PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus HSP78 SLX8 19536198 intact exp TOP2 SLX8 16554755 biogrid,i2d,mint,intact exp SLX8 HMO1 16554755 biogrid,i2d,mint,intact exp HSC82 SLX8 19536198 intact exp UBC5 SLX8 18499666 biogrid exp SLX8 THG1 14690591 i2d,intact exp SLX8 ABF2 16554755 biogrid,i2d,mint,intact exp SLX8 NUP84 18948542 biogrid exp RVS161 SLX8 16554755 biogrid,i2d,mint,intact exp PGI1 SLX8 11805837 dip exp UBC4 SLX8 20388728,24196836 biogrid exp SLX8 SSB2 19536198 intact exp SSA2 SLX8 19536198 intact exp SLX8 ASE1 16554755 biogrid,i2d,mint,intact exp SLX8 ATP14 11283351 i2d,mint,intact,dip exp HMLALPHA2 SLX8 20388728 biogrid exp SLX8 UBC7 14690591 intact exp SSA1 SLX8 19536198 intact exp SWE1 SLX8 16319894 biogrid exp SLX8 ULS1 23550137 biogrid exp SLX8 SIZ1 24196836 biogrid exp SLX8 CCT5 19536198 intact exp SSB1 SLX8 19536198 intact exp HSP82 SLX8 19536198 intact exp RVS167 SLX8 16554755 biogrid,i2d,mint,intact exp SLX8 ELG1 21869594 biogrid exp RAD52 SLX8 17848550 biogrid exp UBI4 SLX8 18032921 biogrid exp SSZ1 SLX8 19536198 intact exp SSE1 SLX8 19536198 intact exp HTA1 SLX8 i2d exp SSS1 SLX8 18467557 mint,intact exp SLX8 SLX8 17848550 biogrid exp SLX8 PUF3 26493364 biogrid exp WSS1 SLX8 20516210, 23023127 biogrid exp, pred PHO85 SLX8 16319894, 23023127 biogrid,i2d exp, pred SLX8 SMT3 23122649,17728242,17669696, 23023127 biogrid exp, pred HHF1, HHF2 SLX8 16554755, 23023127 biogrid,i2d,mint,intact exp, pred STM1 SLX8 16554755, 23023127 biogrid,i2d,mint,intact exp, pred SLX5 SLX8 18032921,20388728,11139495,17728242,16554755,17020915,10688190,24196836,17669696,20516210, 23023127 biogrid,i2d,mint,intact,dip exp, pred SLX8 UBC9 17669696, 23023127 biogrid exp, pred SLX8 NFI1 18499666, 23023127 biogrid exp, pred HTA2 SLX8 16554755, 23023127 biogrid,mint,intact exp, pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q12349 P40072 - 11283351 - X 2 P53215 P40072 - 14690591 - X 2 P32828 P40072 - 10688190 - X 2 P52891 P40072 affinity chromatography technology 18948542 physical association X 2 P52891 P40072 affinity chromatography technology 18948542 physical association X 2 P40072 P62837 pull down 17848550 direct interaction X 2 P40072 Q08562 two hybrid 23550137 direct interaction X 2 P40072 Q04195 pull down 24196836 direct interaction X 2 P40072 Q04195 enzymatic study 24196836 direct interaction X 2 P40072 A0A024R2K3 pull down 18032921 direct interaction X 2 P40072 A0A024R2K3 enzymatic study 18032921 direct interaction X 2 P40072 Q12306 unspecified method 23122649 direct interaction X 2 P40072 P40072 enzymatic study 17848550 direct interaction X 2 P40072 Q12306 pull down 17728242 direct interaction X 2 P40072 P02309 affinity chromatography technology 16554755 physical association X 2 P40072 Q12306 two hybrid 17669696 direct interaction X 2 P15731 P40072 pull down 20388728 direct interaction X 2 P15731 P40072 pull down 24196836 direct interaction X 2 P0CG63 P40072 enzymatic study 18032921 direct interaction X 2 P06778 P40072 enzymatic study 17848550 direct interaction X 2 P17157 P40072 enzymatic study 16319894 direct interaction X 2 P06786 P40072 affinity chromatography technology 16554755 physical association X 2 P04912 P40072 affinity chromatography technology 16554755 physical association X 2 P0CY08 P40072 enzymatic study 20388728 direct interaction X 2 P61088 P40072 pull down 18032921 direct interaction X 2 P61088 P40072 enzymatic study 18032921 direct interaction X 2 P39015 P40072 affinity chromatography technology 16554755 physical association X 2 P40072 P15732 pull down 18499666 direct interaction X 2 P40072 P39743 affinity chromatography technology 16554755 physical association X 2 P40072 P32944 enzymatic study 16319894 direct interaction X 2 P40072 P50623 two hybrid 17669696 direct interaction X 2 P40072 P38838 two hybrid 20516210 direct interaction X 2 P50275 P40072 affinity chromatography technology 16554755 physical association X 2 Q02486 P40072 affinity chromatography technology 16554755 physical association X 2 P25343 P40072 affinity chromatography technology 16554755 physical association X 2 Q03973 P40072 affinity chromatography technology 16554755 physical association X 2 Q12050 P40072 two hybrid 21869594 direct interaction X 2 Q12050 P40072 pull down 21869594 direct interaction X 2 P0CG48 P40072 enzymatic study 18032921 direct interaction X 2 Q12216 P40072 enzymatic study 18499666 direct interaction X 2 P32828 P40072 affinity chromatography technology 11139495 physical association X 2 P32828 P40072 two hybrid 24196836 direct interaction X 2 P32828 P40072 pull down 18032921 direct interaction X 2 P32828 P40072 affinity chromatography technology 16554755 physical association X 2 P32828 P40072 pull down 17020915 direct interaction X 2 P32828 P40072 two hybrid 17669696 direct interaction X 2 P32828 P40072 two hybrid 17669696 direct interaction X 2 P32828 P40072 biochemical 17728242 association X 2 P32828 P40072 affinity chromatography technology 20388728 physical association X 2 P32828 P40072 two hybrid 20516210 direct interaction X 2 P32828 P40072 two hybrid 10688190 direct interaction X 2 Q12349 P40072 two hybrid pooling approach 11283351 physical association X 2 P32828 P40072 two hybrid 10688190 physical association X 2 P12709 P40072 anti tag coimmunoprecipitation 11805837 physical association X 2 P40072 inferred by author 16554755 association C 20 P10592 P40072 tandem affinity purification 19536198 association X 2 P40072 P02309 tandem affinity purification 16554755 physical association X 2 P40072 P40413 tandem affinity purification 19536198 association X 2 P40072 P33416 tandem affinity purification 19536198 association X 2 P11484 P40072 tandem affinity purification 19536198 association X 2 P15108 P40072 tandem affinity purification 19536198 association X 2 P02829 P40072 tandem affinity purification 19536198 association X 2 P06786 P40072 tandem affinity purification 16554755 physical association X 2 P04912 P40072 tandem affinity purification 16554755 physical association X 2 P40150 P40072 tandem affinity purification 19536198 association X 2 P39015 P40072 tandem affinity purification 16554755 physical association X 2 Q12349 P40072 two hybrid fragment pooling approach 11283351 physical association X 2 P32589 P40072 tandem affinity purification 19536198 association X 2 P40072 P39743 tandem affinity purification 16554755 physical association X 2 P35179 P40072 dihydrofolate reductase reconstruction 18467557 physical association X 2 P50275 P40072 tandem affinity purification 16554755 physical association X 2 Q02486 P40072 tandem affinity purification 16554755 physical association X 2 P25343 P40072 tandem affinity purification 16554755 physical association X 2 Q02159 P40072 two hybrid array 14690591 physical association X 2 Q03973 P40072 tandem affinity purification 16554755 physical association X 2 P53215 P40072 two hybrid array 14690591 physical association X 2 P10591 P40072 tandem affinity purification 19536198 association X 2 P38788 P40072 tandem affinity purification 19536198 association X 2 P32828 P40072 two hybrid 10688190 physical association X 2 P32828 P40072 anti bait coimmunoprecipitation 11139495 physical association X 2 P32828 P40072 tandem affinity purification 16554755 physical association X 2 P49956 P40072 interaction detection method 14764870 - X 2 Q01454 P40072 interaction detection method 14764870 - X 2 Q12349 P40072 two hybrid 11283351 - X 2 P38877 P40072 interaction detection method 14764870 - X 2 Q04659 P40072 interaction detection method 14764870 - X 2 Q04659 P40072 interaction detection method 14764870 - X 2 Q12050 P40072 interaction detection method 12912927 - X 2 P32828 P40072 two hybrid 10688190 - X 2

PPI - HINT Gene A Gene B PMID Method Quality RAD52 SLX8 17848550 0415 LC UBI4 SLX8 18032921 0415 LC MATALPHA2 SLX8 20388728 0415 LC HMLALPHA2 SLX8 20388728,26246605 0415,0415 LC PHO85 SLX8 16319894 0415 LC MOT1 SLX8 19139279 0018 LC SLX5 SLX8 17669696,10688190,24196836,17728242,20516210,17848550,10688190 0018,0397,0018,0401,0018,0415,0018 LC,HT SWE1 SLX8 16319894 0415 LC SSS1 SLX8 18467557 0111 HT WSS1 SLX8 20516210 0018 LC SLX8 SLX8 17848550 0415 LC SLX8 UBC9 17669696 0018 LC SLX8 THG1 14690591,14690591 0018,0397 LC SLX8 UBC7 14690591 0397 LC SLX8 SIZ1 24196836,24196836 0415,0096 LC SLX8 ULS1 23550137 0018 LC SLX8 ELG1 21869594,21869594 0096,0018 LC SLX8 NFI1 18499666 0415 LC SLX8 SMT3 17669696,17848550 0018,0415 LC SLX8 ATP14 11283351,11283351,11283351 0018,0399,0398 HT HHF1|HHF2 SLX8 16554755,16554755 0676,0004 HT HSP82 SLX8 19536198 0676 HT HTA2 SLX8 16554755,16554755 0676,0004 HT TOP2 SLX8 16554755,16554755 0676,0004 HT SSA1 SLX8 19536198 0676 HT SSA2 SLX8 19536198 0676 HT SSB1 SLX8 19536198 0676 HT PGI1 SLX8 11805837 0007 HT HSC82 SLX8 19536198 0676 HT UBC4 SLX8 26246605,20388728,24196836 0096,0096,0096 LC UBC5 SLX8 18499666 0096 LC RVS161 SLX8 16554755,16554755 0676,0004 HT SSE1 SLX8 19536198 0676 HT SLX5 SLX8 11139495,16554755,11139495,20388728,17728242,17020915,16554755,18032921 0006,0676,0004,0004,0401,0096,0004,0096 LC,HT HSP78 SLX8 19536198 0676 HT SSZ1 SLX8 19536198 0676 HT STM1 SLX8 16554755,16554755 0676,0004 HT RVS167 SLX8 16554755,16554755 0676,0004 HT SLX8 SSB2 19536198 0676 HT SLX8 CCT5 19536198 0676 HT SLX8 ASE1 16554755,16554755 0676,0004 HT SLX8 NUP84 18948542 0004 LC SLX8 ABF2 16554755,16554755,16554755 0363,0676,0004 HT SLX8 HMO1 16554755,16554755 0676,0004 HT SLX8 SIZ1 24196836,24196836 0415,0096 LC SLX8 ELG1 21869594,21869594 0096,0018 LC SLX8 SMT3 17728242 0096 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P40072 P17157 SLX8 PHO85 0.183 16319894 Q12349 P40072 ATP14 SLX8 0.21 11283351 P40072 P10592 SLX8 SSA2 0.126 19536198 P40072 P02829 SLX8 HSP82 0.126 19536198 P40072 P0CY09 SLX8 HMLALPHA2 0.523 20388728,26246605 P40072 P0CY08 SLX8 MATALPHA2 0.523 20388728,26246605 P40072 P06786 SLX8 TOP2 0.236 16554755 P40072 P04912 SLX8 HTA2 0.236 16554755 P40072 P02309 SLX8 HHF2 0.236 16554755 P40072 P25343 SLX8 RVS161 0.236 16554755 Q04195 P40072 SIZ1 SLX8 0.523 24196836 P40072 P39015 SLX8 STM1 0.236 16554755 P40072 P15731 SLX8 UBC4 0.671 24196836,26246605,20388728 P40072 P38788 SLX8 SSZ1 0.126 19536198 P40072 P32589 SLX8 SSE1 0.126 19536198 P40072 P32828 SLX8 SLX5 0.939 10688190,24196836,17669696,20388728,20516210,16554755,17728242,17020915 P40072 P39743 SLX8 RVS167 0.236 16554755 P40072 P33416 SLX8 HSP78 0.126 19536198 P40072 P06778 SLX8 RAD52 0.309 17848550 P40072 P10591 SLX8 SSA1 0.126 19536198 P40072 P11484 SLX8 SSB1 0.126 19536198 P40072 P12709 SLX8 PGI1 0.126 11805837 P40072 P15108 SLX8 HSC82 0.126 19536198 P40072 P15732 SLX8 UBC5 0.309 18499666 P40072 P35179 SLX8 SSS1 0.126 18467557 P40072 P38838 SLX8 WSS1 0.309 20516210 P40072 P40072 SLX8 SLX8 0.332 17848550 P50275 P40072 ASE1 SLX8 0.236 16554755 P50623 P40072 UBC9 SLX8 0.309 17669696 P53215 P40072 THG1 SLX8 0.126 14690591 P62837 P40072 UBE2D2 SLX8 0.309 17848550 Q02159 P40072 UBC7 SLX8 0.126 14690591 Q02486 P40072 ABF2 SLX8 0.332 16554755 Q03973 P40072 HMO1 SLX8 0.236 16554755 Q12050 P40072 ELG1 SLX8 0.523 21869594 Q12216 P40072 NFI1 SLX8 0.309 18499666 Q12306 P40072 SMT3 SLX8 0.671 17669696,17728242,23122649 P40150 P40072 SSB2 SLX8 0.126 19536198 P40413 P40072 CCT5 SLX8 0.126 19536198 Q08562 P40072 ULS1 SLX8 0.309 23550137