PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus YEF3 UBA2 16429126 intact exp SRM1 UBA2 i2d exp UFE1 UBA2 i2d exp UBA2 ULP1 23403034 biogrid exp UBA2 HAT1 i2d exp YDJ1 UBA2 19536198 intact exp HMT1 UBA2 23706744 biogrid,intact exp HSP78 UBA2 19536198 intact exp UBA2 KAP114 22562154,doi:10.1038/emboj.2012.102 biogrid,mint,intact exp UBA2 BIO5 i2d exp SSE1 UBA2 19536198 biogrid,intact exp NET1 UBA2 i2d exp SSA1 UBA2 16429126,19536198 biogrid,intact exp SSB2 UBA2 23332755,19536198 biogrid,intact exp SSB1 UBA2 16429126,19536198 intact exp SSA2 UBA2 16429126,19536198 intact exp UBC9 UBA2 21209884,21518767,15738391,12354763,9341106, 23023127 biogrid exp, ortho, pred UBA2 AOS1 11805826,16429126,9312010,16554755,9341106, 23023127 biogrid,i2d,mint,intact,dip exp, ortho, pred UBA2 TAF12 21734642, 23023127 biogrid,intact exp, pred PAP1 UBA2 9236779,7629121, 23023127 biogrid,i2d,dip exp, pred UBA2 SMT3 23122649,9312010, 23023127 biogrid,dip exp, pred UBA2 UBC7 14690591, 23023127 intact exp, pred UBA2 UFD1 9236779, 23023127 biogrid,i2d,dip exp, pred UBA2 TAF9 21734642, 23023127 biogrid,intact exp, pred UBA2 UBA2 11805826,7629121, 23023127 biogrid,mint,intact exp, pred PRE8 UBA2 ortho RAD51 UBA2 ortho PRE4 UBA2 ortho PUP3 UBA2 ortho CDC19 UBA2 ortho UBA2 ZPR1 ortho PRE9 UBA2 ortho UBA2 MLC1 ortho RAD23 UBA2 ortho PRE10 UBA2 ortho PDI1 UBA2 ortho UBA2 VPS60 ortho UBA2 UBC12 ortho PUP2 UBA2 ortho NAP1 UBA2 ortho UBA2 SEC10 ortho NPL4 UBA2 ortho UBA2 BRX1 ortho PRE5 UBA2 ortho VMA2 UBA2 ortho UBA2 RUB1 23023127 ortho, pred RAD6 UBA2 23023127 ortho, pred UBC5 UBA2 23023127 pred UBC4 UBA2 23023127 pred UBA2 ESA1 23023127 pred UBA2 UBC13 23023127 pred UBA2 ULA1 23023127 pred CDC16 UBA2 23023127 pred RAD18 UBA2 23023127 pred RSP5 UBA2 23023127 pred UBC1 UBA2 23023127 pred UBP6 UBA2 23023127 pred PRP19 UBA2 23023127 pred UBA2 UBA3 23023127 pred CDC23 UBA2 23023127 pred UBA1 UBA2 23023127 pred CDC20 UBA2 23023127 pred ATG8 UBA2 23023127 pred RPN2 UBA2 23023127 pred ATG12 UBA2 23023127 pred UBA2 UBC11 23023127 pred UBA2 APC11 23023127 pred CDC34 UBA2 23023127 pred MET30 UBA2 23023127 pred UBA2 UBI4 23023127 pred MPE1 UBA2 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q06624 P52488 - 9312010 - X 2 P52488 - 11805826 - C 4 P52488 P29468 - 9236779 - X 2 P52488 P53044 - 9236779 - X 2 P32589 P52488 affinity chromatography technology 19536198 physical association X 2 P32589 P52488 affinity chromatography technology 19536198 physical association X 2 P52488 Q02724 protein complementation assay 23403034 direct interaction X 2 P52488 P50623 pull down 15738391 direct interaction X 2 P52488 P50623 pull down 21518767 direct interaction X 2 P52488 P50623 enzymatic study 12354763 direct interaction X 2 P52488 P50623 pull down 12354763 direct interaction X 2 P52488 P50623 enzymatic study 9341106 direct interaction X 2 P52488 Q03761 affinity chromatography technology 21734642 physical association X 2 P52488 P50623 x-ray crystallography 21209884 association X 2 P52488 P50623 enzymatic study 21209884 direct interaction X 2 P52488 P53067 two hybrid 22562154 direct interaction X 2 Q06624 P52488 pull down 9312010 direct interaction X 2 Q06624 P52488 biochemical 9312010 colocalization X 2 Q06624 P52488 pull down 9341106 direct interaction X 2 Q06624 P52488 affinity chromatography technology 16554755 physical association X 2 Q06624 P52488 affinity chromatography technology 16429126 physical association X 2 Q06624 P52488 affinity chromatography technology 17200106 physical association X 2 Q06624 P52488 affinity chromatography technology 11805826 physical association X 2 Q05027 P52488 affinity chromatography technology 21734642 physical association X 2 P52488 P52488 affinity chromatography technology 7629121 physical association X 2 P52488 P29468 two hybrid 9236779 direct interaction X 2 P52488 Q12306 protein complementation assay 23403034 direct interaction X 2 P52488 Q12306 affinity chromatography technology 15292183 physical association X 2 P52488 P53044 two hybrid 9236779 direct interaction X 2 P52488 Q12306 affinity chromatography technology 23935535 physical association X 2 P52488 P29468 pull down 9236779 direct interaction X 2 P52488 Q12306 unspecified method 23122649 direct interaction X 2 P52488 P40150 biochemical 23332755 association X 2 P52488 Q12306 affinity chromatography technology 15326169 physical association X 2 P52488 Q12306 affinity chromatography technology 15166219 physical association X 2 P52488 Q12306 affinity chromatography technology 15542864 physical association X 2 P0CG63 P52488 affinity chromatography technology 23793018 physical association X 2 P10591 P52488 affinity chromatography technology 19536198 physical association X 2 P10591 P52488 affinity chromatography technology 19536198 physical association X 2 Q06624 P52488 affinity chromatography technology 9341106 direct interaction X 2 Q06624 P52488 molecular sieving 20164921 direct interaction X 2 Q06624 P52488 tandem affinity purification 11805826 direct interaction X 2 P52488 tandem affinity purification 11805826 physical association C 4 P52488 inferred by author 11805826 physical association C 4 P52488 Q12306 cross-linking study 20164921 direct interaction X 2 P52488 Q12306 affinity chromatography technology 9312010 direct interaction X 2 P52488 Q12306 biochemical 9312010 direct interaction X 2 P52488 Q12306 comigration in sds page 20164921 direct interaction X 2 P52488 P29468 two hybrid 7629121 physical association X 2 P52488 P53044 coimmunoprecipitation 9236779 physical association X 2 P52488 P53044 two hybrid 9236779 physical association X 2 P52488 tandem affinity purification 16429126 association C 16 P52488 inferred by author 16429126 physical association C 11 P52488 tandem affinity purification 21734642 association C 76 P52488 tandem affinity purification 21734642 association C 69 P52488 tandem affinity purification 16429126 association C 4 P32589 P52488 tandem affinity purification 19536198 association X 2 P32589 P52488 tandem affinity purification 19536198 association X 2 P52488 P11484 tandem affinity purification 19536198 association X 2 P52488 P10592 tandem affinity purification 19536198 association X 2 P52488 P53067 two hybrid 22562154 physical association X 2 Q06624 P52488 inferred by author 16554755 association X 2 Q06624 P52488 tandem affinity purification 16554755 physical association X 2 Q06624 P52488 tandem affinity purification 16554755 physical association X 2 Q06624 P52488 tandem affinity purification 16554755 physical association X 2 Q06624 P52488 tandem affinity purification 16554755 physical association X 2 Q06624 P52488 tandem affinity purification 16554755 physical association X 2 Q06624 P52488 tandem affinity purification 16554755 physical association X 2 Q06624 P52488 tandem affinity purification 16554755 physical association X 2 Q06624 P52488 tandem affinity purification 16554755 physical association X 2 Q06624 P52488 tandem affinity purification 16554755 physical association X 2 Q06624 P52488 tandem affinity purification 16554755 physical association X 2 Q06624 P52488 tandem affinity purification 16554755 physical association X 2 Q06624 P52488 tandem affinity purification 16554755 physical association X 2 Q06624 P52488 tandem affinity purification 16554755 physical association X 2 Q06624 P52488 tandem affinity purification 16554755 physical association X 2 Q06624 P52488 tandem affinity purification 16554755 physical association X 2 Q06624 P52488 tandem affinity purification 16554755 physical association X 2 Q06624 P52488 tandem affinity purification 16554755 physical association X 2 Q06624 P52488 tandem affinity purification 16554755 physical association X 2 Q06624 P52488 tandem affinity purification 16554755 physical association X 2 Q06624 P52488 tandem affinity purification 16554755 physical association X 2 P52488 tandem affinity purification 11805826 association C 5 P52488 P52488 tandem affinity purification 11805826 physical association X 2 P52488 Q02159 two hybrid array 14690591 physical association X 2 P52488 P40150 tandem affinity purification 19536198 association X 2 P52488 P33416 tandem affinity purification 19536198 association X 2 P52488 P25491 tandem affinity purification 19536198 association X 2 P52488 P38074 dihydrofolate reductase reconstruction 23706744 physical association X 2 P10591 P52488 tandem affinity purification 19536198 association X 2 P10591 P52488 tandem affinity purification 19536198 association X 2 Q06624 P52488 interaction detection method 9312010 - X 2 P52488 mass spectrometry studies of complexes 11805826 - C 5 P52488 P53044 two hybrid 9236779 - X 2 P52488 P29468 interaction detection method - - X 2 P52488 P29468 two hybrid 9236779 - X 2

PPI - HINT Gene A Gene B PMID Method Quality PAP1 UBA2 9236779,9236779,7629121,9236779 0004,0018,0018,0096 LC HMT1 UBA2 23706744,23706744 0111,0090 LC SSB2 UBA2 23332755 0401 LC UBC9 UBA2 12354763,9341106,12354763,21209884,21209884 0415,0415,0096,0415,0114 LC UBA2 UFD1 9236779,9236779 0019,0018 LC UBA2 KAP114 22562154 0018 LC UBA2 UBC7 14690591 0397 LC UBA2 ULP1 23403034 0090 HT UBA2 AOS1 9312010,20164921,9312010 0401,0071,0096 LC UBA2 SMT3 9312010,20164921,9312010,9312010,20164921 0004,0030,0401,0096,0808 LC SSA1 UBA2 19536198,16429126,19536198 0676,0676,0004 HT SSA2 UBA2 19536198,16429126 0676,0676 HT SSB1 UBA2 19536198,16429126 0676,0676 HT YEF3 UBA2 16429126 0363 HT YDJ1 UBA2 19536198 0676 HT PAP1 UBA2 9236779,9236779,9236779 0004,0018,0096 LC SSE1 UBA2 19536198,19536198 0004,0676 HT HSP78 UBA2 19536198 0676 HT SSB2 UBA2 19536198,23332755 0676,0401 HT,LC UBC9 UBA2 12354763,21518767,12354763,15738391 0415,0096,0096,0096 LC UBA2 UBA2 11805826,11805826,7629121 0676,0007,0004 HT,LC UBA2 TAF12 21734642,21734642 0676,0004 LC UBA2 TAF9 21734642,21734642 0676,0004 LC UBA2 AOS1 16554755,16554755,9312010,16429126,9341106,11805826,9341106,11805826,9312010,17200106,11805826,16429126,16554755 0363,0676,0401,0676,0096,0004,0004,0676,0096,0004,0007,0004,0004 HT,LC UBA2 SMT3 9312010,15542864,15292183,9312010,9341106,15326169,9312010,15166219 0004,0004,0004,0401,0004,0004,0096,0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q12306 P52488 SMT3 UBA2 0.692 9312010,20164921,23122649 P52488 P10591 UBA2 SSA1 0.49 19536198,16429126 Q03761 P52488 TAF12 UBA2 0.236 21734642 Q05027 P52488 TAF9 UBA2 0.236 21734642 P52488 P32589 UBA2 SSE1 0.416 19536198 P52488 P10592 UBA2 SSA2 0.236 16429126,19536198 P52488 P11484 UBA2 SSB1 0.236 16429126,19536198 P52488 P40150 UBA2 SSB2 0.236 23332755,19536198 Q06624 P52488 AOS1 UBA2 0.884 11805826,16429126,9341106,20164921,9312010,16554755 P52488 P50623 UBA2 UBC9 0.925 21209884,12354763,15738391,21518767,9341106 P52488 P29468 UBA2 PAP1 0.309 7629121,9236779 P52488 P38074 UBA2 HMT1 0.286 23706744 P52488 P16521 UBA2 YEF3 0.126 16429126 P52488 P0CG48 UBA2 UBC 0.309 26876099 P52488 P25491 UBA2 YDJ1 0.126 19536198 P52488 P33416 UBA2 HSP78 0.126 19536198 P52488 P52488 UBA2 UBA2 0.155 11805826 P53044 P52488 UFD1 UBA2 0.309 9236779 P53067 P52488 KAP114 UBA2 0.523 22562154 Q02159 P52488 UBC7 UBA2 0.126 14690591 Q02724 P52488 ULP1 UBA2 0.183 23403034