PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus TPK1 DON1 16319894 biogrid,i2d exp IKS1 DON1 21460040 biogrid exp SSB1 DON1 19536198 intact exp HSP82 DON1 19536198 intact exp APJ1 DON1 19536198 intact exp DON1 ESA1 19303850 biogrid exp RPN10 DON1 i2d exp YDJ1 DON1 19536198 intact exp SSO2 DON1 11742972 intact exp NAM7 DON1 18087042 biogrid exp RPN12 DON1 10688190,11283351 biogrid,i2d,mint,intact,dip exp HMT1 DON1 23706744 biogrid,intact exp SSB2 DON1 19536198 intact exp DON1 DON1 11742972 intact exp GAL80 DON1 18719252 biogrid,intact exp HRR25 DON1 16990132, 23023127 biogrid exp, pred CDC5 DON1 19013276, 23023127 biogrid,intact exp, pred DON1 ADY3 11283351,11742972,11973299, 23023127 biogrid,i2d,mint,intact,dip exp, pred SSP1 DON1 11742972, 23023127 intact exp, pred SSO1 DON1 11742972, 23023127 intact exp, pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q05610 - 11283351 - X 2 Q05610 - 11283351 - X 2 Q05610 - 10688190 - X 2 P32496 Q05610 two hybrid 10688190 direct interaction X 2 P47042 Q05610 pull down 21460040 direct interaction X 2 P04387 Q05610 two hybrid 18719252 direct interaction X 2 P32562 Q05610 affinity chromatography technology 19013276 physical association X 2 Q08649 Q05610 enzymatic study 19303850 direct interaction X 2 P0CG63 Q05610 affinity chromatography technology 12872131 physical association X 2 Q05610 P29295 affinity chromatography technology 16990132 physical association X 2 Q07732 Q05610 two hybrid 11283351 direct interaction X 2 P06244 Q05610 enzymatic study 16319894 direct interaction X 2 P32496 Q05610 two hybrid 10688190 physical association X 2 P32496 Q05610 two hybrid pooling approach 11283351 physical association X 2 Q05610 two hybrid pooling approach 11283351 physical association X 2 P11484 Q05610 tandem affinity purification 19536198 association X 2 Q05610 Q05610 two hybrid 11742972 physical association X 2 Q05610 P38871 fluorescence microscopy 11742972 colocalization X 2 P32496 Q05610 two hybrid 10688190 physical association X 2 P32496 Q05610 two hybrid fragment pooling approach 11283351 physical association X 2 P04387 Q05610 two hybrid 18719252 physical association X 2 P53940 Q05610 tandem affinity purification 19536198 association X 2 P40150 Q05610 tandem affinity purification 19536198 association X 2 Q05610 tandem affinity purification 19013276 association C 41 Q05610 fluorescence microscopy 11742972 colocalization C 3 Q05610 P25491 tandem affinity purification 19536198 association X 2 P02829 Q05610 tandem affinity purification 19536198 association X 2 Q07732 Q05610 two hybrid fragment pooling approach 11283351 physical association X 2 Q07732 Q05610 fluorescence microscopy 11742972 colocalization X 2 Q07732 Q05610 confocal microscopy 11973299 colocalization X 2 P38074 Q05610 dihydrofolate reductase reconstruction 23706744 physical association X 2 P32496 Q05610 two hybrid 10688190 - X 2 P32496 Q05610 two hybrid 11283351 - X 2 Q07732 Q05610 two hybrid 11283351 - X 2

PPI - HINT Gene A Gene B PMID Method Quality GAL80 DON1 18719252 0018 HT TPK1 DON1 16319894 0415 LC RPN12 DON1 11283351,11283351,10688190,11283351,10688190 0018,0399,0397,0398,0018 HT SSO1 DON1 11742972 0416 LC HMT1 DON1 23706744,23706744 0111,0090 LC SSP1 DON1 11742972 0416 LC SSO2 DON1 11742972 0416 LC DON1 DON1 11742972 0018 LC DON1 ADY3 11742972,11283351,11283351,11283351 0416,0018,0399,0398 LC,HT DON1 ESA1 19303850 0415 LC HSP82 DON1 19536198 0676 HT SSB1 DON1 19536198 0676 HT YDJ1 DON1 19536198 0676 HT HRR25 DON1 16990132 0004 LC CDC5 DON1 19013276,19013276 0004,0676 LC SSB2 DON1 19536198 0676 HT IKS1 DON1 21460040 0096 LC APJ1 DON1 19536198 0676 HT DON1 ADY3 11973299 0663 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q05610 P25491 DON1 YDJ1 0.126 19536198 Q05610 P02829 DON1 HSP82 0.126 19536198 Q05610 P06244 DON1 TPK1 0.183 16319894 Q05610 P38074 DON1 HMT1 0.286 23706744 Q05610 P30771 DON1 NAM7 0.126 18087042 Q05610 P32496 DON1 RPN12 0.472 10688190,11283351 Q05610 P29295 DON1 HRR25 0.21 16990132 Q05610 P32562 DON1 CDC5 0.286 19013276 Q05610 P47042 DON1 IKS1 0.183 21460040 Q07732 Q05610 ADY3 DON1 0.354 11283351 Q05610 P53940 DON1 APJ1 0.126 19536198 Q05610 P40150 DON1 SSB2 0.126 19536198 Q05610 P04387 DON1 GAL80 0.332 18719252 Q05610 P11484 DON1 SSB1 0.126 19536198 Q08649 Q05610 ESA1 DON1 0.183 19303850