PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus HSP78 MMS2 19536198 intact exp MMS2 RCN2 11805837 biogrid,mint,intact,dip exp ERR3 MMS2 16554755 biogrid,i2d,mint,intact exp SSB1 MMS2 19536198 intact exp MMS2 SLF1 22271760 biogrid exp RVS167 MMS2 i2d exp RSM22 MMS2 i2d exp ARG3 MMS2 11805837 dip exp SSA1 MMS2 19536198 intact exp MMS2 APL4 i2d exp TFC3 MMS2 i2d exp SRO9 MMS2 22271760 biogrid exp SIR4 MMS2 i2d exp RVS161 MMS2 i2d exp RRP1 MMS2 i2d exp IRA2 MMS2 11805837 biogrid,mint,intact,dip exp UBI4 MMS2 16980971 biogrid exp NAB2 MMS2 19840948 biogrid exp RSP5 MMS2 11805837, 23023127 biogrid,mint,intact,dip exp, pred MMS2 Uncharacterized membrane glycoprotein YNR065C 18467557, 23023127 biogrid,i2d,mint,intact exp, pred SIP5 MMS2 22615397,18467557,16554755, 23023127 biogrid,i2d,mint,intact exp, pred UBC13 MMS2 10880451,16980971,22615397,18467557,12496280,10089880,16554755,18719252,11805837,11440714,11369780, 23023127 biogrid,i2d,mint,intact,dip exp, pred MMS2 UBC7 14690591, 23023127 intact exp, pred UBA1 MMS2 ortho UBP6 MMS2 ortho MMS2 ZPR1 ortho RHO1 MMS2 ortho VMA2 MMS2 ortho SEC23 MMS2 ortho RAD23 MMS2 23023127 ortho, pred UBC12 MMS2 23023127 ortho, pred RAD6 MMS2 23023127 ortho, pred MPE1 MMS2 23023127 pred RAD52 MMS2 23023127 pred UBC4 MMS2 23023127 pred MMS2 UBI4 23023127 pred UBC1 MMS2 23023127 pred REV1 MMS2 23023127 pred UBC11 MMS2 23023127 pred MMS2 HUB1 23023127 pred MMS2 UBX3 23023127 pred PAN2 MMS2 23023127 pred MMS2 TFB3 23023127 pred UBC6 MMS2 23023127 pred POL30 MMS2 23023127 pred RAD18 MMS2 23023127 pred MMS2 SGT1 23023127 pred UBX6 MMS2 23023127 pred UBC8 MMS2 23023127 pred POL31 MMS2 23023127 pred MMS2 RAD30 23023127 pred UBC5 MMS2 23023127 pred UBX7 MMS2 23023127 pred PEX4 MMS2 23023127 pred UBC9 MMS2 23023127 pred POL3 MMS2 23023127 pred CDC34 MMS2 23023127 pred REV3 MMS2 23023127 pred RAD5 MMS2 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P53152 - 11805837 - C 4 P53152 - 11805837 - C 6 P52490 P53152 - 11440714 - X 2 P52490 P53152 - 11440714 - X 2 P53152 - 11805837 - C 3 P53152 - 11805837 - C 3 P53152 Q94A97 two hybrid 16786304 direct interaction X 2 P53152 Q12044 affinity chromatography technology 11805837 physical association X 2 P0CG63 P53152 x-ray crystallography 16980971 association X 2 P0CG63 P53152 affinity chromatography technology 22106047 physical association X 2 P19158 P53152 affinity chromatography technology 11805837 physical association X 2 P42222 P53152 affinity chromatography technology 16554755 physical association X 2 P52490 P53152 affinity chromatography technology 10880451 physical association X 2 P52490 P53152 pull down 12496280 direct interaction X 2 P52490 P53152 pull down 12496280 direct interaction X 2 P52490 P53152 two hybrid 10880451 direct interaction X 2 P52490 P53152 two hybrid 10880451 direct interaction X 2 P52490 P53152 pull down 11369780 direct interaction X 2 P52490 P53152 pull down 11369780 direct interaction X 2 P52490 P53152 pull down 10089880 direct interaction X 2 P52490 P53152 pull down 10089880 direct interaction X 2 P52490 P53152 x-ray crystallography 11440714 association X 2 P52490 P53152 biochemical 11369780 association X 2 P52490 P53152 biochemical 10089880 association X 2 P52490 P53152 biochemical 11504715 association X 2 P52490 P53152 two hybrid 12496280 direct interaction X 2 P52490 P53152 affinity chromatography technology 16554755 physical association X 2 P52490 P53152 affinity chromatography technology 17200106 physical association X 2 P52490 P53152 x-ray crystallography 16980971 association X 2 P52490 P53152 protein complementation assay 18467557 direct interaction X 2 P52490 P53152 two hybrid 18719252 direct interaction X 2 P52490 P53152 affinity chromatography technology 11805837 physical association X 2 P52490 P53152 affinity chromatography technology 11805837 physical association X 2 P52490 P53152 protein complementation assay 22615397 direct interaction X 2 P53751 P53152 protein complementation assay 18467557 direct interaction X 2 P53152 two hybrid 20556485 direct interaction X 2 P53152 A0A024R5T5 pull down 23751493 direct interaction X 2 P40210 P53152 affinity chromatography technology 16554755 physical association X 2 P40210 P53152 protein complementation assay 18467557 direct interaction X 2 P40210 P53152 protein complementation assay 22615397 direct interaction X 2 Q9FZ48-2 P53152 two hybrid 16786304 direct interaction X 2 P39940 P53152 affinity chromatography technology 11805837 physical association X 2 P53152 anti tag coimmunoprecipitation 11805837 - C 4 P53152 anti tag coimmunoprecipitation 11805837 - C 4 P53152 anti tag coimmunoprecipitation 11805837 - C 6 P53152 Q12044 anti tag coimmunoprecipitation 11805837 physical association X 2 P19158 P53152 anti tag coimmunoprecipitation 11805837 physical association X 2 P52490 P53152 anti tag coimmunoprecipitation 11805837 covalent binding X 2 P52490 P53152 x-ray crystallography 11440714 covalent binding X 2 P52490 P53152 anti tag coimmunoprecipitation 11805837 covalent binding X 2 P52490 P53152 anti tag coimmunoprecipitation 11805837 covalent binding X 2 P52490 P53152 two hybrid 10880451 covalent binding X 2 P52490 P53152 affinity chromatography technology 11369780 covalent binding X 2 P52490 P53152 biochemical 11369780 covalent binding X 2 P52490 P53152 comigration in sds page 16980971 covalent binding X 2 P52490 P53152 coimmunoprecipitation 10880451 covalent binding X 2 P52490 P53152 anti tag coimmunoprecipitation 11805837 covalent binding X 2 P53152 anti tag coimmunoprecipitation 11805837 - C 3 P53152 x-ray crystallography 16980971 physical association C 3 P53152 anti tag coimmunoprecipitation 11805837 - C 3 P53152 anti tag coimmunoprecipitation 11805837 - C 11 P53152 anti tag coimmunoprecipitation 11805837 - C 10 P53152 P05150 anti tag coimmunoprecipitation 11805837 physical association X 2 P39940 P53152 anti tag coimmunoprecipitation 11805837 physical association X 2 P53152 anti tag coimmunoprecipitation 11805837 association C 5 P53152 anti tag coimmunoprecipitation 11805837 association C 6 P53152 Q94A97 two hybrid 16786304 physical association X 2 P42222 P53152 tandem affinity purification 16554755 physical association X 2 P52490 P53152 x-ray crystallography 11440714 direct interaction X 2 P52490 P53152 tandem affinity purification 16554755 physical association X 2 P52490 P53152 tandem affinity purification 16554755 physical association X 2 P52490 P53152 tandem affinity purification 16554755 physical association X 2 P52490 P53152 tandem affinity purification 16554755 physical association X 2 P52490 P53152 tandem affinity purification 16554755 physical association X 2 P52490 P53152 tandem affinity purification 16554755 physical association X 2 P52490 P53152 dihydrofolate reductase reconstruction 18467557 physical association X 2 P52490 P53152 dihydrofolate reductase reconstruction 18467557 physical association X 2 P52490 P53152 two hybrid 18719252 physical association X 2 P53751 P53152 dihydrofolate reductase reconstruction 18467557 physical association X 2 P53152 inferred by author 16554755 association C 3 P11484 P53152 tandem affinity purification 19536198 association X 2 P53152 P33416 tandem affinity purification 19536198 association X 2 P40210 P53152 tandem affinity purification 16554755 physical association X 2 P40210 P53152 tandem affinity purification 16554755 physical association X 2 P40210 P53152 tandem affinity purification 16554755 physical association X 2 P40210 P53152 dihydrofolate reductase reconstruction 18467557 physical association X 2 P40210 P53152 dihydrofolate reductase reconstruction 18467557 physical association X 2 Q02159 P53152 two hybrid array 14690591 physical association X 2 Q9FZ48 P53152 two hybrid 16786304 physical association X 2 P10591 P53152 tandem affinity purification 19536198 association X 2 P53152 mass spectrometry studies of complexes 11805837 - C 4 P53152 mass spectrometry studies of complexes 11805837 - C 7 P53152 mass spectrometry studies of complexes 11805837 - C 4 P53152 mass spectrometry studies of complexes 11805837 - C 4 P48363 P53152 interaction detection method 14764870 - X 2 Q04493 P53152 interaction detection method 14764870 - X 2 Q01454 P53152 interaction detection method 14764870 - X 2 P53152 mass spectrometry studies of complexes 11805837 - C 5 P53152 mass spectrometry studies of complexes 11805837 - C 5 P53152 P40005 interaction detection method 14764870 - X 2 P52553 P53152 interaction detection method 14764870 - X 2

PPI - HINT Gene A Gene B PMID Method Quality UBI4 MMS2 16980971 0114 LC SIP5 MMS2 18467557,18467557,22615397 0111,0090,0090 HT,LC UBC13 MMS2 18467557,12496280,11504715,11369780,11440714,11369780,10880451,10880451,16980971,12496280,10880451,10089880,22615397,18719252,11369780,18467557,16980971,10089880 0111,0096,0401,0096,0114,0401,0004,0019,0808,0018,0018,0096,0090,0018,0004,0090,0114,0401 HT,LC MMS2 P53751 18467557,18467557 0111,0090 HT MMS2 UBC7 14690591 0397 LC ARG3 MMS2 11805837 0007 HT UBI4 MMS2 22106047 0004 LC SSA1 MMS2 19536198 0676 HT SSB1 MMS2 19536198 0676 HT IRA2 MMS2 11805837,11805837 0004,0007 HT NAB2 MMS2 19840948 0004 LC HSP78 MMS2 19536198 0676 HT RSP5 MMS2 11805837,11805837 0004,0007 HT SIP5 MMS2 16554755,16554755,16554755 0363,0676,0004 HT ERR3 MMS2 16554755,16554755 0676,0004 HT UBC13 MMS2 12496280,11504715,11369780,17200106,11369780,10880451,10880451,12496280,11805837,16554755,16554755,10880451,10089880,11805837,16554755,11369780,10089880 0096,0401,0096,0004,0401,0004,0019,0018,0004,0363,0676,0018,0096,0007,0004,0004,0401 LC,HT MMS2 RCN2 11805837,11805837 0004,0007 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P53152 P0CG63 MMS2 UBI4 0.309 16980971 P53152 P39940 MMS2 RSP5 0.286 11805837 P53152 P11484 MMS2 SSB1 0.126 19536198 P53152 P19158 MMS2 IRA2 0.286 11805837 Q02159 P53152 UBC7 MMS2 0.126 14690591 P53751 P53152 P53751 MMS2 0.126 18467557 Q9FZ48 P53152 UBC36 MMS2 0.523 16786304 Q12034 P53152 SLF1 MMS2 0.126 22271760 Q12044 P53152 RCN2 MMS2 0.332 11805837 P53152 P25567 MMS2 SRO9 0.126 22271760 Q6ZNA4 P53152 RNF111 MMS2 0.309 23751493 P53152 P10591 MMS2 SSA1 0.126 19536198 P53152 P05150 MMS2 ARG3 0.126 11805837 P53152 P42222 MMS2 ERR3 0.236 16554755 P53152 P40210 MMS2 SIP5 0.49 16554755,18467557 P53152 P52490 MMS2 UBC13 0.982 11440714,18467557,12496280,16554755,11805837,16980971,11369780,10880451,18719252 Q94A97 P53152 UBC35 MMS2 0.523 16786304 P53152 P32505 MMS2 NAB2 0.126 19840948 P53152 P33416 MMS2 HSP78 0.126 19536198