PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus STM1 CDC40 14759368 mint,intact exp PRP18 CDC40 i2d exp CDC40 PRP43 i2d exp SSM4 CDC40 16179952 biogrid exp AAR2 CDC40 16429126 intact exp SSB1 CDC40 19536198 intact exp CDC40 CWC21 19789211 biogrid exp YAK1 CDC40 21460040 biogrid exp CDC40 CWC25 14690591 intact exp CDC40 SYF2 i2d exp CDC40 SYF1 i2d exp NAM7 CDC40 18087042 biogrid exp SSA1 CDC40 19536198 intact exp SSB2 CDC40 23332755 biogrid exp CDC40 CDC40 14759368,21386897, 23023127 biogrid,mint,intact exp, pred CDC40 CLF1 23023127 i2d exp, pred SPS1 CDC40 21460040, 23023127 biogrid exp, pred CDC40 SNT309 11884590, 23023127 biogrid,intact exp, pred PRP16 CDC40 20089683, 23023127 biogrid,i2d exp, pred STO1 CDC40 14759368, 23023127 biogrid,i2d exp, pred SMB1 CDC40 21558325, 23023127 biogrid exp, pred CDC40 SLU7 11991638, 23023127 biogrid exp, pred PRP22 CDC40 20089683, 23023127 biogrid exp, pred CDC40 CWC22 23023127 i2d exp, pred PRP19 CDC40 14759368,16429126,11884590,21386897,18719252, 23023127 biogrid,i2d,mint,intact exp, pred PRP2 CDC40 20089683, 23023127 biogrid exp, pred CDC40 PRP46 23023127 i2d exp, pred SNU114 CDC40 23023127 i2d exp, pred CDC40 CEF1 11805826,16429126,11884590, 23023127 biogrid,mint,intact,dip exp, pred CDC40 CBC2 14759368,21558325, 23023127 biogrid,i2d exp, pred CDC40 SPP382 14690591, 23023127 biogrid,intact exp, pred SAT4 CDC40 21460040, 23023127 biogrid exp, pred PRP45 CDC40 11805826,16429126, 23023127 biogrid,i2d,mint,intact,dip exp, pred CDC40 CWC2 16429126,11884590,14690591, 23023127 biogrid,i2d,intact exp, pred YJU2 CDC40 11805826,16429126, 23023127 biogrid,mint,intact,dip exp, pred CDC40 LEA1 21558325, 23023127 biogrid exp, pred CDC40 CTF4 23023127 pred CDC20 CDC40 23023127 pred MET30 CDC40 23023127 pred CDC40 DIP2 23023127 pred PRP8 CDC40 23023127 pred PRP4 CDC40 23023127 pred CDC5 CDC40 23023127 pred CDC40 CAC2 23023127 pred SOF1 CDC40 23023127 pred PRP5 CDC40 23023127 pred CDC4 CDC40 23023127 pred MSI1 CDC40 23023127 pred CDC34 CDC40 23023127 pred CDC40 ELP2 23023127 pred MUD2 CDC40 23023127 pred BRR2 CDC40 23023127 pred CDC40 CIA1 23023127 pred CDC25 CDC40 23023127 pred CKA1 CDC40 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P40968 - 11805826 - C 15 P40968 - 11805826 - C 20 P40968 - 11805826 - C 15 P40968 - 14759368 - C 4 P40318 P40968 affinity chromatography technology 16179952 physical association X 2 Q06091 P40968 affinity chromatography technology 11884590 physical association X 2 Q06091 P40968 affinity chromatography technology 17200106 physical association X 2 Q06411 P40968 affinity chromatography technology 14690591 physical association X 2 Q12417 P40968 affinity chromatography technology 17200106 physical association X 2 Q04048 P40968 affinity chromatography technology 17200106 physical association X 2 Q03654 P40968 affinity chromatography technology 11884590 physical association X 2 Q03654 P40968 affinity chromatography technology 16429126 physical association X 2 Q03654 P40968 affinity chromatography technology 11805826 physical association X 2 P40968 P28004 affinity chromatography technology 16429126 physical association X 2 P40968 P28004 affinity chromatography technology 17200106 physical association X 2 P40968 P53333 affinity chromatography technology 17200106 physical association X 2 P40968 P36048 affinity chromatography technology 17200106 physical association X 2 P40968 Q12309 affinity chromatography technology 17200106 physical association X 2 P40968 Q03375 affinity chromatography technology 19789211 physical association X 2 P40968 Q08920 affinity chromatography technology 14759368 physical association X 2 P40968 P34160 affinity chromatography technology 14759368 physical association X 2 P40968 P40968 affinity chromatography technology 14759368 physical association X 2 P40968 P28004 affinity chromatography technology 11805826 physical association X 2 P40968 P40018 affinity chromatography technology 21558325 physical association X 2 P40968 Q08963 affinity chromatography technology 21558325 physical association X 2 P40968 Q08920 affinity chromatography technology 21558325 physical association X 2 P32523 P40968 affinity chromatography technology 11884590 physical association X 2 P32523 P40968 affinity chromatography technology 16429126 physical association X 2 P32523 P40968 affinity chromatography technology 17200106 physical association X 2 P32523 P40968 two hybrid 18719252 direct interaction X 2 P32523 P40968 two hybrid 21386897 direct interaction X 2 P32523 P40968 pull down 21386897 direct interaction X 2 P32523 P40968 affinity chromatography technology 14759368 physical association X 2 P40150 P40968 biochemical 23332755 association X 2 P32639 P40968 affinity chromatography technology 17200106 physical association X 2 P40968 Q12046 affinity chromatography technology 11884590 physical association X 2 P40968 Q02775 biochemical 11991638 colocalization X 2 P40968 Q12046 affinity chromatography technology 16429126 physical association X 2 P40968 Q12046 affinity chromatography technology 17200106 physical association X 2 P40968 P20095 affinity chromatography technology 20089683 physical association X 2 P40968 P15938 affinity chromatography technology 20089683 physical association X 2 P40968 P24384 affinity chromatography technology 20089683 physical association X 2 P40968 Q12046 affinity chromatography technology 14690591 physical association X 2 P40968 P25333 pull down 21460040 direct interaction X 2 P40968 P08458 pull down 21460040 direct interaction X 2 P40968 P14680 pull down 21460040 direct interaction X 2 P40968 P28320 affinity chromatography technology 11805826 physical association X 2 P40968 tandem affinity purification 11805826 - C 20 Q03654 P40968 tandem affinity purification 11805826 physical association X 2 P40968 P28004 tandem affinity purification 11805826 physical association X 2 P40968 tandem affinity purification 11805826 - C 15 P40968 tandem affinity purification 11805826 - C 15 P40968 inferred by author 11805826 physical association C 26 P40968 P28320 tandem affinity purification 11805826 physical association X 2 P40968 tandem affinity purification 16429126 association C 18 P40968 tandem affinity purification 11884590 association C 43 P40968 tandem affinity purification 11884590 association C 41 P40968 pull down 14690591 association C 21 P40968 tandem affinity purification 11805826 association C 16 P40968 tandem affinity purification 11805826 association C 21 P40968 tandem affinity purification 11884590 association C 31 P40968 inferred by author 16429126 physical association C 70 P40968 tandem affinity purification 16429126 association C 20 P11484 P40968 tandem affinity purification 19536198 association X 2 P39015 P40968 anti tag coimmunoprecipitation 14759368 physical association X 2 P40968 P40968 anti tag coimmunoprecipitation 14759368 physical association X 2 P40968 P40968 cosedimentation in solution 21386897 direct interaction Y 1 P40968 pull down 14690591 association C 14 P40968 tandem affinity purification 16429126 association C 20 P40968 tandem affinity purification 11805826 association C 15 P40968 tandem affinity purification 16429126 association C 24 P40968 inferred by author 16429126 physical association C 38 P40968 inferred by author 16429126 physical association C 26 P40968 pull down 14690591 association C 22 P40968 tandem affinity purification 11884590 association C 33 P40968 tandem affinity purification 16429126 association C 25 P32523 P40968 anti tag coimmunoprecipitation 14759368 physical association X 2 P32523 P40968 two hybrid 18719252 physical association X 2 P32523 P40968 pull down 21386897 direct interaction X 2 P32523 P40968 two hybrid 21386897 physical association X 2 P32523 P40968 pull down 21386897 physical association X 2 P32523 P40968 two hybrid 21386897 physical association X 2 P10591 P40968 tandem affinity purification 19536198 association X 2 P40968 confirmational text mining - - C 33 P40968 mass spectrometry studies of complexes 11805826 - C 32 P33411 P40968 interaction detection method 1406691,7568198,8722761 - X 2 Q04048 P40968 interaction detection method 11102353,11105756 - X 2 P40968 Q12309 interaction detection method 11102353,11105756 - X 2 P40968 Q12309 interaction detection method 11102353,11105756 - X 2 P40968 P15938 interaction detection method - - X 2

PPI - HINT Gene A Gene B PMID Method Quality PRP19 CDC40 18719252,21386897,21386897 0018,0096,0018 HT,LC SSB2 CDC40 23332755 0401 LC CDC40 CDC40 21386897 0028 LC CDC40 SLU7 11991638 0401 LC SPS1 CDC40 21460040 0096 LC SSA1 CDC40 19536198 0676 HT SSB1 CDC40 19536198 0676 HT YAK1 CDC40 21460040 0096 LC PRP16 CDC40 20089683 0004 LC PRP2 CDC40 20089683 0004 LC PRP22 CDC40 20089683 0004 LC SAT4 CDC40 21460040 0096 LC PRP45 CDC40 16429126,11805826,11805826,17200106,11805826,16429126 0676,0676,0004,0004,0007,0004 HT YJU2 CDC40 11805826,16429126,11805826,11805826 0004,0676,0007,0676 HT AAR2 CDC40 16429126 0363 HT PRP19 CDC40 14759368,16429126,21386897,21386897,17200106,11884590,14759368,16429126,11884590 0007,0004,0096,0018,0004,0676,0004,0676,0004 HT,LC BRR2 CDC40 17200106 0004 HT STO1 CDC40 14759368 0004 HT SNU114 CDC40 17200106 0004 HT STM1 CDC40 14759368 0007 HT SMB1 CDC40 21558325 0004 LC SSB2 CDC40 23332755 0401 LC SSM4 CDC40 16179952 0004 LC CDC40 CDC40 14759368,14759368 0004,0007 HT CDC40 CWC22 17200106 0004 HT CDC40 SLU7 11991638 0401 LC CDC40 CWC21 19789211 0004 LC CDC40 CEF1 11805826,16429126,11805826,11805826,11884590,16429126,11884590 0007,0676,0004,0676,0676,0004,0004 HT,LC CDC40 SYF1 17200106 0004 HT CDC40 SNT309 17200106,11884590,11884590 0004,0004,0676 HT,LC CDC40 CBC2 21558325,14759368 0004,0004 LC,HT CDC40 LEA1 21558325 0004 LC CDC40 CWC2 16429126,17200106,11884590,16429126,11884590 0676,0004,0676,0004,0004 HT,LC CDC40 CLF1 17200106 0004 HT CDC40 PRP46 17200106 0004 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P40968 P24384 CDC40 PRP22 0.126 20089683 P40968 P15938 CDC40 PRP16 0.126 20089683 P40968 P25333 CDC40 SAT4 0.183 21460040 P40968 P08458 CDC40 SPS1 0.183 21460040 P40968 P10591 CDC40 SSA1 0.126 19536198 P40968 P40968 CDC40 CDC40 0.332 21386897,14759368 P40968 P32523 CDC40 PRP19 0.858 21386897,16429126,11884590,14759368,18719252 Q12046 P40968 CWC2 CDC40 0.49 14690591,16429126,11884590 P40968 P30771 CDC40 NAM7 0.126 18087042 P40968 P32357 CDC40 AAR2 0.126 16429126 P40968 P39015 CDC40 STM1 0.126 14759368 P40968 P40150 CDC40 SSB2 0.126 23332755 P40968 P28320 CDC40 YJU2 0.332 11805826,16429126 P40968 P28004 CDC40 PRP45 0.332 11805826,16429126 P40968 P11484 CDC40 SSB1 0.126 19536198 P40968 P14680 CDC40 YAK1 0.183 21460040 Q06091 P40968 SNT309 CDC40 0.126 11884590 Q03654 P40968 CEF1 CDC40 0.416 11805826,11884590,16429126 P40968 P20095 CDC40 PRP2 0.126 20089683 Q02775 P40968 SLU7 CDC40 0.126 11991638 Q06411 P40968 SPP382 CDC40 0.126 14690591 Q03375 P40968 CWC21 CDC40 0.21 19789211 P53854 P40968 CWC25 CDC40 0.126 14690591 Q08920 P40968 CBC2 CDC40 0.126 21558325 Q08963 P40968 LEA1 CDC40 0.126 21558325