PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus UBC5 SLX5 18499666 biogrid exp UBC5 SLX8 18499666 biogrid exp RPO21 UBC5 17418786 biogrid exp UBC5 SRO9 22271760 biogrid exp CDC31 UBC5 i2d exp UBC5 DRS2 16554755 intact exp UBC5 APC11 17632060 biogrid exp UBC5 RRS1 i2d exp UBC5 DMA2 23442799 biogrid exp RPB2 UBC5 17418786 biogrid exp UBC5 SSB2 23332755 biogrid exp UBC5 RAD53 19578373 biogrid exp UBC5 PBP4 i2d exp UBC5 HUL5 21983566 biogrid exp UBC5 EGD1 16926149 biogrid,intact exp UBC5 HHT1, HHT2 19578373 biogrid exp UBC5 RSP5 19364824,17418786,21685393,12654912,19920177, 23023127 biogrid exp, pred UBC5 UFD4 23023127 i2d exp, pred UBC5 ASR1 18719252, 23023127 biogrid,intact exp, pred UBC5 MOT2 11823428,16926149,15001359, 23023127 biogrid,i2d,intact exp, pred UBC4 UBC5 19578373,16554755, 23023127 biogrid,mint,intact exp, pred UBC5 UBC7 23023127 i2d exp, pred UBC5 HRT1 15960978,19920177, 23023127 biogrid exp, pred UBC5 UBC1 23023127 i2d exp, pred UBC5 EGD2 16926149, 23023127 biogrid,intact exp, pred UBC5 UBC5 23023127 i2d exp, pred UBC5 PRE2 8628401, 23023127 biogrid exp, pred UBC5 IME2 16319894, 23023127 biogrid,i2d exp, pred UBC5 MAC1 23023127 pred UBC5 ATG3 23023127 pred UBC5 PAN1 23023127 pred UBC5 UBP15 23023127 pred UBC5 PEX4 23023127 pred CDC34 UBC5 23023127 pred UBC5 UBA1 23023127 pred UBC5 UBA2 23023127 pred UBC5 RAD23 23023127 pred PEP4 UBC5 23023127 pred UBC5 YAP1802 23023127 pred UBC5 ATG5 23023127 pred UBC5 UBC13 23023127 pred UBC5 UBC11 23023127 pred UBC5 MYO5 23023127 pred UBC5 SLT2 23023127 pred UBC5 MYO3 23023127 pred UBC5 SLA2 23023127 pred UBC5 VPS29 23023127 pred UBC5 DSK2 23023127 pred UBC5 ATG1 23023127 pred UBC5 UBX6 23023127 pred UBC5 MPE1 23023127 pred UBC5 EDE1 23023127 pred UBC5 PEX10 23023127 pred UBC5 APS2 23023127 pred UBC5 KDX1 23023127 pred UBC5 YCK1 23023127 pred CDC16 UBC5 23023127 pred UBC5 PRE3 23023127 pred UBC5 ARP2 23023127 pred UBC5 VPS27 23023127 pred UBC5 FUS3 23023127 pred UBC5 UBC6 23023127 pred UBC5 UBP6 23023127 pred UBC5 RVS161 23023127 pred RAD18 UBC5 23023127 pred UBC5 AOS1 23023127 pred UBC5 SGT1 23023127 pred UBC5 ARF2 23023127 pred UBC5 PUP2 23023127 pred UBC5 END3 23023127 pred UBC5 SMT3 23023127 pred UBC5 CNB1 23023127 pred UBC5 PRP19 23023127 pred UBC5 YPT53 23023127 pred UBC5 SKI8 23023127 pred UBC5 APS1 23023127 pred UBC5 BEM1 23023127 pred UBC5 UBC12 23023127 pred UBC5 HRR25 23023127 pred UBC5 UBX5 23023127 pred UBC5 RFA1 23023127 pred UBC5 PTP2 23023127 pred UBC5 GTS1 23023127 pred UBC5 HUB1 23023127 pred UBC5 UBX7 23023127 pred CPR1 UBC5 23023127 pred UBC5 STE20 23023127 pred KSS1 UBC5 23023127 pred GCN2 UBC5 23023127 pred UBC5 ELC1 23023127 pred UBC5 CDH1 23023127 pred UBC5 MPT5 23023127 pred UBC5 ZIM17 23023127 pred UBC5 LAS17 23023127 pred UBC5 MCK1 23023127 pred UBC5 TFB3 23023127 pred UBC5 VPS21 23023127 pred UBC5 ATG8 23023127 pred UBC5 PRE1 23023127 pred UBC5 UBI4 23023127 pred UBC5 KAR2 23023127 pred UBC5 CDC20 23023127 pred UBC5 VMA3 23023127 pred UBC5 ARL1 23023127 pred UBC5 ATG12 23023127 pred UBC5 YCK2 23023127 pred UBC5 MDY2 23023127 pred UBC5 IRE1 23023127 pred RAS2 UBC5 23023127 pred CDC24 UBC5 23023127 pred UBC5 MET30 23023127 pred UBC5 RUB1 23023127 pred UBC5 UBC8 23023127 pred UBC5 SHP1 23023127 pred RAD6 UBC5 23023127 pred UBC5 URM1 23023127 pred UBC5 MMS2 23023127 pred UBC5 TUL1 23023127 pred UBC5 YPT52 23023127 pred UBC5 DMA1 23023127 pred UBC5 UBC9 23023127 pred UBC5 SLA1 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q12157 P15732 pull down 17632060 direct interaction X 2 P34909 P15732 two hybrid 15001359 direct interaction X 2 P34909 P15732 two hybrid 11823428 direct interaction X 2 P34909 P15732 two hybrid 11823428 direct interaction X 2 P34909 P15732 two hybrid 16926149 direct interaction X 2 Q08273 P15732 pull down 19920177 direct interaction X 2 Q08273 P15732 pull down 15960978 direct interaction X 2 P15731 P15732 affinity chromatography technology 16554755 physical association X 2 P15731 P15732 affinity chromatography technology 19578373 physical association X 2 Q02642 P15732 two hybrid 16926149 direct interaction X 2 P15732 O95628-8 two hybrid 11823428 direct interaction X 2 P15732 O95628-8 two hybrid 11823428 direct interaction X 2 A0A024RCQ4 P15732 pull down 20483786 direct interaction X 2 P15732 P04050 pull down 17418786 direct interaction X 2 P15732 P04050 pull down 17418786 direct interaction X 2 P15732 P32581 enzymatic study 16319894 direct interaction X 2 P15732 P04050 affinity chromatography technology 17418786 physical association X 2 P15732 Q06834 two hybrid 18719252 direct interaction X 2 P15732 P53119 affinity chromatography technology 21983566 physical association X 2 P32828 P15732 pull down 18499666 direct interaction X 2 P39940 P15732 pull down 21685393 direct interaction X 2 P39940 P15732 pull down 19920177 direct interaction X 2 P39940 P15732 pull down 17418786 direct interaction X 2 P39940 P15732 pull down 17418786 direct interaction X 2 P39940 P15732 pull down 12654912 direct interaction X 2 P39940 P15732 pull down 19364824 direct interaction X 2 P40072 P15732 pull down 18499666 direct interaction X 2 P08518 P15732 pull down 17418786 direct interaction X 2 P08518 P15732 pull down 17418786 direct interaction X 2 P0CG63 P15732 affinity chromatography technology 22106047 physical association X 2 P0CG63 P15732 affinity chromatography technology 23749301 physical association X 2 P0CG63 P15732 affinity chromatography technology 21427232 physical association X 2 P30656 P15732 biochemical 8628401 association X 2 P53924 P15732 two hybrid 23442799 direct interaction X 2 P40150 P15732 biochemical 23332755 association X 2 P15732 P62878 pull down 22024926 direct interaction X 2 P15732 P62878 pull down 23707388 direct interaction X 2 P38879 P15732 two hybrid 16926149 direct interaction X 2 P15732 inferred by author 16554755 association C 5 P34909 P15732 two hybrid 16926149 physical association X 2 P15731 P15732 tandem affinity purification 16554755 physical association X 2 Q02642 P15732 two hybrid 16926149 physical association X 2 P15732 Q06834 two hybrid 18719252 physical association X 2 P38879 P15732 two hybrid 16926149 physical association X 2 P15731 P15732 interaction detection method - - X 2 Q02159 P15732 interaction detection method - - X 2 P21734 P15732 interaction detection method - - X 2

PPI - HINT Gene A Gene B PMID Method Quality RPO21 UBC5 15960978 0415 LC UBC5 PRE2 8628401 0401 LC UBC5 IME2 16319894 0415 LC UBC5 MOT2 16926149,15001359,11823428 0018,0018,0018 LC UBC5 EGD2 16926149 0018 LC UBC5 SSB2 23332755 0401 LC UBC5 DMA2 23442799 0018 LC UBC5 EGD1 16926149 0018 LC UBC5 ASR1 18719252 0018 HT RPO21 UBC5 17418786,17418786 0096,0004 LC RPB2 UBC5 17418786 0096 LC UBC4 UBC5 19578373,16554755,16554755 0004,0004,0676 LC,HT UBC5 RAD53 19578373 0004 LC UBC5 PRE2 8628401 0401 LC UBC5 SLX5 18499666 0096 LC UBC5 DRS2 16554755 0363 HT UBC5 RSP5 21685393,19364824,17418786,19920177,12654912 0096,0096,0096,0096,0096 LC UBC5 SLX8 18499666 0096 LC UBC5 SSB2 23332755 0401 LC UBC5 HUL5 21983566 0004 LC UBC5 HHT1|HHT2 19578373 0004 LC UBC5 HRT1 19920177,15960978 0096,0096 LC UBC5 APC11 17632060 0096 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P61830 P15732 HHT2 UBC5 0.21 19578373 P15732 P15731 UBC5 UBC4 0.309 16554755,19578373 P53119 P15732 HUL5 UBC5 0.21 21983566 P39940 P15732 RSP5 UBC5 0.843 17418786,21685393,12654912,19364824 P22216 P15732 RAD53 UBC5 0.21 19578373 P15732 O95628 UBC5 CNOT4 0.523 11823428 P15732 P04050 UBC5 RPO21 0.523 17418786 P15732 P08518 UBC5 RPB2 0.523 17418786 Q12157 P15732 APC11 UBC5 0.309 17632060 Q9HCM9 P15732 TRIM39 UBC5 0.332 27107014 P25567 P15732 SRO9 UBC5 0.126 22271760 P34909 P15732 MOT2 UBC5 0.772 16926149,15001359,11823428 Q06834 P15732 ASR1 UBC5 0.332 18719252 Q08273 P15732 HRT1 UBC5 0.523 19920177,15960978 P62878 P15732 RBX1 UBC5 0.523 22024926,23707388 Q9UJV3 P15732 MID2 UBC5 0.332 27107014 Q9Y4K3 P15732 TRAF6 UBC5 0.332 27107014 P38879 P15732 EGD2 UBC5 0.309 16926149 P32581 P15732 IME2 UBC5 0.183 16319894 Q99942 P15732 RNF5 UBC5 0.309 20483786 P32828 P15732 SLX5 UBC5 0.309 18499666 P39524 P15732 DRS2 UBC5 0.126 16554755 P40072 P15732 SLX8 UBC5 0.309 18499666 P40150 P15732 SSB2 UBC5 0.126 23332755 Q02642 P15732 EGD1 UBC5 0.309 16926149 P53924 P15732 DMA2 UBC5 0.309 23442799