PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus LEU2 SWM1 11805837 dip exp GAL1 SWM1 11805837 dip exp PFK2 SWM1 11805837 dip exp GPM1 SWM1 11805837 dip exp SWM1 SWM1 12477395,15060174 biogrid exp NAM7 SWM1 18087042 biogrid exp VMA2 SWM1 11805837 dip exp RPB9 SWM1 11283351 i2d,mint,intact,dip exp PRP28 SWM1 11805837 biogrid,mint,intact,dip exp SSC1 SWM1 11805837 dip exp CHC1 SWM1 11805837 dip exp MSL5 SWM1 11283351 i2d,mint,intact,dip exp SAM1 SWM1 11805837 dip exp SCJ1 SWM1 11805837 dip exp ARO1 SWM1 11805837 biogrid,mint,intact,dip exp NSE5 SWM1 14690591 biogrid,i2d,intact exp SSB2 SWM1 23332755 biogrid exp CPA1 SWM1 11805837 biogrid,mint,intact,dip exp YDJ1 SWM1 11805837 dip exp URA7 SWM1 11805837 biogrid,mint,intact,dip exp CCT8 SWM1 11805837 dip exp PRB1 SWM1 11805837, 23023127 biogrid,mint,intact,dip exp, pred APC9 SWM1 12477395,15060174,12609981,12574115, 23023127 biogrid,intact exp, pred CDC16 SWM1 12477395,21107322,9469814,16364911,15649358,15060174,16275330,17406682,12609981,12574115,15797379, 23023127 biogrid,intact,dip exp, pred CDC27 SWM1 12477395,15060174,12609981,12574115,9469814, 23023127 biogrid,intact exp, pred MND2 SWM1 12477395,15060174,12609981,12574115, 23023127 biogrid,intact exp, pred CDC26 SWM1 12477395,15060174,12574115,9469814, 23023127 biogrid,intact exp, pred APC11 SWM1 12477395,15060174,12574115, 23023127 biogrid,intact exp, pred APC4 SWM1 12477395,15060174,12609981,12574115, 23023127 biogrid,intact exp, pred DOC1 SWM1 12477395,15060174,12609981, 23023127 biogrid,intact exp, pred APC5 SWM1 12477395,16429126,15060174,12609981,12574115, 23023127 biogrid,intact exp, pred ARP2 SWM1 11805837, 23023127 biogrid,mint,intact,dip exp, pred CDC23 SWM1 12477395,15060174,17634282,12609981,12574115,9469814,11805837, 23023127 biogrid,mint,intact,dip exp, pred RNQ1 SWM1 11805837, 23023127 biogrid,mint,intact,dip exp, pred SWM1 APC2 12477395,15060174,12609981,12574115, 23023127 biogrid,intact exp, pred APC1 SWM1 12477395,15060174,12609981,12574115,9469814, 23023127 biogrid,intact exp, pred TCB3 SWM1 11805837, 23023127 biogrid,mint,intact,dip exp, pred PDS1 SWM1 23023127 pred AMA1 SWM1 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q12379 - 15797379 - C 13 Q12379 - 15649358 - C 13 Q12379 - 11805837 - C 9 Q12379 - 9469814 - C 12 P27999 Q12379 - 11283351 - X 2 Q12379 Q03718 - 14690591 - X 2 Q12379 - 11805837 - C 3 Q12379 Q12186 - 11283351 - X 2 Q12157 Q12379 affinity chromatography technology 12574115 physical association X 2 Q12157 Q12379 affinity chromatography technology 15060174 physical association X 2 Q12157 Q12379 affinity chromatography technology 12477395 physical association X 2 Q12379 P38042 affinity chromatography technology 12609981 physical association X 2 Q12379 P38042 affinity chromatography technology 12609981 physical association X 2 Q12379 P53886 affinity chromatography technology 12609981 physical association X 2 Q12379 P53886 affinity chromatography technology 12574115 physical association X 2 Q12379 P38042 affinity chromatography technology 12574115 physical association X 2 Q12379 P53886 affinity chromatography technology 15060174 physical association X 2 Q12379 P38042 affinity chromatography technology 15060174 physical association X 2 Q12379 Q12379 affinity chromatography technology 15060174 physical association X 2 Q12379 P53886 affinity chromatography technology 12477395 physical association X 2 Q12379 P38042 affinity chromatography technology 12477395 physical association X 2 Q12379 Q12379 affinity chromatography technology 12477395 physical association X 2 Q12379 P53886 biochemical 15060174 colocalization X 2 Q12379 P40150 biochemical 23332755 association X 2 Q12379 Q03718 two hybrid 14690591 direct interaction X 2 Q12379 P28274 affinity chromatography technology 11805837 physical association X 2 Q12379 P32381 affinity chromatography technology 11805837 physical association X 2 Q12379 P23394 affinity chromatography technology 11805837 physical association X 2 P53068 Q12379 affinity chromatography technology 12609981 physical association X 2 Q04601 Q12379 affinity chromatography technology 12609981 physical association X 2 Q04601 Q12379 affinity chromatography technology 12574115 physical association X 2 Q04601 Q12379 affinity chromatography technology 15060174 physical association X 2 Q04601 Q12379 affinity chromatography technology 15060174 physical association X 2 P53068 Q12379 affinity chromatography technology 15060174 physical association X 2 Q04601 Q12379 affinity chromatography technology 12477395 physical association X 2 Q04601 Q12379 affinity chromatography technology 12477395 physical association X 2 Q04601 Q12379 affinity chromatography technology 12477395 physical association X 2 Q04601 Q12379 affinity chromatography technology 12477395 physical association X 2 P14724 Q12379 affinity chromatography technology 12574115 physical association X 2 P14724 Q12379 affinity chromatography technology 15060174 physical association X 2 P14724 Q12379 affinity chromatography technology 12477395 physical association X 2 Q12440 Q12379 affinity chromatography technology 12609981 physical association X 2 Q12440 Q12379 affinity chromatography technology 12574115 physical association X 2 Q12440 Q12379 affinity chromatography technology 15060174 physical association X 2 Q12440 Q12379 affinity chromatography technology 15060174 physical association X 2 Q12440 Q12379 affinity chromatography technology 12477395 physical association X 2 P07258 Q12379 affinity chromatography technology 11805837 physical association X 2 P09232 Q12379 affinity chromatography technology 11805837 physical association X 2 Q12379 P09798 affinity chromatography technology 12574115 physical association X 2 Q12379 P09798 affinity chromatography technology 12574115 physical association X 2 Q12379 P40577 affinity chromatography technology 12609981 physical association X 2 Q12379 P40577 affinity chromatography technology 12609981 physical association X 2 Q12379 Q08683 affinity chromatography technology 12609981 physical association X 2 Q12379 P09798 affinity chromatography technology 12609981 physical association X 2 Q12379 P16522 affinity chromatography technology 12609981 physical association X 2 Q12379 Q08683 affinity chromatography technology 12574115 physical association X 2 Q12379 P16522 affinity chromatography technology 12574115 physical association X 2 Q12379 P40577 affinity chromatography technology 12574115 physical association X 2 Q12379 P09798 affinity chromatography technology 15060174 physical association X 2 Q12379 P09798 affinity chromatography technology 15060174 physical association X 2 Q12379 Q08683 affinity chromatography technology 15060174 physical association X 2 Q12379 P16522 affinity chromatography technology 15060174 physical association X 2 Q12379 P40577 affinity chromatography technology 15060174 physical association X 2 Q12379 Q08683 affinity chromatography technology 12477395 physical association X 2 Q12379 P09798 affinity chromatography technology 12477395 physical association X 2 Q12379 P16522 affinity chromatography technology 12477395 physical association X 2 Q12379 P40577 affinity chromatography technology 12477395 physical association X 2 Q12379 P40577 affinity chromatography technology 12477395 physical association X 2 Q12379 P09798 affinity chromatography technology 15649358 physical association X 2 Q12379 P16522 affinity chromatography technology 12609981 physical association X 2 Q12379 Q08683 affinity chromatography technology 12609981 physical association X 2 Q12379 P09798 affinity chromatography technology 16275330 physical association X 2 Q12379 P16522 two hybrid 17634282 direct interaction X 2 Q12379 P09798 affinity chromatography technology 17406682 physical association X 2 Q12379 P09798 affinity chromatography technology 15797379 physical association X 2 Q12379 P16522 affinity chromatography technology 11805837 physical association X 2 Q12379 P25367 affinity chromatography technology 11805837 physical association X 2 Q12379 P08566 affinity chromatography technology 11805837 physical association X 2 Q12379 Q03640 affinity chromatography technology 11805837 physical association X 2 Q12379 P09798 affinity chromatography technology 16364911 physical association X 2 Q12107 Q12379 affinity chromatography technology 12609981 physical association X 2 Q12107 Q12379 affinity chromatography technology 12574115 physical association X 2 Q12107 Q12379 affinity chromatography technology 15060174 physical association X 2 Q12107 Q12379 affinity chromatography technology 12477395 physical association X 2 Q12379 anti tag coimmunoprecipitation 11805837 - C 9 Q12379 anti tag coimmunoprecipitation 11805837 - C 20 Q12379 pull down 21107322 - C 13 Q12379 anti tag coimmunoprecipitation 11805837 - C 9 Q12379 tandem affinity purification 21107322 - C 12 Q12379 tandem affinity purification 21107322 - C 13 P27999 Q12379 two hybrid pooling approach 11283351 physical association X 2 P04173 Q12379 anti tag coimmunoprecipitation 11805837 physical association X 2 Q12379 P47079 anti tag coimmunoprecipitation 11805837 physical association X 2 Q12379 P16862 anti tag coimmunoprecipitation 11805837 physical association X 2 Q12379 anti tag coimmunoprecipitation 11805837 physical association X 2 Q12379 P23394 anti tag coimmunoprecipitation 11805837 physical association X 2 Q12379 P28274 anti tag coimmunoprecipitation 11805837 physical association X 2 Q12379 P32381 anti tag coimmunoprecipitation 11805837 physical association X 2 Q12379 anti tag coimmunoprecipitation 11805837 - C 3 Q12379 pull down 21107322 - C 14 P04385 Q12379 anti tag coimmunoprecipitation 11805837 physical association X 2 P07258 Q12379 anti tag coimmunoprecipitation 11805837 physical association X 2 P09232 Q12379 anti tag coimmunoprecipitation 11805837 physical association X 2 Q12379 P09798 pull down 21107322 physical association X 2 Q12379 P09798 pull down 21107322 physical association X 2 Q12379 P09798 tandem affinity purification 21107322 physical association X 2 Q12379 P09798 tandem affinity purification 21107322 physical association X 2 Q12379 P22137 anti tag coimmunoprecipitation 11805837 physical association X 2 Q12379 P00950 anti tag coimmunoprecipitation 11805837 physical association X 2 Q12379 P10659 anti tag coimmunoprecipitation 11805837 physical association X 2 Q12379 P0CS90 anti tag coimmunoprecipitation 11805837 physical association X 2 Q12379 P16140 anti tag coimmunoprecipitation 11805837 physical association X 2 Q12379 P25491 anti tag coimmunoprecipitation 11805837 physical association X 2 Q12379 Q12186 two hybrid pooling approach 11283351 physical association X 2 Q12379 P16522 anti tag coimmunoprecipitation 11805837 physical association X 2 Q12379 P08566 anti tag coimmunoprecipitation 11805837 physical association X 2 Q12379 Q03640 anti tag coimmunoprecipitation 11805837 physical association X 2 Q12379 P25367 anti tag coimmunoprecipitation 11805837 physical association X 2 Q12379 affinity chromatography technology 12609981 association C 11 Q12379 affinity chromatography technology 12609981 association C 11 Q12379 tandem affinity purification 12477395 association C 13 Q12379 tandem affinity purification 12477395 association C 13 Q12379 tandem affinity purification 12477395 association C 13 Q12379 affinity chromatography technology 12609981 association C 13 Q12379 anti tag coimmunoprecipitation 11805837 association C 9 Q12379 anti tag coimmunoprecipitation 9469814 association C 12 Q12379 anti tag coimmunoprecipitation 9469814 association C 12 Q12379 anti tag coimmunoprecipitation 9469814 association C 12 Q12379 anti tag coimmunoprecipitation 9469814 association C 12 Q12379 anti tag coimmunoprecipitation 9469814 association C 12 Q12379 affinity chromatography technology 12609981 association C 3 P27999 Q12379 two hybrid fragment pooling approach 11283351 physical association X 2 Q12379 Q03718 two hybrid array 14690591 physical association X 2 Q04601 Q12379 anti tag coimmunoprecipitation 12477395 physical association X 2 Q04601 Q12379 anti tag coimmunoprecipitation 12477395 physical association X 2 Q12379 anti tag coimmunoprecipitation 11805837 association C 3 Q12379 tandem affinity purification 16429126 association C 19 Q12379 Q12186 two hybrid fragment pooling approach 11283351 physical association X 2 Q12379 Q08683 anti tag coimmunoprecipitation 12609981 physical association X 2 Q12379 P16522 anti tag coimmunoprecipitation 12609981 physical association X 2 Q12379 mass spectrometry studies of complexes 11805837 - C 4 Q12379 mass spectrometry studies of complexes 11805837 - C 10 Q12379 mass spectrometry studies of complexes 11805837 - C 10 P12753 Q12379 interaction detection method 14764870 - X 2 P27999 Q12379 two hybrid 11283351 - X 2 Q12379 P17119 interaction detection method 14764870 - X 2 Q12379 Q12186 two hybrid 11283351 - X 2

PPI - HINT Gene A Gene B PMID Method Quality CDC23 SWM1 17634282 0018 HT RPB9 SWM1 11283351,11283351,11283351 0018,0399,0398 HT SSB2 SWM1 23332755 0401 LC PDS1 SWM1 16364911 0415 LC NRM1 SWM1 21562221 0415 LC APC1 SWM1 15060174,15060174 0401,0004 LC NSE5 SWM1 14690591,14690591 0018,0397 LC YHP1 SWM1 21562221 0415 LC MSL5 SWM1 11283351,11283351,11283351 0018,0399,0398 HT GPM1 SWM1 11805837 0007 HT LEU2 SWM1 11805837 0007 HT GAL1 SWM1 11805837 0007 HT CPA1 SWM1 11805837,11805837 0004,0007 HT ARO1 SWM1 11805837,11805837 0004,0007 HT PRB1 SWM1 11805837,11805837 0004,0007 HT CDC16 SWM1 12477395,12609981,12477395,17406682,16364911,15060174,21107322,21107322,15649358,12574115,16275330,15797379,9469814 0676,0004,0004,0004,0004,0004,0096,0676,0004,0004,0004,0004,0007 LC SSC1 SWM1 11805837 0007 HT SAM1 SWM1 11805837 0007 HT CDC26 SWM1 12477395,12477395,15060174,12574115,9469814 0676,0004,0004,0004,0007 LC VMA2 SWM1 11805837 0007 HT CDC23 SWM1 11805837,12477395,12609981,12477395,15060174,12574115,12609981,11805837,9469814 0004,0676,0004,0004,0004,0004,0007,0007,0007 HT,LC PFK2 SWM1 11805837 0007 HT CHC1 SWM1 11805837 0007 HT PRP28 SWM1 11805837,11805837 0004,0007 HT SCJ1 SWM1 11805837 0007 HT RNQ1 SWM1 11805837,11805837 0004,0007 HT YDJ1 SWM1 11805837 0007 HT URA7 SWM1 11805837,11805837 0004,0007 HT ARP2 SWM1 11805837,11805837 0004,0007 HT CDC27 SWM1 12477395,12609981,12477395,15060174,12574115,9469814 0676,0004,0004,0004,0004,0007 LC SSB2 SWM1 23332755 0401 LC MND2 SWM1 12477395,15060174,12477395,12609981,12574115 0676,0004,0004,0004,0004 LC CCT8 SWM1 11805837 0007 HT DOC1 SWM1 12477395,15060174,12609981 0676,0004,0004 LC CDH1 SWM1 21107322 0004 LC APC1 SWM1 15060174,12477395,12609981,12477395,15060174,12574115,9469814 0401,0676,0004,0004,0004,0004,0007 LC TCB3 SWM1 11805837,11805837 0004,0007 HT APC4 SWM1 12477395,12609981,12477395,12477395,15060174,12574115 0676,0004,0007,0004,0004,0004 LC APC5 SWM1 12477395,12609981,12477395,16429126,15060174,12574115,12609981 0676,0004,0004,0676,0004,0004,0007 LC,HT APC9 SWM1 12477395,12609981,12477395,15060174,12574115 0676,0004,0004,0004,0004 LC APC11 SWM1 12477395,12574115,12477395,15060174 0676,0004,0004,0004 LC SWM1 SWM1 12574115,12477395,15060174 0004,0004,0004 LC SWM1 APC2 12477395,15060174,12477395,12609981,12574115 0676,0004,0004,0004,0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q12379 P23394 SWM1 PRP28 0.332 11805837 Q12379 Q12186 SWM1 MSL5 0.236 11283351 Q12379 P07258 SWM1 CPA1 0.286 11805837 Q12379 P08566 SWM1 ARO1 0.286 11805837 Q12379 P10659 SWM1 SAM1 0.126 11805837 Q12379 P12398 SWM1 SSC1 0.126 11805837 Q12379 P16140 SWM1 VMA2 0.126 11805837 Q12379 P16522 SWM1 CDC23 0.681 12609981,12477395,17634282,11805837,9469814 Q12379 P25303 SWM1 SCJ1 0.126 11805837 Q12379 P25491 SWM1 YDJ1 0.126 11805837 Q12379 P27999 SWM1 RPB9 0.21 11283351 Q12379 P28274 SWM1 URA7 0.286 11805837 Q12379 P47079 SWM1 CCT8 0.126 11805837 Q12379 P53068 SWM1 DOC1 0.126 12477395 Q12379 Q03718 SWM1 NSE5 0.126 14690591 Q12379 Q12379 SWM1 SWM1 0.155 12477395 Q12379 P25367 SWM1 RNQ1 0.332 11805837 Q12379 P00950 SWM1 GPM1 0.126 11805837 Q12379 P09232 SWM1 PRB1 0.332 11805837 Q12379 P04173 SWM1 LEU2 0.126 11805837 Q12379 P04385 SWM1 GAL1 0.126 11805837 Q12379 Q04601 SWM1 APC4 0.49 12477395 Q12379 P09798 SWM1 CDC16 0.794 16275330,17406682,15649358,12477395,9469814,15797379,16364911 Q12379 Q12157 SWM1 APC11 0.236 12477395 Q12379 Q12107 SWM1 APC9 0.236 12477395 Q12379 P53886 SWM1 APC1 0.416 9469814,15060174,12477395 Q12379 P40577 SWM1 MND2 0.416 12477395 Q12440 Q12379 APC2 SWM1 0.236 12477395 Q12379 P38042 SWM1 CDC27 0.332 9469814,12477395 Q12379 P30771 SWM1 NAM7 0.126 18087042 Q12379 P32381 SWM1 ARP2 0.332 11805837 Q12379 P40150 SWM1 SSB2 0.126 23332755 Q12379 P14724 SWM1 CDC26 0.332 9469814,12477395 Q12379 Q03640 SWM1 TCB3 0.332 11805837 Q12379 P16862 SWM1 PFK2 0.126 11805837 Q12379 P22137 SWM1 CHC1 0.126 11805837 Q12379 Q08683 SWM1 APC5 0.472 12477395,16429126,12609981