PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus SSA1 CDC26 19536198 intact exp CDC26 SSE1 19536198 intact exp CDC26 WHI3 18667435 biogrid exp CDC26 PHO85 16319894 biogrid,i2d exp SSB1 CDC26 19536198 intact exp CDC26 FRE6 11283351 i2d,mint,intact,dip exp CDC26 CDC27 12609981,9348530,9469814,8895471, 23023127 biogrid,i2d,intact,dip exp, pred CDC26 APC1 16554755,9469814,8895471, 23023127 biogrid,i2d,mint,intact,dip exp, pred CDC26 PAT1 17634282, 23023127 biogrid exp, pred CDC26 APC11 9469814, 23023127 i2d,intact,dip exp, pred CDC26 APC9 9469814, 23023127 i2d,intact exp, pred CDC26 SWM1 12477395,15060174,12574115,9469814, 23023127 biogrid,intact exp, pred CDC26 CDC20 10871278, 23023127 biogrid exp, pred CDC26 JSN1 11283351, 23023127 biogrid,i2d,mint,intact,dip exp, pred CDC26 DOC1 9348530,16554755,9469814, 23023127 biogrid,i2d,intact,dip exp, pred CDC26 APC5 9469814, 23023127 i2d,intact,dip exp, pred CDC26 MND2 12477395, 23023127 biogrid,intact exp, pred CDC26 CDC5 19013276, 23023127 biogrid,intact exp, pred CDC26 CDC23 9348530,10871278,16554755,9469814,8895471, 23023127 biogrid,i2d,mint,intact,dip exp, pred CDC26 APC4 12477395,15060174,9469814, 23023127 biogrid,i2d,intact,dip exp, pred CDC26 APC2 15060174,9469814, 23023127 biogrid,i2d,intact,dip exp, pred CDC16 CDC26 10318877,9469814,16364911,8895471,15060174,16275330,17406682,9348530,12574115,15797379, 23023127 biogrid,i2d,intact,dip exp, pred CDC26 PDS1 23023127 pred CDC26 UBC9 23023127 pred BIK1 CDC26 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P14724 - 15797379 - C 13 P14724 - 15649358 - C 13 P14724 - 9469814 - C 12 Q12107 P14724 - 9469814 - X 2 Q04601 P14724 - 9469814 - X 2 P14724 P53068 - 9348530 - X 2 P14724 P09798 - 9348530 - X 2 P14724 Q08683 - 9469814 - X 2 P14724 P53068 - 9469814 - X 2 P14724 - 15044803 - C 11 P14724 P16522 - 9348530 - X 2 P14724 Q12157 - 9469814 - X 2 P14724 - 9348530 - X 2 P14724 P16522 - 9469814 - X 2 Q04601 P14724 affinity chromatography technology 15060174 physical association X 2 Q04601 P14724 affinity chromatography technology 12477395 physical association X 2 P14724 P09798 affinity chromatography technology 12574115 physical association X 2 P14724 P09798 affinity chromatography technology 10318877 physical association X 2 P14724 P38042 affinity chromatography technology 12609981 physical association X 2 P14724 Q12379 affinity chromatography technology 12574115 physical association X 2 P14724 P09798 affinity chromatography technology 8895471 physical association X 2 P14724 P09798 affinity chromatography technology 8895471 physical association X 2 P14724 P26309 affinity chromatography technology 10871278 physical association X 2 P14724 P09798 affinity chromatography technology 9348530 physical association X 2 P14724 P38042 affinity chromatography technology 9348530 physical association X 2 P14724 P53068 affinity chromatography technology 9348530 physical association X 2 P14724 P53886 affinity chromatography technology 8895471 physical association X 2 P14724 P38042 affinity chromatography technology 8895471 physical association X 2 P14724 P09798 affinity chromatography technology 15060174 physical association X 2 P14724 Q12379 affinity chromatography technology 15060174 physical association X 2 P14724 P09798 affinity chromatography technology 9469814 physical association X 2 P14724 Q12379 affinity chromatography technology 12477395 physical association X 2 P14724 P53886 affinity chromatography technology 16554755 physical association X 2 P14724 P09798 affinity chromatography technology 16275330 physical association X 2 P14724 P47135 two hybrid 11283351 direct interaction X 2 P14724 P25644 two hybrid 17634282 direct interaction X 2 P14724 P09798 affinity chromatography technology 17406682 physical association X 2 P14724 P09798 affinity chromatography technology 15797379 physical association X 2 P14724 P09798 affinity chromatography technology 16364911 physical association X 2 P14724 P16522 affinity chromatography technology 10871278 physical association X 2 P14724 P16522 affinity chromatography technology 9348530 physical association X 2 P14724 P16522 affinity chromatography technology 8895471 physical association X 2 P14724 Q12440 affinity chromatography technology 15060174 physical association X 2 P14724 P40577 affinity chromatography technology 12477395 physical association X 2 P14724 P16522 affinity chromatography technology 16554755 physical association X 2 P14724 P32562 affinity chromatography technology 19013276 physical association X 2 P14724 P17157 enzymatic study 16319894 direct interaction X 2 P14724 pull down 21107322 - C 13 P14724 tandem affinity purification 21107322 - C 12 P14724 tandem affinity purification 21107322 - C 13 Q04601 P14724 coimmunoprecipitation 9469814 physical association X 2 P14724 P47135 two hybrid pooling approach 11283351 physical association X 2 P14724 P38042 coimmunoprecipitation 8895471 physical association X 2 P14724 P38042 coimmunoprecipitation 9348530 physical association X 2 P14724 P09798 cosedimentation through density gradient 8895471 physical association X 2 P14724 P09798 coimmunoprecipitation 8895471 physical association X 2 P14724 P09798 coimmunoprecipitation 9469814 physical association X 2 P14724 P09798 tandem affinity purification 21107322 physical association X 2 P14724 P09798 tandem affinity purification 21107322 physical association X 2 P14724 P09798 pull down 21107322 physical association X 2 P14724 P09798 pull down 21107322 physical association X 2 P14724 Q08683 coimmunoprecipitation 9469814 physical association X 2 P14724 pull down 21107322 - C 14 Q12473 P14724 two hybrid pooling approach 11283351 physical association X 2 P14724 P16522 coimmunoprecipitation 8895471 physical association X 2 P14724 P16522 coimmunoprecipitation 9348530 physical association X 2 P14724 coimmunoprecipitation 8895471 physical association X 2 P14724 coimmunoprecipitation 9348530 physical association X 2 P14724 Q12440 coimmunoprecipitation 9469814 physical association X 2 P14724 Q12157 coimmunoprecipitation 9469814 physical association X 2 P14724 inferred by author 16554755 association C 12 P14724 tandem affinity purification 12477395 association C 13 P14724 tandem affinity purification 12477395 association C 13 P14724 tandem affinity purification 12477395 association C 13 P14724 affinity chromatography technology 12609981 association C 13 P14724 anti tag coimmunoprecipitation 9469814 association C 12 P14724 anti tag coimmunoprecipitation 9469814 association C 12 P14724 anti tag coimmunoprecipitation 9469814 association C 12 P14724 anti tag coimmunoprecipitation 9469814 association C 12 P14724 anti tag coimmunoprecipitation 9469814 association C 12 P32589 P14724 tandem affinity purification 19536198 association X 2 P14724 P47135 two hybrid fragment pooling approach 11283351 physical association X 2 P14724 P53886 tandem affinity purification 16554755 physical association X 2 P14724 tandem affinity purification 19013276 association C 41 Q12473 P14724 two hybrid fragment pooling approach 11283351 physical association X 2 P10591 P14724 tandem affinity purification 19536198 association X 2 P14724 P16522 tandem affinity purification 16554755 physical association X 2 P14724 P11484 tandem affinity purification 19536198 association X 2 P41809 P14724 interaction detection method 14764870 - X 2 Q12107 P14724 coimmunoprecipitation 9469814 - X 2 Q04601 P14724 coimmunoprecipitation 9469814 - X 2 P14724 P47135 two hybrid 11283351 - X 2 P14724 P38877 interaction detection method 14764870 - X 2 P14724 P49956 interaction detection method 14764870 - X 2 P14724 Q01454 interaction detection method 14764870 - X 2 P14724 P17119 interaction detection method 14764870 - X 2 P14724 P53068 interaction detection method - - X 2 P14724 P53068 interaction detection method 9348530 - X 2 P14724 P53068 coimmunoprecipitation 9348530,9469814 - X 2 P14724 P53068 coimmunoprecipitation 9469814 - X 2 P14724 P09798 interaction detection method 9348530 - X 2 P14724 P09798 coimmunoprecipitation 8895471,9469814 - X 2 P14724 P53886 coimmunoprecipitation 8895471,9469814 - X 2 P14724 P53886 coimmunoprecipitation 8895471,9469814 - X 2 P14724 Q08683 coimmunoprecipitation 9469814 - X 2 P14724 P38042 coimmunoprecipitation 8895471,9469814 - X 2 P14724 confirmational text mining - - C 11 Q12473 P14724 two hybrid 11283351 - X 2 P14724 P29465 interaction detection method 14764870 - X 2 P14724 Q12157 coimmunoprecipitation 9469814 - X 2 P14724 P16522 interaction detection method 9348530 - X 2 P14724 P16522 coimmunoprecipitation 8895471,9469814 - X 2 P14724 P16522 coimmunoprecipitation 9469814 - X 2 P14724 Q12440 coimmunoprecipitation 9469814,9469815 - X 2 P14724 Q12440 coimmunoprecipitation 9469814,9469815 - X 2

PPI - HINT Gene A Gene B PMID Method Quality CDC16 CDC26 9348530,9348530,8895471,9469814,8895471,8895471,9469814,9469814 0004,0019,0019,0004,0029,0004,0019,0007 LC CDC26 CDC23 9348530,9348530,8895471,8895471,9469814,9469814 0004,0019,0019,0004,0019,0007 LC CDC26 PHO85 16319894 0415 LC CDC26 PAT1 17634282 0018 HT CDC26 CDC27 9348530,9348530,8895471,9469814,9469814,8895471 0004,0019,0019,0007,0019,0004 LC CDC26 PDS1 16364911 0415 LC CDC26 JSN1 11283351,11283351,11283351 0018,0399,0398 HT CDC26 DOC1 9348530,9348530,9469814,9469814 0004,0019,0019,0007 LC CDC26 APC1 8895471,8895471,9469814,9469814 0019,0004,0019,0007 LC CDC26 APC4 9469814,9469814 0019,0007 LC CDC26 APC5 9469814,9469814 0019,0007 LC CDC26 APC9 9469814,9469814 0019,0007 LC CDC26 APC11 9469814,9469814 0019,0007 LC CDC26 APC2 9469814,9469815,9469814 0019,0019,0007 LC CDC26 FRE6 11283351,11283351,11283351 0018,0399,0398 HT CDC16 CDC26 9348530,9348530,8895471,21107322,15060174,17406682,16364911,9469814,8895471,8895471,10318877,21107322,12574115,9469814,15797379,16275330,9469814 0004,0019,0019,0096,0004,0004,0004,0004,0029,0004,0004,0676,0004,0019,0004,0004,0007 LC SSA1 CDC26 19536198 0676 HT SSB1 CDC26 19536198 0676 HT CDC26 CDC23 9348530,9348530,8895471,16554755,10871278,8895471,9469814,9469814,16554755 0004,0019,0019,0676,0004,0004,0019,0007,0004 LC,HT CDC26 CDC20 10871278 0004 LC CDC26 CDC5 19013276,19013276 0004,0676 LC CDC26 SSE1 19536198 0676 HT CDC26 CDC27 9348530,9348530,12609981,8895471,9469814,9469814,8895471 0004,0019,0004,0019,0007,0019,0004 LC CDC26 MND2 12477395,12477395 0676,0004 LC CDC26 DOC1 9348530,9348530,16554755,9469814,9469814 0004,0019,0363,0019,0007 LC,HT CDC26 CDH1 21107322 0004 LC CDC26 APC1 8895471,16554755,8895471,9469814,9469814,16554755 0019,0004,0004,0019,0007,0676 LC,HT CDC26 APC4 12477395,15060174,12477395,9469814,9469814 0004,0004,0676,0019,0007 LC CDC26 APC5 9469814,9469814 0019,0007 LC CDC26 APC9 9469814,9469814 0019,0007 LC CDC26 APC11 9469814,9469814 0019,0007 LC CDC26 SWM1 12477395,12477395,15060174,12574115,9469814 0676,0004,0004,0004,0007 LC CDC26 APC2 9469814,9469814,15060174 0019,0007,0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q12473 P14724 FRE6 CDC26 0.21 11283351 P14724 P11484 CDC26 SSB1 0.126 19536198 P16522 P14724 CDC23 CDC26 0.416 8895471,9348530,16554755,9469814 P40577 P14724 MND2 CDC26 0.236 12477395 P38042 P14724 CDC27 CDC26 0.236 9469814,8895471,9348530 P32562 P14724 CDC5 CDC26 0.286 19013276 P32589 P14724 SSE1 CDC26 0.126 19536198 P34761 P14724 WHI3 CDC26 0.183 18667435 P47135 P14724 JSN1 CDC26 0.354 11283351 Q08683 P14724 APC5 CDC26 0.126 9469814 Q04601 P14724 APC4 CDC26 0.332 9469814,12477395 P14724 P09798 CDC26 CDC16 0.74 16275330,17406682,9469814,15797379,8895471,16364911 P14724 P10591 CDC26 SSA1 0.126 19536198 P25644 P14724 PAT1 CDC26 0.183 17634282 P53886 P14724 APC1 CDC26 0.396 16554755,9469814,8895471 P53068 P14724 DOC1 CDC26 0.236 16554755,9469814,9348530 Q12440 P14724 APC2 CDC26 0.126 9469814 Q12157 P14724 APC11 CDC26 0.126 9469814 Q12107 P14724 APC9 CDC26 0.126 9469814 Q12379 P14724 SWM1 CDC26 0.332 9469814,12477395 P17157 P14724 PHO85 CDC26 0.183 16319894