PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus MMS21 RRS1 i2d exp SSA1 MMS21 19536198 intact exp MMS21 PNT1 11283351 i2d,mint,intact,dip exp MMS21 SMT3 15738391 biogrid exp MMS21 UBC9 22562154,19748359,15738391 biogrid exp MMS21 KAP114 22562154,doi:10.1038/emboj.2012.102 biogrid,mint,intact exp SSB1 MMS21 19536198 intact exp GDH2 MMS21 16554755 intact exp SSA2 MMS21 19536198 intact exp SSC1 MMS21 19536198 intact exp SSE1 MMS21 19536198 intact exp MMS21 KRE29 15738391 biogrid exp MMS21 RTT107 21642432,20670896 biogrid exp MMS21 NSE1 15738391 biogrid exp MMS21 NSE3 15738391,16554755,14690591, 23023127 biogrid,i2d,mint,intact exp, pred MMS21 NSE5 15738391,14690591, 23023127 biogrid,intact exp, pred MMS21 SMC5 19748359,21999667,19141609,15738391,19652357,16554755,14690591, 23023127 biogrid,i2d,mint,intact exp, pred MMS21 SMC6 15738391, 23023127 biogrid,i2d exp, pred MMS21 NSE4 15738391,16554755, 23023127 biogrid,i2d,mint,intact exp, pred YKU70 MMS21 15738391, 23023127 biogrid exp, pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P38632 - 14690591 - C 6 P38632 - 14690591 - C 6 P38969 P38632 - 11283351 - X 2 P38632 P43124 affinity chromatography technology 15738391 physical association X 2 P38632 P43124 affinity chromatography technology 16554755 physical association X 2 P40026 P38632 affinity chromatography technology 15738391 physical association X 2 P32807 P38632 enzymatic study 15738391 direct interaction X 2 Q12306 P38632 enzymatic study 15738391 direct interaction X 2 Q05541 P38632 affinity chromatography technology 15738391 physical association X 2 Q05541 P38632 affinity chromatography technology 16554755 physical association X 2 Q05541 P38632 affinity chromatography technology 14690591 physical association X 2 P38850 P38632 affinity chromatography technology 20670896 physical association X 2 P38850 P38632 two hybrid 21642432 direct interaction X 2 P53067 P38632 pull down 22562154 direct interaction X 2 P53067 P38632 two hybrid 22562154 direct interaction X 2 P53067 P38632 enzymatic study 22562154 direct interaction X 2 Q08204 P38632 affinity chromatography technology 15738391 physical association X 2 Q08204 P38632 enzymatic study 15738391 direct interaction X 2 Q08204 P38632 affinity chromatography technology 15738391 physical association X 2 Q08204 P38632 x-ray crystallography 19748359 association X 2 Q08204 P38632 pull down 19748359 direct interaction X 2 Q08204 P38632 affinity chromatography technology 16554755 physical association X 2 Q08204 P38632 two hybrid 19141609 direct interaction X 2 Q08204 P38632 biochemical 19141609 association X 2 Q08204 P38632 pull down 21999667 direct interaction X 2 Q08204 P38632 x-ray crystallography 19652357 association X 2 Q12749 P38632 affinity chromatography technology 15738391 physical association X 2 Q12749 P38632 affinity chromatography technology 15738391 physical association X 2 P38632 Q03718 affinity chromatography technology 15738391 physical association X 2 P38632 Q03718 affinity chromatography technology 14690591 physical association X 2 Q07913 P38632 affinity chromatography technology 15738391 physical association X 2 P50623 P38632 pull down 19748359 direct interaction X 2 P50623 P38632 pull down 15738391 direct interaction X 2 P50623 P38632 pull down 22562154 direct interaction X 2 P38969 P38632 two hybrid pooling approach 11283351 physical association X 2 P38632 pull down 14690591 association C 8 P38632 pull down 14690591 association C 6 P38632 pull down 14690591 association C 6 P10592 P38632 tandem affinity purification 19536198 association X 2 P38969 P38632 two hybrid fragment pooling approach 11283351 physical association X 2 P38632 P43124 tandem affinity purification 16554755 physical association X 2 P38632 P43124 tandem affinity purification 16554755 physical association X 2 P38632 P43124 tandem affinity purification 16554755 physical association X 2 P10591 P38632 tandem affinity purification 19536198 association X 2 P0CS90 P38632 tandem affinity purification 19536198 association X 2 P38632 pull down 14690591 association C 35 P38632 inferred by author 16554755 association C 6 P32589 P38632 tandem affinity purification 19536198 association X 2 P11484 P38632 tandem affinity purification 19536198 association X 2 Q05541 P38632 tandem affinity purification 16554755 physical association X 2 Q05541 P38632 tandem affinity purification 16554755 physical association X 2 P53067 P38632 pull down 22562154 direct interaction X 2 P53067 P38632 two hybrid 22562154 physical association X 2 Q08204 P38632 tandem affinity purification 16554755 physical association X 2 P38969 P38632 two hybrid 11283351 - X 2

PPI - HINT Gene A Gene B PMID Method Quality YKU70 MMS21 15738391 0415 LC MMS21 RTT107 21642432 0018 LC MMS21 PNT1 11283351,11283351,11283351 0018,0399,0398 HT MMS21 KAP114 22562154,22562154,22562154 0018,0096,0415 LC MMS21 SMC5 19141609,19748359,19141609,15738391,19748359,21999667,21999667,19652357,15738391,19748359 0401,0114,0018,0004,0096,0096,0401,0114,0415,0004 LC MMS21 SMT3 15738391 0415 LC SSC1 MMS21 19536198 0676 HT SSA1 MMS21 19536198 0676 HT SSA2 MMS21 19536198 0676 HT SSB1 MMS21 19536198 0676 HT SSE1 MMS21 19536198 0676 HT GDH2 MMS21 16554755 0363 HT MMS21 RTT107 20670896 0004 LC MMS21 KRE29 15738391 0004 LC MMS21 NSE4 15738391,16554755,16554755 0004,0676,0004 LC,HT MMS21 UBC9 19748359,22562154,15738391 0096,0096,0096 LC MMS21 KAP114 22562154,22562154,22562154 0018,0096,0415 LC MMS21 NSE5 15738391 0004 LC MMS21 NSE3 15738391,16554755,16554755 0004,0676,0004 LC,HT MMS21 NSE1 15738391 0004 LC MMS21 SMC5 19141609,19748359,19141609,15738391,19748359,21999667,21999667,16554755,16554755,15738391,19748359 0401,0114,0018,0004,0096,0096,0401,0676,0004,0415,0004 LC,HT MMS21 SMC6 15738391 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P38632 P0CS90 MMS21 SSC1 0.126 19536198 P38632 P10591 MMS21 SSA1 0.126 19536198 P38632 P10592 MMS21 SSA2 0.126 19536198 Q05541 P38632 NSE3 MMS21 0.472 16554755,14690591,15738391 P43124 P38632 NSE4 MMS21 0.472 16554755,15738391 P53067 P38632 KAP114 MMS21 0.843 22562154 P38850 P38632 RTT107 MMS21 0.454 20670896,21642432 P50623 P38632 UBC9 MMS21 0.671 22562154,19748359,15738391 Q08204 P38632 SMC5 MMS21 0.955 14690591,19652357,19748359,16554755,21999667,19141609,15738391 P38632 P11484 MMS21 SSB1 0.126 19536198 P38632 P32589 MMS21 SSE1 0.126 19536198 P38632 P32807 MMS21 YKU70 0.309 15738391 P38969 P38632 PNT1 MMS21 0.236 11283351 P40026 P38632 KRE29 MMS21 0.21 15738391 Q03718 P38632 NSE5 MMS21 0.309 15738391,14690591 Q07913 P38632 NSE1 MMS21 0.21 15738391 Q12306 P38632 SMT3 MMS21 0.309 15738391 P38632 P33327 MMS21 GDH2 0.126 16554755 Q12749 P38632 SMC6 MMS21 0.21 15738391