PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus HEK2 UBP5 18805955 biogrid exp UBI4 UBP5 10069815 biogrid exp GCD7 UBP5 18719252 biogrid,intact exp MTF2 UBP5 11283351 i2d,mint,intact,dip exp SSB1 UBP5 19536198 intact exp YEL1 UBP5 i2d exp CSM1 UBP5 18719252 biogrid,intact exp SSA1 UBP5 19536198 intact exp WHI3 UBP5 24386330,18667435 biogrid exp UBP5 HOF1 19841731,11283351 biogrid,i2d,mint,intact,dip exp UBP5 SAS10 i2d exp UBP5 ECM10 19536198 intact exp NAM7 UBP5 18087042 biogrid exp NAB2 UBP5 19840948 biogrid exp RGD1 UBP5 18719252 biogrid,intact exp UBP5 PRK1 18719252 biogrid,intact exp OSH3 UBP5 i2d exp DBR1 UBP5 i2d exp SSA2 UBP5 19536198 intact exp AKL1 UBP5 10688190,11283351, 23023127 biogrid,i2d,mint,intact,dip exp, pred UBP5 AKR2 11283351, 23023127 i2d,mint,intact,dip exp, pred PUP1 UBP5 10688190,11595789, 23023127 biogrid,i2d,mint,intact,dip exp, pred UBP5 UBP15 23023127 pred UBP5 BRE5 23023127 pred UBP5 UBP10 23023127 pred UBP5 UBP3 23023127 pred UBP5 UBP6 23023127 pred UBP5 UBX4 23023127 pred ATG12 UBP5 23023127 pred DOA4 UBP5 23023127 pred UBX7 UBP5 23023127 pred UBP5 UBX6 23023127 pred UBP5 UBP8 23023127 pred UBP5 UBP7 23023127 pred UBP11 UBP5 23023127 pred UBP14 UBP5 23023127 pred UBP5 UBX5 23023127 pred UBP5 UBP16 23023127 pred UBP5 UBI4 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P39944 P25043 - 11595789 - X 2 P39944 P10849 - 11283351 - X 2 P39944 Q05080 - 11283351 - X 2 P39944 P38080 - 11283351 - X 2 P39944 Q12013 - 11283351 - X 2 P39944 P38080 - 10688190 - X 2 P0CG63 P39944 enzymatic study 10069815 direct interaction X 2 P39944 P25043 two hybrid 11595789 direct interaction X 2 P39944 P40494 two hybrid 18719252 direct interaction X 2 P39944 P32502 two hybrid 18719252 direct interaction X 2 P39944 Q05080 two hybrid 11283351 direct interaction X 2 P39944 P38339 two hybrid 18719252 direct interaction X 2 P39944 P25651 two hybrid 18719252 direct interaction X 2 P39944 Q05080 two hybrid 19841731 direct interaction X 2 P39944 Q05080 two hybrid 11283351 direct interaction X 2 P39944 P38080 two hybrid 10688190 direct interaction X 2 P39944 P10849 two hybrid pooling approach 11283351 physical association X 2 P39944 P25043 two hybrid 11595789 physical association X 2 P39944 P25043 two hybrid 10688190 physical association X 2 P39944 Q05080 two hybrid pooling approach 11283351 physical association X 2 P39944 Q05080 two hybrid pooling approach 11283351 physical association X 2 P39944 Q12013 two hybrid pooling approach 11283351 physical association X 2 P39944 P38080 two hybrid 10688190 physical association X 2 P39944 P38080 two hybrid pooling approach 11283351 physical association X 2 P39944 P25043 two hybrid 10688190 physical association X 2 P39944 P10849 two hybrid fragment pooling approach 11283351 physical association X 2 P39944 P25043 two hybrid array 11595789 physical association X 2 P39944 P40494 two hybrid 18719252 physical association X 2 P39944 P32502 two hybrid 18719252 physical association X 2 P39944 P38080 two hybrid 10688190 physical association X 2 P39944 P38080 two hybrid fragment pooling approach 11283351 physical association X 2 P39944 Q05080 two hybrid fragment pooling approach 11283351 physical association X 2 P39944 Q12013 two hybrid fragment pooling approach 11283351 physical association X 2 P39944 Q05080 two hybrid fragment pooling approach 11283351 physical association X 2 P39944 P25651 two hybrid 18719252 physical association X 2 P39944 P38339 two hybrid 18719252 physical association X 2 P39944 P10591 tandem affinity purification 19536198 association X 2 P39944 P11484 tandem affinity purification 19536198 association X 2 P39944 P39987 tandem affinity purification 19536198 association X 2 P39944 P10592 tandem affinity purification 19536198 association X 2 P39944 Q05080 inferred by author 19841731 direct interaction X 2 P39944 Q05080 two hybrid pooling approach 19841731 physical association X 2 P39944 P10849 two hybrid 11283351 - X 2 P39944 P38080 two hybrid 10688190 - X 2 P39944 Q05080 two hybrid 11283351 - X 2 P39944 P38080 two hybrid 11283351 - X 2 P39944 Q05080 two hybrid 11283351 - X 2 P39944 Q12013 two hybrid 11283351 - X 2

PPI - HINT Gene A Gene B PMID Method Quality UBI4 UBP5 10069815 0415 LC MTF2 UBP5 11283351,11283351,11283351 0018,0399,0398 HT PUP1 UBP5 11595789,11595789,10688190 0018,0397,0018 LC,HT CSM1 UBP5 18719252 0018 HT GCD7 UBP5 18719252 0018 HT AKL1 UBP5 11283351,11283351,10688190,11283351,10688190 0018,0399,0397,0398,0018 HT RGD1 UBP5 18719252 0018 HT UBP5 PRK1 18719252 0018 HT UBP5 HOF1 19841731,11283351,11283351,19841731,11283351,19841731 0018,0018,0399,0363,0398,0398 HT UBP5 AKR2 11283351,11283351,11283351 0018,0399,0398 HT SSA1 UBP5 19536198 0676 HT SSA2 UBP5 19536198 0676 HT SSB1 UBP5 19536198 0676 HT NAB2 UBP5 19840948 0004 LC WHI3 UBP5 24386330 0004 LC UBP5 ECM10 19536198 0676 HT UBP5 HOF1 19841731,19841731,19841731 0018,0363,0398 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q12013 P39944 AKR2 UBP5 0.21 11283351 Q12221 P39944 PUF2 UBP5 0.126 26668354 P39944 P10849 UBP5 MTF2 0.21 11283351 P39944 P11484 UBP5 SSB1 0.126 19536198 P39944 P25651 UBP5 CSM1 0.332 18719252 P39944 P32502 UBP5 GCD7 0.332 18719252 P39944 P34761 UBP5 WHI3 0.286 18667435,24386330 P39944 P30771 UBP5 NAM7 0.126 18087042 P39944 P38199 UBP5 HEK2 0.126 18805955 P39944 P38339 UBP5 RGD1 0.332 18719252 P39944 P32505 UBP5 NAB2 0.126 19840948 P39944 P0CG63 UBP5 UBI4 0.309 10069815 P39944 P10591 UBP5 SSA1 0.126 19536198 P39944 P10592 UBP5 SSA2 0.126 19536198 P39944 P25043 UBP5 PUP1 0.286 11595789,10688190 P39944 P38080 UBP5 AKL1 0.472 10688190,11283351 P39987 P39944 ECM10 UBP5 0.126 19536198 P40494 P39944 PRK1 UBP5 0.332 18719252 Q05080 P39944 HOF1 UBP5 0.636 11283351,19841731