PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus TUB3 F-box protein YDR131C 11805837 dip exp LYS14 F-box protein YDR131C 11283351 i2d,mint,intact,dip exp HSP82 F-box protein YDR131C 15766533 biogrid,i2d exp YDJ1 F-box protein YDR131C 11805837 dip exp F-box protein YDR131C THI21 11805837 dip exp F-box protein YDR131C PRP11 9207794 biogrid,i2d,dip exp VMA2 F-box protein YDR131C 11805837 dip exp F-box protein YDR131C ASR1 11805837 biogrid,mint,intact,dip exp TEF1, TEF2 F-box protein YDR131C 11805837 dip exp YRB2 F-box protein YDR131C 11805837 biogrid,intact,dip exp HSP60 F-box protein YDR131C 11805837 dip exp ATP1 F-box protein YDR131C 11805837 dip exp ATP2 F-box protein YDR131C 11805837 dip exp GAL1 F-box protein YDR131C 11805837 dip exp ALD4 F-box protein YDR131C 11805837 dip exp F-box protein YDR131C LAG2 19763088 biogrid exp F-box protein YDR131C THI20 11805837 dip exp PGI1 F-box protein YDR131C 11805837 dip exp SAM1 F-box protein YDR131C 11805837 dip exp SKP1 F-box protein YDR131C 23000173,14747994,11805837, 23023127 biogrid,mint,intact,dip exp, pred F-box protein YDR131C CDC53 10582239,14747994, 23023127 biogrid exp, pred RIX1 F-box protein YDR131C 11805837, 23023127 biogrid,mint,intact,dip exp, pred F-box protein YDR131C HRT1 14747994, 23023127 biogrid exp, pred GRR1 F-box protein YDR131C 23023127 pred F-box protein YDR131C RRI2 23023127 pred F-box protein YDR131C RPN9 23023127 pred F-box protein YDR131C SOV1 23023127 pred Uncharacterized protein YGL117W F-box protein YDR131C 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q03899 - 11805837 - C 7 Q03899 P40517 - 11805837 - X 2 Q03899 - 11805837 - X 2 Q03899 P52286 - 11805837 - X 2 Q03899 P52286 - 11805837 - X 2 Q03899 - 11805837 - C 8 Q03899 P02829 - 15766533 - X 2 Q03899 Q07350 - 9207794 - X 2 Q03899 P40971 - 11283351 - X 2 Q03899 P52286 pull down 23000173 direct interaction X 2 Q03899 P52286 pull down 14747994 direct interaction X 2 Q03899 Q92325 two hybrid 19763088 direct interaction X 2 Q03899 P52286 affinity chromatography technology 11805837 physical association X 2 Q03899 P52286 affinity chromatography technology 11805837 physical association X 2 Q03899 P38883 affinity chromatography technology 11805837 physical association X 2 Q03899 Q06834 affinity chromatography technology 11805837 physical association X 2 Q03899 P40517 affinity chromatography technology 11805837 physical association X 2 Q03899 Q08273 pull down 14747994 direct interaction X 2 Q03899 Q12018 pull down 14747994 direct interaction X 2 Q03899 Q12018 affinity chromatography technology 10582239 physical association X 2 Q03899 Q07350 two hybrid 9207794 direct interaction X 2 Q03899 P02829 two hybrid 15766533 direct interaction X 2 Q03899 anti tag coimmunoprecipitation 11805837 - C 3 Q03899 affinity chromatography technology 14747994 - C 4 Q03899 anti tag coimmunoprecipitation 11805837 - C 7 Q03899 anti tag coimmunoprecipitation 11805837 - C 7 Q03899 P07251 anti tag coimmunoprecipitation 11805837 physical association X 2 Q03899 P04385 anti tag coimmunoprecipitation 11805837 physical association X 2 Q03899 P12709 anti tag coimmunoprecipitation 11805837 physical association X 2 Q03899 P02994 anti tag coimmunoprecipitation 11805837 physical association X 2 Q03899 Q08975 anti tag coimmunoprecipitation 11805837 physical association X 2 Q03899 P16140 anti tag coimmunoprecipitation 11805837 physical association X 2 Q03899 P25491 anti tag coimmunoprecipitation 11805837 physical association X 2 Q03899 P52286 anti tag coimmunoprecipitation 11805837 physical association X 2 Q03899 P52286 affinity chromatography technology 14747994 physical association X 2 Q03899 P52286 anti tag coimmunoprecipitation 11805837 physical association X 2 Q03899 anti tag coimmunoprecipitation 11805837 physical association X 2 Q03899 P40517 anti tag coimmunoprecipitation 11805837 physical association X 2 Q03899 Q06834 anti tag coimmunoprecipitation 11805837 physical association X 2 Q03899 anti tag coimmunoprecipitation 11805837 - C 9 Q03899 anti tag coimmunoprecipitation 11805837 - C 16 Q03899 anti tag coimmunoprecipitation 11805837 - C 13 Q03899 anti tag coimmunoprecipitation 11805837 - C 12 Q03899 anti tag coimmunoprecipitation 11805837 - C 8 Q03899 P46367 anti tag coimmunoprecipitation 11805837 physical association X 2 Q03899 P00830 anti tag coimmunoprecipitation 11805837 physical association X 2 Q03899 P19882 anti tag coimmunoprecipitation 11805837 physical association X 2 Q03899 P10659 anti tag coimmunoprecipitation 11805837 physical association X 2 Q03899 Q08224 anti tag coimmunoprecipitation 11805837 physical association X 2 Q03899 P09734 anti tag coimmunoprecipitation 11805837 physical association X 2 Q03899 Q07350 two hybrid 9207794 physical association X 2 Q03899 P40971 two hybrid pooling approach 11283351 physical association X 2 Q03899 anti tag coimmunoprecipitation 11805837 association C 7 Q03899 P52286 anti tag coimmunoprecipitation 11805837 physical association X 2 Q03899 P38883 anti tag coimmunoprecipitation 11805837 physical association X 2 Q03899 P40517 anti tag coimmunoprecipitation 11805837 physical association X 2 Q03899 P52286 anti tag coimmunoprecipitation 11805837 association X 2 Q03899 anti tag coimmunoprecipitation 11805837 association C 8 Q03899 P40971 two hybrid fragment pooling approach 11283351 physical association X 2 Q03899 mass spectrometry studies of complexes 11805837 - C 4 Q03899 mass spectrometry studies of complexes 11805837 - C 4 Q03899 mass spectrometry studies of complexes 11805837 - C 9 Q03899 mass spectrometry studies of complexes 11805837 - C 8 Q03899 mass spectrometry studies of complexes 11805837 - C 8 Q03899 Q07350 two hybrid 9207794 - X 2 Q03899 P40971 two hybrid 11283351 - X 2

PPI - HINT Gene A Gene B PMID Method Quality HSP82 Q03899 15766533 0018 LC LYS14 Q03899 11283351,11283351,11283351 0018,0399,0398 HT Q03899 PRP11 9207794 0018 HT Q03899 LAG2 19763088 0018 LC ATP2 Q03899 11805837 0007 HT TEF1|TEF2 Q03899 11805837 0007 HT GAL1 Q03899 11805837 0007 HT ATP1 Q03899 11805837 0007 HT TUB3 Q03899 11805837 0007 HT SAM1 Q03899 11805837 0007 HT PGI1 Q03899 11805837 0007 HT VMA2 Q03899 11805837 0007 HT HSP60 Q03899 11805837 0007 HT YDJ1 Q03899 11805837 0007 HT RIX1 Q03899 11805837,11805837 0004,0007 HT YRB2 Q03899 11805837,11805837 0004,0007 HT ALD4 Q03899 11805837 0007 HT SKP1 Q03899 11805837,23000173,14747994,11805837,14747994 0004,0096,0096,0007,0004 HT,LC Q03899 ASR1 11805837,11805837 0004,0007 HT Q03899 THI20 11805837 0007 HT Q03899 HRT1 14747994 0096 LC Q03899 THI21 11805837 0007 HT Q03899 CDC53 14747994,10582239 0096,0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q03899 P16140 Q03899 VMA2 0.126 11805837 Q03899 P00830 Q03899 ATP2 0.126 11805837 Q03899 P10659 Q03899 SAM1 0.126 11805837 Q03899 P02829 Q03899 HSP82 0.183 15766533 Q03899 P02994 Q03899 TEF2 0.126 11805837 Q03899 P12709 Q03899 PGI1 0.126 11805837 Q03899 P04385 Q03899 GAL1 0.126 11805837 Q03899 P07251 Q03899 ATP1 0.126 11805837 Q12018 Q03899 CDC53 Q03899 0.454 10582239,14747994 Q03899 P38883 Q03899 RIX1 0.236 11805837 Q03899 P40517 Q03899 YRB2 0.236 11805837 Q03899 P40971 Q03899 LYS14 0.236 11283351 Q03899 P52286 Q03899 SKP1 0.436 11805837,14747994,23000173 Q03899 P19882 Q03899 HSP60 0.126 11805837 Q07350 Q03899 PRP11 Q03899 0.033 9207794 Q03899 P25491 Q03899 YDJ1 0.126 11805837 Q03899 P09734 Q03899 TUB3 0.126 11805837 Q03899 P46367 Q03899 ALD4 0.126 11805837 Q92325 Q03899 LAG2 Q03899 0.309 19763088 Q06834 Q03899 ASR1 Q03899 0.332 11805837 Q08975 Q03899 THI21 Q03899 0.126 11805837 Q08224 Q03899 THI20 Q03899 0.126 11805837