PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus CDC4 PLM2 16338374 biogrid exp RPC40 CDC4 i2d exp CDC4 CCT3 19536198 intact exp CDC4 ATC1 24389104 biogrid exp CDC4 SWI1 24389104 biogrid exp CDC4 PCL1 24389104 biogrid exp CDC4 SSB1 19536198 intact exp CDC4 UBI4 21070969 biogrid exp CDC4 LAG2 19763088 biogrid,intact exp CDC4 CLN1 22844257 biogrid exp CDC4 HAC1 17108329 biogrid exp GCN4 CDC4 16338374,18787112 biogrid,i2d,dip exp CDC4 Uncharacterized protein YKL050C 16338374 biogrid exp CDC4 SLD2 16338374 biogrid exp CDC4 ISR1 24389104 biogrid exp CDC4 SSZ1 19536198 intact exp CDC4 PFD1 19536198 intact exp CDC4 TEC1 19897738,15620356 biogrid,i2d exp CDC4 PRE6 11500370 biogrid,intact exp CDC4 SSB2 19536198 intact exp STE7 CDC4 23645675 biogrid exp CDC4 SSA2 19536198 intact exp CDC4 SSA1 19536198 intact exp CDC4 KIN2 16338374 biogrid exp CDC4 FPK1 16338374 biogrid exp CDC4 ECO1 23314252 biogrid exp CDC4 CWC2 14690591 intact exp CDC4 FAR1 24389104,16338374 biogrid exp CDC4 ASH1 24389104,21098119 biogrid exp CDC4 HST4 24389104,16338374 biogrid exp CDC4 HST3 24715726,24389104,24648511 biogrid exp CDC4 STE5 24389104 biogrid exp CDC4 RCN1 18787112,17954914 biogrid,dip exp CDC4 WHI5 16338374 biogrid exp CDC4 CDC53 10213691,9844630,9499404,9346239,19882662,10582239,16790494,14747994,9346238, 23023127 biogrid,i2d,intact,dip exp, pred CDC4 SKP1 12582129,10213691,19897738,17960736,9499404,11805837,16338374,11283612,10688190,23000173,8706131,19882662,14747994,17574027,20581844,9844630,23267104,15660125,12553912,18719252,11734846,16751663,16432255,9346239,20581845,9346238, 23023127 biogrid,i2d,mint,intact,dip exp, pred CDC4 CDC16 23023127 i2d exp, pred CDC4 SPO74 18787112, 23023127 biogrid,dip exp, pred CDC4 CLN2 22844257,15200949, 23023127 biogrid exp, pred CDC4 YDJ1 19536198, 23023127 intact exp, pred CDC4 GPA1 20542006, 23023127 biogrid exp, pred CDC4 CDC4 12582129,14747994,17574027,18719252, 23023127 biogrid,intact exp, pred CDC4 SGT1 10445024, 23023127 biogrid,dip exp, pred CDC4 CDC6 24389104,11532947,9312054,25995377,19285403,17108329,11237870,10512865, 23023127 biogrid,i2d,intact,dip exp, pred CDC4 Uncharacterized protein YDR132C 18719252, 23023127 biogrid,intact exp, pred CDC4 SWI5 24389104,18787112, 23023127 biogrid,dip exp, pred CDC4 SIC1 9285816,12820958,17562869,17522259,9636170,20194622,16338374,14747994,17574027,20581844,15448699,16776651,18054791,22328159,12553912,24316736,13678584,19008353,9346239,17114057,9346238, 23023127 biogrid,intact,dip exp, pred CDC4 CDC34 18054791,17562869,9636170,23645675,8943317,16338374,9346239,10213692,9461595,20832729,17114057,20581844, 23023127 biogrid,i2d,dip exp, pred CDC4 CIC1 11500370, 23023127 biogrid,intact exp, pred CDC4 RFA1 9724654, 23023127 biogrid exp, pred CDC4 CLB3 15200949, 23023127 biogrid exp, pred CDC4 CLN3 24389104,22844257, 23023127 biogrid exp, pred CDC4 PRE1 15907469, 23023127 biogrid exp, pred CDC4 HRT1 10880467,10213691,23267104,19882662,14747994,10385629,17574027, 23023127 biogrid,i2d,intact,dip exp, pred CDC4 SIS1 19536198, 23023127 intact exp, pred CDC4 SLA1 23023127 pred CDC4 DAS1 23023127 pred CDC4 CDC5 23023127 pred CDC4 CDC20 23023127 pred CDC4 SAP185 23023127 pred CDC4 ELC1 23023127 pred CDC4 UBI4 23023127 pred CDC4 MET30 23023127 pred CDC4 CDC40 23023127 pred CDC7 CDC4 23023127 pred CDC4 SPR3 23023127 pred CDC4 CDC12 23023127 pred CDC4 PKC1 23023127 pred CDC28 CDC4 23023127 pred RAD6 CDC4 23023127 pred CDC25 CDC4 23023127 pred CDC4 RSP5 23023127 pred CDC4 BIK1 23023127 pred CDC4 GRR1 23023127 pred CDC4 UBC1 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P07834 - 9461595 - C 3 P07834 - 9461595 - C 3 P07834 Q12018 - 9499404 - X 2 P07834 P18412 - 15620356 - X 2 P09119 P07834 - 9312054 - X 2 P09119 P07834 - 9312054 - X 2 P09119 P07834 - 15496876 - X 2 P52286 P07834 - 8706131 - X 2 P52286 P07834 - 11805837 - X 2 P52286 P07834 - 12553912 - X 2 P52286 P07834 - 9499404 - X 2 P52286 P07834 - 8706131 - X 2 P07834 - 15200949 - C 15 P07834 - 15200949 - C 19 P07834 - 11805837 - C 8 Q08273 P07834 - 10880467 - X 2 P07834 - 12553912 - X 2 P14682 P07834 pull down 20581844 direct interaction X 2 P14682 P07834 pull down 9636170 direct interaction X 2 P14682 P07834 pull down 18054791 direct interaction X 2 P14682 P07834 affinity chromatography technology 9461595 physical association X 2 P14682 P07834 affinity chromatography technology 8943317 physical association X 2 P14682 P07834 pull down 9346239 direct interaction X 2 P14682 P07834 biochemical 9461595 colocalization X 2 P14682 P07834 pull down 9461595 direct interaction X 2 P14682 P07834 enzymatic study 10213692 direct interaction X 2 P14682 P07834 pull down 20832729 direct interaction X 2 P14682 P07834 pull down 16338374 direct interaction X 2 P14682 P07834 pull down 17114057 direct interaction X 2 P14682 P07834 pull down 17562869 direct interaction X 2 P14682 P07834 pull down 23645675 direct interaction X 2 P24867 P07834 affinity chromatography technology 24389104 physical association X 2 P07834 P38634 pull down 22328159 direct interaction X 2 P07834 P38634 two hybrid 22328159 direct interaction X 2 P07834 P38634 enzymatic study 22328159 direct interaction X 2 P07834 P13365 affinity chromatography technology 22844257 physical association X 2 P07834 A0A090N7U0 affinity chromatography technology 9636170 physical association X 2 P07834 P38634 enzymatic study 9636170 direct interaction X 2 P07834 Q12018 affinity chromatography technology 10213691 physical association X 2 P07834 Q12018 affinity chromatography technology 9499404 physical association X 2 P07834 Q12018 affinity chromatography technology 9499404 physical association X 2 P07834 Q12018 affinity chromatography technology 9346238 physical association X 2 P07834 Q12018 pull down 9346239 direct interaction X 2 P07834 Q12018 two hybrid 9499404 direct interaction X 2 P07834 Q12018 pull down 14747994 direct interaction X 2 P07834 P38634 pull down 12820958 direct interaction X 2 P07834 Q12018 affinity chromatography technology 10582239 physical association X 2 P07834 P22336 imaging technique 9724654 colocalization X 2 P07834 P43605 unspecified method 23314252 direct interaction X 2 P07834 P07834 affinity chromatography technology 12582129 physical association X 2 P07834 P07834 two hybrid 12582129 direct interaction X 2 P07834 P18412 pull down 15620356 direct interaction X 2 P07834 P38634 enzymatic study 20194622 direct interaction X 2 P07834 P38634 enzymatic study 9285816 direct interaction X 2 P07834 P21268 affinity chromatography technology 24389104 physical association X 2 P07834 Q04005 affinity chromatography technology 24389104 physical association X 2 P07834 P13365 affinity chromatography technology 24389104 physical association X 2 P07834 P21268 affinity chromatography technology 24389104 physical association X 2 P07834 P53688 affinity chromatography technology 24389104 physical association X 2 P07834 P38634 enzymatic study 24316736 direct interaction X 2 P07834 P38634 enzymatic study 13678584 direct interaction X 2 P07834 P38634 enzymatic study 14747994 direct interaction X 2 P07834 P07834 enzymatic study 14747994 direct interaction X 2 P07834 Q12018 affinity chromatography technology 9346238 physical association X 2 P07834 P38634 pull down 9346238 direct interaction X 2 P07834 P38634 enzymatic study 9346238 direct interaction X 2 P07834 P38634 pull down 9346239 direct interaction X 2 P07834 P38634 enzymatic study 9346239 direct interaction X 2 P07834 Q12018 affinity chromatography technology 9844630 physical association X 2 P07834 P38779 pull down 11500370 direct interaction X 2 P07834 P38779 affinity chromatography technology 11500370 physical association X 2 P07834 P38634 unspecified method 16338374 direct interaction X 2 P07834 P53688 unspecified method 16338374 direct interaction X 2 P07834 P38634 enzymatic study 16338374 direct interaction X 2 P07834 P53688 enzymatic study 16338374 direct interaction X 2 P07834 P53688 pull down 16338374 direct interaction X 2 P07834 P38634 pull down 16338374 direct interaction X 2 P07834 P21268 pull down 16338374 direct interaction X 2 P07834 Q12416 pull down 16338374 direct interaction X 2 P07834 P53739 pull down 16338374 direct interaction X 2 P07834 P38634 pull down 16776651 direct interaction X 2 P07834 P38634 enzymatic study 17114057 direct interaction X 2 P07834 P38634 unspecified method 17522259 direct interaction X 2 P07834 P38634 enzymatic study 17562869 direct interaction X 2 P07834 P38634 pull down 12553912 direct interaction X 2 P07834 P38634 enzymatic study 12553912 direct interaction X 2 P07834 P06784 affinity chromatography technology 23645675 physical association X 2 P07834 P06784 enzymatic study 23645675 direct interaction X 2 P07834 Q12018 affinity chromatography technology 16790494 physical association X 2 P07834 P38634 enzymatic study 17574027 direct interaction X 2 P07834 Q03900 two hybrid 18719252 direct interaction X 2 P07834 P07834 two hybrid 18719252 direct interaction X 2 P07834 Q92325 affinity chromatography technology 19763088 physical association X 2 P07834 Q92325 pull down 19763088 direct interaction X 2 P07834 P38634 x-ray crystallography 19008353 association X 2 P07834 Q12018 affinity chromatography technology 19882662 physical association X 2 P07834 P07834 pull down 17574027 direct interaction X 2 P07834 P38634 enzymatic study 20581844 direct interaction X 2 P07834 P18412 pull down 19897738 direct interaction X 2 P07834 P38634 enzymatic study 18054791 direct interaction X 2 P53687 P07834 affinity chromatography technology 24389104 physical association X 2 P53687 P07834 enzymatic study 24648511 direct interaction X 2 P53687 P07834 affinity chromatography technology 24715726 physical association X 2 P09119 P07834 two hybrid 10512865 direct interaction X 2 P09119 P07834 two hybrid 9312054 direct interaction X 2 P09119 P07834 two hybrid 11237870 direct interaction X 2 P09119 P07834 two hybrid 11532947 direct interaction X 2 P09119 P07834 affinity chromatography technology 24389104 physical association X 2 P09119 P07834 two hybrid 17108329 direct interaction X 2 P09119 P07834 two hybrid 19285403 direct interaction X 2 P52286 P07834 affinity chromatography technology 10213691 physical association X 2 P52286 P07834 pull down 23000173 direct interaction X 2 P52286 P07834 biochemical 16338374 association X 2 P52286 P07834 affinity chromatography technology 9346238 physical association X 2 P52286 P07834 pull down 9346239 direct interaction X 2 P52286 P07834 two hybrid 11283612 direct interaction X 2 P52286 P07834 pull down 14747994 direct interaction X 2 P52286 P07834 x-ray crystallography 12553912 association X 2 P52286 P07834 affinity chromatography technology 8706131 physical association X 2 P52286 P07834 two hybrid 12582129 direct interaction X 2 P52286 P07834 pull down 11734846 direct interaction X 2 P52286 P07834 affinity chromatography technology 9499404 physical association X 2 P52286 P07834 affinity chromatography technology 15660125 physical association X 2 P52286 P07834 affinity chromatography technology 9346238 physical association X 2 P52286 P07834 pull down 9346239 direct interaction X 2 P52286 P07834 affinity chromatography technology 9844630 physical association X 2 P52286 P07834 affinity chromatography technology 16751663 physical association X 2 P52286 P07834 pull down 12553912 direct interaction X 2 P52286 P07834 affinity chromatography technology 16432255 physical association X 2 P52286 P07834 pull down 17960736 direct interaction X 2 P52286 P07834 two hybrid 18719252 direct interaction X 2 P52286 P07834 biochemical 19897738 association X 2 P52286 P07834 affinity chromatography technology 19882662 physical association X 2 P52286 P07834 pull down 17574027 direct interaction X 2 P52286 P07834 pull down 20581844 direct interaction X 2 P52286 P07834 affinity chromatography technology 20581845 physical association X 2 P52286 P07834 affinity chromatography technology 11805837 physical association X 2 P52286 P07834 affinity chromatography technology 11805837 physical association X 2 P52286 P07834 two hybrid 10688190 direct interaction X 2 P32917 P07834 affinity chromatography technology 24389104 physical association X 2 Q08273 P07834 affinity chromatography technology 10213691 physical association X 2 Q08273 P07834 affinity chromatography technology 10213691 physical association X 2 Q08273 P07834 affinity chromatography technology 10385629 physical association X 2 Q08273 P07834 pull down 17574027 direct interaction X 2 Q08273 P07834 two hybrid 10880467 direct interaction X 2 Q08273 P07834 pull down 14747994 direct interaction X 2 Q08273 P07834 affinity chromatography technology 19882662 physical association X 2 P0CG63 P07834 affinity chromatography technology 23749301 physical association X 2 P0CG63 P07834 biochemical 23583075 association X 2 P0CG63 P07834 affinity chromatography technology 17644757 physical association X 2 P0CG63 P07834 affinity chromatography technology 23793018 physical association X 2 P0CG63 P07834 affinity chromatography technology 9844630 physical association X 2 P0CG63 P07834 affinity chromatography technology 9844630 physical association X 2 P0CG63 P07834 affinity chromatography technology 11500370 physical association X 2 P0CG63 P07834 x-ray crystallography 21070969 association X 2 P0CG63 P07834 pull down 21070969 direct interaction X 2 P0CG63 P07834 affinity chromatography technology 21427232 physical association X 2 Q08446 P07834 pull down 10445024 direct interaction X 2 P08153 P07834 affinity chromatography technology 24389104 physical association X 2 P08153 P07834 two hybrid 18787112 direct interaction X 2 P24870 P07834 affinity chromatography technology 15200949 physical association X 2 P40303 P07834 affinity chromatography technology 11500370 physical association X 2 P07834 P20438 affinity chromatography technology 15200949 physical association X 2 P07834 P22141 affinity chromatography technology 15907469 physical association X 2 P07834 P09547 affinity chromatography technology 24389104 physical association X 2 P07834 Q06098 affinity chromatography technology 24389104 physical association X 2 P07834 P34233 affinity chromatography technology 24389104 physical association X 2 P07834 P35736 unspecified method 16338374 direct interaction X 2 P07834 P03069 unspecified method 16338374 direct interaction X 2 P07834 P35736 enzymatic study 16338374 direct interaction X 2 P07834 P03069 enzymatic study 16338374 direct interaction X 2 P07834 Q04383 pull down 16338374 direct interaction X 2 P07834 P13186 pull down 16338374 direct interaction X 2 P07834 P34252 pull down 16338374 direct interaction X 2 P07834 P34233 unspecified method 21098119 direct interaction X 2 P07834 P41546 two hybrid 17108329 direct interaction X 2 P07834 P36054 two hybrid 17954914 direct interaction X 2 P07834 P03069 two hybrid 18787112 direct interaction X 2 P07834 P36054 two hybrid 18787112 direct interaction X 2 P07834 P34233 pull down 21098119 direct interaction X 2 P07834 P08539 enzymatic study 20542006 direct interaction X 2 P07834 P34233 enzymatic study 21098119 direct interaction X 2 P45819 P07834 two hybrid 18787112 direct interaction X 2 P63208 P07834 affinity chromatography technology 16275325 physical association X 2 P07834 coimmunoprecipitation 9346238 - C 3 P07834 molecular sieving 10445024 physical association C 3 P07834 coimmunoprecipitation 9346238 - C 4 P14682 P07834 affinity chromatography technology 8943317 physical association X 2 P14682 P07834 affinity chromatography technology 9461595 physical association X 2 P07834 Q12018 coimmunoprecipitation 10213692 physical association X 2 P07834 Q12018 coimmunoprecipitation 10445024 physical association X 2 P07834 Q12018 coimmunoprecipitation 9346238 physical association X 2 P07834 Q12018 coimmunoprecipitation 9461595 physical association X 2 P07834 Q12018 coimmunoprecipitation 9346238 physical association X 2 P07834 Q12018 two hybrid 9499404 physical association X 2 P07834 Q12018 coimmunoprecipitation 9499404 physical association X 2 P07834 Q12018 coimmunoprecipitation 9346239 physical association X 2 P07834 P38634 nuclear magnetic resonance 19008353 direct interaction X 2 P07834 P38634 coimmunoprecipitation 9346239 direct interaction X 2 P07834 P38634 classical fluorescence spectroscopy 19008353 direct interaction X 2 P07834 P38634 affinity chromatography technology 9346239 direct interaction X 2 P07834 P38634 two hybrid 18787112 direct interaction X 2 P07834 P38634 two hybrid 18787112 direct interaction X 2 P07834 P38634 coimmunoprecipitation 9346239 direct interaction X 2 P09119 P07834 two hybrid 11532947 physical association X 2 P09119 P07834 two hybrid 9312054 physical association X 2 P09119 P07834 two hybrid 11237870 physical association X 2 P52286 P07834 anti tag coimmunoprecipitation 11805837 physical association X 2 P52286 P07834 coimmunoprecipitation 9346238 physical association X 2 P52286 P07834 coimmunoprecipitation 10213692 physical association X 2 P52286 P07834 coimmunoprecipitation 9346239 physical association X 2 P52286 P07834 affinity chromatography technology 14747994 physical association X 2 P52286 P07834 affinity chromatography technology 8706131 physical association X 2 P52286 P07834 coimmunoprecipitation 10445024 physical association X 2 P52286 P07834 two hybrid 10688190 physical association X 2 P52286 P07834 coimmunoprecipitation 9346238 physical association X 2 P52286 P07834 two hybrid 10688190 physical association X 2 P52286 P07834 anti tag coimmunoprecipitation 11805837 physical association X 2 P07834 anti tag coimmunoprecipitation 11805837 - C 9 P07834 affinity chromatography technology 14747994 - C 4 P07834 anti tag coimmunoprecipitation 11805837 - C 8 P07834 coimmunoprecipitation 9346238 - C 4 Q08273 P07834 coimmunoprecipitation 10213692 physical association X 2 Q08273 P07834 affinity chromatography technology 10385629 physical association X 2 Q08273 P07834 two hybrid 10880467 physical association X 2 Q08446 P07834 coimmunoprecipitation 10445024 physical association X 2 P08153 P07834 two hybrid 18787112 physical association X 2 P08153 P07834 two hybrid 18787112 physical association X 2 P07834 P36054 two hybrid 18787112 direct interaction X 2 P07834 P36054 two hybrid 17954914 direct interaction X 2 P07834 P36054 two hybrid 18787112 direct interaction X 2 P07834 P36054 two hybrid 17954914 direct interaction X 2 P07834 P03069 two hybrid 18787112 physical association X 2 P07834 P03069 two hybrid 18787112 physical association X 2 P45819 P07834 two hybrid 18787112 physical association X 2 P45819 P07834 two hybrid 18787112 physical association X 2 P07834 pull down 19882662 association C 41 P07834 anti tag coimmunoprecipitation 19763088 physical association C 5 P07834 anti tag coimmunoprecipitation 9499404 association C 6 P07834 pull down 19882662 association C 35 P07834 anti tag coimmunoprecipitation 9499404 association C 3 P07834 anti tag coimmunoprecipitation 9499404 association C 4 P07834 anti tag coimmunoprecipitation 9499404 association C 4 P07834 anti tag coimmunoprecipitation 11500370 association C 3 P39077 P07834 tandem affinity purification 19536198 association X 2 P46988 P07834 tandem affinity purification 19536198 association X 2 P07834 P38779 pull down 11500370 direct interaction X 2 P07834 P38634 two hybrid 15448699 physical association X 2 P07834 Q03900 two hybrid 18719252 physical association X 2 P07834 P07834 two hybrid 18719252 physical association Y 1 P07834 P25491 tandem affinity purification 19536198 association X 2 P07834 P38788 tandem affinity purification 19536198 association X 2 P07834 Q12018 anti tag coimmunoprecipitation 19882662 physical association X 2 P07834 Q12018 two hybrid 9499404 physical association X 2 P07834 Q12018 two hybrid 9499404 physical association X 2 P40150 P07834 tandem affinity purification 19536198 association X 2 P09119 P07834 two hybrid 9312054 physical association X 2 P52286 P07834 two hybrid 10688190 physical association X 2 P52286 P07834 anti tag coimmunoprecipitation 11805837 physical association X 2 P52286 P07834 cross-linking study 17960736 physical association X 2 P52286 P07834 two hybrid 18719252 physical association X 2 P52286 P07834 anti tag coimmunoprecipitation 19882662 physical association X 2 P52286 P07834 miniaturized immunoprecipitation 23267104 direct interaction X 2 P52286 P07834 pull down 8706131 physical association X 2 P52286 P07834 coimmunoprecipitation 8706131 physical association X 2 P07834 anti tag coimmunoprecipitation 9499404 association C 5 P07834 pull down 19882662 association C 51 P07834 anti tag coimmunoprecipitation 11805837 association C 8 P10592 P07834 tandem affinity purification 19536198 association X 2 P11484 P07834 tandem affinity purification 19536198 association X 2 Q08273 P07834 anti tag coimmunoprecipitation 19882662 physical association X 2 Q08273 P07834 miniaturized immunoprecipitation 23267104 direct interaction X 2 P07834 Q12046 two hybrid array 14690591 physical association X 2 P07834 P25294 tandem affinity purification 19536198 association X 2 P10591 P07834 tandem affinity purification 19536198 association X 2 P07834 mass spectrometry studies of complexes 11805837 - C 9 P07834 confirmational text mining - - C 4 P14682 P07834 interaction detection method 9499404 - X 2 P14682 P07834 affinity chromatography technology 9461595 - X 2 P07834 Q12018 interaction detection method 9499404 - X 2 P07834 Q12018 coimmunoprecipitation - - X 2 P07834 Q12018 two hybrid 9499404 - X 2 P07834 P38634 interaction detection method 9334303 - X 2 P09119 P07834 interaction detection method 9312054 - X 2 P09119 P07834 two hybrid 9312054 - X 2 P52286 P07834 two hybrid 10688190 - X 2 P52286 P07834 coimmunoprecipitation 9499404 - X 2 P52286 P07834 two hybrid 10688190,9499404 - X 2 P07834 mass spectrometry studies of complexes 11805837 - C 3 P07834 mass spectrometry studies of complexes 11805837 - C 3 Q08273 P07834 two hybrid 10880467 - X 2 P07834 P32564 interaction detection method - - X 2 P32558 P07834 interaction detection method 9199353 - X 2

PPI - HINT Gene A Gene B PMID Method Quality GCN4 CDC4 16338374,18787112 0415,0018 LC STE7 CDC4 23645675,23645675 0415,0004 LC CDC4 CDC4 12582129,18719252,12582129,14747994,17574027,17574027 0004,0018,0018,0415,0114,0096 LC,HT CDC4 SWI5 18787112 0018 LC CDC4 GPA1 20542006 0415 LC CDC4 CDC6 17108329,9312054,19285403,11237870,10512865,11532947,25995377 0018,0018,0018,0018,0018,0018,0018 LC CDC4 UBI4 21070969,21070969,21070969 0004,0114,0096 LC CDC4 CDC34 9461595,9461595,10213692,9461595 0401,0004,0415,0096 LC CDC4 TEC1 15620356,15620356 0019,0096 LC CDC4 ASH1 21098119,21098119 0415,0096 LC CDC4 P35736 16338374 0415 LC CDC4 RCN1 17954914,18787112 0018,0018 LC CDC4 SIC1 24316736,9346238,12553912,9346239,9346238,9346239,20194622,16338374,17114057,16338374,22328159,20581844,18054791,19008353,22328159,17574027,13678584,18787112,12553912,22328159,19008353,15448699,19008353,9346239,14747994,9346239,22328159,17562869,9285816,9636170 0415,0096,0096,0415,0415,0096,0415,0415,0415,0096,0114,0415,0415,0077,0096,0415,0415,0018,0415,0018,0017,0018,0114,0019,0415,0004,0415,0415,0415,0415 LC CDC4 HAC1 17108329 0018 LC CDC4 SPO74 18787112 0018 LC CDC4 SKP1 10445024,8706131,9499404,9346239,8706131,20581844,17960736,11283612,19897738,12553912,20581844,12582129,9499404,22328159,12553912,10688190,10688190,16338374,23267104,9499404,17960736,10213692,18719252,9346239,9346238,9346238,9499404,8706131 0019,0096,0018,0096,0004,0114,0030,0018,0401,0114,0096,0018,0019,0114,0096,0397,0018,0401,0946,0007,0096,0019,0018,0019,0004,0019,0004,0019 LC,HT CDC4 HST3 24648511 0415 LC CDC4 HST4 16338374,16338374 0415,0096 LC CDC4 Q03900 18719252 0018 HT CDC4 HRT1 10213692,23267104,10880467 0019,0946,0018 LC CDC4 SGT1 10445024,10445024 0019,0096 LC CDC4 CDC53 10445024,9499404,9346239,9499404,9461595,9499404,10213692,9346239,9346238,9346238,9499404 0019,0018,0096,0019,0019,0007,0019,0019,0004,0019,0004 LC CDC4 CWC2 14690591 0397 LC STE7 CDC4 23645675,23645675 0415,0004 LC CDC4 CDC4 12582129,12582129,17574027,17574027 0004,0018,0114,0096 LC CDC4 SWI5 24389104 0004 LC CDC4 CDC6 15496876,24389104 0004,0004 LC CDC4 SWI1 24389104 0004 LC CDC4 UBI4 21070969,21070969,21070969 0004,0114,0096 LC CDC4 SSA1 19536198 0676 HT CDC4 SSA2 19536198 0676 HT CDC4 SSB1 19536198 0676 HT CDC4 KIN2 16338374 0096 LC CDC4 CLN3 22844257,24389104 0004,0004 LC CDC4 CDC34 9461595,8943317,9636170,9461595,18054791,20832729,17562869,17114057,16338374,9461595,9346239,23645675,20581844 0401,0004,0096,0004,0096,0096,0096,0096,0096,0096,0096,0096,0096 LC CDC4 TEC1 15620356,15620356,19897738 0019,0096,0096 LC CDC4 CLN1 22844257 0004 LC CDC4 CLN2 22844257,15200949 0004,0004 LC CDC4 FAR1 16338374,24389104 0096,0004 LC CDC4 PRE1 15907469 0004 LC CDC4 RFA1 9724654 0428 LC CDC4 PCL1 24389104 0004 LC CDC4 CLB3 15200949 0004 LC CDC4 SIS1 19536198 0676 HT CDC4 YDJ1 19536198 0676 HT CDC4 STE5 24389104 0004 LC CDC4 ASH1 21098119,21098119,24389104 0415,0096,0004 LC CDC4 SLD2 16338374 0096 LC CDC4 SIC1 9346238,12553912,9346239,9346238,12820958,9346239,16338374,16338374,22328159,22328159,12553912,22328159,16776651,9346239,9346239,22328159 0096,0096,0415,0415,0096,0096,0415,0096,0114,0096,0415,0018,0096,0019,0004,0415 LC CDC4 CIC1 11500370,11500370,11500370 0096,0007,0004 LC CDC4 SSZ1 19536198 0676 HT CDC4 CCT3 19536198 0676 HT CDC4 SSB2 19536198 0676 HT CDC4 PRE6 11500370,11500370 0007,0004 LC CDC4 PFD1 19536198 0676 HT CDC4 SKP1 8706131,19882662,15660125,20581845,9499404,9346239,14747994,8706131,20581844,17960736,19882662,19897738,12553912,20581844,9499404,11734846,16751663,19882662,17574027,12553912,11805837,16338374,10213691,9499404,16432255,11805837,17960736,23000173,9346239,14747994,9346238,9346238,9499404,8706131,9844630 0096,0096,0004,0004,0018,0096,0096,0004,0114,0030,0007,0401,0114,0096,0019,0096,0004,0004,0096,0096,0004,0401,0004,0007,0004,0007,0096,0096,0019,0004,0004,0019,0004,0019,0004 LC,HT CDC4 HST3 24715726,24389104 0004,0004 LC CDC4 HST4 16338374,16338374,24389104 0415,0096,0004 LC CDC4 FPK1 16338374 0096 LC CDC4 ATC1 24389104 0004 LC CDC4 PLM2 16338374 0096 LC CDC4 ISR1 24389104 0004 LC CDC4 HRT1 10213691,10385629,19882662,14747994,17574027,19882662,19882662 0004,0004,0096,0096,0096,0004,0007 LC CDC4 SGT1 10445024,10445024 0019,0096 LC CDC4 CDC53 19882662,9499404,9346239,14747994,19882662,9499404,16790494,19882662,10213691,9499404,9346239,9346238,10582239,9346238,9499404,9844630 0096,0018,0096,0096,0007,0019,0004,0004,0004,0007,0019,0004,0004,0019,0004,0004 LC CDC4 WHI5 16338374 0096 LC CDC4 LAG2 19763088,19763088,19763088 0007,0004,0096 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P22336 P07834 RFA1 CDC4 0.126 9724654 P10591 P07834 SSA1 CDC4 0.126 19536198 P10592 P07834 SSA2 CDC4 0.126 19536198 P07834 P03069 CDC4 GCN4 0.748 18787112,16338374 P08153 P07834 SWI5 CDC4 0.597 24389104,18787112 P08539 P07834 GPA1 CDC4 0.309 20542006 P09547 P07834 SWI1 CDC4 0.21 24389104 P11484 P07834 SSB1 CDC4 0.126 19536198 P13186 P07834 KIN2 CDC4 0.309 16338374 P20437 P07834 CLN1 CDC4 0.21 22844257 P20438 P07834 CLN2 CDC4 0.21 22844257 P24867 P07834 PCL1 CDC4 0.21 24389104 P25294 P07834 SIS1 CDC4 0.126 19536198 P25491 P07834 YDJ1 CDC4 0.126 19536198 P32917 P07834 STE5 CDC4 0.21 24389104 P34252 P07834 SLD2 CDC4 0.309 16338374 P40150 P07834 SSB2 CDC4 0.126 19536198 P53739 P07834 FPK1 CDC4 0.309 16338374 P63208 P07834 SKP1 CDC4 0.21 16275325 Q04005 P07834 ATC1 CDC4 0.21 24389104 Q04383 P07834 PLM2 CDC4 0.309 16338374 Q06098 P07834 ISR1 CDC4 0.21 24389104 Q08273 P07834 HRT1 CDC4 0.692 23267104,10880467,17574027,19882662,10385629,10213692 Q12046 P07834 CWC2 CDC4 0.126 14690591 Q12416 P07834 WHI5 CDC4 0.309 16338374 P0CG63 P07834 UBI4 CDC4 0.523 21070969 P09119 P07834 CDC6 CDC4 0.82 11237870,19285403,11532947,25995377,9312054,24389104 P07834 P06784 CDC4 STE7 0.454 23645675 P35736 P07834 P35736 CDC4 0.523 16338374 P14682 P07834 CDC34 CDC4 0.976 18054791,20832729,17562869,10213692,8943317,16338374,20581844,23645675,9461595,17114057 P13365 P07834 CLN3 CDC4 0.376 24389104,22844257 P21268 P07834 FAR1 CDC4 0.454 24389104,16338374 P36054 P07834 RCN1 CDC4 0.772 17954914,18787112 P40303 P07834 PRE6 CDC4 0.376 11500370 P18412 P07834 TEC1 CDC4 0.523 19897738,15620356 Q03900 P07834 Q03900 CDC4 0.332 18719252 Q92325 P07834 LAG2 CDC4 0.569 19763088 P53687 P07834 HST3 CDC4 0.569 24389104,24648511,24715726 P53688 P07834 HST4 CDC4 0.74 24389104,16338374 P38634 P07834 SIC1 CDC4 1 18054791,9636170,13678584,17574027,9285816,20581844,16338374,17522259,17114057,9346238,18787112,12820958,12553912,24316736,14747994,20194622,19008353,9346239,16776651,17562869,22328159 Q12018 P07834 CDC53 CDC4 0.93 9499404,10582239,19882662,9346239,10213692,16790494,10445024,9844630,9461595,9346238 P07834 P07834 CDC4 CDC4 0.858 14747994,12582129,18719252,17574027 P52286 P07834 SKP1 CDC4 1 9499404,23267104,11805837,18719252,9346238,11283612,8706131,19882662,12553912,15660125,10213692,14747994,19897738,23000173,10445024,10688190,20581845,16751663,9346239,11734846,17960736,16338374,17574027,12582129,20581844,9844630 P38779 P07834 CIC1 CDC4 0.702 11500370 P38788 P07834 SSZ1 CDC4 0.126 19536198 P39077 P07834 CCT3 CDC4 0.126 19536198 P34233 P07834 ASH1 CDC4 0.74 24389104,21098119 P43605 P07834 ECO1 CDC4 0.309 23314252 P45819 P07834 SPO74 CDC4 0.523 18787112 P46988 P07834 PFD1 CDC4 0.126 19536198 Q13616 P07834 CUL1 CDC4 0.21 9636170 Q08446 P07834 SGT1 CDC4 0.332 10445024 P22141 P07834 PRE1 CDC4 0.21 15907469