PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus VMA2 TFB3 16429126 intact exp TFB3 BUD20 16429126 intact exp SSE1 TFB3 19536198 intact exp TFB3 TFB5 22308316 biogrid exp LYS12 TFB3 16429126 intact exp SSB1 TFB3 19536198 biogrid,intact exp TUB1 TFB3 16429126 intact exp TUB2 TFB3 16429126 intact exp UBC12 TFB3 21816351 biogrid exp ARB1 TFB3 16429126 intact exp PSA1 TFB3 16429126 intact exp TFB3 NSE5 14690591 intact exp HSP82 TFB3 19536198 intact exp TFB3 DBP9 16429126 intact exp TFB3 SWA2 19536198 intact exp RPB3 TFB3 i2d exp TYE7 TFB3 22875988 biogrid exp SSB2 TFB3 19536198 intact exp TFB3 Uncharacterized protein YOR352W 22411836 biogrid exp HEK2 TFB3 18805955 biogrid exp SSA2 TFB3 19536198 intact exp SSZ1 TFB3 19536198 intact exp TFB3 HRT1 21816351 biogrid exp HSP60 TFB3 11805837 dip exp ADE3 TFB3 16429126 intact exp TFB3 TFB4 22308316,19818408,8657139,22411836,16554755, 23023127 biogrid,i2d,mint,intact exp, ortho, pred TFB3 SSL1 22308316,19818408,22411836,16554755, 23023127 biogrid,i2d,mint,intact exp, ortho, pred TFB2 TFB3 22308316,19818408,22411836, 23023127 biogrid exp, ortho, pred RAD3 TFB3 22308316,10681587,11007479,16554755,11805837,19818408,8557668,22411836, 23023127 biogrid,i2d,mint,intact,dip exp, ortho, pred SSL2 TFB3 22308316,19818408,22411836, 23023127 biogrid exp, ortho, pred KIN28 TFB3 22308316,20489023,9235928,14500720,16554755,19818408,17956857,22411836, 23023127 biogrid,i2d,mint,intact,dip exp, ortho, pred HTB1 TFB3 21179020, 23023127 intact exp, pred MEC3 TFB3 10688190, 23023127 mint,intact,dip exp, pred TFA1 TFB3 22411836, 23023127 biogrid exp, pred TFA2 TFB3 22411836, 23023127 biogrid exp, pred SSA1 TFB3 19536198, 23023127 biogrid,intact exp, pred TFB1 TFB3 22308316,19818408,22411836,16554755, 23023127 biogrid,i2d,mint,intact exp, pred UBC4 TFB3 21816351, 23023127 biogrid exp, pred TAF1 TFB3 20026583, 23023127 biogrid exp, pred ADA2 TFB3 21734642, 23023127 biogrid,intact exp, pred CCL1 TFB3 22308316,20489023,16429126,11283351,11839796,14500720,16554755,11805826,19818408,22411836, 23023127 biogrid,i2d,mint,intact,dip exp, pred CDC28 TFB3 ortho RFA2 TFB3 ortho TFB3 TFB3 ortho SPT5 TFB3 ortho MCM7 TFB3 ortho RFA1 TFB3 23023127 ortho, pred RPO21 TFB3 23023127 ortho, pred TFB3 TAF7 23023127 pred SRB7 TFB3 23023127 pred UBI4 TFB3 23023127 pred TOA1 TFB3 23023127 pred RSP5 TFB3 23023127 pred SIR3 TFB3 23023127 pred TFB3 TAF11 23023127 pred RPB7 TFB3 23023127 pred SUA7 TFB3 23023127 pred MCM1 TFB3 23023127 pred TFB3 TAF10 23023127 pred MIG1 TFB3 23023127 pred RPB2 TFB3 23023127 pred ELC1 TFB3 23023127 pred SSU72 TFB3 23023127 pred GAT1 TFB3 23023127 pred TFB3 TAF3 23023127 pred MSI1 TFB3 23023127 pred RAD1 TFB3 23023127 pred RAD53 TFB3 23023127 pred PRP21 TFB3 23023127 pred RAD6 TFB3 23023127 pred POL31 TFB3 23023127 pred TFB3 PEX10 23023127 pred SPT15 TFB3 23023127 pred RAD4 TFB3 23023127 pred MMS2 TFB3 23023127 pred RAD18 TFB3 23023127 pred TAF13 TFB3 23023127 pred RAD2 TFB3 23023127 pred RTF1 TFB3 23023127 pred TFG2 TFB3 23023127 pred SSN8 TFB3 23023127 pred TOA2 TFB3 23023127 pred TFB3 NCB2 23023127 pred TFB3 TAF12 23023127 pred RDH54 TFB3 23023127 pred RPB4 TFB3 23023127 pred GZF3 TFB3 23023127 pred RAD23 TFB3 23023127 pred UBC5 TFB3 23023127 pred POL2 TFB3 23023127 pred RAD14 TFB3 23023127 pred TAF5 TFB3 23023127 pred SPT6 TFB3 23023127 pred TFB3 ESA1 23023127 pred RAD54 TFB3 23023127 pred RPB5 TFB3 23023127 pred TFB3 TAF9 23023127 pred TAF6 TFB3 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q03290 - 15044803 - C 11 Q03290 - 15960978 - C 3 Q03290 - 14500720 - C 3 Q03290 - 11805826 - C 6 Q03290 - 11805837 - C 12 Q03290 - 12590263 - C 46 Q03290 P06839 - 11805837 - X 2 Q03290 P37366 - 11283351 - X 2 P52491 Q03290 pull down 21816351 direct interaction X 2 Q03290 Q12004 biochemical 8657139 association X 2 Q03290 Q04673 affinity chromatography technology 16554755 physical association X 2 Q03290 Q12004 affinity chromatography technology 16554755 physical association X 2 Q03290 Q04673 affinity chromatography technology 17200106 physical association X 2 Q03290 Q12004 affinity chromatography technology 17200106 physical association X 2 Q03290 P46677 imaging technique 20026583 colocalization X 2 Q03290 Q00578 affinity chromatography technology 19818408 physical association X 2 Q03290 Q02939 affinity chromatography technology 19818408 physical association X 2 Q03290 Q04673 affinity chromatography technology 19818408 physical association X 2 Q03290 Q12004 affinity chromatography technology 19818408 physical association X 2 Q03290 Q12004 affinity chromatography technology 19818408 physical association X 2 Q03290 Q00578 affinity chromatography technology 22308316 physical association X 2 Q03290 Q02939 affinity chromatography technology 22308316 physical association X 2 Q03290 Q04673 affinity chromatography technology 22308316 physical association X 2 Q03290 Q12004 affinity chromatography technology 22308316 physical association X 2 Q03290 Q00578 x-ray crystallography 22308316 association X 2 Q03290 Q02939 x-ray crystallography 22308316 association X 2 Q03290 Q04673 x-ray crystallography 22308316 association X 2 Q03290 Q12004 x-ray crystallography 22308316 association X 2 Q03290 Q02939 biochemical 22411836 association X 2 Q03290 Q04673 biochemical 22411836 association X 2 Q03290 Q12004 biochemical 22411836 association X 2 Q03290 Q00578 biochemical 22411836 association X 2 Q03290 Q08816 biochemical 22411836 association X 2 Q03290 P36100 biochemical 22411836 association X 2 P10591 Q03290 affinity chromatography technology 19536198 physical association X 2 P10591 Q03290 affinity chromatography technology 19536198 physical association X 2 P06242 Q03290 two hybrid 9235928 direct interaction X 2 P06242 Q03290 affinity chromatography technology 14500720 physical association X 2 P06242 Q03290 affinity chromatography technology 16554755 physical association X 2 P06242 Q03290 affinity chromatography technology 17200106 physical association X 2 P06242 Q03290 affinity chromatography technology 17956857 physical association X 2 P06242 Q03290 affinity chromatography technology 19818408 physical association X 2 P06242 Q03290 affinity chromatography technology 20489023 physical association X 2 P06242 Q03290 affinity chromatography technology 22308316 physical association X 2 P06242 Q03290 x-ray crystallography 22308316 association X 2 P06242 Q03290 biochemical 22411836 association X 2 Q08273 Q03290 pull down 21816351 direct interaction X 2 Q03290 P33122 two hybrid 22875988 direct interaction X 2 Q03290 P06839 two hybrid 10681587 direct interaction X 2 Q03290 P06839 two hybrid 10681587 direct interaction X 2 Q03290 P37366 affinity chromatography technology 14500720 physical association X 2 Q03290 P37366 biochemical 11839796 association X 2 Q03290 P06839 biochemical 11007479 association X 2 Q03290 P06839 biochemical 8557668 association X 2 Q03290 P32776 affinity chromatography technology 16554755 physical association X 2 Q03290 P06839 affinity chromatography technology 16554755 physical association X 2 Q03290 P37366 affinity chromatography technology 16554755 physical association X 2 Q03290 P37366 affinity chromatography technology 17200106 physical association X 2 Q03290 P37366 two hybrid 11283351 direct interaction X 2 Q03290 P11484 affinity chromatography technology 19536198 physical association X 2 Q03290 P11484 affinity chromatography technology 19536198 physical association X 2 Q03290 P06839 affinity chromatography technology 19818408 physical association X 2 Q03290 P32776 affinity chromatography technology 19818408 physical association X 2 Q03290 P37366 affinity chromatography technology 19818408 physical association X 2 Q03290 P37366 affinity chromatography technology 20489023 physical association X 2 Q03290 P37366 affinity chromatography technology 11805826 physical association X 2 Q03290 Q02336 affinity chromatography technology 21734642 physical association X 2 Q03290 P15731 pull down 21816351 direct interaction X 2 Q03290 P06839 affinity chromatography technology 11805837 physical association X 2 Q03290 P06839 affinity chromatography technology 11805837 physical association X 2 Q03290 P06839 affinity chromatography technology 22308316 physical association X 2 Q03290 P32776 affinity chromatography technology 22308316 physical association X 2 Q03290 P37366 affinity chromatography technology 22308316 physical association X 2 Q03290 Q3E7C1 affinity chromatography technology 22308316 physical association X 2 Q03290 P06839 x-ray crystallography 22308316 association X 2 Q03290 P32776 x-ray crystallography 22308316 association X 2 Q03290 P37366 x-ray crystallography 22308316 association X 2 Q03290 Q3E7C1 x-ray crystallography 22308316 association X 2 Q03290 P06839 biochemical 22411836 association X 2 Q03290 P32776 biochemical 22411836 association X 2 Q03290 P37366 biochemical 22411836 association X 2 Q03290 P36145 biochemical 22411836 association X 2 Q03290 anti tag coimmunoprecipitation 11805837 - C 30 P06242 Q03290 two hybrid 9235928 physical association X 2 Q03290 tandem affinity purification 11805826 - C 6 Q03290 inferred by author 11805826 physical association C 14 Q03290 anti tag coimmunoprecipitation 11805837 - C 12 Q03290 anti tag coimmunoprecipitation 11805837 - C 3 Q03290 P37366 tandem affinity purification 11805826 physical association X 2 Q03290 P37366 two hybrid pooling approach 11283351 physical association X 2 Q03290 P19882 anti tag coimmunoprecipitation 11805837 physical association X 2 Q03290 P06839 anti tag coimmunoprecipitation 11805837 physical association X 2 Q03290 P06839 two hybrid 10681587 physical association X 2 Q03290 P06839 anti tag coimmunoprecipitation 11805837 physical association X 2 Q03290 Q02574 two hybrid 10688190 physical association X 2 Q03290 inferred by author 16554755 association C 8 Q03290 inferred by author 16429126 physical association C 21 Q03290 anti tag coimmunoprecipitation 20489023 association C 5 Q03290 tandem affinity purification 21179020 association C 193 Q03290 anti tag coimmunoprecipitation 11805837 association C 21 Q03290 anti tag coimmunoprecipitation 20489023 association C 5 Q03290 tandem affinity purification 20489023 association C 4 Q03290 inferred by author 16429126 physical association C 21 Q03290 inferred by author 16429126 physical association C 24 Q03290 tandem affinity purification 16429126 association C 45 P32589 Q03290 tandem affinity purification 19536198 association X 2 Q03290 Q03718 two hybrid array 14690591 physical association X 2 Q03290 Q04673 tandem affinity purification 16554755 physical association X 2 Q03290 Q04673 tandem affinity purification 16554755 physical association X 2 Q03290 Q12004 tandem affinity purification 16554755 physical association X 2 Q03290 Q04673 tandem affinity purification 16554755 physical association X 2 Q03290 Q12004 tandem affinity purification 16554755 physical association X 2 Q03290 Q12004 tandem affinity purification 16554755 physical association X 2 Q03290 P10592 tandem affinity purification 19536198 association X 2 Q03290 P38788 tandem affinity purification 19536198 association X 2 Q03290 P02829 tandem affinity purification 19536198 association X 2 P10591 Q03290 tandem affinity purification 19536198 association X 2 P10591 Q03290 tandem affinity purification 19536198 association X 2 P06242 Q03290 tandem affinity purification 16554755 physical association X 2 P06242 Q03290 tandem affinity purification 16554755 physical association X 2 Q03290 tandem affinity purification 11805826 association C 7 Q03290 tandem affinity purification 21734642 association C 49 Q03290 tandem affinity purification 16429126 association C 6 Q03290 inferred by author 16429126 physical association C 27 Q03290 Q02574 two hybrid 10688190 physical association X 2 Q03290 P37366 two hybrid fragment pooling approach 11283351 physical association X 2 Q03290 P06839 anti tag coimmunoprecipitation 11805837 physical association X 2 Q03290 P06839 tandem affinity purification 16554755 physical association X 2 Q03290 P37366 tandem affinity purification 16554755 physical association X 2 Q03290 P37366 tandem affinity purification 16554755 physical association X 2 Q03290 P32776 tandem affinity purification 16554755 physical association X 2 Q03290 P37366 tandem affinity purification 16554755 physical association X 2 Q03290 P37366 tandem affinity purification 16554755 physical association X 2 Q03290 P37366 tandem affinity purification 16554755 physical association X 2 Q03290 P06839 tandem affinity purification 16554755 physical association X 2 Q03290 P32776 tandem affinity purification 16554755 physical association X 2 Q03290 P32776 tandem affinity purification 16554755 physical association X 2 Q03290 P06839 tandem affinity purification 16554755 physical association X 2 Q03290 P37366 tandem affinity purification 16554755 physical association X 2 Q03290 P11484 tandem affinity purification 19536198 association X 2 Q03290 Q06677 tandem affinity purification 19536198 association X 2 Q03290 P11484 tandem affinity purification 19536198 association X 2 Q03290 P40150 tandem affinity purification 19536198 association X 2 Q03290 mass spectrometry studies of complexes 11805837 - C 3 Q03290 mass spectrometry studies of complexes 11805837 - C 3 Q03290 confirmational text mining - - C 9 Q03290 mass spectrometry studies of complexes 11805826 - C 18 Q03290 confirmational text mining - - C 9 Q03290 P37366 two hybrid 11283351 - X 2

PPI - HINT Gene A Gene B PMID Method Quality KIN28 TFB3 22411836,22308316,22308316,9235928 0401,0114,0004,0018 LC RAD3 TFB3 10681587,22411836,22308316,11007479,22308316,8557668 0018,0401,0114,0401,0004,0401 LC TFB1 TFB3 22411836,22308316,22308316 0401,0114,0004 LC TYE7 TFB3 22875988 0018 HT TFA1 TFB3 22411836 0401 LC TFA2 TFB3 22411836 0401 LC CCL1 TFB3 11283351,11283351,11283351,11839796,22411836,22308316,22308316 0018,0399,0398,0401,0401,0114,0004 HT,LC SSL2 TFB3 22411836,22308316,22308316 0401,0004,0114 LC MEC3 TFB3 10688190 0018 HT TFB2 TFB3 22411836,22308316,22308316 0401,0004,0114 LC TFB3 NSE5 14690591 0397 LC TFB3 SSL1 22411836,22308316,22308316 0401,0114,0004 LC TFB3 Q08816 22411836 0401 LC TFB3 TFB4 22411836,22308316,22308316,8657139 0401,0114,0004,0401 LC TFB3 TFB5 22308316,22308316 0004,0114 LC HTB1 TFB3 21179020 0676 HT TUB2 TFB3 16429126 0676 HT HSP82 TFB3 19536198 0676 HT KIN28 TFB3 16554755,19818408,20489023,20489023,22411836,20489023,22308316,17956857,22308316,14500720,17200106,16554755 0676,0004,0007,0004,0401,0676,0114,0004,0004,0004,0004,0004 HT,LC RAD3 TFB3 11805837,16554755,19818408,22411836,22308316,11007479,22308316,8557668,11805837,16554755 0004,0676,0004,0401,0114,0401,0004,0401,0007,0004 HT,LC ADE3 TFB3 16429126 0363 HT TUB1 TFB3 16429126 0676 HT SSA1 TFB3 19536198,19536198 0004,0676 HT SSA2 TFB3 19536198 0676 HT SSB1 TFB3 19536198,19536198 0004,0676 HT UBC4 TFB3 21816351 0096 LC VMA2 TFB3 16429126 0676 HT HSP60 TFB3 11805837 0007 HT SSE1 TFB3 19536198 0676 HT TFB1 TFB3 16554755,19818408,22411836,22308316,22308316,16554755 0676,0004,0401,0114,0004,0004 HT,LC TFA1 TFB3 22411836 0401 LC TFA2 TFB3 22411836 0401 LC CCL1 TFB3 16554755,16554755,19818408,16429126,11839796,22411836,11805826,20489023,22308316,11805826,20489023,14500720,11805826,17200106,22308316,16554755 0363,0676,0004,0676,0401,0401,0676,0004,0114,0004,0007,0004,0007,0004,0004,0004 HT,LC SSZ1 TFB3 19536198 0676 HT ARB1 TFB3 16429126 0363 HT SSB2 TFB3 19536198 0676 HT LYS12 TFB3 16429126 0676 HT PSA1 TFB3 16429126 0676 HT TAF1 TFB3 20026583 0428 LC UBC12 TFB3 21816351 0096 LC SSL2 TFB3 19818408,22411836,22308316,22308316 0004,0401,0004,0114 LC ADA2 TFB3 21734642,21734642 0676,0004 LC TFB2 TFB3 19818408,22411836,22308316,22308316 0004,0401,0004,0114 LC TFB3 SSL1 16554755,19818408,22411836,22308316,22308316,17200106,16554755 0676,0004,0401,0114,0004,0004,0004 HT,LC TFB3 DBP9 16429126 0363 HT TFB3 SWA2 19536198 0676 HT TFB3 BUD20 16429126 0363 HT TFB3 HRT1 21816351 0096 LC TFB3 Q08816 22411836 0401 LC TFB3 TFB4 16554755,19818408,22411836,22308316,22308316,17200106,8657139,16554755 0676,0004,0401,0114,0004,0004,0401,0004 HT,LC TFB3 TFB5 22308316,22308316 0004,0114 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q03290 P15731 TFB3 UBC4 0.309 21816351 Q04673 Q03290 SSL1 TFB3 0.74 22411836,19818408,22308316,16554755 Q03290 P10592 TFB3 SSA2 0.126 19536198 Q03290 P02293 TFB3 HTB1 0.126 21179020 Q03290 P06839 TFB3 RAD3 0.814 10681587,19818408,22308316,16554755,11805837,22411836 Q03290 P07245 TFB3 ADE3 0.126 16429126 Q03290 P11484 TFB3 SSB1 0.416 19536198 Q12004 Q03290 TFB4 TFB3 0.82 22411836,19818408,22308316,16554755 Q3E7C1 Q03290 TFB5 TFB3 0.454 22308316 Q03290 P37366 TFB3 CCL1 0.932 16429126,19818408,14500720,22308316,16554755,11283351,22411836,20489023,11805826 Q03290 P06242 TFB3 KIN28 0.939 19818408,14500720,17956857,22308316,16554755,22411836,20489023,9235928 Q03290 Q00578 TFB3 SSL2 0.659 22411836,19818408,22308316 Q03290 Q02939 TFB3 TFB2 0.659 22411836,19818408,22308316 Q03290 P36145 TFB3 TFA2 0.21 22411836 Q03290 P38199 TFB3 HEK2 0.126 18805955 Q03290 P36100 TFB3 TFA1 0.21 22411836 Q03290 P32589 TFB3 SSE1 0.126 19536198 Q03290 P32776 TFB3 TFB1 0.74 22411836,19818408,22308316,16554755 Q03290 P40024 TFB3 ARB1 0.126 16429126 Q03290 P46677 TFB3 TAF1 0.126 20026583 Q03290 P19882 TFB3 HSP60 0.126 11805837 Q03290 Q02336 TFB3 ADA2 0.126 21734642 Q03290 P52491 TFB3 UBC12 0.309 21816351 Q03290 Q02574 TFB3 MEC3 0.21 10688190 Q06218 Q03290 DBP9 TFB3 0.126 16429126 Q03290 P02557 TFB3 TUB2 0.126 16429126 Q03290 P02829 TFB3 HSP82 0.126 19536198 Q03290 P09733 TFB3 TUB1 0.126 16429126 Q03290 P10591 TFB3 SSA1 0.332 19536198 Q03290 P16140 TFB3 VMA2 0.126 16429126 Q03290 P38788 TFB3 SSZ1 0.126 19536198 Q03290 P40150 TFB3 SSB2 0.126 19536198 Q03290 P40495 TFB3 LYS12 0.126 16429126 Q03290 P41940 TFB3 PSA1 0.126 16429126 Q03718 Q03290 NSE5 TFB3 0.126 14690591 Q06677 Q03290 SWA2 TFB3 0.126 19536198 Q08816 Q03290 Q08816 TFB3 0.21 22411836 Q08004 Q03290 BUD20 TFB3 0.126 16429126 Q08273 Q03290 HRT1 TFB3 0.309 21816351