PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus SSB2 UFD2 23332755,19536198 biogrid,intact exp BFA1 UFD2 16554755 intact exp HSP78 UFD2 19536198 intact exp RAD4 UFD2 19889839 biogrid exp HSC82 UFD2 19536198,15766533 i2d,intact exp ECM10 UFD2 19536198 intact exp UFD2 SOV1 11805837 dip exp HSP82 UFD2 19536198,15766533,11805837 biogrid,intact,dip exp IST1 UFD2 i2d exp SPT23 UFD2 i2d exp UFD2 UBX2 21211725 biogrid exp UBI4 UFD2 10089879,17890322,15699485,11805121,11805837 biogrid,mint,intact exp RPL40A UFD2 10089879,11805837 intact,dip exp HYP2 UFD2 i2d exp SPT6 UFD2 i2d exp SSA1 UFD2 19536198 i2d,intact exp YKE2 UFD2 19536198 intact exp UBP10 UFD2 i2d exp YDJ1 UFD2 19536198 intact exp SIS1 UFD2 19536198 intact exp SSA2 UFD2 19536198 intact exp SSC1 UFD2 19536198 intact exp CDH1 UFD2 22189709 biogrid exp UFD4 UFD2 17890322 dip exp MDL2 UFD2 i2d exp SSE1 UFD2 19536198 intact exp SSB1 UFD2 19536198 i2d,intact exp UFD2 PEX29 20159987 biogrid exp YEF3 UFD2 i2d exp MAD2 UFD2 17634282 biogrid exp HMF1 UFD2 11805837 biogrid,mint,intact,dip exp UFD2 HCR1 i2d exp CHZ1 UFD2 i2d exp TAO3 UFD2 i2d exp TSL1 UFD2 11805837 biogrid,mint,intact,dip exp PRP21 UFD2 i2d exp JEM1 UFD2 19536198 intact exp UFD2 UFD2 17890322 biogrid exp, ortho CDC48 UFD2 10089879,15652483,21148305,21211725,16554755,21282470,18719252,22718752,16427015,21807993, 23023127 biogrid,i2d,mint,intact,dip exp, ortho, pred UBC4 UFD2 17890322, 23023127 biogrid exp, ortho, pred UFD2 VMS1 22718752,21148305,11805837, 23023127 biogrid,mint,intact,dip exp, pred RAD23 UFD2 15652483,20427284,19898607,15121879,16554755,11805837,16427015,21807993,16401726, 23023127 biogrid,i2d,mint,intact,dip exp, pred OTU1 UFD2 16427015,18719252, 23023127 biogrid,intact exp, pred DSK2 UFD2 15652483,20427284,16427015,16338354,18719252,11805837, 23023127 biogrid,i2d,mint,intact,dip exp, pred NPL4 UFD2 16427015,21211725,18719252,11805837, 23023127 biogrid,mint,intact,dip exp, pred UBX7 UFD2 18719252, 23023127 biogrid,intact exp, pred UFD1 UFD2 16427015,21211725, 23023127 biogrid,i2d exp, pred SHP1 UFD2 16427015,21211725,18719252,11805837, 23023127 biogrid,mint,intact,dip exp, pred UFD2 ENV7 11805837, 23023127 biogrid,mint,intact,dip exp, pred UBC11 UFD2 ortho PRE7 UFD2 ortho CPR1 UFD2 ortho CNS1 UFD2 ortho VPS35 UFD2 ortho UFD2 SDO1 ortho VPS4 UFD2 ortho VMA7 UFD2 ortho ZPR1 UFD2 ortho UFD2 VPS36 ortho YUH1 UFD2 ortho UFD2 UBI4 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P0CG63 P54860 two hybrid 11805121 direct interaction X 2 P0CG63 P54860 affinity chromatography technology 10089879 physical association X 2 P0CG63 P54860 affinity chromatography technology 23749301 physical association X 2 P0CG63 P54860 biochemical 23583075 association X 2 P0CG63 P54860 affinity chromatography technology 17644757 physical association X 2 P0CG63 P54860 affinity chromatography technology 23793018 physical association X 2 P0CG63 P54860 enzymatic study 17890322 direct interaction X 2 P0CG63 P54860 pull down 10089879 direct interaction X 2 P0CG63 P54860 pull down 10089879 direct interaction X 2 P0CG63 P54860 affinity chromatography technology 12872131 physical association X 2 P0CG63 P54860 affinity chromatography technology 15699485 physical association X 2 P0CG63 P54860 affinity chromatography technology 21427232 physical association X 2 P0CG63 P54860 affinity chromatography technology 11805837 physical association X 2 P0CG63 P54860 affinity chromatography technology 14557538 physical association X 2 P34223 P54860 biochemical 16427015 association X 2 P34223 P54860 affinity chromatography technology 16427015 physical association X 2 P34223 P54860 two hybrid 18719252 direct interaction X 2 P34223 P54860 affinity chromatography technology 21211725 physical association X 2 P34223 P54860 affinity chromatography technology 11805837 physical association X 2 P40958 P54860 two hybrid 17634282 direct interaction X 2 P54860 P25694 affinity chromatography technology 22718752 physical association X 2 P54860 Q04311 affinity chromatography technology 22718752 physical association X 2 P54860 P25694 affinity chromatography technology 15652483 physical association X 2 P54860 P25694 two hybrid 15652483 direct interaction X 2 P54860 Q06182 pull down 20427284 direct interaction X 2 P54860 Q10169 pull down 20427284 direct interaction X 2 P54860 P15731 pull down 17890322 direct interaction X 2 P54860 P40150 biochemical 23332755 association X 2 P54860 P25694 affinity chromatography technology 16554755 physical association X 2 P54860 P25694 biochemical 16427015 association X 2 P54860 P53044 biochemical 16427015 association X 2 P54860 P25694 affinity chromatography technology 16427015 physical association X 2 P54860 P53044 affinity chromatography technology 16427015 physical association X 2 P54860 P25694 pull down 16427015 direct interaction X 2 P54860 P43558 pull down 16427015 direct interaction X 2 P54860 P43558 affinity chromatography technology 16427015 physical association X 2 P54860 P25694 pull down 10089879 direct interaction X 2 P54860 P25694 two hybrid 10089879 direct interaction X 2 P54860 P43558 two hybrid 18719252 direct interaction X 2 P54860 P25694 two hybrid 18719252 direct interaction X 2 P54860 P14736 affinity chromatography technology 19889839 physical association X 2 P54860 P25694 affinity chromatography technology 21211725 physical association X 2 P54860 P53044 affinity chromatography technology 21211725 physical association X 2 P54860 P25694 two hybrid 21282470 direct interaction X 2 P54860 P25694 affinity chromatography technology 21282470 physical association X 2 P54860 P25694 affinity chromatography technology 21282470 physical association X 2 P54860 P55072 affinity chromatography technology 21282470 physical association X 2 P54860 P25694 unspecified method 21282470 direct interaction X 2 P54860 Q04311 affinity chromatography technology 21148305 physical association X 2 P54860 P25694 affinity chromatography technology 21148305 physical association X 2 P54860 P25694 two hybrid 21807993 direct interaction X 2 P54860 P25694 pull down 21807993 direct interaction X 2 P54860 P25694 affinity chromatography technology 21807993 physical association X 2 P54860 P40037 affinity chromatography technology 11805837 physical association X 2 P54860 Q04311 affinity chromatography technology 11805837 physical association X 2 P38349 P54860 two hybrid 18719252 direct interaction X 2 P33755 P54860 biochemical 16427015 association X 2 P33755 P54860 affinity chromatography technology 16427015 physical association X 2 P33755 P54860 two hybrid 18719252 direct interaction X 2 P33755 P54860 affinity chromatography technology 21211725 physical association X 2 P33755 P54860 affinity chromatography technology 11805837 physical association X 2 P32628 P54860 two hybrid 15121879 direct interaction X 2 P32628 P54860 affinity chromatography technology 15121879 physical association X 2 P32628 P54860 pull down 15121879 direct interaction X 2 P32628 P54860 affinity chromatography technology 15652483 physical association X 2 P32628 P54860 two hybrid 15652483 direct interaction X 2 P32628 P54860 two hybrid 16401726 direct interaction X 2 P32628 P54860 affinity chromatography technology 16401726 physical association X 2 P32628 P54860 two hybrid 16401726 direct interaction X 2 P32628 P54860 x-ray crystallography 20427284 association X 2 P32628 P54860 affinity chromatography technology 16554755 physical association X 2 P32628 P54860 biochemical 16427015 association X 2 P32628 P54860 pull down 20427284 direct interaction X 2 P32628 P54860 affinity chromatography technology 19898607 physical association X 2 P32628 P54860 two hybrid 21807993 direct interaction X 2 P32628 P54860 pull down 21807993 direct interaction X 2 P32628 P54860 affinity chromatography technology 21807993 physical association X 2 P32628 P54860 affinity chromatography technology 11805837 physical association X 2 P54860 P02829 affinity chromatography technology 15766533 physical association X 2 P54860 P54860 enzymatic study 17890322 direct interaction X 2 P54860 Q03370 affinity chromatography technology 20159987 physical association X 2 P54860 Q04228 affinity chromatography technology 21211725 physical association X 2 P54860 Q12003 affinity chromatography technology 11805837 physical association X 2 P54860 P38427 affinity chromatography technology 11805837 physical association X 2 P48510 P54860 affinity chromatography technology 15652483 physical association X 2 P48510 P54860 x-ray crystallography 20427284 association X 2 P48510 P54860 biochemical 16427015 association X 2 P48510 P54860 two hybrid 18719252 direct interaction X 2 P48510 P54860 two hybrid 16338354 direct interaction X 2 P48510 P54860 pull down 20427284 direct interaction X 2 P48510 P54860 affinity chromatography technology 11805837 physical association X 2 P53197 P54860 affinity chromatography technology 22189709 physical association X 2 P54860 pull down 21807993 - C 3 P33202 P54860 pull down 17890322 direct interaction X 2 P33202 P54860 pull down 17890322 direct interaction X 2 P34223 P54860 anti tag coimmunoprecipitation 11805837 physical association X 2 P54860 P25694 anti tag coimmunoprecipitation 21807993 direct interaction X 2 P54860 P25694 two hybrid 21807993 direct interaction X 2 P54860 P25694 pull down 21807993 direct interaction X 2 P54860 P25694 anti tag coimmunoprecipitation 21807993 direct interaction X 2 P54860 P25694 anti tag coimmunoprecipitation 11805837 direct interaction X 2 P54860 P40037 anti tag coimmunoprecipitation 11805837 physical association X 2 P54860 Q04311 anti tag coimmunoprecipitation 11805837 physical association X 2 Q04748 P54860 anti tag coimmunoprecipitation 11805837 physical association X 2 P33755 P54860 anti tag coimmunoprecipitation 11805837 physical association X 2 P54860 anti tag coimmunoprecipitation 11805837 - C 9 P54860 anti tag coimmunoprecipitation 11805837 - C 4 P54860 anti tag coimmunoprecipitation 11805837 - C 12 P32628 P54860 anti tag coimmunoprecipitation 21807993 direct interaction X 2 P32628 P54860 anti tag coimmunoprecipitation 21807993 direct interaction X 2 P32628 P54860 two hybrid 21807993 direct interaction X 2 P32628 P54860 anti tag coimmunoprecipitation 11805837 direct interaction X 2 P32628 P54860 anti tag coimmunoprecipitation 21807993 direct interaction X 2 P54860 P02829 anti tag coimmunoprecipitation 11805837 physical association X 2 P54860 P05759 coimmunoprecipitation 10089879 physical association X 2 P54860 P05759 anti tag coimmunoprecipitation 11805837 physical association X 2 P54860 P05759 affinity chromatography technology 10089879 physical association X 2 P54860 P38427 anti tag coimmunoprecipitation 11805837 physical association X 2 P54860 Q12003 anti tag coimmunoprecipitation 11805837 physical association X 2 P48510 P54860 anti tag coimmunoprecipitation 11805837 physical association X 2 P54860 inferred by author 16554755 association C 22 P32589 P54860 tandem affinity purification 19536198 association X 2 P15108 P54860 affinity chromatography technology 15766533 physical association X 2 P15108 P54860 tandem affinity purification 19536198 association X 2 P0CG63 P54860 affinity chromatography technology 15699485 covalent binding X 2 P34223 P54860 two hybrid 18719252 physical association X 2 P54860 P25694 tandem affinity purification 16554755 physical association X 2 P54860 P25694 tandem affinity purification 16554755 physical association X 2 P54860 P25694 tandem affinity purification 16554755 physical association X 2 P54860 P25694 tandem affinity purification 16554755 physical association X 2 P54860 P25694 tandem affinity purification 16554755 physical association X 2 P54860 P25694 tandem affinity purification 16554755 physical association X 2 P54860 P25694 tandem affinity purification 16554755 physical association X 2 P54860 P43558 two hybrid 18719252 physical association X 2 P54860 P25694 two hybrid 18719252 physical association X 2 P54860 P40358 tandem affinity purification 19536198 association X 2 P54860 P25294 tandem affinity purification 19536198 association X 2 P54860 P10592 tandem affinity purification 19536198 association X 2 P54860 P40150 tandem affinity purification 19536198 association X 2 P54860 P33416 tandem affinity purification 19536198 association X 2 P38349 P54860 two hybrid 18719252 physical association X 2 P33755 P54860 two hybrid 18719252 physical association X 2 P54860 anti tag coimmunoprecipitation 11805837 association C 9 P32628 P54860 tandem affinity purification 16554755 physical association X 2 P32628 P54860 tandem affinity purification 16554755 physical association X 2 P54860 Q12003 anti tag coimmunoprecipitation 11805837 physical association X 2 P54860 P25491 tandem affinity purification 19536198 association X 2 P54860 P11484 tandem affinity purification 19536198 association X 2 P54860 P0CS90 tandem affinity purification 19536198 association X 2 P54860 P39987 tandem affinity purification 19536198 association X 2 P54860 P02829 tandem affinity purification 19536198 association X 2 P54860 P52553 tandem affinity purification 19536198 association X 2 P48510 P54860 two hybrid 18719252 physical association X 2 P10591 P54860 tandem affinity purification 19536198 association X 2 P54860 mass spectrometry studies of complexes 11805837 - C 3 P54860 P25694 two hybrid 10089879 - X 2 P54860 mass spectrometry studies of complexes 11805837 - C 10 P54860 mass spectrometry studies of complexes 11805837 - C 10

PPI - HINT Gene A Gene B PMID Method Quality RPS31 UFD2 10089879,10089879 0004,0019 LC UBI4 UFD2 11805121,17890322 0018,0415 LC CDC48 UFD2 10089879,21807993,10089879,15652483,15652483,16427015,21807993,15652483,16427015,21282470,21282470,18719252,21807993,21807993,16427015 0096,0004,0018,0018,0004,0401,0007,0019,0004,0004,0018,0018,0096,0018,0096 LC,HT RAD23 UFD2 21807993,15121879,15652483,15652483,16427015,20427284,15121879,21807993,15652483,20427284,20427284,16401726,21807993,16401726,21807993,15121879 0004,0004,0018,0004,0401,0004,0096,0007,0019,0114,0096,0018,0096,0004,0018,0018 LC NPL4 UFD2 16427015,18719252,16427015 0401,0018,0004 LC,HT SAS3 UFD2 16427015,18719252,16427015 0401,0018,0004 LC,HT SPT23 UFD2 15652483 0019 LC UBX7 UFD2 18719252 0018 HT SSB2 UFD2 23332755 0401 LC MAD2 UFD2 17634282 0018 HT OTU1 UFD2 18719252 0018 HT DSK2 UFD2 16427015,18719252,20427284,16338354,20427284,20427284 0401,0018,0004,0018,0096,0114 LC,HT UFD1 UFD2 16427015,16427015 0401,0004 LC UFD2 UFD2 17890322 0415 LC UFD2 ARR1 26276098,26276098 0018,0004 LC HSP82 UFD2 19536198,15766533,11805837 0676,0004,0007 HT,LC RPS31 UFD2 10089879,11805837,10089879 0004,0007,0019 LC,HT UBI4 UFD2 11805837,10089879,10089879,14557538,15699485,11805837 0004,0004,0096,0004,0004,0007 HT,LC RPL40B UFD2 11805837 0007 HT SSC1 UFD2 19536198 0676 HT SSA1 UFD2 19536198 0676 HT SSA2 UFD2 19536198 0676 HT SSB1 UFD2 19536198,15766533 0676,0004 HT,LC RAD4 UFD2 19889839 0004 LC HSC82 UFD2 19536198,15766533 0676,0004 HT,LC UBC4 UFD2 17890322,17890322 0096,0004 LC SIS1 UFD2 19536198 0676 HT YDJ1 UFD2 19536198 0676 HT CDC48 UFD2 21211725,10089879,21807993,10089879,15652483,15652483,22718752,16427015,21807993,15652483,16554755,16427015,21148305,21282470,11805837,21282470,21807993,16554755,21807993,16427015 0004,0096,0004,0018,0018,0004,0004,0401,0007,0019,0676,0004,0004,0004,0007,0018,0096,0004,0018,0096 LC,HT SSE1 UFD2 19536198 0676 HT RAD23 UFD2 21807993,15121879,15652483,15652483,16554755,16427015,20427284,15121879,21807993,15652483,20427284,11805837,19898607,20427284,16401726,11805837,21807993,16554755,16401726,21807993,15121879 0004,0004,0018,0004,0676,0401,0004,0096,0007,0019,0114,0004,0004,0096,0018,0007,0096,0004,0004,0018,0018 LC,HT UFD4 UFD2 17890322 0096 LC HSP78 UFD2 19536198 0676 HT NPL4 UFD2 16427015,11805837,21211725,16427015,11805837 0401,0004,0004,0004,0007 LC,HT SAS3 UFD2 16427015,11805837,21211725,16427015,11805837 0401,0004,0004,0004,0007 LC,HT TSL1 UFD2 11805837,11805837 0004,0007 HT ECM10 UFD2 19536198 0676 HT HMF1 UFD2 11805837,11805837 0004,0007 HT SSB2 UFD2 19536198,23332755 0676,0401 HT,LC JEM1 UFD2 19536198 0676 HT OTU1 UFD2 16427015,16427015 0096,0004 LC BFA1 UFD2 16554755 0363 HT DSK2 UFD2 16427015,11805837,20427284,20427284,20427284,15652483,11805837 0401,0004,0004,0096,0114,0004,0007 LC,HT YKE2 UFD2 19536198 0676 HT UFD1 UFD2 16427015,21211725,16427015 0401,0004,0004 LC CDH1 UFD2 22189709 0004 LC UFD2 PEX29 20159987 0004 LC UFD2 UBX2 21211725 0004 LC UFD2 VMS1 11805837,21148305,22718752,11805837 0004,0004,0004,0007 HT,LC UFD2 SOV1 11805837 0007 HT UFD2 ARR1 26276098,26276098 0018,0004 LC UFD2 ENV7 11805837,11805837 0004,0007 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P54860 P53197 UFD2 CDH1 0.21 22189709 Q04748 P54860 SOV1 UFD2 0.126 11805837 P54860 P25491 UFD2 YDJ1 0.126 19536198 P54860 P11484 UFD2 SSB1 0.126 19536198 P54860 P15108 UFD2 HSC82 0.236 15766533,19536198 P54860 P0CG63 UFD2 UBI4 0.848 11805121,10089879,17890322,15699485,11805837 P54860 P38349 UFD2 UBX7 0.332 18719252 P54860 P38427 UFD2 TSL1 0.332 11805837 P54860 P32589 UFD2 SSE1 0.126 19536198 P54860 P32628 UFD2 RAD23 0.993 20427284,15652483,19898607,15121879,16554755,11805837,21807993,16401726 P54860 P39987 UFD2 ECM10 0.126 19536198 P54860 P33755 UFD2 NPL4 0.648 11805837,18719252,21211725 Q9UMX0 P54860 UBQLN1 UFD2 0.332 27107014 P54860 P34223 UFD2 SHP1 0.636 11805837,18719252,21211725 P54860 P40150 UFD2 SSB2 0.126 19536198 P54860 P40958 UFD2 MAD2 0.183 17634282 P54860 P47113 UFD2 BFA1 0.126 16554755 P54860 P48510 UFD2 DSK2 0.876 20427284,15652483,16338354,18719252,11805837 P54860 P14736 UFD2 RAD4 0.21 19889839 P54860 P43558 UFD2 OTU1 0.332 18719252 Q03370 P54860 PEX29 UFD2 0.21 20159987 P54860 P02829 UFD2 HSP82 0.332 11805837,15766533,19536198 P54860 P0CS90 UFD2 SSC1 0.126 19536198 P54860 P10591 UFD2 SSA1 0.126 19536198 P54860 P10592 UFD2 SSA2 0.126 19536198 P54860 P15731 UFD2 UBC4 0.309 17890322 P54860 P25294 UFD2 SIS1 0.126 19536198 P54860 P25694 UFD2 CDC48 0.991 15652483,21148305,22718752,16554755,11805837,10089879,21282470,21807993,18719252,21211725 P54860 P33202 UFD2 UFD4 0.309 17890322 P54860 P33416 UFD2 HSP78 0.126 19536198 P54860 P40037 UFD2 HMF1 0.286 11805837 P54860 P40358 UFD2 JEM1 0.126 19536198 P54860 P52553 UFD2 YKE2 0.126 19536198 P54860 P53044 UFD2 UFD1 0.21 21211725 P54860 P54860 UFD2 UFD2 0.332 17890322 P55072 P54860 VCP UFD2 0.21 21282470 P61864 P54860 RPL40A UFD2 0.286 11805837,10089879 Q04228 P54860 UBX2 UFD2 0.21 21211725 Q04311 P54860 VMS1 UFD2 0.554 11805837,21148305,22718752 Q06182 P54860 SWI10 UFD2 0.309 20427284 Q06596 P54860 ARR1 UFD2 0.569 26276098 Q10169 P54860 DPH1 UFD2 0.309 20427284 Q12003 P54860 ENV7 UFD2 0.126 11805837