PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus TVP18 YFH1 18719252 biogrid,intact exp TVP15 YFH1 18719252 biogrid,intact exp SSB2 YFH1 23332755 biogrid exp YHB1 YFH1 15961414 biogrid,intact exp DUP240 protein YCR007C YFH1 18719252 biogrid,intact exp YFH1 PUF3 23409723 biogrid exp CIR1 YFH1 15961414 biogrid,intact exp ACO1 YFH1 i2d exp SSQ1 YFH1 12947415 intact exp ISU1 YFH1 17186026,20815377,18784075,18319250,12947415,19884169,19491103,25228696, 23023127 biogrid,mint,intact exp, pred YFH1 ISD11 18319250,19491103, 23023127 biogrid exp, pred YFH1 AIM45 15961414, 23023127 biogrid,intact exp, pred HEM15 YFH1 12668611,15610019, 23023127 biogrid exp, pred YFH1 YFH1 22051511,18784075,19460301,19491103,17027502,12022884, 23023127 biogrid,dip exp, pred SDH1 YFH1 15961414, 23023127 biogrid,intact exp, pred NFS1 YFH1 18784075,18319250,12947415,25228696, 23023127 biogrid,intact exp, pred SDH2 YFH1 15961414, 23023127 biogrid,intact exp, pred SCO1 YFH1 23023127 pred ALR2 YFH1 23023127 pred CCS1 YFH1 23023127 pred YFH1 ALR1 23023127 pred ATM1 YFH1 23023127 pred YFH1 YAH1 23023127 pred UTR1 YFH1 23023127 pred YFH1 FRE6 23023127 pred FRE4 YFH1 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q07540 P19414 - 15247478 - X 2 Q07540 Q03020 affinity chromatography technology 12947415 physical association X 2 Q07540 P39676 two hybrid 15961414 direct interaction X 2 Q07540 P39676 affinity chromatography technology 15961414 physical association X 2 Q07540 Q00711 affinity chromatography technology 15961414 physical association X 2 Q07540 Q03020 pull down 25228696 direct interaction X 2 Q07540 Q03020 affinity chromatography technology 17186026 physical association X 2 Q07540 Q03020 affinity chromatography technology 18319250 physical association X 2 Q07540 Q03020 pull down 18319250 direct interaction X 2 Q07540 Q07540 biochemical 18784075 colocalization X 2 Q07540 Q03020 biochemical 18784075 colocalization X 2 Q07540 Q07540 pull down 12022884 direct interaction X 2 Q07540 Q03020 affinity chromatography technology 19884169 physical association X 2 Q07540 Q07540 biochemical 19460301 colocalization X 2 Q07540 Q03020 pull down 19491103 direct interaction X 2 Q07540 Q07540 pull down 19491103 direct interaction X 2 Q07540 Q03020 affinity chromatography technology 19491103 physical association X 2 Q07540 Q03020 pull down 20815377 direct interaction X 2 Q07540 Q07540 x-ray crystallography 22051511 association X 2 Q07540 Q07540 pull down 22051511 direct interaction X 2 Q07540 P16622 pull down 12668611 direct interaction X 2 Q07540 P21801 affinity chromatography technology 15961414 physical association X 2 Q07540 P42940 affinity chromatography technology 15961414 physical association X 2 Q07540 Q12480 affinity chromatography technology 15961414 physical association X 2 Q07540 P25374 pull down 25228696 direct interaction X 2 Q07540 P40150 biochemical 23332755 association X 2 Q07540 P16622 x-ray crystallography 15610019 association X 2 Q07540 P25374 affinity chromatography technology 18319250 physical association X 2 Q07540 Q6Q560 affinity chromatography technology 18319250 physical association X 2 Q07540 P25354 two hybrid 18719252 direct interaction X 2 Q07540 Q04767 two hybrid 18719252 direct interaction X 2 Q07540 Q03860 two hybrid 18719252 direct interaction X 2 Q07540 P25374 biochemical 18784075 colocalization X 2 Q07540 Q6Q560 affinity chromatography technology 19491103 physical association X 2 Q07540 Q07540 electron tomography 17027502 direct interaction Y 1 Q07540 Q07540 x-ray crystallography 17027502 direct interaction Y 1 Q07540 pull down 12947415 association C 4 Q07540 P39676 anti tag coimmunoprecipitation 15961414 physical association X 2 Q07540 P39676 two hybrid 15961414 physical association X 2 Q07540 Q00711 anti tag coimmunoprecipitation 15961414 physical association X 2 Q07540 Q03020 anti bait coimmunoprecipitation 17186026 physical association X 2 Q07540 anti bait coimmunoprecipitation 12947415 association C 3 Q07540 pull down 12947415 association C 3 Q07540 P21801 anti tag coimmunoprecipitation 15961414 physical association X 2 Q07540 Q12480 anti tag coimmunoprecipitation 15961414 physical association X 2 Q07540 P42940 anti tag coimmunoprecipitation 15961414 physical association X 2 Q07540 P25354 two hybrid 18719252 physical association X 2 Q07540 Q04767 two hybrid 18719252 physical association X 2 Q07540 Q03860 two hybrid 18719252 physical association X 2

PPI - HINT Gene A Gene B PMID Method Quality HEM15 YFH1 15610019 0114 LC ACO1 YFH1 15247478 0019 LC P25354 YFH1 18719252 0018 HT NFS1 YFH1 18784075 0401 LC YHB1 YFH1 15961414,15961414,15961414 0004,0007,0018 LC SSB2 YFH1 23332755 0401 LC ISU1 YFH1 18784075 0401 LC TVP15 YFH1 18719252 0018 HT TVP18 YFH1 18719252 0018 HT YFH1 YFH1 22051511,17027502,19460301,22051511,17027502,18784075 0114,0410,0401,0096,0114,0401 LC HEM15 YFH1 12668611 0096 LC SDH2 YFH1 15961414,15961414 0004,0007 LC NFS1 YFH1 18319250,12947415,18784075,25228696 0004,0096,0401,0096 LC YHB1 YFH1 15961414,15961414,15961414 0004,0007,0018 LC SSB2 YFH1 23332755 0401 LC CIR1 YFH1 15961414,15961414 0004,0007 LC SDH1 YFH1 15961414,15961414 0004,0007 LC ISU1 YFH1 12947415,19491103,17186026,19884169,12947415,18319250,17186026,12947415,19491103,18784075,25228696,18319250,20815377 0004,0004,0004,0004,0006,0096,0006,0096,0096,0401,0096,0004,0096 LC SSQ1 YFH1 12947415 0006 LC YFH1 YFH1 22051511,19460301,22051511,19491103,18784075,12022884 0114,0401,0096,0096,0401,0096 LC YFH1 AIM45 15961414,15961414 0004,0007 LC YFH1 ISD11 19491103,18319250 0004,0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q07540 P0CS90 YFH1 SSC1 0.126 25792736 Q07540 P25354 YFH1 P25354 0.332 18719252 Q07540 Q07540 YFH1 YFH1 0.891 19491103,19460301,18784075,22051511,12022884,17027502 Q07540 P25374 YFH1 NFS1 0.623 12947415,25228696,18784075,18319250 Q07540 Q03020 YFH1 ISU1 0.962 12947415,19491103,20815377,25228696,18784075,17186026,19884169,18319250 Q92609 Q07540 TBC1D5 YFH1 0.332 27107014 Q96DZ9 Q07540 CMTM5 YFH1 0.332 27107014 Q07540 P40150 YFH1 SSB2 0.126 23332755 Q07540 Q03860 YFH1 TVP15 0.332 18719252 Q07540 A0A024R0Y4 YFH1 TADA2L {ECO:0000313|EMBL:EAW57589.1} 0.332 27107014 Q07540 P16622 YFH1 HEM15 0.309 12668611 Q07540 Q04767 YFH1 TVP18 0.332 18719252 Q07540 Q05931 YFH1 SSQ1 0.21 12947415 Q6Q560 Q07540 ISD11 YFH1 0.376 19491103,18319250