PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus PUF3 RRI1 26493364 biogrid exp CST6 RRI1 i2d exp SIS1 RRI1 19536198 intact exp CDC53 RRI1 12183637 biogrid,i2d exp ECM10 RRI1 19536198 intact exp UBI4 RRI1 23105008 biogrid exp RPN5 RRI1 11805826,16429126,21289098,16554755 biogrid,i2d,mint,intact,dip exp SSB2 RRI1 23332755 biogrid exp SSB1 RRI1 19536198 intact exp PHS1 RRI1 14690591 intact exp SGV1 RRI1 i2d exp PAT1 RRI1 11283351 i2d,mint,intact,dip exp NAB2 RRI1 19840948 biogrid exp APJ1 RRI1 19536198 intact exp CSN9 RRI1 11805826,16429126,21289098,16554755, 23023127 biogrid,i2d,mint,intact,dip exp, pred SKP1 RRI1 16554755, 23023127 biogrid,i2d,mint,intact exp, pred CSI1 RRI1 11805826,16429126,10688190,12446563,16554755, 23023127 biogrid,i2d,mint,intact,dip exp, pred RRI1 RRI1 11805826, 23023127 mint,intact exp, pred CSN12 RRI1 12446563,12672462, 23023127 biogrid,intact exp, pred RRI2 RRI1 11805826,16429126,21289098,16554755, 23023127 biogrid,i2d,mint,intact,dip exp, pred PCI8 RRI1 11805826,16429126,16554755, 23023127 biogrid,mint,intact,dip exp, pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q12468 B2RBV7 enzymatic study 22956996 direct interaction X 2 Q12468 P52286 affinity chromatography technology 16554755 physical association X 2 Q12468 Q12348 affinity chromatography technology 16554755 physical association X 2 Q12468 Q12348 affinity chromatography technology 16429126 physical association X 2 Q12468 Q12348 affinity chromatography technology 17200106 physical association X 2 Q12468 Q12348 affinity chromatography technology 21289098 physical association X 2 Q12468 Q12348 affinity chromatography technology 11805826 physical association X 2 Q03981 Q12468 affinity chromatography technology 16554755 physical association X 2 Q03981 Q12468 affinity chromatography technology 16429126 physical association X 2 Q03981 Q12468 affinity chromatography technology 16429126 physical association X 2 Q03981 Q12468 affinity chromatography technology 17200106 physical association X 2 Q03981 Q12468 affinity chromatography technology 21289098 physical association X 2 Q03981 Q12468 affinity chromatography technology 11805826 physical association X 2 P47130 Q12468 two hybrid 12446563 direct interaction X 2 P47130 Q12468 two hybrid 12446563 direct interaction X 2 P47130 Q12468 two hybrid 12672462 direct interaction X 2 P47130 Q12468 biochemical 12672462 colocalization X 2 Q12468 Q12018 affinity chromatography technology 12183637 physical association X 2 Q12468 P40150 biochemical 23332755 association X 2 Q12468 Q04368 affinity chromatography technology 16429126 physical association X 2 Q12468 Q04368 affinity chromatography technology 17200106 physical association X 2 Q12468 Q04368 affinity chromatography technology 11805826 physical association X 2 Q12468 Q04368 two hybrid 10688190 direct interaction X 2 P0CG63 Q12468 enzymatic study 23105008 direct interaction X 2 P40512 Q12468 affinity chromatography technology 16554755 physical association X 2 P40512 Q12468 affinity chromatography technology 16429126 physical association X 2 P40512 Q12468 affinity chromatography technology 16429126 physical association X 2 P40512 Q12468 affinity chromatography technology 17200106 physical association X 2 P40512 Q12468 affinity chromatography technology 11805826 physical association X 2 Q12250 Q12468 affinity chromatography technology 16554755 physical association X 2 Q12250 Q12468 affinity chromatography technology 16429126 physical association X 2 Q12250 Q12468 affinity chromatography technology 17200106 physical association X 2 Q12250 Q12468 affinity chromatography technology 21289098 physical association X 2 Q12250 Q12468 affinity chromatography technology 11805826 physical association X 2 Q12468 inferred by author 16554755 association C 52 Q12468 tandem affinity purification 16429126 association C 6 Q12468 tandem affinity purification 16429126 association C 6 Q12468 tandem affinity purification 16429126 association C 6 Q12468 inferred by author 16429126 physical association C 6 Q12468 tandem affinity purification 11805826 association C 7 Q12468 tandem affinity purification 11805826 association C 7 Q12468 P25644 two hybrid fragment pooling approach 11283351 physical association X 2 Q12468 Q12348 tandem affinity purification 16554755 physical association X 2 Q12468 P52286 tandem affinity purification 16554755 physical association X 2 Q12468 P52286 tandem affinity purification 16554755 physical association X 2 Q12468 Q12348 tandem affinity purification 16554755 physical association X 2 Q12468 Q12348 tandem affinity purification 16554755 physical association X 2 Q12468 P25294 tandem affinity purification 19536198 association X 2 Q12468 P11484 tandem affinity purification 19536198 association X 2 Q12468 P53940 tandem affinity purification 19536198 association X 2 Q12468 P39987 tandem affinity purification 19536198 association X 2 Q03981 Q12468 tandem affinity purification 16554755 physical association X 2 Q03981 Q12468 tandem affinity purification 16554755 physical association X 2 Q03981 Q12468 tandem affinity purification 16554755 physical association X 2 Q03981 Q12468 tandem affinity purification 16554755 physical association X 2 Q03981 Q12468 tandem affinity purification 16554755 physical association X 2 P47130 Q12468 two hybrid 12446563 physical association X 2 P47130 Q12468 two hybrid 12672462 physical association X 2 P47130 Q12468 cosedimentation 12672462 physical association X 2 Q12468 tandem affinity purification 16429126 association C 8 Q12468 Q04368 two hybrid 10688190 physical association X 2 Q12468 Q04368 cosedimentation 12446563 physical association X 2 P40857 Q12468 two hybrid array 14690591 physical association X 2 P40512 Q12468 tandem affinity purification 16554755 physical association X 2 P40512 Q12468 tandem affinity purification 16554755 physical association X 2 P40512 Q12468 tandem affinity purification 16554755 physical association X 2 Q12250 Q12468 tandem affinity purification 16554755 physical association X 2 Q12250 Q12468 tandem affinity purification 16554755 physical association X 2 Q12250 Q12468 tandem affinity purification 16554755 physical association X 2 Q12468 mass spectrometry studies of complexes 11805826 - C 7 Q12468 mass spectrometry studies of complexes 11805826 - C 7 Q12468 P25644 two hybrid 11283351 - X 2 Q12468 Q04368 two hybrid 10688190 - X 2

PPI - HINT Gene A Gene B PMID Method Quality UBI4 RRI1 23105008 0415 LC PAT1 RRI1 11283351,11283351,11283351 0018,0399,0398 HT SSB2 RRI1 23332755 0401 LC PHS1 RRI1 14690591 0397 LC CSN12 RRI1 12446563,12672462,12672462,12672462 0018,0027,0401,0018 LC CSI1 RRI1 10688190,12446563,10688190 0397,0027,0018 HT,LC SSB1 RRI1 19536198 0676 HT SIS1 RRI1 19536198 0676 HT NAB2 RRI1 19840948 0004 LC ECM10 RRI1 19536198 0676 HT SSB2 RRI1 23332755 0401 LC PCI8 RRI1 16554755,16429126,11805826,11805826,17200106,11805826,16429126,16554755 0004,0676,0676,0004,0004,0007,0004,0676 HT CSN12 RRI1 12672462,12672462,12672462 0027,0401,0018 LC SKP1 RRI1 16554755,16554755 0676,0004 HT APJ1 RRI1 19536198 0676 HT CSN9 RRI1 21289098,16554755,16429126,11805826,11805826,17200106,11805826,16429126,16554755 0004,0676,0004,0676,0004,0004,0007,0676,0004 LC,HT CSI1 RRI1 16554755,16429126,11805826,11805826,17200106,11805826,16429126,16429126 0363,0004,0676,0004,0004,0007,0676,0363 HT CDC53 RRI1 12183637 0004 LC RPN5 RRI1 21289098,16554755,16429126,11805826,11805826,17200106,11805826,16429126,16554755 0004,0676,0004,0676,0004,0004,0007,0676,0004 LC,HT RRI2 RRI1 21289098,16554755,16429126,11805826,11805826,17200106,11805826,16429126,16554755 0004,0676,0004,0676,0004,0004,0007,0676,0004 LC,HT RRI1 RRI1 11805826,11805826 0676,0007 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q12468 Q12250 RRI1 RPN5 0.636 11805826,21289098,16429126,16554755 Q12468 P11484 RRI1 SSB1 0.126 19536198 Q12468 P25294 RRI1 SIS1 0.126 19536198 Q12468 P39987 RRI1 ECM10 0.126 19536198 Q12468 P40857 RRI1 PHS1 0.126 14690591 Q12468 P47130 RRI1 CSN12 0.126 12672462 Q12468 Q03981 RRI1 CSN9 0.692 11805826,21289098,16429126,16554755 Q12468 Q12018 RRI1 CDC53 0.21 12183637 Q12468 Q12348 RRI1 RRI2 0.61 11805826,21289098,16429126,16554755 Q12468 Q12468 RRI1 RRI1 0.155 11805826 Q13619 Q12468 CUL4A RRI1 0.309 22956996 Q12468 P25644 RRI1 PAT1 0.21 11283351 Q12468 Q04368 RRI1 CSI1 0.671 11805826,10688190,16429126,16554755 Q12468 P32505 RRI1 NAB2 0.126 19840948 Q12468 P40512 RRI1 PCI8 0.659 16554755,11805826,16429126 Q12468 P52286 RRI1 SKP1 0.236 16554755 Q12468 P53940 RRI1 APJ1 0.126 19536198