PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus UBC8 ECM10 19536198 intact exp UBC8 GCD7 18719252 biogrid,intact exp UBC8 RMD5 i2d exp SSA1 UBC8 19536198 intact exp UBC8 NAB2 19840948 biogrid exp UBC8 FRK1 21460040 biogrid exp UBC8 Uncharacterized protein YIL152W i2d exp UBC8 SSE1 19536198 intact exp UBC8 PUF3 26493364 biogrid exp UBC8 ELM1 21460040 biogrid exp UBC8 CRM1 26673895 biogrid exp SCH9 UBC8 21460040 biogrid exp UBC8 SRB4 11283351 i2d,mint,intact,dip exp UBC8 VID28 i2d exp HTA1 UBC8 i2d exp XRN1 UBC8 i2d exp PDR1 UBC8 i2d exp CKA2 UBC8 i2d exp UBC8 RLP7 i2d exp UBC8 PSH1 21070970 biogrid exp FBP1 UBC8 20617129 biogrid exp UBC8 SIP5 i2d exp SSB1 UBC8 19536198 intact exp UBC8 Putative uncharacterized protein YDL068W i2d exp UBC8 SSB2 19536198 intact exp UBC8 SWE1 16319894 biogrid exp UBC8 FYV10 i2d exp UBC8 UBC7 23023127 i2d exp, ortho, pred UBC8 UBC8 11805826,1869573,14747994, 23023127 biogrid,mint,intact exp, ortho, pred HTA2 UBC8 16554755, 23023127 biogrid,mint,intact exp, pred UBC8 RSP5 9108033, 23023127 biogrid exp, pred UBC8 GIN4 21460040,16554755, 23023127 biogrid,intact exp, pred UBC8 VIP1 16554755, 23023127 biogrid,i2d,mint,intact exp, pred UBC8 TDA1 21460040, 23023127 biogrid exp, pred UBC8 MEU1 ortho UBC8 ENP1 ortho UBC8 SSU72 ortho UBC8 ETP1 ortho UBC8 DYS1 ortho IDP1 UBC8 ortho UBC8 DNM1 ortho AAT2 UBC8 ortho UBC8 TSA1 ortho UBA1 UBC8 23023127 ortho, pred UBC8 HUB1 23023127 pred UBC8 UBC9 23023127 pred UBC8 VID30 23023127 pred UBC1 UBC8 23023127 pred UBC8 YSC84 23023127 pred UBC8 PRP19 23023127 pred UBC8 UBP6 23023127 pred UBC8 SMT3 23023127 pred UBC8 UBI4 23023127 pred UBC4 UBC8 23023127 pred UBC8 HRT1 23023127 pred UBC8 UBC12 23023127 pred UBC8 MPE1 23023127 pred UBC8 UBC11 23023127 pred GID7 UBC8 23023127 pred UBC8 UBX6 23023127 pred RAD6 UBC8 23023127 pred CDC34 UBC8 23023127 pred YIH1 UBC8 23023127 pred UBC8 PEX4 23023127 pred UBC8 DMA1 23023127 pred UBC8 AHA1 23023127 pred UBC8 RAD23 23023127 pred UBC8 UBC13 23023127 pred UBC8 PEX10 23023127 pred UBC8 UBX7 23023127 pred UBC8 ATG8 23023127 pred UBC8 GGA1 23023127 pred UBC8 TUL1 23023127 pred RAD18 UBC8 23023127 pred UBC8 MMS2 23023127 pred UBC8 CDC53 23023127 pred UBC8 UBX3 23023127 pred UBC8 RUB1 23023127 pred UBC8 DSK2 23023127 pred UBC8 UBP14 23023127 pred UBC5 UBC8 23023127 pred UBC8 UBX5 23023127 pred UBC8 SKP1 23023127 pred PHO85 UBC8 23023127 pred UBC8 UBC6 23023127 pred UBC8 SHP1 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P32569 P28263 - 11283351 - X 2 Q02159 P28263 - 8982460 - X 2 Q06685 P28263 affinity chromatography technology 16554755 physical association X 2 P0CG63 P28263 affinity chromatography technology 21427232 physical association X 2 P09201 P28263 affinity chromatography technology 20617129 physical association X 2 Q03002 P28263 pull down 21460040 direct interaction X 2 P11792 P28263 pull down 21460040 direct interaction X 2 Q12161 P28263 affinity chromatography technology 21070970 physical association X 2 P28263 P28263 enzymatic study 1869573 direct interaction X 2 P28263 P28263 enzymatic study 14747994 direct interaction X 2 P28263 P32944 enzymatic study 16319894 direct interaction X 2 Q12263 P28263 pull down 21460040 direct interaction X 2 Q03533 P28263 pull down 21460040 direct interaction X 2 P04912 P28263 affinity chromatography technology 16554755 physical association X 2 P32801 P28263 pull down 21460040 direct interaction X 2 P32502 P28263 two hybrid 18719252 direct interaction X 2 P39940 P28263 pull down 9108033 direct interaction X 2 P32569 P28263 two hybrid pooling approach 11283351 physical association X 2 P28263 inferred by author 16554755 association C 14 Q06685 P28263 tandem affinity purification 16554755 physical association X 2 Q06685 P28263 tandem affinity purification 16554755 physical association X 2 Q06685 P28263 tandem affinity purification 16554755 physical association X 2 P11484 P28263 tandem affinity purification 19536198 association X 2 P32569 P28263 two hybrid fragment pooling approach 11283351 physical association X 2 P10591 P28263 tandem affinity purification 19536198 association X 2 P39987 P28263 tandem affinity purification 19536198 association X 2 P32589 P28263 tandem affinity purification 19536198 association X 2 P28263 P28263 tandem affinity purification 11805826 physical association X 2 P04912 P28263 tandem affinity purification 16554755 physical association X 2 P40150 P28263 tandem affinity purification 19536198 association X 2 P32502 P28263 two hybrid 18719252 physical association X 2 P32569 P28263 two hybrid 11283351 - X 2 Q02159 P28263 interaction detection method 8982460 - X 2 Q02159 P28263 interaction detection method 8982460 - X 2

PPI - HINT Gene A Gene B PMID Method Quality UBC8 UBC8 1869573,14747994 0415,0415 LC UBC8 GCD7 18719252 0018 HT UBC8 SRB4 11283351,11283351,11283351 0018,0399,0398 HT UBC8 SWE1 16319894 0415 LC HTA2 UBC8 16554755,16554755 0676,0004 HT FBP1 UBC8 20617129 0004 LC SSA1 UBC8 19536198 0676 HT SSB1 UBC8 19536198 0676 HT SCH9 UBC8 21460040 0096 LC UBC8 UBC8 11805826,11805826 0676,0007 HT UBC8 CRM1 26673895,26673895 0096,0004 LC UBC8 NAB2 19840948 0004 LC UBC8 SSE1 19536198 0676 HT UBC8 ELM1 21460040 0096 LC UBC8 DOA1 26349035 0004 LC UBC8 RSP5 9108033 0096 LC UBC8 ECM10 19536198 0676 HT UBC8 SSB2 19536198 0676 HT UBC8 FRK1 21460040 0096 LC UBC8 TDA1 21460040 0096 LC UBC8 VIP1 16554755,16554755 0676,0004 HT UBC8 PSH1 21070970 0004 LC UBC8 GIN4 21460040,16554755 0096,0363 LC,HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P28263 P11484 UBC8 SSB1 0.126 19536198 P28263 P11792 UBC8 SCH9 0.183 21460040 Q12263 P28263 GIN4 UBC8 0.286 16554755,21460040 P30822 P28263 CRM1 UBC8 0.236 26673895 P28263 P04912 UBC8 HTA2 0.236 16554755 P28263 P28263 UBC8 UBC8 0.623 1869573,11805826,14747994 P28263 P10591 UBC8 SSA1 0.126 19536198 P28263 P09201 UBC8 FBP1 0.21 20617129 P32569 P28263 SRB4 UBC8 0.21 11283351 P32502 P28263 GCD7 UBC8 0.332 18719252 P40150 P28263 SSB2 UBC8 0.126 19536198 P39987 P28263 ECM10 UBC8 0.126 19536198 Q12161 P28263 PSH1 UBC8 0.21 21070970 P32505 P28263 NAB2 UBC8 0.126 19840948 P32589 P28263 SSE1 UBC8 0.126 19536198 P32801 P28263 ELM1 UBC8 0.183 21460040 P39940 P28263 RSP5 UBC8 0.309 9108033 P36037 P28263 DOA1 UBC8 0.126 26349035 Q03002 P28263 FRK1 UBC8 0.183 21460040 Q06685 P28263 VIP1 UBC8 0.332 16554755 Q03533 P28263 TDA1 UBC8 0.183 21460040