PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus PGA1 UBX5 14690591 intact exp UBX5 ISW2 i2d exp MCK1 UBX5 16319894 biogrid,i2d exp SSB2 UBX5 23332755,19536198 biogrid,intact exp SSA2 UBX5 16429126,19536198 intact exp CTF19 UBX5 17634282 biogrid exp ATG1 UBX5 16319894 biogrid,i2d exp YCK1 UBX5 16319894 biogrid exp SSZ1 UBX5 19536198 intact exp BFA1 UBX5 16554755 intact exp SWE1 UBX5 16319894 biogrid,i2d exp UBX5 CDC53 22466964 biogrid,dip exp ZIM17 UBX5 14690591 intact exp BNI1 UBX5 24133141 biogrid exp RPL40A UBX5 16007098,18719252 intact,dip exp SSA1 UBX5 19536198 intact exp GFA1 UBX5 16429126 intact exp GCN20 UBX5 16429126 intact exp YCK2 UBX5 16319894 biogrid,i2d exp GUS1 UBX5 i2d exp STU1 UBX5 11283351 i2d,mint,intact,dip exp SSB1 UBX5 16429126,19536198 intact exp CDC28 UBX5 16319894 biogrid exp URA2 UBX5 16429126 intact exp KSP1 UBX5 16319894 biogrid,i2d exp NAB2 UBX5 19840948 biogrid exp UBI4 UBX5 15258615,18719252 biogrid exp PRE1 UBX5 21211725, 23023127 biogrid exp, pred CDC48 UBX5 22466964,21211725,15258615,16554755, 23023127 biogrid,i2d,mint,intact,dip exp, pred UFD1 UBX5 21211725, 23023127 biogrid,i2d exp, pred YDJ1 UBX5 19536198, 23023127 intact exp, pred NPL4 UBX5 21211725, 23023127 biogrid exp, pred UBX5 SMT3 18719252, 23023127 biogrid,intact exp, pred HUA1 UBX5 18719252, 23023127 biogrid,intact exp, pred CUL3 UBX5 21211725, 23023127 biogrid exp, pred UBX5 HRT1 18719252, 23023127 biogrid,intact exp, pred STE20 UBX5 16319894, 23023127 biogrid,i2d exp, pred UBC13 UBX5 23023127 pred DSK2 UBX5 23023127 pred UBX5 MEX67 23023127 pred DOA4 UBX5 23023127 pred VPS20 UBX5 23023127 pred UBX7 UBX5 23023127 pred UBX5 HUB1 23023127 pred RAD6 UBX5 23023127 pred UBX5 UBX5 23023127 pred UBI4 UBX5 23023127 pred UBP16 UBX5 23023127 pred CUE2 UBX5 23023127 pred RAD23 UBX5 23023127 pred DDI1 UBX5 23023127 pred UBC9 UBX5 23023127 pred RPT5 UBX5 23023127 pred GGA2 UBX5 23023127 pred CUE1 UBX5 23023127 pred UBC4 UBX5 23023127 pred VPS9 UBX5 23023127 pred UBP15 UBX5 23023127 pred UBP11 UBX5 23023127 pred OTU1 UBX5 23023127 pred YUH1 UBX5 23023127 pred UBP6 UBX5 23023127 pred UBC6 UBX5 23023127 pred CDC34 UBX5 23023127 pred UBX4 UBX5 23023127 pred UBC7 UBX5 23023127 pred SNF7 UBX5 23023127 pred GGA1 UBX5 23023127 pred UBP8 UBX5 23023127 pred UBC5 UBX5 23023127 pred PEX4 UBX5 23023127 pred UBC12 UBX5 23023127 pred UBP7 UBX5 23023127 pred UBX6 UBX5 23023127 pred ATG8 UBX5 23023127 pred UBA1 UBX5 23023127 pred SHP1 UBX5 23023127 pred UBX5 RUP1 23023127 pred RVS167 UBX5 23023127 pred UBC1 UBX5 23023127 pred CUE3 UBX5 23023127 pred UBX5 CUE5 23023127 pred UBC8 UBX5 23023127 pred UBP14 UBX5 23023127 pred EDE1 UBX5 23023127 pred UBP5 UBX5 23023127 pred SLA1 UBX5 23023127 pred UBX5 UBX3 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q06682 P38198 - 11283351 - X 2 Q06682 P25694 two hybrid 15258615 direct interaction X 2 Q06682 P25694 affinity chromatography technology 15258615 physical association X 2 Q06682 P25694 pull down 15258615 direct interaction X 2 Q06682 P25694 affinity chromatography technology 16554755 physical association X 2 Q06682 P38691 enzymatic study 16319894 direct interaction X 2 Q06682 P21965 enzymatic study 16319894 direct interaction X 2 Q06682 P32944 enzymatic study 16319894 direct interaction X 2 Q06682 P40325 two hybrid 18719252 direct interaction X 2 Q06682 P25694 affinity chromatography technology 21211725 physical association X 2 Q06682 P53044 affinity chromatography technology 21211725 physical association X 2 Q06682 P25694 affinity chromatography technology 21211725 physical association X 2 Q06682 P53044 affinity chromatography technology 21211725 physical association X 2 P23292 Q06682 enzymatic study 16319894 direct interaction X 2 Q06682 P40150 biochemical 23332755 association X 2 Q06682 P53104 enzymatic study 16319894 direct interaction X 2 Q06682 Q03497 enzymatic study 16319894 direct interaction X 2 Q06682 P23291 enzymatic study 16319894 direct interaction X 2 Q06682 Q12306 two hybrid 18719252 direct interaction X 2 Q06682 P00546 enzymatic study 16319894 direct interaction X 2 Q06682 P53202 affinity chromatography technology 21211725 physical association X 2 Q06682 P22141 affinity chromatography technology 21211725 physical association X 2 Q08273 Q06682 two hybrid 18719252 direct interaction X 2 P0CG63 Q06682 affinity chromatography technology 23749301 physical association X 2 P0CG63 Q06682 two hybrid 18719252 direct interaction X 2 P0CG63 Q06682 biochemical 23583075 association X 2 P0CG63 Q06682 two hybrid 15258615 direct interaction X 2 P0CG63 Q06682 pull down 15258615 direct interaction X 2 P0CG63 Q06682 affinity chromatography technology 12872131 physical association X 2 P0CG63 Q06682 affinity chromatography technology 22106047 physical association X 2 Q02732 Q06682 two hybrid 17634282 direct interaction X 2 P33755 Q06682 affinity chromatography technology 21211725 physical association X 2 P33755 Q06682 affinity chromatography technology 21211725 physical association X 2 Q06682 P25694 anti tag coimmunoprecipitation 22466964 physical association X 2 Q06682 Q12018 anti tag coimmunoprecipitation 22466964 physical association X 2 Q06682 P05759 pull down 16007098 direct interaction X 2 Q06682 P38198 two hybrid pooling approach 11283351 physical association X 2 Q06682 tandem affinity purification 16429126 association C 6 Q06682 inferred by author 16554755 association C 22 Q06682 P53896 two hybrid array 14690591 physical association X 2 Q06682 P25694 anti tag coimmunoprecipitation 15258615 physical association X 2 Q06682 P25694 pull down 15258615 physical association X 2 Q06682 P25694 two hybrid 15258615 physical association X 2 Q06682 P25694 tandem affinity purification 16554755 physical association X 2 Q06682 P25694 tandem affinity purification 16554755 physical association X 2 Q06682 P40325 two hybrid 18719252 physical association X 2 P10591 Q06682 tandem affinity purification 19536198 association X 2 Q06682 P38198 two hybrid fragment pooling approach 11283351 physical association X 2 Q06682 P42844 two hybrid array 14690591 physical association X 2 Q06682 Q12306 two hybrid 18719252 physical association X 2 Q06682 P11484 tandem affinity purification 19536198 association X 2 Q06682 P38788 tandem affinity purification 19536198 association X 2 Q06682 P10592 tandem affinity purification 19536198 association X 2 Q06682 P40150 tandem affinity purification 19536198 association X 2 Q06682 P25491 tandem affinity purification 19536198 association X 2 P0CH08 Q06682 two hybrid 18719252 physical association X 2 Q08273 Q06682 two hybrid 18719252 physical association X 2 Q06682 P38198 two hybrid 11283351 - X 2

PPI - HINT Gene A Gene B PMID Method Quality CDC28 UBX5 16319894 0415 LC UBI4 UBX5 18719252,15258615,15258615 0018,0018,0096 HT,LC RPL40A UBX5 18719252 0018 HT RPL40B UBX5 18719252 0018 HT MCK1 UBX5 16319894 0415 LC YCK1 UBX5 16319894 0415 LC YCK2 UBX5 16319894 0415 LC CDC48 UBX5 15258615,15258615,15258615,15258615 0096,0004,0007,0018 LC SWE1 UBX5 16319894 0415 LC STU1 UBX5 11283351,11283351,11283351 0018,0399,0398 HT KSP1 UBX5 16319894 0415 LC SSB2 UBX5 23332755 0401 LC HUA1 UBX5 18719252 0018 HT ZIM17 UBX5 14690591 0397 LC ATG1 UBX5 16319894 0415 LC PGA1 UBX5 14690591 0397 LC CTF19 UBX5 17634282 0018 HT STE20 UBX5 16319894 0415 LC UBX5 HRT1 18719252 0018 HT UBX5 SMT3 18719252 0018 HT URA2 UBX5 16429126 0676 HT UBI4 UBX5 15258615,15258615,22106047 0018,0096,0004 LC SSA1 UBX5 19536198 0676 HT SSA2 UBX5 19536198,16429126 0676,0676 HT SSB1 UBX5 19536198,16429126 0676,0676 HT GFA1 UBX5 16429126 0676 HT PRE1 UBX5 21211725 0004 LC YDJ1 UBX5 19536198 0676 HT CDC48 UBX5 21211725,22466964,15258615,22466964,15258615,16554755,15258615,15258615,16554755 0004,0007,0096,0004,0004,0004,0007,0018,0676 LC,HT NAB2 UBX5 19840948 0004 LC NPL4 UBX5 21211725 0004 LC SSZ1 UBX5 19536198 0676 HT SSB2 UBX5 19536198,23332755 0676,0401 HT,LC BNI1 UBX5 24133141 0096 LC GCN20 UBX5 16429126 0676 HT BFA1 UBX5 16554755 0363 HT UFD1 UBX5 21211725 0004 LC CUL3 UBX5 21211725 0004 LC ARP5 UBX5 26656161 0004 LC UBX5 CDC53 22466964,22466964 0004,0007 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q06682 P53104 UBX5 ATG1 0.183 16319894 Q06682 P23291 UBX5 YCK1 0.183 16319894 Q06682 P00546 UBX5 CDC28 0.183 16319894 Q06682 P11484 UBX5 SSB1 0.236 16429126,19536198 Q06682 P25694 UBX5 CDC48 0.858 16554755,22466964,15258615,21211725 Q06682 P40150 UBX5 SSB2 0.236 23332755,19536198 Q06682 P0CG63 UBX5 UBI4 0.61 18719252,15258615 Q06682 P38691 UBX5 KSP1 0.183 16319894 Q06682 P38788 UBX5 SSZ1 0.126 19536198 Q06682 P32505 UBX5 NAB2 0.126 19840948 Q06682 P32944 UBX5 SWE1 0.183 16319894 Q06682 P33755 UBX5 NPL4 0.376 21211725 Q06682 P40325 UBX5 HUA1 0.332 18719252 Q06682 P47113 UBX5 BFA1 0.126 16554755 Q06682 P41832 UBX5 BNI1 0.183 24133141 Q06682 Q02732 UBX5 CTF19 0.183 17634282 Q06682 P07259 UBX5 URA2 0.126 16429126 Q06682 P10591 UBX5 SSA1 0.126 19536198 Q06682 P10592 UBX5 SSA2 0.236 16429126,19536198 Q06682 P14742 UBX5 GFA1 0.126 16429126 Q06682 P14796 UBX5 RPL40A 0.183 18719252 Q06682 P25491 UBX5 YDJ1 0.126 19536198 Q06682 P38198 UBX5 STU1 0.21 11283351 Q06682 P42844 UBX5 ZIM17 0.126 14690591 Q06682 P43535 UBX5 GCN20 0.126 16429126 Q06682 P53044 UBX5 UFD1 0.376 21211725 Q06682 P53202 UBX5 CUL3 0.21 21211725 Q06682 P53896 UBX5 PGA1 0.126 14690591 Q06682 P53946 UBX5 ARP5 0.21 26656161 Q08273 Q06682 HRT1 UBX5 0.332 18719252 Q12018 Q06682 CDC53 UBX5 0.21 22466964 Q12306 Q06682 SMT3 UBX5 0.332 18719252 Q06682 Q03497 UBX5 STE20 0.183 16319894 Q06682 P21965 UBX5 MCK1 0.183 16319894 Q06682 P22141 UBX5 PRE1 0.21 21211725