PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus RPS8A DOA4 16429126 intact exp SSA2 DOA4 16429126 intact exp DOA4 GCN1 16429126 intact exp RPL4A DOA4 16429126 intact exp DOA4 SWC4 14690591 intact exp PDB1 DOA4 11805826,16429126 biogrid,mint,intact,dip exp SSB1 DOA4 19536198 intact exp FAS1 DOA4 16429126 intact exp DOA4 SPT7 i2d exp RPS11A DOA4 16429126 intact exp DOA4 PSF1 14690591 intact exp DOA4 SSE1 16429126 intact exp TEF1, TEF2 DOA4 16429126 intact exp RPL20A DOA4 16429126 intact exp URA2 DOA4 16429126 biogrid,intact exp DOA4 ISW1 16429126 intact exp BMH1 DOA4 16429126 intact exp DOA4 BRE2 16429126 intact exp DOA4 UME6 i2d exp RPL5 DOA4 16429126 intact exp DUR1,2 DOA4 16429126 intact exp DOA4 IMD3 16429126 intact exp DOA4 PRX1 11805826,16429126 biogrid,mint,intact,dip exp DOA4 VPS24 23444383 biogrid exp VMA2 DOA4 16429126 intact exp RPS4A DOA4 16429126 intact exp DOA4 PAA1 16429126 intact exp DOA4 CYM1 16429126 intact exp HHF1, HHF2 DOA4 16429126 intact exp DOA4 MPC54 16554755 biogrid,i2d,mint,intact exp DOA4 AVT1 16554755 biogrid,i2d,mint,intact exp SRB4 DOA4 11283351, 23023127 i2d,mint,intact,dip exp, pred STP22 DOA4 17513562, 23023127 biogrid exp, pred PRE2 DOA4 8628401, 23023127 biogrid exp, pred DOA4 BZZ1 11283351, 23023127 i2d,mint,intact,dip exp, pred DOA4 RPN5 11595789, 23023127 biogrid,i2d,dip exp, pred DOA4 VPS20 23444383, 23023127 biogrid exp, pred DOA4 SWD1 11805826,16429126, 23023127 biogrid,mint,intact,dip exp, pred DOA4 SNF7 15086794,23444383,17513562, 23023127 biogrid,i2d exp, pred DOA4 UBP15 16429126, 23023127 biogrid,intact exp, pred TOP2 DOA4 16429126, 23023127 biogrid,intact exp, pred DOA4 BRO1 17446860,15326198,17513562, 23023127 biogrid,mint,intact exp, pred DOA4 RFU1 19410548, 23023127 biogrid,intact exp, pred DOA4 HEK2 18805955, 23023127 biogrid exp, pred DOA4 YEF1 16554755, 23023127 biogrid,i2d,mint,intact exp, pred DED1 DOA4 16429126, 23023127 biogrid,intact exp, pred DOA4 TFA1 16554755, 23023127 biogrid,i2d,mint,intact exp, pred DOA4 RPT1 10069815, 23023127 biogrid exp, pred DOA4 SEC17 23023127 pred DOA4 SFH1 23023127 pred DOA4 UBX5 23023127 pred DOA4 UBP7 23023127 pred DOA4 DUN1 23023127 pred DOA4 APC2 23023127 pred DOA4 UBP16 23023127 pred DOA4 APC1 23023127 pred DOA4 ATG12 23023127 pred UBC4 DOA4 23023127 pred CDC24 DOA4 23023127 pred DOA4 ATG8 23023127 pred DOA4 UBP8 23023127 pred CDC16 DOA4 23023127 pred DOA4 VPS36 23023127 pred DOA4 RAD23 23023127 pred DOA4 UBP10 23023127 pred DOA4 ROM2 23023127 pred DOA4 TUL1 23023127 pred CDC6 DOA4 23023127 pred DOA4 GPI1 23023127 pred DOA4 AKR1 23023127 pred DOA4 UBP2 23023127 pred UBP1 DOA4 23023127 pred DOA4 UBI4 23023127 pred SIR2 DOA4 23023127 pred DOA4 UBP5 23023127 pred DOA4 ATG5 23023127 pred DOA4 VPS28 23023127 pred RAD18 DOA4 23023127 pred SBA1 DOA4 23023127 pred DOA4 DSK2 23023127 pred DOA4 RSP5 23023127 pred DOA4 UBX3 23023127 pred DOA4 CDH1 23023127 pred DOA4 UBX7 23023127 pred DOA4 HRD1 23023127 pred DOA4 UBX6 23023127 pred DOA4 UBP3 23023127 pred DOA4 UBP6 23023127 pred DOA4 ATG4 23023127 pred DOA4 SHP1 23023127 pred DOA4 UBP11 23023127 pred DOA4 RPN4 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P32571 - 11805826 - C 11 P32571 P38822 - 11283351 - X 2 P39929 P32571 - 15086794 - X 2 Q12250 P32571 - 11595789 - X 2 P32571 - 11805826 - C 8 P32571 P34227 - 11805826 - X 2 P32571 P32569 - 11283351 - X 2 P32571 P30656 biochemical 8628401 association X 2 P32571 P36100 affinity chromatography technology 16554755 physical association X 2 P32571 P06786 affinity chromatography technology 16429126 physical association X 2 P32622 P32571 affinity chromatography technology 16554755 physical association X 2 P39929 P32571 two hybrid 15086794 direct interaction X 2 P39929 P32571 affinity chromatography technology 23444383 physical association X 2 P39929 P32571 protein complementation assay 17513562 direct interaction X 2 P0CG63 P32571 affinity chromatography technology 23793018 physical association X 2 P39706 P32571 affinity chromatography technology 16429126 physical association X 2 P39706 P32571 affinity chromatography technology 11805826 physical association X 2 P25604 P32571 protein complementation assay 17513562 direct interaction X 2 P48582 P32571 imaging technique 15326198 colocalization X 2 P48582 P32571 affinity chromatography technology 15326198 physical association X 2 P48582 P32571 protein complementation assay 17513562 direct interaction X 2 P48582 P32571 protein complementation assay 17513562 direct interaction X 2 P48582 P32571 affinity chromatography technology 17513562 physical association X 2 P48582 P32571 affinity chromatography technology 17446860 physical association X 2 P48582 P32571 two hybrid 17446860 direct interaction X 2 Q12250 P32571 two hybrid 11595789 direct interaction X 2 P06634 P32571 affinity chromatography technology 16429126 physical association X 2 P50101 P32571 affinity chromatography technology 16429126 physical association X 2 P32571 P36095 affinity chromatography technology 23444383 physical association X 2 P32571 P47082 affinity chromatography technology 16554755 physical association X 2 P32571 P07259 affinity chromatography technology 16429126 physical association X 2 P32571 Q08003 affinity chromatography technology 19410548 physical association X 2 P32571 P34227 affinity chromatography technology 11805826 physical association X 2 Q08550 P32571 affinity chromatography technology 16554755 physical association X 2 P32473 P32571 affinity chromatography technology 16429126 physical association X 2 P32473 P32571 affinity chromatography technology 11805826 physical association X 2 Q04272 P32571 pull down 23444383 direct interaction X 2 P33299 P32571 biochemical 10069815 association X 2 P32571 inferred by author 11805826 physical association C 9 P32571 tandem affinity purification 11805826 - C 11 P32571 P38822 two hybrid pooling approach 11283351 physical association X 2 P39706 P32571 tandem affinity purification 11805826 physical association X 2 Q12250 P32571 two hybrid 11595789 physical association X 2 P32571 inferred by author 11805826 physical association C 13 P32571 tandem affinity purification 11805826 - C 8 P32571 P32569 two hybrid pooling approach 11283351 physical association X 2 P32571 P34227 inferred by author 11805826 physical association X 2 P32571 P34227 tandem affinity purification 11805826 physical association X 2 P32473 P32571 tandem affinity purification 11805826 physical association X 2 P32571 tandem affinity purification 16429126 association C 13 P32571 tandem affinity purification 11805826 association C 9 P32571 tandem affinity purification 11805826 association C 12 P32571 tandem affinity purification 16429126 association C 21 P32571 inferred by author 16429126 physical association C 6 P32571 tandem affinity purification 16429126 association C 20 P32571 tandem affinity purification 16429126 association C 4 P32571 anti tag coimmunoprecipitation 19410548 physical association C 3 P32571 P38822 two hybrid fragment pooling approach 11283351 physical association X 2 P32571 Q12488 two hybrid array 14690591 physical association X 2 P32571 P53201 two hybrid array 14690591 physical association X 2 P32571 P36100 tandem affinity purification 16554755 physical association X 2 P32571 P36100 tandem affinity purification 16554755 physical association X 2 P32622 P32571 tandem affinity purification 16554755 physical association X 2 P32622 P32571 tandem affinity purification 16554755 physical association X 2 P11484 P32571 tandem affinity purification 19536198 association X 2 P48582 P32571 anti tag coimmunoprecipitation 15326198 physical association X 2 P48582 P32571 anti tag coimmunoprecipitation 15326198 physical association X 2 P48582 P32571 anti tag coimmunoprecipitation 15326198 physical association X 2 P48582 P32571 two hybrid 17446860 physical association X 2 P48582 P32571 two hybrid 17446860 physical association X 2 P48582 P32571 two hybrid 17446860 physical association X 2 P48582 P32571 two hybrid 17446860 physical association X 2 P48582 P32571 two hybrid 17446860 physical association X 2 P48582 P32571 two hybrid 17446860 physical association X 2 P48582 P32571 two hybrid 17446860 physical association X 2 P48582 P32571 anti tag coimmunoprecipitation 17446860 physical association X 2 P48582 P32571 two hybrid 17446860 physical association X 2 P48582 P32571 two hybrid 17446860 physical association X 2 P48582 P32571 two hybrid 17446860 physical association X 2 P48582 P32571 two hybrid 17446860 physical association X 2 P32571 tandem affinity purification 11805826 association C 3 P32571 inferred by author 16554755 association C 4 P32571 tandem affinity purification 16429126 association C 12 P32571 inferred by author 16429126 physical association C 9 P32571 inferred by author 16429126 physical association C 17 P32571 inferred by author 16429126 physical association C 11 P32571 P32569 two hybrid fragment pooling approach 11283351 physical association X 2 P32571 P32528 inferred by author 16429126 physical association X 2 P32571 P47082 tandem affinity purification 16554755 physical association X 2 P32571 P47082 tandem affinity purification 16554755 physical association X 2 P32571 Q08003 pull down 19410548 direct interaction X 2 Q08550 P32571 tandem affinity purification 16554755 physical association X 2 Q08550 P32571 tandem affinity purification 16554755 physical association X 2 P32571 P38822 two hybrid 11283351 - X 2 P0CG63 P32571 interaction detection method 8657109 - X 2 P32571 mass spectrometry studies of complexes 11805826 - C 3 P32571 confirmational text mining - - C 3 P32571 mass spectrometry studies of complexes 11805826 - C 11 P32571 P32569 two hybrid 11283351 - X 2

PPI - HINT Gene A Gene B PMID Method Quality STP22 DOA4 17513562 0090 LC PRE2 DOA4 8628401 0401 LC SRB4 DOA4 11283351,11283351,11283351 0018,0399,0398 HT DOA4 RPT1 10069815 0401 LC DOA4 BZZ1 11283351,11283351,11283351 0018,0399,0398 HT DOA4 SNF7 15086794,17513562 0018,0090 LC DOA4 BRO1 17446860,17446860,17513562,17513562,17446860 0018,0004,0004,0090,0007 LC DOA4 SWC4 14690591 0397 LC DOA4 RPN5 11595789 0018 LC DOA4 PSF1 14690591 0397 LC HHF1|HHF2 DOA4 16429126 0676 HT TEF1|TEF2 DOA4 16429126 0676 HT DED1 DOA4 16429126,16429126,16429126 0676,0004,0363 HT TOP2 DOA4 16429126,16429126 0676,0004 HT FAS1 DOA4 16429126 0676 HT URA2 DOA4 16429126,16429126 0676,0004 HT RPL20A DOA4 16429126 0676 HT RPS4A DOA4 16429126 0676 HT RPS8A DOA4 16429126 0676 HT RPS11A DOA4 16429126 0676 HT SSA2 DOA4 16429126 0676 HT RPL4A DOA4 16429126 0676 HT SSB1 DOA4 19536198 0676 HT VMA2 DOA4 16429126 0676 HT RPL5 DOA4 16429126 0676 HT BMH1 DOA4 16429126 0363 HT PRE2 DOA4 8628401 0401 LC PDB1 DOA4 11805826,16429126,11805826,16429126,11805826 0004,0004,0007,0676,0676 HT DUR1,2 DOA4 16429126 0363 HT DOA4 SSE1 16429126 0676 HT DOA4 YEF1 16554755,16554755 0676,0004 HT DOA4 CYM1 16429126 0363 HT DOA4 RPT1 10069815 0401 LC DOA4 GCN1 16429126 0676 HT DOA4 PRX1 11805826,16429126,11805826,11805826,11805826 0004,0676,0007,0676,0363 HT DOA4 VPS24 23444383 0004 LC DOA4 TFA1 16554755,16554755 0676,0004 HT DOA4 ISW1 16429126 0676 HT DOA4 SWD1 11805826,16429126,11805826,16429126,11805826 0004,0004,0007,0676,0676 HT DOA4 SNF7 26427873,23444383 0096,0004 LC DOA4 BRE2 16429126 0363 HT DOA4 AVT1 16554755,16554755,16554755 0363,0676,0004 HT DOA4 BRO1 17446860,17446860,17513562,15326198,15326198,15326198,17513562,17446860 0018,0004,0004,0004,0428,0007,0090,0007 LC DOA4 IMD3 16429126 0676 HT DOA4 UBP15 16429126,16429126 0676,0004 HT DOA4 VPS20 23444383 0096 LC DOA4 RFU1 19410548,19410548,19410548 0004,0007,0096 LC DOA4 MPC54 16554755,16554755 0676,0004 HT DOA4 PAA1 16429126 0676 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q12250 P32571 RPN5 DOA4 0.033 11595789 Q8N6Y0 P32571 USHBP1 DOA4 0.332 27107014 Q9Y6D9 P32571 MAD1L1 DOA4 0.332 27107014 P32571 P11484 DOA4 SSB1 0.126 19536198 P47082 P32571 AVT1 DOA4 0.416 16554755 P48582 P32571 BRO1 DOA4 0.74 17446860,15326198 P39929 P32571 SNF7 DOA4 0.454 23444383,26427873 P34227 P32571 PRX1 DOA4 0.376 11805826,16429126 P32571 O94972 DOA4 TRIM37 0.332 27107014 Q5JR59 P32571 MTUS2 DOA4 0.332 27107014 Q08003 P32571 RFU1 DOA4 0.569 19410548 P38199 P32571 HEK2 DOA4 0.126 18805955 P32571 P29311 DOA4 BMH1 0.126 16429126 Q96MT8 P32571 CEP63 DOA4 0.332 27107014 P36100 P32571 TFA1 DOA4 0.236 16554755 P38822 P32571 BZZ1 DOA4 0.236 11283351 P32571 P32528 DOA4 DUR1,2 0.126 16429126 P32571 P32569 DOA4 SRB4 0.236 11283351 P32571 P02309 DOA4 HHF2 0.126 16429126 P32571 P02994 DOA4 TEF2 0.126 16429126 P32571 P05753 DOA4 RPS4B 0.126 16429126 P32571 P05754 DOA4 RPS8B 0.126 16429126 P32571 P06634 DOA4 DED1 0.236 16429126 P32571 P06786 DOA4 TOP2 0.126 16429126 P32571 P07149 DOA4 FAS1 0.126 16429126 P32571 P07259 DOA4 URA2 0.126 16429126 P32571 P0C2I0 DOA4 RPL20B 0.126 16429126 P32571 P10592 DOA4 SSA2 0.126 16429126 P32571 P10664 DOA4 RPL4A 0.126 16429126 P32571 P16140 DOA4 VMA2 0.126 16429126 P32571 P26321 DOA4 RPL5 0.126 16429126 P32571 P26781 DOA4 RPS11B 0.126 16429126 P32571 P32473 DOA4 PDB1 0.416 11805826,16429126 P32589 P32571 SSE1 DOA4 0.126 16429126 P32622 P32571 YEF1 DOA4 0.236 16554755 P33892 P32571 GCN1 DOA4 0.126 16429126 P36095 P32571 VPS24 DOA4 0.21 23444383 P38144 P32571 ISW1 DOA4 0.126 16429126 P39706 P32571 SWD1 DOA4 0.332 11805826,16429126 P50095 P32571 IMD3 DOA4 0.126 16429126 P53201 P32571 SWC4 DOA4 0.126 14690591 Q04272 P32571 VPS20 DOA4 0.309 23444383 Q12447 P32571 PAA1 DOA4 0.126 16429126 Q12488 P32571 PSF1 DOA4 0.126 14690591 Q15025 P32571 TNIP1 DOA4 0.332 27107014 Q96ED9 P32571 HOOK2 DOA4 0.332 27107014 Q9NSC5 P32571 HOMER3 DOA4 0.332 27107014 P32898 P32571 CYM1 DOA4 0.126 16429126 P43132 P32571 BRE2 DOA4 0.126 16429126 P50101 P32571 UBP15 DOA4 0.126 16429126 Q08550 P32571 MPC54 DOA4 0.332 16554755