PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus FZF1 APC4 17634282 biogrid exp SNF1 APC4 17634282 biogrid exp RFA1 APC4 25719602 biogrid exp SSA2 APC4 19536198 intact exp APC4 APC4 12477395,15060174 biogrid exp SSA1 APC4 19536198 intact exp KAR4 APC4 17634282 biogrid exp HSP82 APC4 19536198 intact exp APC4 DUS3 17634282 biogrid exp SSB1 APC4 19536198 intact exp JJJ3 APC4 19536198 intact exp NAB2 APC4 19840948 biogrid exp SNF4 APC4 17634282 biogrid exp Uncharacterized protein YMR134W APC4 17634282 biogrid exp SSE1 APC4 19536198 intact exp ECM13 APC4 17634282 biogrid exp SSB2 APC4 19536198 intact exp CDC5 APC4 19013276, 23023127 biogrid,intact exp, pred CDC23 APC4 12477395,15060174,16481473,17634282,21186364,16554755,9469814, 23023127 biogrid,i2d,mint,intact,dip exp, pred CDC16 APC4 10318877,16429126,12402045,21186364,9469814,16364911,16275330,15060174,17406682,12887895,15797379,12477395,21107322,16554755,15649358,12574115,23751495, 23023127 biogrid,i2d,mint,intact,dip exp, pred YDJ1 APC4 19536198, 23023127 intact exp, pred DOC1 APC4 12477395,10318877,15060174,21186364,16554755,9469814, 23023127 biogrid,i2d,mint,intact,dip exp, pred APC4 APC9 12477395,15060174,21186364,16554755,9469814, 23023127 biogrid,i2d,mint,intact,dip exp, pred CDC27 APC4 12477395,15060174,12609981,21186364,16554755,9469814, 23023127 biogrid,i2d,mint,intact,dip exp, pred APC4 SWM1 12477395,15060174,12609981,12574115, 23023127 biogrid,intact exp, pred MND2 APC4 12477395,15060174,12609981,21186364,12574115, 23023127 biogrid,intact exp, pred APC4 APC11 12477395,15060174,21186364,9469814, 23023127 biogrid,i2d,intact,dip exp, pred APC4 RLF2 17634282, 23023127 biogrid exp, pred APC4 APC2 12477395,15060174,21186364,16554755,9469814,15797379, 23023127 biogrid,i2d,mint,intact,dip exp, pred APC1 APC4 12477395,16429126,15060174,16481473,21186364,9469814, 23023127 biogrid,i2d,intact,dip exp, pred CDC26 APC4 12477395,15060174,9469814, 23023127 biogrid,i2d,intact,dip exp, pred APC4 APC5 12477395,16429126,21307936,15060174,17634282,21186364,9469814, 23023127 biogrid,i2d,intact,dip exp, pred DUO1 APC4 23023127 pred CEP3 APC4 23023127 pred CBF2 APC4 23023127 pred PDS1 APC4 23023127 pred ESP1 APC4 23023127 pred UBC9 APC4 23023127 pred SDS22 APC4 23023127 pred CDC20 APC4 23023127 pred MET30 APC4 23023127 pred SCC2 APC4 23023127 pred CDH1 APC4 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q04601 - 15797379 - C 13 Q04601 - 15649358 - C 13 Q04601 - 15916961 - C 7 Q04601 - 9469814 - C 12 Q04601 - 15916960 - C 3 Q04601 Q12157 - 9469814 - X 2 Q04601 P14724 - 9469814 - X 2 Q04601 - 9469814 - X 2 Q04601 Q12440 - 9469814 - X 2 Q04601 Q08683 - 9469814 - X 2 Q04601 P16522 - 9469814 - X 2 Q04601 - 15797379 - C 6 Q04601 - 15916960 - C 3 Q04601 - 15044803 - C 11 Q12107 Q04601 - 9469814 - X 2 Q04601 P53068 - 9469814 - X 2 Q04601 P09798 - 9469814 - X 2 Q04601 Q12379 affinity chromatography technology 12609981 physical association X 2 Q04601 Q12379 affinity chromatography technology 12574115 physical association X 2 Q04601 Q12379 affinity chromatography technology 15060174 physical association X 2 Q04601 Q12379 affinity chromatography technology 15060174 physical association X 2 Q04601 Q12440 affinity chromatography technology 15060174 physical association X 2 Q04601 Q12440 affinity chromatography technology 15060174 physical association X 2 Q04601 P53886 affinity chromatography technology 15060174 physical association X 2 Q04601 Q04601 affinity chromatography technology 15060174 physical association X 2 Q04601 Q08683 affinity chromatography technology 15060174 physical association X 2 Q04601 P16522 affinity chromatography technology 15060174 physical association X 2 Q04601 Q12157 affinity chromatography technology 15060174 physical association X 2 Q04601 P14724 affinity chromatography technology 15060174 physical association X 2 Q04601 P16522 affinity chromatography technology 9469814 physical association X 2 Q04601 Q12379 affinity chromatography technology 12477395 physical association X 2 Q04601 Q12379 affinity chromatography technology 12477395 physical association X 2 Q04601 P53886 affinity chromatography technology 12477395 physical association X 2 Q04601 Q12440 affinity chromatography technology 12477395 physical association X 2 Q04601 Q04601 affinity chromatography technology 12477395 physical association X 2 Q04601 Q08683 affinity chromatography technology 12477395 physical association X 2 Q04601 P16522 affinity chromatography technology 12477395 physical association X 2 Q04601 Q12157 affinity chromatography technology 12477395 physical association X 2 Q04601 P14724 affinity chromatography technology 12477395 physical association X 2 Q04601 Q12379 affinity chromatography technology 12477395 physical association X 2 Q04601 Q12379 affinity chromatography technology 12477395 physical association X 2 Q04601 P53886 affinity chromatography technology 9469814 physical association X 2 Q04601 Q12440 affinity chromatography technology 9469814 physical association X 2 Q04601 Q08683 affinity chromatography technology 9469814 physical association X 2 Q04601 Q12157 affinity chromatography technology 9469814 physical association X 2 Q04601 P53886 affinity chromatography technology 16481473 physical association X 2 Q04601 P16522 affinity chromatography technology 16481473 physical association X 2 Q04601 P16522 affinity chromatography technology 16554755 physical association X 2 Q04601 Q12440 affinity chromatography technology 16554755 physical association X 2 Q04601 Q08683 affinity chromatography technology 16429126 physical association X 2 Q04601 P16522 affinity chromatography technology 16481473 physical association X 2 Q04601 P16522 affinity chromatography technology 17200106 physical association X 2 Q04601 Q12440 affinity chromatography technology 17200106 physical association X 2 Q04601 P53886 affinity chromatography technology 17200106 physical association X 2 Q04601 Q08683 affinity chromatography technology 17200106 physical association X 2 Q04601 P25583 two hybrid 17634282 direct interaction X 2 Q04601 P06782 two hybrid 17634282 direct interaction X 2 Q04601 P12904 two hybrid 17634282 direct interaction X 2 Q04601 P32805 two hybrid 17634282 direct interaction X 2 Q04601 P16522 two hybrid 17634282 direct interaction X 2 Q04601 Q06053 two hybrid 17634282 direct interaction X 2 Q04601 P40207 two hybrid 17634282 direct interaction X 2 Q04601 Q08683 two hybrid 17634282 direct interaction X 2 Q04601 Q08683 two hybrid 17634282 direct interaction X 2 Q04601 P32562 affinity chromatography technology 19013276 physical association X 2 Q04601 Q12440 affinity chromatography technology 15797379 physical association X 2 Q04601 P53886 affinity chromatography technology 21186364 physical association X 2 Q04601 Q12440 affinity chromatography technology 21186364 physical association X 2 Q04601 Q08683 affinity chromatography technology 21186364 physical association X 2 Q04601 P16522 affinity chromatography technology 21186364 physical association X 2 Q04601 Q12157 affinity chromatography technology 21186364 physical association X 2 Q04601 Q08683 x-ray crystallography 21307936 association X 2 Q04601 Q08683 pull down 21307936 direct interaction X 2 Q12107 Q04601 affinity chromatography technology 15060174 physical association X 2 Q12107 Q04601 affinity chromatography technology 12477395 physical association X 2 Q12107 Q04601 affinity chromatography technology 9469814 physical association X 2 Q12107 Q04601 affinity chromatography technology 16554755 physical association X 2 Q12107 Q04601 affinity chromatography technology 17200106 physical association X 2 Q12107 Q04601 affinity chromatography technology 21186364 physical association X 2 Q04601 P09798 affinity chromatography technology 12574115 physical association X 2 Q04601 P09798 affinity chromatography technology 10318877 physical association X 2 Q04601 P38042 affinity chromatography technology 12609981 physical association X 2 Q04601 P53068 affinity chromatography technology 10318877 physical association X 2 Q04601 P40577 affinity chromatography technology 12609981 physical association X 2 Q04601 P40577 affinity chromatography technology 12574115 physical association X 2 Q04601 P09798 affinity chromatography technology 12887895 physical association X 2 Q04601 P09798 affinity chromatography technology 12402045 physical association X 2 Q04601 P09798 affinity chromatography technology 15649358 physical association X 2 Q04601 P09798 affinity chromatography technology 15060174 physical association X 2 Q04601 P09798 affinity chromatography technology 15060174 physical association X 2 Q04601 P38042 affinity chromatography technology 15060174 physical association X 2 Q04601 P40577 affinity chromatography technology 15060174 physical association X 2 Q04601 P53068 affinity chromatography technology 15060174 physical association X 2 Q04601 P09798 affinity chromatography technology 9469814 physical association X 2 Q04601 P40577 affinity chromatography technology 12477395 physical association X 2 Q04601 P40577 affinity chromatography technology 12477395 physical association X 2 Q04601 P38042 affinity chromatography technology 12477395 physical association X 2 Q04601 P09798 affinity chromatography technology 12477395 physical association X 2 Q04601 P53068 affinity chromatography technology 12477395 physical association X 2 Q04601 P40577 affinity chromatography technology 12477395 physical association X 2 Q04601 P40577 affinity chromatography technology 12477395 physical association X 2 Q04601 P38042 affinity chromatography technology 9469814 physical association X 2 Q04601 P53068 affinity chromatography technology 9469814 physical association X 2 Q04601 P09798 affinity chromatography technology 23751495 physical association X 2 Q04601 P53068 affinity chromatography technology 16554755 physical association X 2 Q04601 P38042 affinity chromatography technology 16554755 physical association X 2 Q04601 P09798 affinity chromatography technology 16554755 physical association X 2 Q04601 P09798 affinity chromatography technology 16429126 physical association X 2 Q04601 P09798 affinity chromatography technology 16275330 physical association X 2 Q04601 P38042 affinity chromatography technology 17200106 physical association X 2 Q04601 P09798 affinity chromatography technology 17200106 physical association X 2 Q04601 P38195 two hybrid 17634282 direct interaction X 2 Q04601 Q12495 two hybrid 17634282 direct interaction X 2 Q04601 P09798 affinity chromatography technology 17406682 physical association X 2 Q04601 P09798 affinity chromatography technology 15797379 physical association X 2 Q04601 P09798 affinity chromatography technology 21186364 physical association X 2 Q04601 P38042 affinity chromatography technology 21186364 physical association X 2 Q04601 P40577 affinity chromatography technology 21186364 physical association X 2 Q04601 P53068 affinity chromatography technology 21186364 physical association X 2 Q04601 P09798 affinity chromatography technology 21186364 physical association X 2 Q04601 P09798 affinity chromatography technology 16364911 physical association X 2 Q04601 pull down 21107322 - C 13 Q04601 tandem affinity purification 21107322 - C 12 Q04601 tandem affinity purification 21107322 - C 13 Q04601 coimmunoprecipitation 9469814 physical association X 2 Q04601 P16522 coimmunoprecipitation 9469814 physical association X 2 Q04601 Q12440 coimmunoprecipitation 9469814 physical association X 2 Q04601 Q08683 coimmunoprecipitation 9469814 physical association X 2 Q04601 Q08683 tandem affinity purification 21186364 physical association X 2 Q04601 Q08683 tandem affinity purification 21186364 physical association X 2 Q04601 coimmunoprecipitation 9469814 physical association X 2 Q04601 tandem affinity purification 21186364 physical association X 2 Q04601 Q12157 coimmunoprecipitation 9469814 physical association X 2 Q04601 P14724 coimmunoprecipitation 9469814 physical association X 2 Q04601 tandem affinity purification 21186364 - C 3 Q04601 tandem affinity purification 21186364 physical association C 11 Q04601 electron tomography 21186364 physical association C 11 Q04601 pull down 21107322 - C 14 Q12107 Q04601 coimmunoprecipitation 9469814 physical association X 2 Q04601 P09798 tandem affinity purification 21186364 physical association X 2 Q04601 P09798 tandem affinity purification 21107322 physical association X 2 Q04601 P09798 tandem affinity purification 21107322 physical association X 2 Q04601 P09798 pull down 21107322 physical association X 2 Q04601 P09798 pull down 21107322 physical association X 2 Q04601 P38042 coimmunoprecipitation 9469814 physical association X 2 Q04601 anti tag coimmunoprecipitation 9469814 association C 9 Q04601 anti tag coimmunoprecipitation 9469814 association C 9 Q04601 anti tag coimmunoprecipitation 9469814 association C 9 Q04601 anti tag coimmunoprecipitation 9469814 association C 9 Q04601 anti tag coimmunoprecipitation 9469814 association C 9 Q04601 tandem affinity purification 16429126 association C 22 Q04601 affinity chromatography technology 12609981 association C 11 Q04601 affinity chromatography technology 12609981 association C 11 Q04601 inferred by author 16554755 association C 12 Q04601 tandem affinity purification 12477395 association C 13 Q04601 tandem affinity purification 12477395 association C 13 Q04601 tandem affinity purification 12477395 association C 13 Q04601 affinity chromatography technology 12609981 association C 13 Q04601 anti tag coimmunoprecipitation 9469814 association C 7 Q04601 anti tag coimmunoprecipitation 9469814 association C 10 Q04601 anti tag coimmunoprecipitation 9469814 association C 10 Q04601 anti tag coimmunoprecipitation 9469814 association C 10 Q04601 anti tag coimmunoprecipitation 9469814 association C 12 Q04601 anti tag coimmunoprecipitation 9469814 association C 12 Q04601 anti tag coimmunoprecipitation 9469814 association C 12 Q04601 anti tag coimmunoprecipitation 9469814 association C 12 Q04601 anti tag coimmunoprecipitation 9469814 association C 12 Q04601 Q12379 anti tag coimmunoprecipitation 12477395 physical association X 2 Q04601 Q12379 anti tag coimmunoprecipitation 12477395 physical association X 2 Q04601 Q12440 tandem affinity purification 16554755 physical association X 2 Q04601 P16522 tandem affinity purification 16554755 physical association X 2 Q04601 P25491 tandem affinity purification 19536198 association X 2 Q04601 P10591 tandem affinity purification 19536198 association X 2 Q04601 P40150 tandem affinity purification 19536198 association X 2 Q04601 P02829 tandem affinity purification 19536198 association X 2 Q04601 tandem affinity purification 19013276 association C 41 Q04601 tandem affinity purification 16429126 association C 19 Q04601 inferred by author 16429126 physical association C 9 Q04601 anti tag coimmunoprecipitation 9469814 association C 8 Q04601 anti tag coimmunoprecipitation 9469814 association C 8 Q04601 anti tag coimmunoprecipitation 9469814 association C 7 Q04601 anti tag coimmunoprecipitation 9469814 association C 7 Q12107 Q04601 tandem affinity purification 16554755 physical association X 2 Q04601 P40577 anti tag coimmunoprecipitation 12477395 physical association X 2 Q04601 P40577 anti tag coimmunoprecipitation 12477395 physical association X 2 Q04601 P09798 tandem affinity purification 16554755 physical association X 2 Q04601 P38042 tandem affinity purification 16554755 physical association X 2 Q04601 P53068 tandem affinity purification 16554755 physical association X 2 Q04601 P53068 tandem affinity purification 16554755 physical association X 2 Q04601 P47138 tandem affinity purification 19536198 association X 2 Q04601 P11484 tandem affinity purification 19536198 association X 2 Q04601 P10592 tandem affinity purification 19536198 association X 2 Q04601 P32589 tandem affinity purification 19536198 association X 2 Q04601 Q12157 coimmunoprecipitation 9469814 - X 2 Q04601 P14724 coimmunoprecipitation 9469814 - X 2 Q04601 P16522 coimmunoprecipitation 9469814 - X 2 Q04601 Q12440 coimmunoprecipitation 9469814 - X 2 Q04601 P53886 coimmunoprecipitation 9469814 - X 2 Q04601 Q08683 coimmunoprecipitation 9469814 - X 2 Q04601 confirmational text mining - - C 11 Q12107 Q04601 coimmunoprecipitation 9469814 - X 2 Q04601 P53068 coimmunoprecipitation 9469814 - X 2 Q04601 P09798 coimmunoprecipitation 9469814 - X 2 Q04601 P38042 coimmunoprecipitation 7925276,9348530 - X 2 Q04601 P38042 coimmunoprecipitation 9469814 - X 2

PPI - HINT Gene A Gene B PMID Method Quality SNF1 APC4 17634282 0018 HT CDC16 APC4 9469814,9469814,9469814 0004,0019,0007 LC SNF4 APC4 17634282 0018 HT CDC26 APC4 9469814,9469814 0019,0007 LC CDC23 APC4 9469814,17634282,9469814,9469814 0004,0018,0019,0007 LC,HT RFA1 APC4 25719602 0018 LC KAR4 APC4 17634282 0018 HT FZF1 APC4 17634282 0018 HT CDC27 APC4 7925276,9469814,9348530,9469814,9469814 0019,0004,0019,0019,0007 LC ECM13 APC4 17634282 0018 HT P40207 APC4 17634282 0018 HT PDS1 APC4 16364911 0415 LC DOC1 APC4 9469814,9469814,9469814 0004,0019,0007 LC NRM1 APC4 21562221 0415 LC APC1 APC4 9469814,9469814,9469814 0004,0019,0007 LC YHP1 APC4 21562221 0415 LC APC4 DUS3 17634282 0018 HT APC4 APC5 9469814,21307936,17634282,21307936,9469814,9469814 0004,0114,0018,0096,0019,0007 LC,HT APC4 APC9 9469814,9469814,9469814 0004,0019,0007 LC APC4 APC11 9469814,9469814,9469814 0004,0019,0007 LC APC4 APC2 9469814,9469814,9469814 0004,0019,0007 LC APC4 RLF2 17634282 0018 HT HSP82 APC4 19536198 0676 HT CDC16 APC4 12477395,23751495,17406682,21186364,21107322,12574115,17200106,9469814,12887895,12402045,9469814,15797379,16554755,21107322,16429126,10318877,15649358,12477395,16554755,15060174,16429126,21186364,16275330,16364911,9469814 0676,0004,0004,0676,0096,0004,0004,0004,0004,0004,0019,0004,0676,0676,0676,0004,0004,0004,0004,0004,0004,0004,0004,0004,0007 LC,HT SSA1 APC4 19536198 0676 HT SSA2 APC4 19536198 0676 HT SSB1 APC4 19536198 0676 HT CDC26 APC4 12477395,15060174,12477395,9469814,9469814 0004,0004,0676,0019,0007 LC CDC23 APC4 12477395,16554755,9469814,15060174,12477395,16481473,21186364,9469814,17200106,9469814,16554755 0676,0676,0004,0004,0004,0004,0004,0019,0004,0007,0004 LC,HT YDJ1 APC4 19536198 0676 HT NAB2 APC4 19840948 0004 LC CDC5 APC4 19013276,19013276 0004,0676 LC SSE1 APC4 19536198 0676 HT CDC27 APC4 12609981,16554755,12477395,9469814,12477395,15060174,21186364,9469814,17200106,9469814,16554755 0004,0676,0676,0004,0004,0004,0004,0019,0004,0007,0004 LC,HT SSB2 APC4 19536198 0676 HT MND2 APC4 12477395,12609981,12477395,12477395,15060174,21186364,12574115 0676,0004,0007,0004,0004,0004,0004 LC JJJ3 APC4 19536198 0676 HT DOC1 APC4 12477395,16554755,16554755,9469814,15060174,12477395,21186364,10318877,21186364,9469814,9469814,16554755 0676,0363,0676,0004,0004,0004,0004,0004,0676,0019,0007,0004 LC,HT CDH1 APC4 21107322 0004 LC APC1 APC4 12477395,9469814,15060174,12477395,16481473,21186364,9469814,17200106,9469814,16429126 0676,0004,0004,0004,0004,0004,0019,0004,0007,0363 LC,HT APC4 APC4 12477395,15060174 0004,0004 LC APC4 APC5 12477395,9469814,21307936,16429126,15060174,12477395,21186364,21307936,17200106,21186364,9469814,16429126,9469814 0676,0004,0114,0004,0004,0004,0004,0096,0004,0676,0019,0676,0007 LC,HT APC4 APC9 12477395,16554755,9469814,15060174,12477395,21186364,9469814,17200106,9469814,16554755 0676,0676,0004,0004,0004,0004,0019,0004,0007,0004 LC,HT APC4 APC11 12477395,9469814,15060174,12477395,21186364,9469814,9469814 0676,0004,0004,0004,0004,0019,0007 LC APC4 SWM1 12477395,12609981,12477395,12477395,15060174,12574115 0676,0004,0007,0004,0004,0004 LC APC4 APC2 12477395,16554755,9469814,15060174,12477395,16554755,21186364,9469814,17200106,9469814,15797379 0676,0676,0004,0004,0004,0004,0004,0019,0004,0007,0004 LC,HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q04601 P53068 APC4 DOC1 0.731 10318877,12477395,16554755,9469814,21186364 Q04601 P22336 APC4 RFA1 0.309 25719602 Q04601 P47138 APC4 JJJ3 0.126 19536198 Q04601 P11484 APC4 SSB1 0.126 19536198 Q04601 P10592 APC4 SSA2 0.126 19536198 Q04601 P02829 APC4 HSP82 0.126 19536198 Q04601 P06782 APC4 SNF1 0.183 17634282 Q04601 P10591 APC4 SSA1 0.126 19536198 Q04601 P12904 APC4 SNF4 0.183 17634282 Q04601 P16522 APC4 CDC23 0.765 12477395,17634282,16554755,9469814,16481473,21186364 Q04601 P32562 APC4 CDC5 0.332 19013276 Q04601 P25491 APC4 YDJ1 0.126 19536198 Q04601 P25583 APC4 KAR4 0.183 17634282 Q04601 P32805 APC4 FZF1 0.183 17634282 Q04601 P40150 APC4 SSB2 0.126 19536198 Q04601 P40207 APC4 P40207 0.183 17634282 Q04601 P38195 APC4 ECM13 0.183 17634282 Q08683 Q04601 APC5 APC4 0.863 16429126,12477395,21307936,17634282,9469814,21186364 Q06053 Q04601 DUS3 APC4 0.183 17634282 Q04601 Q04601 APC4 APC4 0.155 12477395 Q12107 Q04601 APC9 APC4 0.569 12477395,16554755,9469814,21186364 Q12440 Q04601 APC2 APC4 0.722 12477395,16554755,9469814,15797379,21186364 Q12495 Q04601 RLF2 APC4 0.183 17634282 Q12157 Q04601 APC11 APC4 0.523 9469814,21186364,12477395 Q12379 Q04601 SWM1 APC4 0.49 12477395 Q04601 P40577 APC4 MND2 0.597 21186364,12477395 Q04601 P09798 APC4 CDC16 0.934 16275330,17406682,16429126,12477395,16554755,9469814,15797379,21186364,16364911,23751495 Q04601 P38042 APC4 CDC27 0.648 12477395,16554755,9469814,21186364 Q04601 P32505 APC4 NAB2 0.126 19840948 Q04601 P32589 APC4 SSE1 0.126 19536198 Q04601 P14724 APC4 CDC26 0.332 9469814,12477395 Q04601 P53886 APC4 APC1 0.692 16429126,12477395,9469814,21186364,16481473