PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus PAN1 PAN2 1339314 i2d,dip exp SSA3 PAN2 19536198 intact exp DUR3 PAN2 i2d exp SSB2 PAN2 19536198 intact exp PAN2 RNH1 i2d exp PAN2 PUF3 23409723 biogrid exp SSA2 PAN2 16429126 intact exp PRO3 PAN2 i2d exp ARO1 PAN2 i2d exp AAR2 PAN2 16429126 intact exp PAN2 CAB5 i2d exp DBP7 PAN2 i2d exp PAN2 HSP42 19536198 intact exp SSE1 PAN2 19536198 intact exp GLO1 PAN2 i2d exp PAN2 RPN6 i2d exp EMW1 PAN2 i2d exp PAN2 Maf-like protein YOR111W i2d exp RPE1 PAN2 i2d exp SBP1 PAN2 23222640 biogrid exp SSB1 PAN2 16429126,19536198 intact exp PAN3 PAN2 16429126,24880344,24872509,16554755,18719252,11805826,20826334,15169912,8816488, 23023127 biogrid,i2d,mint,intact,dip exp, ortho, pred PAB1 PAN2 16429126, 23023127 biogrid,intact exp, ortho, pred DEF1 PAN2 18467557, 23023127 biogrid,i2d,mint,intact exp, pred PRP40 PAN2 16429126, 23023127 biogrid,intact exp, pred NAB2 PAN2 19840948, 23023127 biogrid exp, pred SEM1 PAN2 16554755, 23023127 biogrid,i2d,mint,intact exp, pred PAN2 PBP1 15169912, 23023127 biogrid exp, pred PAN2 PAN2 11805826, 23023127 mint,intact exp, pred ATP1 PAN2 ortho NIC96 PAN2 ortho CCT7 PAN2 ortho RPS2 PAN2 ortho MYO2 PAN2 ortho PAN2 CBK1 ortho FRS2 PAN2 ortho RPL3 PAN2 ortho RPS3 PAN2 ortho PAN2 COF1 ortho CCT5 PAN2 ortho PRT1 PAN2 ortho PAN2 RVB2 ortho TUB2 PAN2 ortho PAN2 RPT6 ortho PAN2 SMD2 ortho CCT3 PAN2 ortho CAP1 PAN2 ortho CCT4 PAN2 ortho CDC19 PAN2 ortho RPL30 PAN2 ortho CAP2 PAN2 ortho MRE11 PAN2 ortho CCT8 PAN2 ortho PAN2 CRN1 ortho PAN2 TIF35 ortho GPA1 PAN2 ortho RPS5 PAN2 ortho CCT6 PAN2 ortho RPS31 PAN2 ortho RPL32 PAN2 ortho PAN2 GIS2 ortho RFA1 PAN2 ortho TRX3 PAN2 ortho SNU114 PAN2 ortho YDJ1 PAN2 ortho CHC1 PAN2 ortho KAR2 PAN2 ortho RPL5 PAN2 ortho RPL28 PAN2 ortho NOP1 PAN2 ortho TIF34 PAN2 ortho ASC1 PAN2 ortho PAN2 RAT1 ortho RFA2 PAN2 ortho RPL22A PAN2 ortho RPP0 PAN2 ortho ARC40 PAN2 ortho PAN2 RIO1 ortho PAN2 RVB1 ortho CCT2 PAN2 ortho RPS7B PAN2 ortho RPS12 PAN2 ortho HSP60 PAN2 ortho TUF1 PAN2 ortho PAN2 BRX1 ortho TCP1 PAN2 ortho VMA2 PAN2 ortho PAC10 PAN2 ortho SSC1 PAN2 ortho PCF11 PAN2 23023127 pred PAN2 CTK1 23023127 pred RAD6 PAN2 23023127 pred PAN2 MMS2 23023127 pred PAN2 HRP1 23023127 pred RNA14 PAN2 23023127 pred RNA15 PAN2 23023127 pred POL30 PAN2 23023127 pred SHP1 PAN2 23023127 pred PAN2 THO2 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P04147 P53010 - 8550599 - X 2 P36102 P53010 - 11805826 - X 2 P36102 P53010 - 15044803 - X 2 P0CG63 P53010 biochemical 23583075 association X 2 P53010 P33203 affinity chromatography technology 16429126 physical association X 2 P53297 P53010 two hybrid 15169912 direct interaction X 2 P04147 P53010 affinity chromatography technology 16429126 physical association X 2 P53010 O94742 affinity chromatography technology 16554755 physical association X 2 P36102 P53010 affinity chromatography technology 8816488 physical association X 2 P36102 P53010 two hybrid 8816488 direct interaction X 2 P36102 P53010 two hybrid 15169912 direct interaction X 2 P36102 P53010 biochemical 8816488 association X 2 P36102 P53010 x-ray crystallography 24880344 association X 2 P36102 P53010 pull down 24880344 direct interaction X 2 P36102 P53010 affinity chromatography technology 16554755 physical association X 2 P36102 P53010 affinity chromatography technology 16429126 physical association X 2 P36102 P53010 affinity chromatography technology 17200106 physical association X 2 P36102 P53010 two hybrid 18719252 direct interaction X 2 P36102 P53010 affinity chromatography technology 20826334 physical association X 2 P36102 P53010 affinity chromatography technology 11805826 physical association X 2 P35732 P53010 protein complementation assay 18467557 direct interaction X 2 P32521 P53010 biochemical 1339314 physical association X 2 P36102 P53010 inferred by author 11805826 physical association X 2 P36102 P53010 tandem affinity purification 11805826 physical association X 2 P53010 tandem affinity purification 16429126 association C 5 P53010 tandem affinity purification 16429126 association C 12 P53010 inferred by author 16429126 physical association C 62 P32589 P53010 tandem affinity purification 19536198 association X 2 P11484 P53010 tandem affinity purification 19536198 association X 2 P53010 P09435 tandem affinity purification 19536198 association X 2 P53010 Q12329 tandem affinity purification 19536198 association X 2 P53010 inferred by author 16429126 physical association C 3 P53010 tandem affinity purification 11805826 association C 3 P53010 tandem affinity purification 11805826 association C 3 P53010 O94742 tandem affinity purification 16554755 physical association X 2 P53010 O94742 tandem affinity purification 16554755 physical association X 2 P53010 O94742 tandem affinity purification 16554755 physical association X 2 P53010 O94742 tandem affinity purification 16554755 physical association X 2 P36102 P53010 inferred by author 16429126 physical association X 2 P36102 P53010 inferred by author 16554755 association X 2 P36102 P53010 tandem affinity purification 16554755 physical association X 2 P36102 P53010 tandem affinity purification 16554755 physical association X 2 P36102 P53010 tandem affinity purification 16554755 physical association X 2 P36102 P53010 tandem affinity purification 16554755 physical association X 2 P36102 P53010 two hybrid 18719252 physical association X 2 P36102 P53010 pull down 24872509 direct interaction X 2 P36102 P53010 ion mobility mass spectrometry of complexes 24872509 direct interaction X 2 P40150 P53010 tandem affinity purification 19536198 association X 2 P35732 P53010 dihydrofolate reductase reconstruction 18467557 physical association X 2 P32521 P53010 coimmunoprecipitation 1339314,8550599 - X 2 P53010 mass spectrometry studies of complexes 11805826 - C 3 P53010 mass spectrometry studies of complexes 11805826 - C 3 P36102 P53010 two hybrid - - X 2

PPI - HINT Gene A Gene B PMID Method Quality PAN1 PAN2 1339314,8550599,1339314 0401,0019,0019 LC DEF1 PAN2 18467557,18467557 0111,0090 HT PAN3 PAN2 8816488,15169912,24880344,8816488,8816488,24880344,18719252 0401,0018,0114,0018,0004,0096,0018 LC,HT PAN2 PAN2 24880344 0114 LC PAN2 PBP1 15169912 0018 LC SEM1 PAN2 16554755,16554755 0676,0004 HT PAB1 PAN2 16429126,16429126,16429126 0004,0676,0363 HT SSA3 PAN2 19536198 0676 HT SSA2 PAN2 16429126 0676 HT SSB1 PAN2 19536198,16429126 0676,0676 HT AAR2 PAN2 16429126 0363 HT NAB2 PAN2 19840948 0004 LC PAN1 PAN2 1339314,1339314 0401,0019 LC SSE1 PAN2 19536198 0676 HT PRP40 PAN2 16429126,16429126 0676,0004 HT PAN3 PAN2 17200106,8816488,20826334,11805826,24880344,8816488,8816488,16429126,24872509,24880344,16554755,16554755,16429126,11805826,16554755,16429126,11805826,24872509,11805826 0004,0401,0004,0363,0114,0018,0004,0363,0096,0096,0363,0676,0676,0004,0004,0004,0676,1246,0007 HT,LC SSB2 PAN2 19536198 0676 HT PAN2 PAN2 11805826,11805826 0676,0007 HT PAN2 HSP42 19536198 0676 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P53010 P10080 PAN2 SBP1 0.126 23222640 P53010 P04147 PAN2 PAB1 0.332 16429126 P53010 P11484 PAN2 SSB1 0.236 16429126,19536198 P53010 P36102 PAN2 PAN3 0.988 16429126,16554755,20826334,15169912,8816488,24872509,18719252,24880344,11805826 P53010 P32357 PAN2 AAR2 0.126 16429126 P53010 P32505 PAN2 NAB2 0.126 19840948 P53010 P33203 PAN2 PRP40 0.126 16429126 P53010 P35732 PAN2 DEF1 0.126 18467557 P53010 P40150 PAN2 SSB2 0.126 19536198 Q07807 P53010 PUF3 PAN2 0.126 23409723 P53010 P09435 PAN2 SSA3 0.126 19536198 P53010 O94742 PAN2 SEM1 0.332 16554755 P53010 P32589 PAN2 SSE1 0.126 19536198 P53010 P32521 PAN2 PAN1 0.033 1339314 P53010 P10592 PAN2 SSA2 0.126 16429126 P53010 P53010 PAN2 PAN2 0.155 11805826 P53297 P53010 PBP1 PAN2 0.309 15169912 Q12329 P53010 HSP42 PAN2 0.126 19536198