PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus RTT101 F-box protein YDR306C i2d exp MET28 F-box protein YDR306C 11283351 i2d,mint,intact,dip exp YDJ1 F-box protein YDR306C 19536198 intact exp SSE2 F-box protein YDR306C 19536198 intact exp F-box protein YDR306C SWA2 19536198 intact exp SER33 F-box protein YDR306C i2d exp MDH1 F-box protein YDR306C 11805837 biogrid,mint,intact,dip exp F-box protein YDR306C F-box protein YDR306C 14747994 biogrid exp SSZ1 F-box protein YDR306C 19536198 intact exp SSB2 F-box protein YDR306C 19536198 intact exp PFD1 F-box protein YDR306C 19536198 intact exp NAB2 F-box protein YDR306C 19840948 biogrid exp SER3 F-box protein YDR306C 11283351 i2d,mint,intact,dip exp HSP60 F-box protein YDR306C 11805837 dip exp SSE1 F-box protein YDR306C 19536198 intact exp HHF1, HHF2 F-box protein YDR306C i2d exp SSA2 F-box protein YDR306C 19536198 intact exp STI1 F-box protein YDR306C 11805837 biogrid,intact,dip exp PGM2 F-box protein YDR306C 11805837 biogrid,intact,dip exp GIM5 F-box protein YDR306C 19536198 intact exp GAL1 F-box protein YDR306C 11805837 dip exp BMH2 F-box protein YDR306C 11805837 dip exp YKE2 F-box protein YDR306C 19536198 intact exp ECM10 F-box protein YDR306C 19536198 intact exp SRV2 F-box protein YDR306C 11805837 biogrid,intact,dip exp PAC10 F-box protein YDR306C 19536198 intact exp SSB1 F-box protein YDR306C 19536198 intact exp CDC34 F-box protein YDR306C i2d exp HSP82 F-box protein YDR306C 19536198,11805837 intact,dip exp HSP78 F-box protein YDR306C 19536198 intact exp SSA3 F-box protein YDR306C 19536198 intact exp TEF1, TEF2 F-box protein YDR306C 11805837 dip exp F-box protein YDR306C LAG2 19763088 biogrid,mint,intact exp F-box protein YDR306C HRT1 14747994 biogrid exp SSC1 F-box protein YDR306C 11805837 dip exp SSA1 F-box protein YDR306C 19536198 intact exp GIM3 F-box protein YDR306C 19536198 intact exp F-box protein YDR306C HSP42 19536198 intact exp SAH1 F-box protein YDR306C 11805837 biogrid,intact,dip exp SKP1 F-box protein YDR306C 23000173,14747994,11805837, 23023127 biogrid,mint,intact,dip exp, pred F-box protein YDR306C CDC53 19882662,14747994,11805837, 23023127 biogrid,intact,dip exp, pred BEM1 F-box protein YDR306C 19841731, 23023127 biogrid,mint,intact exp, pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q06640 - 11805837 - C 6 Q06640 P40054 - 11283351 - X 2 Q06640 - 11805837 - C 3 Q06640 P40573 - 11283351 - X 2 Q08273 Q06640 pull down 14747994 direct interaction X 2 P0CG63 Q06640 biochemical 23583075 association X 2 Q06640 P52286 pull down 23000173 direct interaction X 2 Q06640 P52286 pull down 14747994 direct interaction X 2 Q06640 Q06640 enzymatic study 14747994 direct interaction X 2 Q06640 P29366 two hybrid 19841731 direct interaction X 2 Q06640 P39954 affinity chromatography technology 11805837 physical association X 2 Q06640 P37012 affinity chromatography technology 11805837 physical association X 2 Q06640 P52286 affinity chromatography technology 11805837 physical association X 2 P15705 Q06640 affinity chromatography technology 11805837 physical association X 2 P17555 Q06640 affinity chromatography technology 11805837 physical association X 2 Q06640 Q12018 pull down 14747994 direct interaction X 2 Q06640 Q92325 two hybrid 19763088 direct interaction X 2 Q06640 Q12018 affinity chromatography technology 11805837 physical association X 2 Q06640 P17505 affinity chromatography technology 11805837 physical association X 2 Q06640 affinity chromatography technology 14747994 - C 4 Q06640 anti tag coimmunoprecipitation 11805837 - C 14 Q06640 P0CS90 anti tag coimmunoprecipitation 11805837 physical association X 2 Q06640 P02994 anti tag coimmunoprecipitation 11805837 physical association X 2 Q06640 P40054 two hybrid pooling approach 11283351 physical association X 2 Q06640 P37012 anti tag coimmunoprecipitation 11805837 physical association X 2 Q06640 P52286 anti tag coimmunoprecipitation 11805837 physical association X 2 Q06640 P52286 affinity chromatography technology 14747994 physical association X 2 Q06640 P39954 anti tag coimmunoprecipitation 11805837 physical association X 2 P15705 Q06640 anti tag coimmunoprecipitation 11805837 physical association X 2 Q06640 anti tag coimmunoprecipitation 11805837 - C 8 P04385 Q06640 anti tag coimmunoprecipitation 11805837 physical association X 2 P17555 Q06640 anti tag coimmunoprecipitation 11805837 physical association X 2 Q06640 P34730 anti tag coimmunoprecipitation 11805837 physical association X 2 Q06640 P19882 anti tag coimmunoprecipitation 11805837 physical association X 2 Q06640 P02829 anti tag coimmunoprecipitation 11805837 physical association X 2 Q06640 P40573 two hybrid pooling approach 11283351 physical association X 2 Q06640 P17505 anti tag coimmunoprecipitation 11805837 physical association X 2 Q06640 Q12018 anti tag coimmunoprecipitation 11805837 physical association X 2 Q06640 anti tag coimmunoprecipitation 11805837 association C 6 Q06640 pull down 19882662 association C 35 Q04493 Q06640 tandem affinity purification 19536198 association X 2 Q06640 P40054 two hybrid fragment pooling approach 11283351 physical association X 2 Q06640 P10592 tandem affinity purification 19536198 association X 2 Q06640 Q12329 tandem affinity purification 19536198 association X 2 Q06640 P39987 tandem affinity purification 19536198 association X 2 Q06640 P38788 tandem affinity purification 19536198 association X 2 Q06640 P40150 tandem affinity purification 19536198 association X 2 Q06640 P46988 tandem affinity purification 19536198 association X 2 Q06640 P52553 tandem affinity purification 19536198 association X 2 Q06640 P33416 tandem affinity purification 19536198 association X 2 Q06640 P29366 two hybrid pooling approach 19841731 physical association X 2 P10591 Q06640 tandem affinity purification 19536198 association X 2 Q06640 anti tag coimmunoprecipitation 11805837 association C 3 P32589 Q06640 tandem affinity purification 19536198 association X 2 Q06640 P40573 two hybrid fragment pooling approach 11283351 physical association X 2 Q06640 Q06677 tandem affinity purification 19536198 association X 2 Q06640 P09435 tandem affinity purification 19536198 association X 2 Q06640 P32590 tandem affinity purification 19536198 association X 2 Q06640 P25491 tandem affinity purification 19536198 association X 2 Q06640 P11484 tandem affinity purification 19536198 association X 2 Q06640 P48363 tandem affinity purification 19536198 association X 2 Q06640 P53900 tandem affinity purification 19536198 association X 2 Q06640 P02829 tandem affinity purification 19536198 association X 2 Q06640 Q92325 two hybrid 19763088 physical association X 2 Q06640 P40054 two hybrid 11283351 - X 2 Q06640 mass spectrometry studies of complexes 11805837 - C 9 Q06640 mass spectrometry studies of complexes 11805837 - C 9 Q06640 P40573 two hybrid 11283351 - X 2

PPI - HINT Gene A Gene B PMID Method Quality BEM1 Q06640 19841731,19841731 0398,0018 HT SER3 Q06640 11283351,11283351,11283351 0018,0399,0398 HT MET28 Q06640 11283351,11283351,11283351 0018,0399,0398 HT Q06640 Q06640 14747994 0415 LC Q06640 LAG2 19763088 0018 LC HSP82 Q06640 19536198,11805837 0676,0007 HT TEF1|TEF2 Q06640 11805837 0007 HT GAL1 Q06640 11805837 0007 HT SSA3 Q06640 19536198 0676 HT SSC1 Q06640 11805837 0007 HT SSA1 Q06640 19536198 0676 HT SSA2 Q06640 19536198 0676 HT SSB1 Q06640 19536198 0676 HT STI1 Q06640 11805837,11805837 0004,0007 HT MDH1 Q06640 11805837,11805837 0004,0007 HT SRV2 Q06640 11805837,11805837 0004,0007 HT HSP60 Q06640 11805837 0007 HT YDJ1 Q06640 19536198 0676 HT NAB2 Q06640 19840948 0004 LC SSE1 Q06640 19536198 0676 HT SSE2 Q06640 19536198 0676 HT HSP78 Q06640 19536198 0676 HT BMH2 Q06640 11805837 0007 HT PGM2 Q06640 11805837,11805837 0004,0007 HT SSZ1 Q06640 19536198 0676 HT WSS1 Q06640 26349035 0004 LC SAH1 Q06640 11805837,11805837 0004,0007 HT ECM10 Q06640 19536198 0676 HT SSB2 Q06640 19536198 0676 HT PFD1 Q06640 19536198 0676 HT PAC10 Q06640 19536198 0676 HT SKP1 Q06640 11805837,23000173,14747994,11805837,14747994 0004,0096,0096,0007,0004 HT,LC YKE2 Q06640 19536198 0676 HT GIM3 Q06640 19536198 0676 HT GIM5 Q06640 19536198 0676 HT Q06640 SWA2 19536198 0676 HT Q06640 HRT1 14747994 0096 LC Q06640 CDC53 11805837,19882662,14747994,11805837 0004,0096,0096,0007 HT,LC Q06640 HSP42 19536198 0676 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q06640 P11484 Q06640 SSB1 0.126 19536198 Q06640 P12398 Q06640 SSC1 0.126 11805837 Q06640 P04385 Q06640 GAL1 0.126 11805837 Q92325 Q06640 LAG2 Q06640 0.523 19763088 Q06640 P29366 Q06640 BEM1 0.286 19841731 Q06640 P38788 Q06640 SSZ1 0.126 19536198 Q06640 P38838 Q06640 WSS1 0.126 26349035 Q06640 P32505 Q06640 NAB2 0.126 19840948 Q06640 P32590 Q06640 SSE2 0.126 19536198 Q06640 P39954 Q06640 SAH1 0.236 11805837 Q06640 P17505 Q06640 MDH1 0.236 11805837 Q06640 P48363 Q06640 PAC10 0.126 19536198 Q06640 P52286 Q06640 SKP1 0.454 11805837,14747994,23000173 Q06640 P19882 Q06640 HSP60 0.126 11805837 Q06640 P52553 Q06640 YKE2 0.126 19536198 Q06640 P02829 Q06640 HSP82 0.236 11805837,19536198 Q06640 P02994 Q06640 TEF2 0.126 11805837 Q06640 P09435 Q06640 SSA3 0.126 19536198 Q06640 P10591 Q06640 SSA1 0.126 19536198 Q06640 P10592 Q06640 SSA2 0.126 19536198 Q06640 P15705 Q06640 STI1 0.236 11805837 Q06640 P17555 Q06640 SRV2 0.21 11805837 Q06640 P25491 Q06640 YDJ1 0.126 19536198 Q06640 P32589 Q06640 SSE1 0.126 19536198 Q06640 P33416 Q06640 HSP78 0.126 19536198 Q06640 P34730 Q06640 BMH2 0.126 11805837 Q06640 P37012 Q06640 PGM2 0.21 11805837 Q06640 P39987 Q06640 ECM10 0.126 19536198 Q06640 P40054 Q06640 SER3 0.21 11283351 Q06640 P40150 Q06640 SSB2 0.126 19536198 Q06640 P40573 Q06640 MET28 0.21 11283351 Q06640 P46988 Q06640 PFD1 0.126 19536198 Q06640 Q04493 Q06640 GIM5 0.126 19536198 Q06640 Q06640 Q06640 Q06640 0.332 14747994 Q12018 Q06640 CDC53 Q06640 0.569 11805837,19882662,14747994 Q12329 Q06640 HSP42 Q06640 0.126 19536198 Q06677 Q06640 SWA2 Q06640 0.126 19536198 Q06640 P53900 Q06640 GIM3 0.126 19536198