 biogrid,dip exp TUB2 TSC13 16429126 intact exp RSC8 TSC13 i2d exp GCN1 TSC13 16429126 biogrid,intact exp SRP102 TSC13 16093310 biogrid,dip exp GSF2 TSC13 16093310 biogrid,dip exp GTT1 TSC13 18719252 biogrid,intact exp SSA2 TSC13 16429126 intact exp RPS17A TSC13 16429126 intact exp YET1 TSC13 16093310 biogrid,dip exp BSD2 TSC13 16093310 biogrid,dip exp GAS2 TSC13 16093310 biogrid,dip exp TAT1 TSC13 16093310 biogrid,dip exp BNI1 TSC13 16429126 intact exp FRS2 TSC13 16429126 intact exp CTR3 TSC13 16093310 biogrid,dip exp RPL7A TSC13 16429126 intact exp Putative cation exchanger YDL206W TSC13 16093310 biogrid,dip exp ECM29 TSC13 16429126 intact exp Putative proline--tRNA ligase YHR020W TSC13 16429126 intact exp TUB1 TSC13 16429126 biogrid,intact exp CSG2 TSC13 16093310 biogrid,dip exp PHO86 TSC13 16093310 biogrid,dip exp RPL4B TSC13 16429126 intact exp KAP123 TSC13 16429126 intact exp HHF1, HHF2 TSC13 16429126 intact exp NVJ1 TSC13 15958487,16912077 biogrid exp VMA2 TSC13 16429126 intact exp COS8 TSC13 16093310 biogrid,dip exp OLE1 TSC13 16554755 intact exp HSP82 TSC13 15879519,19536198 i2d,intact exp YOP1 TSC13 16093310 biogrid,dip exp RPL17A TSC13 16429126 intact exp BZZ1 TSC13 11283351 i2d,mint,intact,dip exp PHO88 TSC13 16093310 biogrid,dip exp TSC13 TSC13 16093310 biogrid exp, ortho ERV29 TSC13 16093310 biogrid,dip exp, ortho IFA38 TSC13 16093310, 23023127 biogrid,dip exp, ortho, pred FAS1 TSC13 16429126, 23023127 biogrid,intact exp, pred NSG1 TSC13 16093310, 23023127 biogrid,dip exp, pred OST1 TSC13 16093310, 23023127 biogrid,dip exp, pred VMA16 TSC13 16093310, 23023127 biogrid,dip exp, pred FRS1 TSC13 16429126, 23023127 biogrid,intact exp, pred ELO3 TSC13 11113186,16093310, 23023127 biogrid,dip exp, pred ERP4 TSC13 16093310, 23023127 biogrid,dip exp, pred LAC1 TSC13 16093310, 23023127 biogrid,dip exp, pred PMT7 TSC13 16093310, 23023127 biogrid,dip exp, pred GPI8 TSC13 16093310, 23023127 biogrid,dip exp, pred ELO2 TSC13 11113186,16093310, 23023127 biogrid,dip exp, pred ERG25 TSC13 16093310, 23023127 biogrid,dip exp, pred EMP24 TSC13 16093310, 23023127 biogrid,dip exp, pred ALG1 TSC13 16093310, 23023127 biogrid,dip exp, pred GMC1 TSC13 16093310, 23023127 biogrid,dip exp, pred ELO1 TSC13 16093310, 23023127 biogrid,dip exp, pred UPF0641 membrane protein YHR140W TSC13 16093310, 23023127 biogrid,dip exp, pred YDC1 TSC13 16093310, 23023127 biogrid,dip exp, pred DPL1 TSC13 ortho GEM1 TSC13 ortho CHC1 TSC13 ortho POR1 TSC13 ortho YHC3 TSC13 ortho SUB2 TSC13 ortho ATP3 TSC13 ortho CCT6 TSC13 ortho AHA1 TSC13 ortho RLI1 TSC13 ortho CDS1 TSC13 ortho IDH2 TSC13 ortho RER1 TSC13 ortho SEC61 TSC13 ortho OST3 TSC13 ortho ZRC1 TSC13 ortho PIC2 TSC13 ortho ERD2 TSC13 ortho TPD3 TSC13 ortho AIM45 TSC13 ortho LCB1 TSC13 ortho URA6 TSC13 ortho RPT1 TSC13 ortho YCF1 TSC13 ortho NFS1 TSC13 ortho SEC26 TSC13 ortho PSE1 TSC13 ortho YPT1 TSC13 ortho

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P38822 Q99190 - 11283351 - X 2 P02829 Q99190 - 15879519 - X 2 P39540 Q99190 protein complementation assay 16093310 direct interaction X 2 P19358 Q99190 affinity chromatography technology 16429126 physical association X 2 Q06686 Q99190 protein complementation assay 16093310 direct interaction X 2 P11484 Q99190 affinity chromatography technology 22940862 physical association X 2 Q99190 P53337 protein complementation assay 16093310 direct interaction X 2 Q99190 Q12402 protein complementation assay 16093310 direct interaction X 2 Q99190 Q99190 protein complementation assay 16093310 direct interaction X 2 Q04697 Q99190 protein complementation assay 16093310 direct interaction X 2 P0CG63 Q99190 affinity chromatography technology 23749301 physical association X 2 P0CG63 Q99190 affinity chromatography technology 23793018 physical association X 2 P0CG63 Q99190 affinity chromatography technology 12872131 physical association X 2 P0CG63 Q99190 affinity chromatography technology 14557538 physical association X 2 Q06135 Q99190 protein complementation assay 16093310 direct interaction X 2 Q03655 Q99190 protein complementation assay 16093310 direct interaction X 2 P35723 Q99190 protein complementation assay 16093310 direct interaction X 2 Q99380 Q99190 protein complementation assay 16093310 direct interaction X 2 P53045 Q99190 protein complementation assay 16093310 direct interaction X 2 P47154 Q99190 protein complementation assay 16093310 direct interaction X 2 P16661 Q99190 protein complementation assay 16093310 direct interaction X 2 P41543 Q99190 protein complementation assay 16093310 direct interaction X 2 P28496 Q99190 protein complementation assay 16093310 direct interaction X 2 P33892 Q99190 affinity chromatography technology 16429126 physical association X 2 P46965 Q99190 affinity chromatography technology 16554755 physical association X 2 Q08980 Q99190 protein complementation assay 16093310 direct interaction X 2 P38217 Q99190 affinity chromatography technology 16429126 physical association X 2 P40582 Q99190 two hybrid 18719252 direct interaction X 2 P38842 Q99190 protein complementation assay 16093310 direct interaction X 2 P38723 Q99190 protein complementation assay 16093310 direct interaction X 2 P19882 Q99190 affinity chromatography technology 16429126 physical association X 2 P40319 Q99190 affinity chromatography technology 11113186 physical association X 2 P40319 Q99190 protein complementation assay 16093310 direct interaction X 2 P15624 Q99190 affinity chromatography technology 16429126 physical association X 2 P25358 Q99190 affinity chromatography technology 11113186 physical association X 2 P25358 Q99190 protein complementation assay 16093310 direct interaction X 2 P50944 Q99190 protein complementation assay 16093310 direct interaction X 2 P09733 Q99190 affinity chromatography technology 16429126 physical association X 2 Q12450 Q99190 protein complementation assay 16093310 direct interaction X 2 Q99190 P38254 protein complementation assay 16093310 direct interaction X 2 Q99190 Q04399 protein complementation assay 16093310 direct interaction X 2 P23968 Q99190 protein complementation assay 16093310 direct interaction X 2 P46956 Q99190 protein complementation assay 16093310 direct interaction X 2 P38356 Q99190 protein complementation assay 16093310 direct interaction X 2 P38286 Q99190 protein complementation assay 16093310 direct interaction X 2 Q02896 Q99190 protein complementation assay 16093310 direct interaction X 2 P36057 Q99190 protein complementation assay 16093310 direct interaction X 2 Q12424 Q99190 protein complementation assay 16093310 direct interaction X 2 Q08234 Q99190 protein complementation assay 23831759 direct interaction X 2 P49018 Q99190 protein complementation assay 16093310 direct interaction X 2 P35206 Q99190 protein complementation assay 16093310 direct interaction X 2 P32803 Q99190 protein complementation assay 16093310 direct interaction X 2 P38264 Q99190 protein complementation assay 16093310 direct interaction X 2 P07149 Q99190 affinity chromatography technology 16429126 physical association X 2 Q99332 Q99190 two hybrid 18719252 direct interaction X 2 P38881 Q99190 affinity chromatography technology 15958487 physical association X 2 P38881 Q99190 imaging technique 15958487 colocalization X 2 P38881 Q99190 affinity chromatography technology 16912077 physical association X 2 P38085 Q99190 protein complementation assay 16093310 direct interaction X 2 P38837 Q99190 protein complementation assay 16093310 direct interaction X 2 Q06644 Q99190 protein complementation assay 16093310 direct interaction X 2 P39540 Q99190 ubiquitin reconstruction 16093310 physical association X 2 P39540 Q99190 ubiquitin reconstruction 16093310 physical association X 2 Q06686 Q99190 ubiquitin reconstruction 16093310 physical association X 2 Q99190 P53337 ubiquitin reconstruction 16093310 physical association X 2 Q99190 Q12402 ubiquitin reconstruction 16093310 physical association X 2 Q04697 Q99190 ubiquitin reconstruction 16093310 physical association X 2 Q06135 Q99190 ubiquitin reconstruction 16093310 physical association X 2 Q03655 Q99190 ubiquitin reconstruction 16093310 physical association X 2 P35723 Q99190 ubiquitin reconstruction 16093310 physical association X 2 Q99380 Q99190 ubiquitin reconstruction 16093310 physical association X 2 P53045 Q99190 ubiquitin reconstruction 16093310 physical association X 2 P47154 Q99190 ubiquitin reconstruction 16093310 physical association X 2 P16661 Q99190 ubiquitin reconstruction 16093310 physical association X 2 P41543 Q99190 ubiquitin reconstruction 16093310 physical association X 2 P28496 Q99190 ubiquitin reconstruction 16093310 physical association X 2 Q08980 Q99190 ubiquitin reconstruction 16093310 physical association X 2 P38822 Q99190 two hybrid pooling approach 11283351 physical association X 2 P38842 Q99190 ubiquitin reconstruction 16093310 physical association X 2 P38842 Q99190 ubiquitin reconstruction 16093310 physical association X 2 P38723 Q99190 ubiquitin reconstruction 16093310 physical association X 2 P40319 Q99190 ubiquitin reconstruction 16093310 physical association X 2 P25358 Q99190 ubiquitin reconstruction 16093310 physical association X 2 P50944 Q99190 ubiquitin reconstruction 16093310 physical association X 2 Q12450 Q99190 ubiquitin reconstruction 16093310 physical association X 2 Q99190 P38254 ubiquitin reconstruction 16093310 physical association X 2 Q99190 Q04399 ubiquitin reconstruction 16093310 physical association X 2 P23968 Q99190 ubiquitin reconstruction 16093310 physical association X 2 P46956 Q99190 ubiquitin reconstruction 16093310 physical association X 2 P38356 Q99190 ubiquitin reconstruction 16093310 physical association X 2 P38286 Q99190 ubiquitin reconstruction 16093310 physical association X 2 Q02896 Q99190 ubiquitin reconstruction 16093310 physical association X 2 P36057 Q99190 ubiquitin reconstruction 16093310 physical association X 2 Q12424 Q99190 ubiquitin reconstruction 16093310 physical association X 2 Q12424 Q99190 ubiquitin reconstruction 16093310 physical association X 2 P49018 Q99190 ubiquitin reconstruction 16093310 physical association X 2 P35206 Q99190 ubiquitin reconstruction 16093310 physical association X 2 P32803 Q99190 ubiquitin reconstruction 16093310 physical association X 2 P38264 Q99190 ubiquitin reconstruction 16093310 physical association X 2 P38085 Q99190 ubiquitin reconstruction 16093310 physical association X 2 P38837 Q99190 ubiquitin reconstruction 16093310 physical association X 2 Q06644 Q99190 ubiquitin reconstruction 16093310 physical association X 2 Q99190 inferred by author 16429126 physical association C 3 Q99190 tandem affinity purification 16429126 association C 22 P11484 Q99190 tandem affinity purification 19536198 association X 2 P46965 Q99190 tandem affinity purification 16554755 physical association X 2 P38822 Q99190 two hybrid fragment pooling approach 11283351 physical association X 2 P40582 Q99190 two hybrid 18719252 physical association X 2 Q99190 tandem affinity purification 16429126 association C 7 Q99190 inferred by author 16429126 physical association C 26 Q99190 inferred by author 16554755 association C 19 P02829 Q99190 two hybrid array 15879519 physical association X 2 P02829 Q99190 tandem affinity purification 19536198 association X 2 Q99332 Q99190 two hybrid 18719252 physical association X 2 P38822 Q99190 two hybrid 11283351 - X 2 P35206 Q99190 interaction detection method 9804843 - X 2

PPI - HINT Gene A Gene B PMID Method Quality HSP82 TSC13 15879519,15879519 0018,0397 HT ALG1 TSC13 16093310,16093310 0090,0112 HT VMA16 TSC13 16093310,16093310 0090,0112 HT ELO2 TSC13 16093310,16093310 0090,0112 HT LAC1 TSC13 16093310,16093310 0090,0112 HT EMP24 TSC13 16093310,16093310 0090,0112 HT CSG2 TSC13 16093310,16093310 0090,0112 HT YET1 TSC13 16093310,16093310 0090,0112 HT SRP102 TSC13 16093310,16093310 0090,0112 HT TAT1 TSC13 16093310,16093310 0090,0112 HT PBY1 TSC13 16093310,16093310 0090,0112 HT PHO88 TSC13 16093310,16093310 0090,0112 HT IFA38 TSC13 16093310,16093310 0090,0112 HT BSD2 TSC13 16093310,16093310 0090,0112 HT COS8 TSC13 16093310,16093310 0090,0112 HT BZZ1 TSC13 11283351,11283351,11283351 0018,0399,0398 HT NSG1 TSC13 16093310,16093310 0090,0112 HT P38842 TSC13 16093310,16093310 0090,0112 HT ELO1 TSC13 16093310,16093310 0090,0112 HT ELO3 TSC13 16093310,16093310 0090,0112 HT GTT1 TSC13 18719252 0018 HT OST1 TSC13 16093310,16093310 0090,0112 HT PHO86 TSC13 16093310,16093310 0090,0112 HT STE24 TSC13 16093310,16093310 0090,0112 HT GPI8 TSC13 16093310,16093310 0090,0112 HT AVT4 TSC13 16093310,16093310 0090,0112 HT ERG25 TSC13 16093310,16093310 0090,0112 HT ERV29 TSC13 16093310,16093310 0090,0112 HT YDC1 TSC13 16093310,16093310 0090,0112 HT GAS3 TSC13 16093310,16093310 0090,0112 HT GMC1 TSC13 16093310,16093310 0090,0112 HT GSF2 TSC13 16093310,16093310 0090,0112 HT GAS2 TSC13 16093310,16093310 0090,0112 HT PMT7 TSC13 16093310,16093310 0090,0112 HT CTR3 TSC13 16093310,16093310 0090,0112 HT Q08234 TSC13 23831759 0090 HT Q08980 TSC13 16093310,16093310 0090,0112 HT YOP1 TSC13 16093310,16093310 0090,0112 HT Q12424 TSC13 16093310,16093310 0090,0112 HT ERP4 TSC13 16093310,16093310 0090,0112 HT TSC13 TSC13 16093310 0090 HT TSC13 FRT1 18719252 0018 HT TSC13 OST4 16093310,16093310 0090,0112 HT HHF1|HHF2 TSC13 16429126 0676 HT RPS17A TSC13 16429126 0676 HT TUB2 TSC13 16429126 0676 HT HSP82 TSC13 19536198 0676 HT TEF1|TEF2 TSC13 16429126 0676 HT RPP0 TSC13 16429126 0676 HT RPL7A TSC13 16429126 0676 HT RPL17A TSC13 16429126 0676 HT TOP2 TSC13 16429126 0676 HT FAS1 TSC13 16429126,16429126 0676,0004 HT TUB1 TSC13 16429126,16429126 0676,0004 HT UBI4 TSC13 14557538 0004 LC SSA2 TSC13 16429126 0676 HT SSB1 TSC13 22940862,19536198,16429126 0004,0676,0676 HT RAD50 TSC13 16429126 0676 HT FRS1 TSC13 16429126,16429126 0676,0004 HT FRS2 TSC13 16429126 0363 HT VMA2 TSC13 16429126 0676 HT SAM2 TSC13 16429126,16429126 0676,0004 HT HSP60 TSC13 16429126,16429126 0676,0004 HT OLE1 TSC13 16554755 0363 HT ELO2 TSC13 11113186 0004 LC NIP1 TSC13 16429126 0676 HT GCN1 TSC13 16429126,16429126 0676,0004 HT KAP104 TSC13 16429126,16429126 0676,0004 HT P38708 TSC13 16429126 0676 HT ECM29 TSC13 16429126 0363 HT NVJ1 TSC13 15958487,15958487,16912077 0428,0004,0004 LC KAP123 TSC13 16429126 0676 HT ELO3 TSC13 11113186 0004 LC BNI1 TSC13 16429126 0676 HT SPC1 TSC13 16554755,16554755 0676,0004 HT RPL4B TSC13 16429126 0676 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q99190 Q12424 TSC13 Q12424 0.183 16093310 Q99190 P07149 TSC13 FAS1 0.236 16429126 Q99190 P09733 TSC13 TUB1 0.236 16429126 Q99190 P11484 TSC13 SSB1 0.236 16429126,19536198 Q99190 P19358 TSC13 SAM2 0.236 16429126 Q99190 P19882 TSC13 HSP60 0.236 16429126 Q99190 P33892 TSC13 GCN1 0.236 16429126 Q99190 P38217 TSC13 KAP104 0.236 16429126 Q99332 Q99190 FRT1 TSC13 0.332 18719252 Q99190 P35206 TSC13 CSG2 0.183 16093310 Q99190 P38085 TSC13 TAT1 0.183 16093310 Q99190 P38254 TSC13 PBY1 0.21 16093310 Q99190 P38286 TSC13 IFA38 0.21 16093310 Q99190 P38356 TSC13 BSD2 0.183 16093310 Q99190 P38723 TSC13 COS8 0.21 16093310 Q99190 P38737 TSC13 ECM29 0.126 16429126 Q99190 P38822 TSC13 BZZ1 0.236 11283351 Q99190 P46956 TSC13 PHO86 0.183 16093310 Q99190 P38837 TSC13 NSG1 0.183 16093310 Q99190 P41832 TSC13 BNI1 0.126 16429126 Q99190 P38842 TSC13 P38842 0.183 16093310 Q99190 P41543 TSC13 OST1 0.21 16093310 Q99190 P40582 TSC13 GTT1 0.332 18719252 Q99190 P06786 TSC13 TOP2 0.126 16429126 Q99190 P05740 TSC13 RPL17A 0.126 16429126 Q99190 P05737 TSC13 RPL7A 0.126 16429126 Q99190 P02557 TSC13 TUB2 0.126 16429126 Q99190 P02309 TSC13 HHF2 0.126 16429126 Q99190 P02407 TSC13 RPS17A 0.126 16429126 Q99190 P05317 TSC13 RPP0 0.126 16429126 Q99190 P02829 TSC13 HSP82 0.236 15879519,19536198 Q99190 P02994 TSC13 TEF2 0.126 16429126 Q99190 P15624 TSC13 FRS1 0.126 16429126 Q99190 P10592 TSC13 SSA2 0.126 16429126 Q99190 P12753 TSC13 RAD50 0.126 16429126 Q99190 P35723 TSC13 YET1 0.21 16093310 Q99190 P16140 TSC13 VMA2 0.126 16429126 Q99190 P16661 TSC13 ALG1 0.21 16093310 Q99190 P28496 TSC13 LAC1 0.183 16093310 Q99190 P23968 TSC13 VMA16 0.21 16093310 Q99190 P25358 TSC13 FEN1 0.354 16093310,11113186 Q99190 P32803 TSC13 EMP24 0.21 16093310 Q99190 P32497 TSC13 NIP1 0.126 16429126 Q99190 P40319 TSC13 SUR4 0.354 16093310,11113186 Q99190 P36057 TSC13 SRP102 0.183 16093310 Q99190 P38264 TSC13 PHO88 0.183 16093310 Q99190 P40069 TSC13 KAP123 0.126 16429126 Q99190 P38708 TSC13 P38708 0.126 16429126 Q99190 P39540 TSC13 ELO1 0.183 16093310 Q99190 Q06135 TSC13 GAS2 0.183 16093310 Q99190 P47154 TSC13 STE24 0.21 16093310 Q99190 Q02896 TSC13 YDC1 0.183 16093310 Q99190 P53337 TSC13 ERV29 0.21 16093310 Q99190 P49018 TSC13 GPI8 0.21 16093310 Q99190 P49626 TSC13 RPL4B 0.126 16429126 Q99190 Q04399 TSC13 GMC1 0.183 16093310 Q99190 Q03655 TSC13 GAS3 0.21 16093310 Q99190 Q04697 TSC13 GSF2 0.183 16093310 Q99190 Q99190 TSC13 TSC13 0.21 16093310 Q99190 Q12402 TSC13 YOP1 0.183 16093310 Q99190 Q06686 TSC13 CTR3 0.21 16093310 Q99190 Q08980 TSC13 Q08980 0.21 16093310 Q99190 Q12450 TSC13 ERP4 0.183 16093310 Q99380 Q99190 OST4 TSC13 0.21 16093310 Q99190 P38881 TSC13 NVJ1 0.21 16912077 Q99190 P46965 TSC13 SPC1 0.126 16554755 Q99190 P50944 TSC13 AVT4 0.183 16093310 Q99190 Q06644 TSC13 PMT7 0.183 16093310 Q99190 P21147 TSC13 OLE1 0.126 16554755 Q99190 Q08234 TSC13 Q08234 0.183 23831759 Q99190 P15625 TSC13 FRS2 0.126 16429126 Q99190 P53045 TSC13 ERG25 0.183 16093310