PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus LEU2 VPS41 11805837 dip exp VPS41 CSM3 18809726 biogrid exp VPS41 GEA2 18809726 biogrid exp VPS41 PGD1 18809726 biogrid exp TKL1 VPS41 i2d exp GLC7 VPS41 21179020 intact exp VPS41 SNU71 11805826,16429126 biogrid,mint,intact,dip exp VMA2 VPS41 16429126 intact exp YPT7 VPS41 19386605,20604902,21325627,18809726 biogrid exp TEF1, TEF2 VPS41 16429126 intact exp AAP1 VPS41 16429126 intact exp RPL4A VPS41 16429126 intact exp VPS41 LUC7 11805826,16429126 biogrid,mint,intact,dip exp VPS41 PUF3 26493364 biogrid exp VPS41 NSL1 18809726 biogrid exp VPS21 VPS41 i2d exp VPS41 SSB2 23332755,19536198 biogrid,intact exp RCK2 VPS41 11805837 biogrid,mint,intact,dip exp HEK2 VPS41 18805955 biogrid exp VPS41 YCK3 19386605,21079247 biogrid exp VPS41 APL5 11160821,21079247,19741093,10559961, 23023127 biogrid,dip exp, pred VPS41 VTI1 21613544,15889152, 23023127 biogrid exp, pred YPT52 VPS41 21325627, 23023127 biogrid exp, pred VPS3 VPS41 20604902,21325627,17488625, 23023127 biogrid exp, pred PEP3 VPS41 11805826,16429126,19193765,20604902,21325627,17488625,10944212, 23023127 biogrid,mint,intact,dip exp, pred KEX2 VPS41 10559961, 23023127 biogrid exp, pred VPS41 VAM6 16429126,19193765,15889152,17488625,25026036,11805826,9111041,22940862,10725336,22754631,20604902,21325627,21079247,10944212, 23023127 biogrid,i2d,mint,intact,dip exp, pred VPS33 VPS41 18385512,16429126,19193765,15889152,17488625,11805826,22940862,16601699,20604902,10944212, 23023127 biogrid,i2d,mint,intact,dip exp, pred YKT6 VPS41 21613544,10725336, 23023127 biogrid exp, pred VPS41 NYV1 21613544,10725336, 23023127 biogrid exp, pred VPS41 ARF3 18809726, 23023127 biogrid exp, pred VPS41 VAM3 21613544,10725336,15889152,23051737,18809726,10559961, 23023127 biogrid,dip exp, pred VAM7 VPS41 21613544,16601699,15889152, 23023127 biogrid,mint,intact exp, pred VPS41 VPS41 11805826,22754631,11160821, 23023127 biogrid,mint,intact exp, pred VPS41 VPS16 11805826,16429126,22940862,19193765,20604902,17488625,10944212, 23023127 biogrid,mint,intact,dip exp, pred PEP5 VPS41 16429126,19193765,17488625,11805826,21325627,20604902,10944212,21079247, 23023127 biogrid,mint,intact,dip exp, pred ATG12 VPS41 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P38959 - 15889152 - C 11 P38959 - 15044803 - C 7 P38959 - 15889152 - C 6 P38959 - 11805826 - C 7 P38959 - 11805826 - C 8 P38959 P38623 - 11805837 - X 2 P53207 P38959 affinity chromatography technology 11805826 physical association X 2 P0CG63 P38959 affinity chromatography technology 23749301 physical association X 2 P0CG63 P38959 affinity chromatography technology 23793018 physical association X 2 P38959 P38959 affinity chromatography technology 22754631 physical association X 2 P38959 P20795 affinity chromatography technology 22940862 physical association X 2 P38959 Q12255 affinity chromatography technology 10725336 physical association X 2 P38959 P12868 affinity chromatography technology 10944212 physical association X 2 P38959 P12868 affinity chromatography technology 10944212 physical association X 2 P38959 P20795 affinity chromatography technology 10944212 physical association X 2 P38959 P20795 affinity chromatography technology 10944212 physical association X 2 P38959 Q08951 two hybrid 11160821 direct interaction X 2 P38959 Q08951 affinity chromatography technology 11160821 physical association X 2 P38959 P38959 pull down 11160821 direct interaction X 2 P38959 Q08951 two hybrid 10559961 direct interaction X 2 P38959 Q08951 pull down 10559961 direct interaction X 2 P38959 P12868 affinity chromatography technology 21079247 physical association X 2 P38959 Q08951 affinity chromatography technology 21079247 physical association X 2 P38959 Q08951 two hybrid 21079247 direct interaction X 2 P38959 Q08951 biochemical 21079247 colocalization X 2 P38959 Q08951 affinity chromatography technology 10559961 physical association X 2 P38959 P12868 affinity chromatography technology 16429126 physical association X 2 P38959 P20795 affinity chromatography technology 16429126 physical association X 2 P38959 Q04338 affinity chromatography technology 15889152 physical association X 2 P38959 P20795 biochemical 15889152 association X 2 P38959 P20795 affinity chromatography technology 16601699 physical association X 2 P38959 P20795 affinity chromatography technology 17200106 physical association X 2 P38959 P12868 affinity chromatography technology 17200106 physical association X 2 P38959 P12868 affinity chromatography technology 17488625 physical association X 2 P38959 P20795 affinity chromatography technology 17488625 physical association X 2 P38959 P20795 affinity chromatography technology 17488625 physical association X 2 P38959 P20795 pull down 18385512 direct interaction X 2 P38959 P32939 two hybrid 18809726 direct interaction X 2 P38959 Q04659 two hybrid 18809726 direct interaction X 2 P38959 P32939 pull down 18809726 direct interaction X 2 P38959 P40356 two hybrid 18809726 direct interaction X 2 P38959 Q12143 two hybrid 18809726 direct interaction X 2 P38959 P32939 affinity chromatography technology 18809726 physical association X 2 P38959 P12868 affinity chromatography technology 19193765 physical association X 2 P38959 P20795 affinity chromatography technology 19193765 physical association X 2 P38959 Q08951 pull down 19741093 direct interaction X 2 P38959 P32939 affinity chromatography technology 19386605 physical association X 2 P38959 P32939 pull down 21325627 direct interaction X 2 P38959 P12868 pull down 21325627 direct interaction X 2 P38959 P12868 two hybrid 21325627 direct interaction X 2 P38959 P12868 two hybrid 21325627 direct interaction X 2 P38959 P32939 two hybrid 21325627 direct interaction X 2 P38959 P12868 affinity chromatography technology 20604902 physical association X 2 P38959 P20795 affinity chromatography technology 20604902 physical association X 2 P38959 P32939 affinity chromatography technology 20604902 physical association X 2 P38959 P32939 two hybrid 20604902 direct interaction X 2 P38959 Q07508 affinity chromatography technology 11805826 physical association X 2 P38959 P12868 affinity chromatography technology 11805826 physical association X 2 P38959 P20795 affinity chromatography technology 11805826 physical association X 2 P38959 Q04338 affinity chromatography technology 21613544 physical association X 2 P38959 Q12255 affinity chromatography technology 21613544 physical association X 2 P38959 Q04338 pull down 21613544 direct interaction X 2 P38959 Q07468 affinity chromatography technology 22754631 physical association X 2 P38959 Q07468 affinity chromatography technology 22940862 physical association X 2 P38959 Q03308 affinity chromatography technology 22940862 physical association X 2 P38959 Q12241 affinity chromatography technology 23051737 physical association X 2 P38959 Q07468 affinity chromatography technology 10944212 physical association X 2 P38959 Q07468 affinity chromatography technology 10944212 physical association X 2 P38959 Q03308 affinity chromatography technology 10944212 physical association X 2 P38959 Q03308 affinity chromatography technology 10944212 physical association X 2 P38959 P27801 affinity chromatography technology 10944212 physical association X 2 P38959 P27801 affinity chromatography technology 10944212 physical association X 2 P38959 Q07468 affinity chromatography technology 10725336 physical association X 2 P38959 Q12241 affinity chromatography technology 10725336 physical association X 2 P38959 Q07468 affinity chromatography technology 9111041 physical association X 2 P38959 Q12241 affinity chromatography technology 10559961 physical association X 2 P38959 Q07468 affinity chromatography technology 21079247 physical association X 2 P38959 P39962 enzymatic study 21079247 direct interaction X 2 P38959 P13134 biochemical 10559961 colocalization X 2 P38959 P40150 biochemical 23332755 association X 2 P38959 P27801 affinity chromatography technology 16429126 physical association X 2 P38959 Q07468 affinity chromatography technology 16429126 physical association X 2 P38959 Q03308 affinity chromatography technology 16429126 physical association X 2 P38959 P27801 affinity chromatography technology 16429126 physical association X 2 P38959 Q03308 affinity chromatography technology 16429126 physical association X 2 P38959 P32912 affinity chromatography technology 15889152 physical association X 2 P38959 Q12241 affinity chromatography technology 15889152 physical association X 2 P38959 Q07468 biochemical 15889152 association X 2 P38959 P32912 affinity chromatography technology 16601699 physical association X 2 P38959 Q07468 affinity chromatography technology 17200106 physical association X 2 P38959 P27801 affinity chromatography technology 17200106 physical association X 2 P38959 Q03308 affinity chromatography technology 17200106 physical association X 2 P38959 Q07468 affinity chromatography technology 17488625 physical association X 2 P38959 P27801 affinity chromatography technology 17488625 physical association X 2 P38959 Q03308 affinity chromatography technology 17488625 physical association X 2 P38959 P23643 affinity chromatography technology 17488625 physical association X 2 P38959 P23643 affinity chromatography technology 17488625 physical association X 2 P38959 Q12241 two hybrid 18809726 direct interaction X 2 P38959 P40994 two hybrid 18809726 direct interaction X 2 P38959 P39993 two hybrid 18809726 direct interaction X 2 P38959 Q07468 affinity chromatography technology 19193765 physical association X 2 P38959 P27801 affinity chromatography technology 19193765 physical association X 2 P38959 Q03308 affinity chromatography technology 19193765 physical association X 2 P38959 Q07468 pull down 21325627 direct interaction X 2 P38959 Q07468 pull down 21325627 direct interaction X 2 P38959 P23643 two hybrid 21325627 direct interaction X 2 P38959 Q07468 two hybrid 21325627 direct interaction X 2 P38959 Q07468 two hybrid 21325627 direct interaction X 2 P38959 P27801 two hybrid 21325627 direct interaction X 2 P38959 P36018 two hybrid 21325627 direct interaction X 2 P38959 Q07468 affinity chromatography technology 20604902 physical association X 2 P38959 P27801 affinity chromatography technology 20604902 physical association X 2 P38959 Q03308 affinity chromatography technology 20604902 physical association X 2 P38959 Q07468 affinity chromatography technology 20604902 physical association X 2 P38959 P27801 two hybrid 20604902 direct interaction X 2 P38959 P23643 affinity chromatography technology 20604902 physical association X 2 P38959 P23643 affinity chromatography technology 20604902 physical association X 2 P38959 P27801 affinity chromatography technology 11805826 physical association X 2 P38959 P27801 affinity chromatography technology 11805826 physical association X 2 P38959 Q07468 affinity chromatography technology 11805826 physical association X 2 P38959 Q03308 affinity chromatography technology 11805826 physical association X 2 P38959 P38623 affinity chromatography technology 11805837 physical association X 2 P38959 P39962 enzymatic study 19386605 direct interaction X 2 P38959 Q12241 affinity chromatography technology 21613544 physical association X 2 P38959 P32912 affinity chromatography technology 21613544 physical association X 2 P38959 Q12241 pull down 21613544 direct interaction X 2 P38959 P32912 pull down 21613544 direct interaction X 2 P36015 P38959 affinity chromatography technology 10725336 physical association X 2 P36015 P38959 affinity chromatography technology 21613544 physical association X 2 P36015 P38959 pull down 21613544 direct interaction X 2 P38959 tandem affinity purification 11805826 - C 7 P38959 anti tag coimmunoprecipitation 11805837 - C 4 P38959 anti tag coimmunoprecipitation 11805837 - C 6 P53207 P38959 tandem affinity purification 11805826 physical association X 2 P38959 Q07508 tandem affinity purification 11805826 physical association X 2 P38959 P12868 tandem affinity purification 11805826 physical association X 2 P38959 P20795 tandem affinity purification 11805826 physical association X 2 P38959 Q08951 two hybrid 10559961 physical association X 2 P38959 Q08951 affinity chromatography technology 10559961 physical association X 2 P38959 inferred by author 11805826 physical association C 10 P38959 tandem affinity purification 11805826 - C 8 P38959 pull down 23051737 - C 4 P38959 P04173 anti tag coimmunoprecipitation 11805837 physical association X 2 P38959 Q12241 pull down 23051737 physical association X 2 P38959 P38623 anti tag coimmunoprecipitation 11805837 physical association X 2 P38959 P27801 tandem affinity purification 11805826 physical association X 2 P38959 P27801 tandem affinity purification 11805826 physical association X 2 P38959 Q03308 tandem affinity purification 11805826 physical association X 2 P38959 Q07468 tandem affinity purification 11805826 physical association X 2 P38959 Q07468 coimmunoprecipitation 9111041 physical association X 2 P38959 inferred by author 16429126 physical association C 9 P38959 tandem affinity purification 16429126 association C 7 P38959 anti bait coimmunoprecipitation 10944212 association C 6 P38959 anti bait coimmunoprecipitation 10944212 association C 6 P38959 anti bait coimmunoprecipitation 10944212 association C 6 P38959 anti bait coimmunoprecipitation 10944212 association C 6 P38959 anti bait coimmunoprecipitation 10944212 association C 6 P38959 cosedimentation through density gradient 10944212 physical association C 6 P38959 anti bait coimmunoprecipitation 10944212 association C 6 P38959 tandem affinity purification 21179020 association C 57 P38959 tandem affinity purification 16429126 association C 11 P38959 P20795 affinity chromatography technology 16601699 physical association X 2 P38959 tandem affinity purification 11805826 association C 8 P38959 tandem affinity purification 11805826 association C 9 P38959 tandem affinity purification 11805826 association C 9 P38959 tandem affinity purification 16429126 association C 10 P38959 P38623 anti tag coimmunoprecipitation 11805837 physical association X 2 P38959 P32912 pull down 16601699 physical association X 2 P38959 P40150 tandem affinity purification 19536198 association X 2 P38959 mass spectrometry studies of complexes 11805837 - C 5 P38959 mass spectrometry studies of complexes 11805826 - C 13 P38959 mass spectrometry studies of complexes 11805826 - C 13 P38959 P40395 interaction detection method 14764870 - X 2 P38959 Q99260 interaction detection method 14764870 - X 2 P38959 Q07468 protein cross-linking with a bifunctional reagent - - X 2 P38959 Q07468 confirmational text mining - - X 2 P38959 P36017 interaction detection method 9438133 - X 2

PPI - HINT Gene A Gene B PMID Method Quality PEP5 VPS41 21325627,21325627 0018,0096 LC KEX2 VPS41 10559961 0401 LC VPS33 VPS41 15889152 0401 LC VPS3 VPS41 21325627 0018 LC PEP3 VPS41 25324549,20604902,25324549,21325627,10944212,20604902,10944212,10944212 0401,0004,0004,0018,0004,0018,0029,0006 LC YPT7 VPS41 20604902,18809726,21325627,18809726,20604902,18809726,21325627 0004,0096,0018,0018,0018,0004,0096 LC YPT52 VPS41 21325627 0018 LC VPS41 YCK3 21079247,19386605,25411340 0415,0415,0415 LC VPS41 GEA2 18809726 0018 LC VPS41 SSB2 23332755 0401 LC VPS41 PGD1 18809726 0018 LC VPS41 ARF3 18809726 0018 LC VPS41 CSM3 18809726 0018 LC VPS41 VAM6 21325627,15889152,9111041,9111041,21325627 0018,0401,0004,0019,0096 LC VPS41 APL5 10559961,11160821,11160821,10559961,21079247,21079247,10559961,21079247 0096,0018,0004,0018,0004,0401,0004,0018 LC VPS41 NSL1 18809726 0018 LC VPS41 VAM3 18809726 0018 LC TEF1|TEF2 VPS41 16429126 0676 HT LEU2 VPS41 11805837 0007 HT RPL4A VPS41 16429126 0676 HT PEP5 VPS41 20604902,16429126,25324549,21325627,16429126,11805826,17488625,10944212,11805826,21079247,17200106,19193765,11805826,10944212,21325627 0004,0004,0004,0018,0676,0676,0004,0004,0004,0004,0004,0004,0007,0006,0096 LC,HT KEX2 VPS41 10559961 0401 LC VMA2 VPS41 16429126 0676 HT VPS33 VPS41 20604902,16429126,25324549,22940862,16429126,11805826,17488625,10944212,18385512,11805826,17200106,16601699,15889152,19193765,11805826,10944212 0004,0004,0004,0004,0676,0676,0004,0004,0096,0004,0004,0004,0401,0004,0007,0006 LC,HT VPS3 VPS41 17488625,20604902 0004,0004 LC PEP3 VPS41 25324549,11805826,20604902,16429126,25324549,16429126,11805826,17488625,10944212,19193765,11805826,17200106,20604902,10944212,10944212 0401,0007,0004,0004,0004,0676,0676,0004,0004,0004,0004,0004,0018,0029,0006 LC,HT GLC7 VPS41 21179020 0676 HT VAM7 VPS41 21613544,15889152,16601699,16601699,21613544 0096,0004,0096,0004,0004 LC YPT7 VPS41 21062894,20604902,18809726,21325627,18809726,20604902,18809726,19386605,21325627 0004,0004,0096,0018,0018,0018,0004,0004,0096 LC YKT6 VPS41 21613544,10725336,21613544 0004,0004,0096 LC AAP1 VPS41 16429126 0363 HT RCK2 VPS41 11805837,11805837 0004,0007 HT VPS41 VPS41 11805826,11160821,22754631,11805826 0676,0096,0004,0007 HT,LC VPS41 SSB2 19536198,23332755 0676,0401 HT,LC VPS41 SNU71 11805826,16429126,11805826,11805826 0004,0676,0007,0676 HT VPS41 VPS16 20604902,16429126,25324549,22940862,10944212,11805826,17488625,10944212,11805826,17200106,19193765,11805826,16429126 0004,0004,0004,0004,0006,0676,0004,0004,0004,0004,0004,0007,0676 LC,HT VPS41 VTI1 15889152,21613544,21613544 0004,0004,0096 LC VPS41 MMS22 26849847 0004 LC VPS41 VAM6 19193765,17200106,22754631,25324549,22940862,10944212,17488625,21325627,16429126,10725336,11805826,21079247,15889152,20604902,9111041,10944212,9111041,11805826,11805826,16429126,21325627 0004,0004,0004,0004,0004,0004,0004,0018,0676,0004,0004,0004,0401,0004,0004,0006,0019,0676,0007,0004,0096 LC,HT VPS41 LUC7 11805826,16429126,11805826,11805826 0004,0676,0007,0676 HT VPS41 APL5 10559961,11160821,11160821,10559961,21079247,21079247,10559961,19741093,21079247 0096,0018,0004,0018,0004,0401,0004,0096,0018 LC VPS41 VAM3 23051737,10725336,15889152,21613544,23051737,10559961,21613544 0096,0004,0004,0096,0004,0004,0004 LC VPS41 NYV1 21613544,10725336 0004,0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P53207 P38959 SNU71 VPS41 0.332 11805826,16429126 Q12255 P38959 NYV1 VPS41 0.21 21613544 P38959 P12868 VPS41 PEP5 0.88 11805826,21079247,16429126,21325627,19193765,17488625,20604902,25324549 Q04338 P38959 VTI1 VPS41 0.454 21613544 P38959 P23643 VPS41 VPS3 0.681 20604902,21325627,17488625 Q12241 P38959 VAM3 VPS41 0.765 18809726,23051737,21613544,10559961 Q07468 P38959 VAM6 VPS41 0.946 21079247,9111041,21325627,19193765,17488625,25026036,20604902,22754631,25324549,11805826,16429126 Q08951 P38959 APL5 VPS41 0.932 21079247,19741093,11160821,10559961 P38959 P38959 VPS41 VPS41 0.569 11805826,11160821,22754631 P38959 P36015 VPS41 YKT6 0.569 10725336,21613544 P38959 P32939 VPS41 YPT7 0.914 21062894,18809726,20604902,21325627,19386605 P39962 P38959 YCK3 VPS41 0.772 21079247,25995379,19386605,25411340 P38959 P37898 VPS41 AAP1 0.126 16429126 P38959 P38199 VPS41 HEK2 0.126 18805955 P38959 P38623 VPS41 RCK2 0.309 11805837 P38959 P02994 VPS41 TEF2 0.126 16429126 P38959 P04173 VPS41 LEU2 0.126 11805837 P38959 P10664 VPS41 RPL4A 0.126 16429126 P38959 P13134 VPS41 KEX2 0.126 10559961 P38959 P16140 VPS41 VMA2 0.126 16429126 P38959 P27801 VPS41 PEP3 0.908 11805826,16429126,21325627,19193765,17488625,20604902,25324549 P38959 P32912 VPS41 VAM7 0.569 16601699,21613544 P38959 P36018 VPS41 YPT52 0.183 21325627 P39993 P38959 GEA2 VPS41 0.309 18809726 P40356 P38959 PGD1 VPS41 0.309 18809726 P40994 P38959 ARF3 VPS41 0.309 18809726 Q04659 P38959 CSM3 VPS41 0.309 18809726 Q07508 P38959 LUC7 VPS41 0.286 11805826,16429126 Q12143 P38959 NSL1 VPS41 0.309 18809726 P38959 P32598 VPS41 GLC7 0.126 21179020 P40150 P38959 SSB2 VPS41 0.126 19536198 Q03308 P38959 VPS16 VPS41 0.765 11805826,16429126,19193765,17488625,20604902,25324549 P38959 P20795 VPS41 VPS33 0.853 16601699,11805826,16429126,19193765,17488625,18385512,20604902,25324549 Q07807 P38959 PUF3 VPS41 0.126 26493364