PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus RPN14 ALD6 11805837 dip exp GAL1 RPN14 11805837 dip exp MET10 RPN14 11805837 dip exp PGI1 RPN14 11805837 dip exp TDH1 RPN14 11805837 dip exp SEM1 RPN14 19446323 intact exp SSA3 RPN14 19536198,11805837 intact,dip exp SSB1 RPN14 19536198 intact exp MIR1 RPN14 11805837 dip exp HSP26 RPN14 11805837 dip exp RPN14 RVB2 11805837 biogrid,mint,intact,dip exp PDC1 RPN14 11805837 dip exp YDJ1 RPN14 19536198 intact exp VMA2 RPN14 11805837 dip exp HSM3 RPN14 19446323,20471945,19446322,11805837 biogrid,mint,intact,dip exp FBA1 RPN14 11805837 dip exp SSC1 RPN14 11805837 dip exp LYS12 RPN14 11805837 dip exp IDH2 RPN14 11805837 dip exp SPT4 RPN14 i2d exp ALD4 RPN14 11805837 dip exp MPM1 RPN14 11805837 dip exp RPN14 RVB1 11805837 dip exp SSB2 RPN14 23332755 biogrid exp ECM29 RPN14 21321079 biogrid exp PRE1 RPN14 19412160 dip exp RPN14 CSI1 16554755 intact exp LEU2 RPN14 11805837 dip exp IDH1 RPN14 11805837 dip exp RPT2 RPN14 19446323,11805837, 23023127 biogrid,intact,dip exp, pred RPN14 RPN7 19446323,11805837, 23023127 biogrid,intact,dip exp, pred RPT3 RPN14 19446323,11805837, 23023127 biogrid,mint,intact,dip exp, pred RPN11 RPN14 19412159,19446323,17499717,11805837, 23023127 biogrid,intact,dip exp, pred RPN14 RPN5 19446323,21289098,11805837, 23023127 biogrid,intact,dip exp, pred RPN13 RPN14 19446323,11805837, 23023127 biogrid,mint,intact,dip exp, pred RPN14 RPN6 19446323,11805837, 23023127 biogrid,intact,dip exp, pred RPT1 RPN14 19412159,19446323,23562395,19412160,23644457,11805837, 23023127 biogrid,intact,dip exp, pred RPN14 RPT4 19412159,19446323,11805837, 23023127 biogrid,mint,intact,dip exp, pred RPN14 RPN8 19412159,19446323,11805837, 23023127 biogrid,intact,dip exp, pred RPN14 RPN9 19446323,11805837, 23023127 biogrid,intact,dip exp, pred RPN2 RPN14 19446323,11805837, 23023127 biogrid,intact,dip exp, pred RPN10 RPN14 19446323,11805837, 23023127 biogrid,intact,dip exp, pred UBP6 RPN14 19446323, 23023127 intact exp, pred RPN1 RPN14 19446323,21658604,11805837, 23023127 biogrid,intact,dip exp, pred RPN14 RPT6 19412159,19446323,23562395,16554755,18719252, 23023127 biogrid,i2d,mint,intact,dip exp, pred RPT5 RPN14 19412159,19446323,17499717,11805837, 23023127 biogrid,mint,intact,dip exp, pred RPN12 RPN14 19446323, 23023127 intact exp, pred NAS6 RPN14 19446323,18719252,11805837, 23023127 biogrid,mint,intact,dip exp, pred NAS2 RPN14 19446323,20471945, 23023127 biogrid,intact exp, pred RPN3 RPN14 19446323,11805837, 23023127 biogrid,intact,dip exp, pred GID7 RPN14 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P53196 - 11805837 - C 6 P53196 - 11805837 - C 24 P53196 - 11805837 - C 16 P53196 - 11805837 - C 6 P33297 P53196 affinity chromatography technology 17499717 physical association X 2 P33297 P53196 affinity chromatography technology 19412159 physical association X 2 P33297 P53196 affinity chromatography technology 19446323 physical association X 2 P33297 P53196 affinity chromatography technology 11805837 physical association X 2 P53549 P53196 pull down 19412159 direct interaction X 2 P53549 P53196 affinity chromatography technology 19446323 physical association X 2 P53549 P53196 affinity chromatography technology 11805837 physical association X 2 P38886 P53196 affinity chromatography technology 11805837 physical association X 2 P38764 P53196 affinity chromatography technology 19446323 physical association X 2 P38764 P53196 biochemical 21658604 association X 2 P38764 P53196 affinity chromatography technology 11805837 physical association X 2 P40555 P53196 affinity chromatography technology 20471945 physical association X 2 P40555 P53196 affinity chromatography technology 20471945 physical association X 2 Q06103 P53196 affinity chromatography technology 19446323 physical association X 2 Q06103 P53196 affinity chromatography technology 11805837 physical association X 2 P32565 P53196 affinity chromatography technology 19446323 physical association X 2 O13563 P53196 affinity chromatography technology 11805837 physical association X 2 P40150 P53196 biochemical 23332755 association X 2 P53196 P40016 affinity chromatography technology 19446323 physical association X 2 P53196 P40327 affinity chromatography technology 19446323 physical association X 2 Q12377 P53196 affinity chromatography technology 19446323 physical association X 2 P53196 P40327 affinity chromatography technology 11805837 physical association X 2 P53196 P40016 affinity chromatography technology 11805837 physical association X 2 Q12377 P53196 affinity chromatography technology 11805837 physical association X 2 P43588 P53196 affinity chromatography technology 17499717 physical association X 2 P43588 P53196 affinity chromatography technology 19412159 physical association X 2 P43588 P53196 affinity chromatography technology 19446323 physical association X 2 P43588 P53196 affinity chromatography technology 19446323 physical association X 2 P43588 P53196 affinity chromatography technology 11805837 physical association X 2 Q12464 P53196 affinity chromatography technology 11805837 physical association X 2 Q08723 P53196 affinity chromatography technology 19412159 physical association X 2 Q08723 P53196 affinity chromatography technology 19446323 physical association X 2 Q08723 P53196 affinity chromatography technology 11805837 physical association X 2 P38348 P53196 affinity chromatography technology 19446322 physical association X 2 P38348 P53196 affinity chromatography technology 20471945 physical association X 2 P38348 P53196 affinity chromatography technology 11805837 physical association X 2 P33299 P53196 affinity chromatography technology 23562395 physical association X 2 P33299 P53196 affinity chromatography technology 23644457 physical association X 2 P33299 P53196 affinity chromatography technology 19412159 physical association X 2 P33299 P53196 affinity chromatography technology 19412160 physical association X 2 P33299 P53196 affinity chromatography technology 19412160 physical association X 2 P33299 P53196 affinity chromatography technology 19446323 physical association X 2 P33299 P53196 affinity chromatography technology 11805837 physical association X 2 P53196 Q01939 pull down 23562395 direct interaction X 2 P53196 Q01939 x-ray crystallography 23562395 association X 2 P53196 Q01939 affinity chromatography technology 16554755 physical association X 2 P53196 Q01939 two hybrid 18719252 direct interaction X 2 P53196 Q01939 affinity chromatography technology 19412159 physical association X 2 P53196 Q01939 pull down 19412159 direct interaction X 2 P53196 P33298 affinity chromatography technology 19446323 physical association X 2 P53196 Q01939 affinity chromatography technology 19446323 physical association X 2 P53196 Q01939 two hybrid 19446323 direct interaction X 2 P53196 P38737 affinity chromatography technology 21321079 physical association X 2 P53196 P33298 affinity chromatography technology 11805837 physical association X 2 P53196 P33298 affinity chromatography technology 11805837 physical association X 2 Q04062 P53196 affinity chromatography technology 19446323 physical association X 2 Q04062 P53196 affinity chromatography technology 11805837 physical association X 2 Q12250 P53196 affinity chromatography technology 19446323 physical association X 2 Q12250 P53196 affinity chromatography technology 21289098 physical association X 2 Q12250 P53196 affinity chromatography technology 11805837 physical association X 2 P50086 P53196 two hybrid 18719252 direct interaction X 2 P50086 P53196 affinity chromatography technology 19446323 physical association X 2 P50086 P53196 affinity chromatography technology 19446323 physical association X 2 P50086 P53196 affinity chromatography technology 11805837 physical association X 2 P53196 affinity chromatography technology 24013205 physical association C 12 P53196 molecular sieving 24013205 physical association C 12 P53196 pull down 19412160 - C 4 P53196 pull down 23562395 - C 3 P53196 anti tag coimmunoprecipitation 11805837 - C 40 P33297 P53196 anti tag coimmunoprecipitation 11805837 physical association X 2 P00360 P53196 anti tag coimmunoprecipitation 11805837 physical association X 2 P06169 P53196 anti tag coimmunoprecipitation 11805837 physical association X 2 P53549 P53196 anti tag coimmunoprecipitation 11805837 physical association X 2 P38886 P53196 anti tag coimmunoprecipitation 11805837 physical association X 2 P38764 P53196 anti tag coimmunoprecipitation 11805837 physical association X 2 Q06103 P53196 anti tag coimmunoprecipitation 11805837 physical association X 2 P32565 P53196 anti tag coimmunoprecipitation 11805837 physical association X 2 P28241 P53196 anti tag coimmunoprecipitation 11805837 physical association X 2 O13563 P53196 anti tag coimmunoprecipitation 11805837 physical association X 2 P04173 P53196 anti tag coimmunoprecipitation 11805837 physical association X 2 P53196 P15992 anti tag coimmunoprecipitation 11805837 physical association X 2 P53196 P28834 anti tag coimmunoprecipitation 11805837 physical association X 2 P53196 Q03940 anti tag coimmunoprecipitation 11805837 physical association X 2 P53196 P09435 anti tag coimmunoprecipitation 11805837 physical association X 2 P53196 P22141 pull down 19412160 physical association X 2 P53196 P40016 anti tag coimmunoprecipitation 11805837 physical association X 2 Q12377 P53196 anti tag coimmunoprecipitation 11805837 physical association X 2 P53196 P40327 anti tag coimmunoprecipitation 11805837 physical association X 2 P12709 P53196 anti tag coimmunoprecipitation 11805837 physical association X 2 P53196 anti tag coimmunoprecipitation 11805837 - C 47 P53196 anti tag coimmunoprecipitation 11805837 - C 27 P53196 pull down 19412160 - C 13 P53196 anti tag coimmunoprecipitation 11805837 - C 19 P53196 pull down 23562395 - C 3 P43588 P53196 anti tag coimmunoprecipitation 11805837 physical association X 2 P14540 P53196 anti tag coimmunoprecipitation 11805837 physical association X 2 Q12464 P53196 anti tag coimmunoprecipitation 11805837 physical association X 2 P04385 P53196 anti tag coimmunoprecipitation 11805837 physical association X 2 P54115 P53196 anti tag coimmunoprecipitation 11805837 physical association X 2 P23641 P53196 anti tag coimmunoprecipitation 11805837 physical association X 2 P40364 P53196 anti tag coimmunoprecipitation 11805837 physical association X 2 Q08723 P53196 anti tag coimmunoprecipitation 11805837 physical association X 2 P38348 P53196 anti tag coimmunoprecipitation 11805837 physical association X 2 P40495 P53196 anti tag coimmunoprecipitation 11805837 physical association X 2 P33299 P53196 pull down 19412160 physical association X 2 P33299 P53196 pull down 23562395 physical association X 2 P33299 P53196 pull down 23562395 physical association X 2 P33299 P53196 pull down 23562395 physical association X 2 P33299 P53196 anti tag coimmunoprecipitation 11805837 physical association X 2 P33299 P53196 affinity chromatography technology 24013205 physical association X 2 P53196 P46367 anti tag coimmunoprecipitation 11805837 physical association X 2 P53196 P39692 anti tag coimmunoprecipitation 11805837 physical association X 2 P53196 Q01939 anti tag coimmunoprecipitation 11805837 direct interaction X 2 P53196 Q01939 cosedimentation in solution 23562395 direct interaction X 2 P53196 Q01939 nuclear magnetic resonance 23562395 direct interaction X 2 P53196 P16140 anti tag coimmunoprecipitation 11805837 physical association X 2 P53196 P33298 anti tag coimmunoprecipitation 11805837 physical association X 2 P53196 P33298 affinity chromatography technology 24013205 physical association X 2 P53196 P33298 anti tag coimmunoprecipitation 11805837 physical association X 2 Q04062 P53196 anti tag coimmunoprecipitation 11805837 physical association X 2 Q12250 P53196 anti tag coimmunoprecipitation 11805837 physical association X 2 P50086 P53196 anti tag coimmunoprecipitation 11805837 physical association X 2 P0CS90 P53196 anti tag coimmunoprecipitation 11805837 physical association X 2 P53196 inferred by author 16554755 association C 52 P53196 anti tag coimmunoprecipitation 19446323 physical association C 3 P53196 anti tag coimmunoprecipitation 19446322 physical association C 12 P53196 anti tag coimmunoprecipitation 19446323 physical association C 10 P53196 anti tag coimmunoprecipitation 11805837 association C 6 P53196 tandem affinity purification 17499717 association C 3 P33297 P53196 tandem affinity purification 17499717 physical association X 2 P53196 P09435 tandem affinity purification 19536198 association X 2 P53196 anti tag coimmunoprecipitation 19446322 physical association C 3 P53196 comigration in non denaturing gel electrophoresis 19446323 physical association C 3 P53196 comigration in non denaturing gel electrophoresis 19446323 physical association C 3 P53196 anti tag coimmunoprecipitation 11805837 association C 24 P53196 anti tag coimmunoprecipitation 11805837 association C 16 P53196 anti tag coimmunoprecipitation 19446323 association C 24 P53196 anti tag coimmunoprecipitation 11805837 association C 6 P53196 anti tag coimmunoprecipitation 19446323 association C 23 P53196 anti tag coimmunoprecipitation 19446323 physical association C 5 P53196 anti tag coimmunoprecipitation 19446323 physical association C 10 P11484 P53196 tandem affinity purification 19536198 association X 2 P38348 P53196 anti tag coimmunoprecipitation 19446322 physical association X 2 P53196 Q01939 tandem affinity purification 16554755 physical association X 2 P53196 Q01939 tandem affinity purification 16554755 physical association X 2 P53196 Q01939 two hybrid 18719252 physical association X 2 P53196 Q01939 two hybrid 19446323 physical association X 2 P53196 P25491 tandem affinity purification 19536198 association X 2 P50086 P53196 two hybrid 18719252 physical association X 2 P50086 P53196 comigration in non denaturing gel electrophoresis 19446323 physical association X 2 P53196 mass spectrometry studies of complexes 11805837 - C 28 P53196 mass spectrometry studies of complexes 11805837 - C 20 P53196 mass spectrometry studies of complexes 11805837 - C 20

PPI - HINT Gene A Gene B PMID Method Quality HSM3 RPN14 19446323,19446323 0007,0404 LC RPN1 RPN14 21658604 0401 LC SSB2 RPN14 23332755 0401 LC NAS6 RPN14 19446323,18719252,19446323,19446323 0007,0018,0404,0004 LC,HT RPN14 RPN14 22691779 0114 LC RPN14 RPT6 19446323,18719252,19446323,23562395,23562395,23562395,19446323,23562395 0007,0018,0018,0028,0096,0077,0004,0114 LC,HT RPN13 RPN14 19446323,11805837,11805837 0007,0004,0007 LC,HT SEM1 RPN14 19446323 0007 LC TDH1 RPN14 11805837 0007 HT LEU2 RPN14 11805837 0007 HT GAL1 RPN14 11805837 0007 HT PDC1 RPN14 11805837 0007 HT SSA3 RPN14 19536198,11805837 0676,0007 HT SSC1 RPN14 11805837 0007 HT SSB1 RPN14 19536198 0676 HT PGI1 RPN14 11805837 0007 HT FBA1 RPN14 11805837 0007 HT HSP26 RPN14 11805837 0007 HT VMA2 RPN14 11805837 0007 HT PRE1 RPN14 19412160 0096 LC MIR1 RPN14 11805837 0007 HT YDJ1 RPN14 19536198 0676 HT IDH2 RPN14 11805837 0007 HT IDH1 RPN14 11805837 0007 HT RPN12 RPN14 19446323 0007 LC RPN2 RPN14 19446323,19446323,11805837 0007,0004,0007 LC,HT RPT5 RPN14 19446323,11805837,19412159,17499717,19446323,17499717,11805837 0007,0004,0004,0004,0004,0676,0007 LC,HT RPT3 RPN14 26301997,19446323,24013205,11805837,11805837,19446323 0096,0007,0004,0007,0004,0004 LC,HT RPT1 RPN14 26301997,19446323,19412160,23644457,11805837,24013205,19412159,23562395,19412160,23562395,19446323,11805837 0096,0007,0004,0004,0004,0004,0004,0004,0096,0096,0004,0007 LC,HT HSM3 RPN14 19446323,11805837,20471945,19446323,19446322,19446322,11805837 0007,0004,0004,0404,0007,0004,0007 LC,HT ECM29 RPN14 21321079 0004 LC RPN1 RPN14 19446323,11805837,21658604,19446323,11805837 0007,0004,0401,0004,0007 LC,HT WSS1 RPN14 26349035 0004 LC RPN10 RPN14 19446323,11805837,11805837 0007,0004,0007 LC,HT MET10 RPN14 11805837 0007 HT RPN3 RPN14 19446323,11805837,19446323,11805837 0007,0004,0004,0007 LC,HT SSB2 RPN14 23332755 0401 LC RPT2 RPN14 19446323,11805837,19446323,11805837 0007,0004,0004,0007 LC,HT MPM1 RPN14 11805837 0007 HT LYS12 RPN14 11805837 0007 HT NAS2 RPN14 19446323,20471945 0007,0004 LC RPN11 RPN14 19446323,11805837,19412159,17499717,19446323,17499717,11805837 0007,0004,0004,0004,0004,0676,0007 LC,HT UBP6 RPN14 19446323 0007 LC ALD4 RPN14 11805837 0007 HT NAS6 RPN14 19446323,11805837,19446323,19446323,11805837 0007,0004,0404,0004,0007 LC,HT RPN14 RPT4 19446323,19412159,11805837,19446323,11805837 0007,0096,0004,0004,0007 LC,HT RPN14 ALD6 11805837 0007 HT RPN14 RPT6 19446323,16554755,19446323,23562395,19412159,11805837,19412159,23562395,23562395,19446323,23562395,16554755 0007,0676,0018,0028,0004,0007,0096,0096,0077,0004,0114,0004 LC,HT RPN14 RVB1 11805837 0007 HT RPN14 RPN9 19446323,11805837,19446323,11805837 0007,0004,0004,0007 LC,HT RPN14 CSI1 16554755 0363 HT RPN14 RPN7 19446323,11805837,19446323,11805837 0007,0004,0004,0007 LC,HT RPN14 RPN8 19446323,11805837,19446323,11805837,19412159 0007,0004,0004,0007,0004 LC,HT RPN14 RPN5 19446323,11805837,21289098,19446323,11805837 0007,0004,0004,0004,0007 LC,HT RPN14 RPN6 19446323,11805837,19446323,11805837 0007,0004,0004,0007 LC,HT RPN14 RVB2 11805837,11805837 0004,0007 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P53196 P15992 RPN14 HSP26 0.126 11805837 P53196 P14540 RPN14 FBA1 0.126 11805837 P53196 P12398 RPN14 SSC1 0.126 11805837 P53196 O13563 RPN14 RPN13 0.416 11805837,19446323 P53196 P11484 RPN14 SSB1 0.126 19536198 P53196 P00360 RPN14 TDH1 0.126 11805837 P53196 O94742 RPN14 SEM1 0.126 19446323 P53196 P06169 RPN14 PDC1 0.126 11805837 P53196 P04385 RPN14 GAL1 0.126 11805837 P53196 P25491 RPN14 YDJ1 0.126 19536198 P53196 P23641 RPN14 MIR1 0.126 11805837 P53196 P33298 RPN14 RPT3 0.692 11805837,19446323,26301997 P53196 P40016 RPN14 RPN3 0.416 11805837,19446323 P53196 P38886 RPN14 RPN10 0.416 11805837,19446323 P53196 P40327 RPN14 RPT2 0.416 11805837,19446323 P53196 P43593 RPN14 UBP6 0.21 19446323 Q08723 P53196 RPN8 RPN14 0.472 11805837,19412159,19446323 Q04062 P53196 RPN9 RPN14 0.416 11805837,19446323 Q06103 P53196 RPN7 RPN14 0.416 11805837,19446323 Q12250 P53196 RPN5 RPN14 0.49 11805837,21289098,19446323 Q12377 P53196 RPN6 RPN14 0.416 11805837,19446323 Q12464 P53196 RVB2 RPN14 0.21 11805837 Q12221 P53196 PUF2 RPN14 0.126 26668354 P53196 P16140 RPN14 VMA2 0.126 11805837 P53196 P12709 RPN14 PGI1 0.126 11805837 P53196 P09435 RPN14 SSA3 0.21 11805837,19536198 P53196 P04173 RPN14 LEU2 0.126 11805837 Q01939 P53196 RPT6 RPN14 0.908 19412159,23562395,18719252,19446323,16554755,11805837 P53196 P32565 RPN14 RPN2 0.416 11805837,19446323 P53196 P32496 RPN14 RPN12 0.236 19446323 P53196 P38348 RPN14 HSM3 0.702 19446322,20471945,19446323,11805837 P53196 P33299 RPN14 RPT1 0.848 19412159,23562395,26301997,19446323,19412160,23644457,11805837 P53549 P53196 RPT4 RPN14 0.636 11805837,19412159,19446323 P53196 P28241 RPN14 IDH2 0.126 11805837 P53196 P38764 RPN14 RPN1 0.49 11805837,21658604,19446323 P53196 P38838 RPN14 WSS1 0.126 26349035 P53196 P39692 RPN14 MET10 0.126 11805837 P53196 P33297 RPN14 RPT5 0.722 19412159,19446323,11805837,17499717 P53196 P40150 RPN14 SSB2 0.126 23332755 P53196 P28834 RPN14 IDH1 0.126 11805837 P53196 P40364 RPN14 MPM1 0.126 11805837 P53196 P43588 RPN14 RPN11 0.597 19412159,19446323,11805837,17499717 P53196 P40495 RPN14 LYS12 0.126 11805837 P53196 P40555 RPN14 NAS2 0.507 19446323,20471945 P53196 P46367 RPN14 ALD4 0.126 11805837 P53196 P50086 RPN14 NAS6 0.648 11805837,18719252,19446323 Q03940 P53196 RVB1 RPN14 0.126 11805837 P54115 P53196 ALD6 RPN14 0.126 11805837 Q04368 P53196 CSI1 RPN14 0.126 16554755